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Compile Data Set for Download or QSAR

Found 18 hits Enz. Inhib. hit(s) with Target = 'Ribonuclease H' AND taxid = 83333   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50343049
PNG
((1S,3R,4R,5R)-3-[(E)-3-(3,4-Dihydroxy-phenyl)-acry...)
Show SMILES COC(=O)[C@]1(O)C[C@@H](O)[C@@H](O)[C@@H](C1)OC(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C17H20O9/c1-25-16(23)17(24)7-12(20)15(22)13(8-17)26-14(21)5-3-9-2-4-10(18)11(19)6-9/h2-6,12-13,15,18-20,22,24H,7-8H2,1H3/b5-3+/t12-,13-,15-,17+/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50343049
PNG
((1S,3R,4R,5R)-3-[(E)-3-(3,4-Dihydroxy-phenyl)-acry...)
Show SMILES COC(=O)[C@]1(O)C[C@@H](O)[C@@H](O)[C@@H](C1)OC(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C17H20O9/c1-25-16(23)17(24)7-12(20)15(22)13(8-17)26-14(21)5-3-9-2-4-10(18)11(19)6-9/h2-6,12-13,15,18-20,22,24H,7-8H2,1H3/b5-3+/t12-,13-,15-,17+/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50343045
PNG
((1R,2R,4S)-p-menthane-1,2,8-triol-1-O-beta-D-gluco...)
Show SMILES CC(C)(O)[C@H]1CC[C@@](C)(O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)C1
Show InChI InChI=1S/C16H30O8/c1-15(2,22)8-4-5-16(3,10(18)6-8)24-14-13(21)12(20)11(19)9(7-17)23-14/h8-14,17-22H,4-7H2,1-3H3/t8-,9-,10+,11-,12+,13-,14+,16+/m0/s1
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Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50343046
PNG
((4R)-p-menth-1-ene-7,8-diol-7-O-[beta-D-xylopyrano...)
Show SMILES CC(C)(O)[C@@H]1CCC(CO[C@H]2O[C@@H](CO[C@H]3OC[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@@H](O)[C@@H]2O)=CC1
Show InChI InChI=1S/C21H36O11/c1-21(2,28)11-5-3-10(4-6-11)7-29-20-18(27)16(25)15(24)13(32-20)9-31-19-17(26)14(23)12(22)8-30-19/h3,11-20,22-28H,4-9H2,1-2H3/t11-,12-,13-,14+,15-,16+,17-,18-,19+,20-/m0/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50343047
PNG
(CHEMBL1770694 | iso-dihydrodendranthemoside A)
Show SMILES C[C@H](O)CC[C@@]1(O)[C@@H](C)C[C@@H](CC1(C)C)O[C@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C19H36O8/c1-10-7-12(8-18(3,4)19(10,25)6-5-11(2)21)26-17-16(24)15(23)14(22)13(9-20)27-17/h10-17,20-25H,5-9H2,1-4H3/t10-,11-,12-,13-,14-,15+,16-,17-,19+/m0/s1
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Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50187665
PNG
((-)-epigallocatechin | CHEMBL47386)
Show SMILES O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50269651
PNG
(CHEMBL465208 | salidroside)
Show SMILES OC[C@H]1O[C@@H](OCCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50343048
PNG
(6''-O-galloylsalidroside | CHEMBL1770695)
Show SMILES O[C@H]1[C@H](O)[C@@H](COC(=O)c2cc(O)c(O)c(O)c2)O[C@@H](OCCc2ccc(O)cc2)[C@@H]1O
Show InChI InChI=1S/C21H24O11/c22-12-3-1-10(2-4-12)5-6-30-21-19(28)18(27)17(26)15(32-21)9-31-20(29)11-7-13(23)16(25)14(24)8-11/h1-4,7-8,15,17-19,21-28H,5-6,9H2/t15-,17-,18+,19-,21-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50241356
PNG
(4-[(1E)-3-hydroxyprop-1-en-1-yl]-2,6-dimethoxyphen...)
Show SMILES COc1cc(\C=C\CO)cc(OC)c1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C17H24O9/c1-23-10-6-9(4-3-5-18)7-11(24-2)16(10)26-17-15(22)14(21)13(20)12(8-19)25-17/h3-4,6-7,12-15,17-22H,5,8H2,1-2H3/b4-3+/t12-,13-,14+,15-,17+/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50241356
