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Found 249 hits Enz. Inhib. hit(s) with Target = 'Runt-Related Transcription Factor 1 Isoform AML1C'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31183
PNG
(thiazol-2-amine, 14)
Show SMILES Nc1nc(cs1)-c1ccccc1Cl
Show InChI InChI=1S/C9H7ClN2S/c10-7-4-2-1-3-6(7)8-5-13-9(11)12-8/h1-5H,(H2,11,12)
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n/an/a 700n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29675
PNG
(2-methyl-N-(4-thiazolo[5,4-b]pyridin-2-ylphenyl)-1...)
Show SMILES Cc1nc2ccc(cc2s1)S(=O)(=O)Nc1ccc(cc1)-c1nc2cccnc2s1
Show InChI InChI=1S/C20H14N4O2S3/c1-12-22-16-9-8-15(11-18(16)27-12)29(25,26)24-14-6-4-13(5-7-14)19-23-17-3-2-10-21-20(17)28-19/h2-11,24H,1H3
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n/an/a 713n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q25D8Q6Q
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31183
PNG
(thiazol-2-amine, 14)
Show SMILES Nc1nc(cs1)-c1ccccc1Cl
Show InChI InChI=1S/C9H7ClN2S/c10-7-4-2-1-3-6(7)8-5-13-9(11)12-8/h1-5H,(H2,11,12)
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n/an/a 1.10E+3n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434071
PNG
(US10562890, Compound Al-12-16)
Show SMILES COc1cnc(-c2nc3cc(OC(F)(F)F)ccc3[nH]2)c(OC)c1
Show InChI InChI=1S/C15H12F3N3O3/c1-22-9-6-12(23-2)13(19-7-9)14-20-10-4-3-8(5-11(10)21-14)24-15(16,17)18/h3-7H,1-2H3,(H,20,21)
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n/an/a 1.69E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434079
PNG
(US10562890, Compound Al-14-72)
Show SMILES COc1ccnc(-c2nc3cc(OC(F)(F)F)ccc3[nH]2)c1OC
Show InChI InChI=1S/C15H12F3N3O3/c1-22-11-5-6-19-12(13(11)23-2)14-20-9-4-3-8(7-10(9)21-14)24-15(16,17)18/h3-7H,1-2H3,(H,20,21)
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n/an/a 1.72E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29652
PNG
(5-chloranyl-N-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl...)
Show SMILES Clc1ccc(s1)S(=O)(=O)Nc1ccc(cc1)-c1nc2cccnc2s1
Show InChI InChI=1S/C16H10ClN3O2S3/c17-13-7-8-14(23-13)25(21,22)20-11-5-3-10(4-6-11)15-19-12-2-1-9-18-16(12)24-15/h1-9,20H
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n/an/a 1.87E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q25D8Q6Q
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434076
PNG
(US10562890, Compound Al-14-100)
Show SMILES COc1cc(OCCN2CCN(Cc3ccccc3)CC2)cnc1-c1nc2cc(OC(F)(F)F)ccc2[nH]1
Show InChI InChI=1S/C27H28F3N5O3/c1-36-24-16-21(37-14-13-34-9-11-35(12-10-34)18-19-5-3-2-4-6-19)17-31-25(24)26-32-22-8-7-20(15-23(22)33-26)38-27(28,29)30/h2-8,15-17H,9-14,18H2,1H3,(H,32,33)
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n/an/a 2.16E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434075
PNG
(US10562890, Compound Al-14-95)
Show SMILES FC(F)(F)Oc1ccc2[nH]c(nc2c1)-c1ccc(OCCN2CCN(Cc3ccccc3)CC2)cn1
Show InChI InChI=1S/C26H26F3N5O2/c27-26(28,29)36-20-6-8-22-24(16-20)32-25(31-22)23-9-7-21(17-30-23)35-15-14-33-10-12-34(13-11-33)18-19-4-2-1-3-5-19/h1-9,16-17H,10-15,18H2,(H,31,32)
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n/an/a 2.65E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434070
PNG
(US10562890, Compound Al-10-104)
Show SMILES OCc1cccnc1-c1nc2cc(OC(F)(F)F)ccc2[nH]1
Show InChI InChI=1S/C14H10F3N3O2/c15-14(16,17)22-9-3-4-10-11(6-9)20-13(19-10)12-8(7-21)2-1-5-18-12/h1-6,21H,7H2,(H,19,20)
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n/an/a 2.65E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434074
PNG
(US10562890, Compound Al-14-91)
Show SMILES OCc1cc(OCCN2CCOCC2)cnc1-c1nc2cc(OC(F)(F)F)ccc2[nH]1
Show InChI InChI=1S/C20H21F3N4O4/c21-20(22,23)31-14-1-2-16-17(10-14)26-19(25-16)18-13(12-28)9-15(11-24-18)30-8-5-27-3-6-29-7-4-27/h1-2,9-11,28H,3-8,12H2,(H,25,26)
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n/an/a 2.97E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31175
PNG
