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Found 2 hits Enz. Inhib. hit(s) with Target = 'Rhomboid protease (AfROM)' AND taxid = 224325   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rhomboid protease (AfROM)


(Archaeoglobus fulgidus (AfROM))
BDBM165195
PNG
((4S)‐4‐(pent‐4‐yn‐1&...)
Show SMILES COc1cc(cc(OC)c1OC)[C@H]1[C@H](CCCC#C)OC1=O
Show InChI InChI=1/C17H20O5/c1-5-6-7-8-12-15(17(18)22-12)11-9-13(19-2)16(21-4)14(10-11)20-3/h1,9-10,12,15H,6-8H2,2-4H3/t12-,15-/s2
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 5.00E+3n/an/an/an/a7.437



Technische Universität München



Assay Description
We selected several inhibitor structures and determined their apparent IC50 by competitive ABPP.


Citation and Details
More data for this
Ligand-Target Pair
Rhomboid protease (AfROM)


(Archaeoglobus fulgidus (AfROM))
BDBM50199883
PNG
(3,4‐Dichloroisocoumarin (2) | 3,4-Dichloro-i...)
Show SMILES Clc1oc(=O)c2ccccc2c1Cl
Show InChI InChI=1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 8.10E+3n/an/an/an/a7.437



Technische Universität München



Assay Description
We selected several inhibitor structures and determined their apparent IC50 by competitive ABPP.


Citation and Details
More data for this
Ligand-Target Pair