PNG
(4-[(1E)-3-hydroxyprop-1-en-1-yl]-2,6-dimethoxyphen...)
Show SMILES COc1cc(\C=C\CO)cc(OC)c1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C17H24O9/c1-23-10-6-9(4-3-5-18)7-11(24-2)16(10)26-17-15(22)14(21)13(20)12(8-19)25-17/h3-4,6-7,12-15,17-22H,5,8H2,1-2H3/b4-3+/t12-,13-,14+,15-,17+/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50343045
PNG
((1R,2R,4S)-p-menthane-1,2,8-triol-1-O-beta-D-gluco...)
Show SMILES CC(C)(O)[C@H]1CC[C@@](C)(O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)C1
Show InChI InChI=1S/C16H30O8/c1-15(2,22)8-4-5-16(3,10(18)6-8)24-14-13(21)12(20)11(19)9(7-17)23-14/h8-14,17-22H,4-7H2,1-3H3/t8-,9-,10+,11-,12+,13-,14+,16+/m0/s1
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Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50343046
PNG
((4R)-p-menth-1-ene-7,8-diol-7-O-[beta-D-xylopyrano...)
Show SMILES CC(C)(O)[C@@H]1CCC(CO[C@H]2O[C@@H](CO[C@H]3OC[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@@H](O)[C@@H]2O)=CC1
Show InChI InChI=1S/C21H36O11/c1-21(2,28)11-5-3-10(4-6-11)7-29-20-18(27)16(25)15(24)13(32-20)9-31-19-17(26)14(23)12(22)8-30-19/h3,11-20,22-28H,4-9H2,1-2H3/t11-,12-,13-,14+,15-,16+,17-,18-,19+,20-/m0/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50343047
PNG
(CHEMBL1770694 | iso-dihydrodendranthemoside A)
Show SMILES C[C@H](O)CC[C@@]1(O)[C@@H](C)C[C@@H](CC1(C)C)O[C@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C19H36O8/c1-10-7-12(8-18(3,4)19(10,25)6-5-11(2)21)26-17-16(24)15(23)14(22)13(9-20)27-17/h10-17,20-25H,5-9H2,1-4H3/t10-,11-,12-,13-,14-,15+,16-,17-,19+/m0/s1
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Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50187665
PNG
((-)-epigallocatechin | CHEMBL47386)
Show SMILES O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50269651
PNG
(CHEMBL465208 | salidroside)
Show SMILES OC[C@H]1O[C@@H](OCCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM50343048
PNG
(6''-O-galloylsalidroside | CHEMBL1770695)
Show SMILES O[C@H]1[C@H](O)[C@@H](COC(=O)c2cc(O)c(O)c(O)c2)O[C@@H](OCCc2ccc(O)cc2)[C@@H]1O
Show InChI InChI=1S/C21H24O11/c22-12-3-1-10(2-4-12)5-6-30-21-19(28)18(27)17(26)15(32-21)9-31-20(29)11-7-13(23)16(25)14(24)8-11/h1-4,7-8,15,17-19,21-28H,5-6,9H2/t15-,17-,18+,19-,21-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM33963
PNG
(vinylogous urea, NSC727448)
Show SMILES Cc1sc(NC(=O)c2ccco2)c(C(N)=O)c1C
Show InChI InChI=1S/C12H12N2O3S/c1-6-7(2)18-12(9(6)10(13)15)14-11(16)8-4-3-5-17-8/h3-5H,1-2H3,(H2,13,15)(H,14,16)
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n/an/a 7.30E+4n/an/an/an/a8.020



National Cancer Institute



Assay Description
RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H


(Escherichia coli (strain K12))
BDBM33045
PNG
(2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophe...)
Show SMILES NC(=O)c1c(N)sc2CCCCCc12
Show InChI InChI=1S/C10H14N2OS/c11-9(13)8-6-4-2-1-3-5-7(6)14-10(8)12/h1-5,12H2,(H2,11,13)
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n/an/a 1.00E+5n/an/an/an/a8.020



National Cancer Institute



Assay Description
RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...


Citation and Details
More data for this
Ligand-Target Pair