(thiazol-2-amine, 5)
Show SMILES Nc1nc(cs1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C10H7F3N2S/c11-10(12,13)7-3-1-6(2-4-7)8-5-16-9(14)15-8/h1-5H,(H2,14,15)
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434069
PNG
(US10562890, Compound Al-10-47)
Show SMILES FC(F)(F)Oc1ccc2[nH]c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C13H8F3N3O/c14-13(15,16)20-8-4-5-9-11(7-8)19-12(18-9)10-3-1-2-6-17-10/h1-7H,(H,18,19)
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n/an/a 3.19E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31185
PNG
(thiazol-2-amine, 17)
Show SMILES CCc1sc(N)nc1-c1ccc(OC)cc1
Show InChI InChI=1S/C12H14N2OS/c1-3-10-11(14-12(13)16-10)8-4-6-9(15-2)7-5-8/h4-7H,3H2,1-2H3,(H2,13,14)
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n/an/a 3.20E+3n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31186
PNG
(thiazol-2-amine, 18)
Show SMILES CCCc1sc(N)nc1-c1ccc(OC)cc1
Show InChI InChI=1S/C13H16N2OS/c1-3-4-11-12(15-13(14)17-11)9-5-7-10(16-2)8-6-9/h5-8H,3-4H2,1-2H3,(H2,14,15)
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31182
PNG
(thiazol-2-amine, 13)
Show SMILES Cc1ccccc1-c1csc(N)n1
Show InChI InChI=1S/C10H10N2S/c1-7-4-2-3-5-8(7)9-6-13-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31185
PNG
(thiazol-2-amine, 17)
Show SMILES CCc1sc(N)nc1-c1ccc(OC)cc1
Show InChI InChI=1S/C12H14N2OS/c1-3-10-11(14-12(13)16-10)8-4-6-9(15-2)7-5-8/h4-7H,3H2,1-2H3,(H2,13,14)
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n/an/a 3.50E+3n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29666
PNG
((9-Oxo-9H-acridin-10-yl)-acetic acid [1-(4-chloro-...)
Show SMILES Cc1cc(C=NNC(=O)Cn2c3ccccc3c(=O)c3ccccc23)c(C)n1-c1ccc(Cl)cc1
Show InChI InChI=1S/C28H23ClN4O2/c1-18-15-20(19(2)33(18)22-13-11-21(29)12-14-22)16-30-31-27(34)17-32-25-9-5-3-7-23(25)28(35)24-8-4-6-10-26(24)32/h3-16H,17H2,1-2H3,(H,31,34)
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n/an/a 3.58E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q25D8Q6Q
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM30648
PNG
(MLS-0062362.0001 | N-(4-thiazolo[5,4-b]pyridin-2-y...)
Show SMILES O=S(=O)(Nc1ccc(cc1)-c1nc2cccnc2s1)c1cccs1
Show InChI InChI=1S/C16H11N3O2S3/c20-24(21,14-4-2-10-22-14)19-12-7-5-11(6-8-12)15-18-13-3-1-9-17-16(13)23-15/h1-10,19H
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n/an/a 3.64E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q25D8Q6Q
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434072
PNG
(US10562890, Compound Al-14-55)
Show SMILES FC(F)(F)Oc1ccc2[nH]c(nc2c1)-c1ncccc1OCCN1CCOCC1
Show InChI InChI=1S/C19H19F3N4O3/c20-19(21,22)29-13-3-4-14-15(12-13)25-18(24-14)17-16(2-1-5-23-17)28-11-8-26-6-9-27-10-7-26/h1-5,12H,6-11H2,(H,24,25)
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n/an/a 4.83E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434078
PNG
(US10562890, Compound Al-14-18)
Show SMILES CN(C)c1cccnc1-c1nc2cc(OC(F)(F)F)ccc2[nH]1
Show InChI InChI=1S/C15H13F3N4O/c1-22(2)12-4-3-7-19-13(12)14-20-10-6-5-9(8-11(10)21-14)23-15(16,17)18/h3-8H,1-2H3,(H,20,21)
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n/an/a 4.97E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31182
PNG
(thiazol-2-amine, 13)
Show SMILES Cc1ccccc1-c1csc(N)n1
Show InChI InChI=1S/C10H10N2S/c1-7-4-2-3-5-8(7)9-6-13-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/a 5.00E+3n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31178
PNG
(thiazol-2-amine, 8)
Show SMILES Nc1nc(cs1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C10H8N2O2S/c11-10-12-7(4-15-10)6-1-2-8-9(3-6)14-5-13-8/h1-4H,5H2,(H2,11,12)
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31179
PNG
(thiazol-2-amine, 9)
Show SMILES Nc1nc(cs1)-c1cccc(Cl)c1
Show InChI InChI=1S/C9H7ClN2S/c10-7-3-1-2-6(4-7)8-5-13-9(11)12-8/h1-5H,(H2,11,12)
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29658
PNG
(MLS000557330 | N-[3-Cyano-1-furan-2-ylmethyl-8-met...)
