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Compile Data Set for Download or QSAR

Found 9 hits Enz. Inhib. hit(s) with Target = 'Ribonuclease H1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribonuclease H1


(Homo sapiens (Human))
BDBM33045
PNG
(2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophe...)
Show SMILES NC(=O)c1c(N)sc2CCCCCc12
Show InChI InChI=1S/C10H14N2OS/c11-9(13)8-6-4-2-1-3-5-7(6)14-10(8)12/h1-5,12H2,(H2,11,13)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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UniChem

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Article
PubMed
n/an/a 1.06E+4n/an/an/an/a8.020



National Cancer Institute



Assay Description
RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H1


(Homo sapiens (Human))
BDBM33963
PNG
(vinylogous urea, NSC727448)
Show SMILES Cc1sc(NC(=O)c2ccco2)c(C(N)=O)c1C
Show InChI InChI=1S/C12H12N2O3S/c1-6-7(2)18-12(9(6)10(13)15)14-11(16)8-4-3-5-17-8/h3-5H,1-2H3,(H2,13,15)(H,14,16)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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antibodypedia
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UniChem

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Article
PubMed
n/an/a 2.90E+4n/an/an/an/a8.020



National Cancer Institute



Assay Description
RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H1


(Homo sapiens (Human))
BDBM33419
PNG
(pyrimidinol carboxylic acid, 11)
Show SMILES OC(=O)c1nc(Cc2c(Br)sc3ccc(Cl)cc23)[nH]c(=O)c1O
Show InChI InChI=1S/C14H8BrClN2O4S/c15-12-7(6-3-5(16)1-2-8(6)23-12)4-9-17-10(14(21)22)11(19)13(20)18-9/h1-3,19H,4H2,(H,21,22)(H,17,18,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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PC cid
PC sid
UniChem
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Article
PubMed
n/an/a 4.85E+4n/an/an/an/a8.020



Gilead Sciences Inc.



Assay Description
Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H1


(Homo sapiens (Human))
BDBM50292881
PNG
(5-nitro-furan-2-carboxylic acid [[4-(4-bromo-pheny...)
Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)OCC(=O)N(CC1CCCO1)c1nc(cs1)-c1ccc(Br)cc1
Show InChI InChI=1S/C21H18BrN3O7S/c22-14-5-3-13(4-6-14)16-12-33-21(23-16)24(10-15-2-1-9-30-15)18(26)11-31-20(27)17-7-8-19(32-17)25(28)29/h3-8,12,15H,1-2,9-11H2
PDB
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 5.00E+4n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Inhibition of human RNase H1 by real time monitoring assay


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H1


(Homo sapiens (Human))
BDBM33418
PNG
(pyrimidinol carboxylic acid, 10)
Show SMILES COc1ccc(Cc2nc(C(O)=O)c(O)c(=O)[nH]2)cc1Br
Show InChI InChI=1S/C13H11BrN2O5/c1-21-8-3-2-6(4-7(8)14)5-9-15-10(13(19)20)11(17)12(18)16-9/h2-4,17H,5H2,1H3,(H,19,20)(H,15,16,18)
PDB
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UniChem

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Article
PubMed
n/an/a 7.40E+4n/an/an/an/a8.020



Gilead Sciences Inc.



Assay Description
Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H1


(Homo sapiens (Human))
BDBM33414
PNG
(CHEMBL440562 | pyrimidinol carboxylic acid, 6)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccccc1
Show InChI InChI=1S/C11H8N2O4/c14-8-7(11(16)17)12-9(13-10(8)15)6-4-2-1-3-5-6/h1-5,14H,(H,16,17)(H,12,13,15)
PDB
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CHEMBL
PC cid
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UniChem

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Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.020



Gilead Sciences Inc.



Assay Description
Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H1


(Homo sapiens (Human))
BDBM33416
PNG
(pyrimidinol carboxylic acid, 8)
Show SMILES OC(=O)c1nc(CCc2ccccc2)[nH]c(=O)c1O
Show InChI InChI=1S/C13H12N2O4/c16-11-10(13(18)19)14-9(15-12(11)17)7-6-8-4-2-1-3-5-8/h1-5,16H,6-7H2,(H,18,19)(H,14,15,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.020



Gilead Sciences Inc.



Assay Description
Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H1


(Homo sapiens (Human))
BDBM33415
PNG
(CHEMBL204900 | pyrimidinol carboxylic acid, 7)
Show SMILES OC(=O)c1nc(Cc2ccccc2)[nH]c(=O)c1O
Show InChI InChI=1S/C12H10N2O4/c15-10-9(12(17)18)13-8(14-11(10)16)6-7-4-2-1-3-5-7/h1-5,15H,6H2,(H,17,18)(H,13,14,16)
PDB
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UniProtKB/SwissProt

B.MOAD
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

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AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.020



Gilead Sciences Inc.



Assay Description
Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...


Citation and Details
More data for this
Ligand-Target Pair
Ribonuclease H1


(Homo sapiens (Human))
BDBM33417
PNG
(pyrimidinol carboxylic acid, 9)
Show SMILES OC(=O)c1nc(Cc2ccc(Cl)c(Cl)c2)[nH]c(=O)c1O
Show InChI InChI=1S/C12H8Cl2N2O4/c13-6-2-1-5(3-7(6)14)4-8-15-9(12(19)20)10(17)11(18)16-8/h1-3,17H,4H2,(H,19,20)(H,15,16,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.020



Gilead Sciences Inc.



Assay Description
Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...


Citation and Details
More data for this
Ligand-Target Pair