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Found 3 hits Enz. Inhib. hit(s) with Target = 'Rhomboid protease (HiGlpG)' AND taxid = 727   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rhomboid protease (HiGlpG)


(Haemophilus influenzae (g-Proteobacteria))
BDBM50199883
PNG
(3,4‐Dichloroisocoumarin (2) | 3,4-Dichloro-i...)
Show SMILES Clc1oc(=O)c2ccccc2c1Cl
Show InChI InChI=1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
PDB

GoogleScholar
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CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 660n/an/an/an/a7.437



Technische Universität München



Assay Description
We selected several inhibitor structures and determined their apparent IC50 by competitive ABPP.


Citation and Details
More data for this
Ligand-Target Pair
Rhomboid protease (HiGlpG)


(Haemophilus influenzae (g-Proteobacteria))
BDBM165194
PNG
(4‐Chloro‐7‐nitro‐3‐[...)
Show SMILES [O-][N+](=O)c1ccc2c(Cl)c(OCCCCCc3ccccc3)oc(=O)c2c1
Show InChI InChI=1S/C20H18ClNO5/c21-18-16-11-10-15(22(24)25)13-17(16)19(23)27-20(18)26-12-6-2-5-9-14-7-3-1-4-8-14/h1,3-4,7-8,10-11,13H,2,5-6,9,12H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 4.60E+3n/an/an/an/a7.437



Technische Universität München



Assay Description
We selected several inhibitor structures and determined their apparent IC50 by competitive ABPP.


Citation and Details
More data for this
Ligand-Target Pair
Rhomboid protease (HiGlpG)


(Haemophilus influenzae (g-Proteobacteria))
BDBM165195
PNG
((4S)‐4‐(pent‐4‐yn‐1&...)
Show SMILES COc1cc(cc(OC)c1OC)[C@H]1[C@H](CCCC#C)OC1=O
Show InChI InChI=1/C17H20O5/c1-5-6-7-8-12-15(17(18)22-12)11-9-13(19-2)16(21-4)14(10-11)20-3/h1,9-10,12,15H,6-8H2,2-4H3/t12-,15-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 6.50E+4n/an/an/an/a7.437



Technische Universität München



Assay Description
We selected several inhibitor structures and determined their apparent IC50 by competitive ABPP.


Citation and Details
More data for this
Ligand-Target Pair