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Found 4 hits Enz. Inhib. hit(s) with Target = 'Rhomboid protease (TmROM)' AND taxid = 243274   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rhomboid protease (TmROM)


(Thermotoga maritima (Thermotogales))
BDBM50199883
PNG
(3,4‐Dichloroisocoumarin (2) | 3,4-Dichloro-i...)
Show SMILES Clc1oc(=O)c2ccccc2c1Cl
Show InChI InChI=1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 1.00E+3n/an/an/an/a7.437



Technische Universität München



Assay Description
We selected several inhibitor structures and determined their apparent IC50 by competitive ABPP.


Citation and Details
More data for this
Ligand-Target Pair
Rhomboid protease (TmROM)


(Thermotoga maritima (Thermotogales))
BDBM165196
PNG
((4S)‐4‐(pent‐4‐yn‐1&...)
Show SMILES CCCCC[C@H]1[C@H](CCCC#C)OC1=O
Show InChI InChI=1/C13H20O2/c1-3-5-7-9-11-12(15-13(11)14)10-8-6-4-2/h2,11-12H,3,5-10H2,1H3/t11-,12-/s2
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.70E+4n/an/an/an/a7.437



Technische Universität München



Assay Description
We selected several inhibitor structures and determined their apparent IC50 by competitive ABPP.


Citation and Details
More data for this
Ligand-Target Pair
Rhomboid protease (TmROM)


(Thermotoga maritima (Thermotogales))
BDBM165194
PNG
(4‐Chloro‐7‐nitro‐3‐[...)
Show SMILES [O-][N+](=O)c1ccc2c(Cl)c(OCCCCCc3ccccc3)oc(=O)c2c1
Show InChI InChI=1S/C20H18ClNO5/c21-18-16-11-10-15(22(24)25)13-17(16)19(23)27-20(18)26-12-6-2-5-9-14-7-3-1-4-8-14/h1,3-4,7-8,10-11,13H,2,5-6,9,12H2
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 2.80E+4n/an/an/an/a7.437



Technische Universität München



Assay Description
We selected several inhibitor structures and determined their apparent IC50 by competitive ABPP.


Citation and Details
More data for this
Ligand-Target Pair
Rhomboid protease (TmROM)


(Thermotoga maritima (Thermotogales))
BDBM165197
PNG
((4S)‐3‐butyl‐4‐(pent‐...)
Show SMILES CCCC[C@H]1[C@H](CCCC#C)OC1=O
Show InChI InChI=1/C12H18O2/c1-3-5-7-9-11-10(8-6-4-2)12(13)14-11/h1,10-11H,4-9H2,2H3/t10-,11-/s2
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.80E+4n/an/an/an/a7.437



Technische Universität München



Assay Description
We selected several inhibitor structures and determined their apparent IC50 by competitive ABPP.


Citation and Details
More data for this
Ligand-Target Pair