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Found 4 hits Enz. Inhib. hit(s) with Target = 'Ribose-phosphate pyrophosphokinase I' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribose-phosphate pyrophosphokinase I


(Homo sapiens)
BDBM50280245
PNG
(CHEMBL432846 | Phosphoric acid mono-{2-[(1R,3S)-3-...)
Show SMILES Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](CCOP(O)(O)=O)C1
Show InChI InChI=1S/C12H18N5O4P/c13-11-10-12(15-6-14-11)17(7-16-10)9-2-1-8(5-9)3-4-21-22(18,19)20/h6-9H,1-5H2,(H2,13,14,15)(H2,18,19,20)/t8-,9-/m0/s1
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n/an/a 6.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory concentration against Escherichia coli Pyrophosphate Synthetase (PRPP)


Citation and Details
More data for this
Ligand-Target Pair
Ribose-phosphate pyrophosphokinase I


(Homo sapiens)
BDBM50280243
PNG
(CHEMBL289455 | {2-[(1R,3S)-3-(6-Amino-purin-9-yl)-...)
Show SMILES Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](CC(F)(F)P(O)(O)=O)C1
Show InChI InChI=1S/C12H16F2N5O3P/c13-12(14,23(20,21)22)4-7-1-2-8(3-7)19-6-18-9-10(15)16-5-17-11(9)19/h5-8H,1-4H2,(H2,15,16,17)(H2,20,21,22)/t7-,8+/m1/s1
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n/an/a 1.00E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory concentration against Escherichia coli Pyrophosphate Synthetase (PRPP)


Citation and Details
More data for this
Ligand-Target Pair
Ribose-phosphate pyrophosphokinase I


(Homo sapiens)
BDBM50001103
PNG
((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Show SMILES Nc1ncnc2n(CCOCP(O)(O)=O)cnc12
Show InChI InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
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n/an/a 3.20E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory concentration against Escherichia coli Pyrophosphate Synthetase (PRPP)


Citation and Details
More data for this
Ligand-Target Pair
Ribose-phosphate pyrophosphokinase I


(Homo sapiens)
BDBM50280244
PNG
(Phosphoric acid mono-[(2R,3R,4S,5R)-5-(6-amino-pur...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6+,7+,10-/m1/s1
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n/an/a 5.10E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory concentration against Escherichia coli Pyrophosphate Synthetase (PRPP)


Citation and Details
More data for this
Ligand-Target Pair