Show SMILES Cc1cccc(c1)C(=O)\N=c1/c(cc2c(nc3c(C)cccn3c2=O)n1Cc1ccco1)C#N
Show InChI InChI=1S/C26H19N5O3/c1-16-6-3-8-18(12-16)25(32)29-23-19(14-27)13-21-24(31(23)15-20-9-5-11-34-20)28-22-17(2)7-4-10-30(22)26(21)33/h3-13H,15H2,1-2H3/b29-23+
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n/an/a 6.54E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2DV1H7P
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29658
PNG
(MLS000557330 | N-[3-Cyano-1-furan-2-ylmethyl-8-met...)
Show SMILES Cc1cccc(c1)C(=O)\N=c1/c(cc2c(nc3c(C)cccn3c2=O)n1Cc1ccco1)C#N
Show InChI InChI=1S/C26H19N5O3/c1-16-6-3-8-18(12-16)25(32)29-23-19(14-27)13-21-24(31(23)15-20-9-5-11-34-20)28-22-17(2)7-4-10-30(22)26(21)33/h3-13H,15H2,1-2H3/b29-23+
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n/an/a 6.54E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


Article DOI: 10.1038/42506
BindingDB Entry DOI: 10.7270/Q2T72FSX
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29639
PNG
((4E)-3-methyl-4-[[3-[(2-methyl-4-oxidanyl-phenyl)a...)
Show SMILES Cc1cc(O)ccc1Nc1nc2ccccc2nc1Nc1ccc(O)cc1C
Show InChI InChI=1S/C22H20N4O2/c1-13-11-15(27)7-9-17(13)23-21-22(24-18-10-8-16(28)12-14(18)2)26-20-6-4-3-5-19(20)25-21/h3-12,27-28H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 7.08E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2DV1H7P
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29639
PNG
((4E)-3-methyl-4-[[3-[(2-methyl-4-oxidanyl-phenyl)a...)
Show SMILES Cc1cc(O)ccc1Nc1nc2ccccc2nc1Nc1ccc(O)cc1C
Show InChI InChI=1S/C22H20N4O2/c1-13-11-15(27)7-9-17(13)23-21-22(24-18-10-8-16(28)12-14(18)2)26-20-6-4-3-5-19(20)25-21/h3-12,27-28H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 7.08E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


Article DOI: 10.1038/42506
BindingDB Entry DOI: 10.7270/Q2T72FSX
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29643
PNG
((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Show SMILES CN1CCc2cccc-3c2[C@@H]1Cc1ccc(O)c(O)c-31
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m0/s1
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n/an/a 7.12E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


Article DOI: 10.1038/42506
BindingDB Entry DOI: 10.7270/Q2T72FSX
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29643
PNG
((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Show SMILES CN1CCc2cccc-3c2[C@@H]1Cc1ccc(O)c(O)c-31
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m0/s1
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n/an/a 7.12E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2DV1H7P
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29672
PNG
(5-(2-keto-7-methoxy-4-propionyloxy-6-propyl-chrome...)
Show SMILES CCCc1cc2c(OC(=O)CC)c(-c3ccc(o3)C(=O)OCC)c(=O)oc2cc1OC
Show InChI InChI=1S/C23H24O8/c1-5-8-13-11-14-18(12-17(13)27-4)30-23(26)20(21(14)31-19(24)6-2)15-9-10-16(29-15)22(25)28-7-3/h9-12H,5-8H2,1-4H3
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n/an/a 7.94E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2DV1H7P
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29672
PNG
(5-(2-keto-7-methoxy-4-propionyloxy-6-propyl-chrome...)
Show SMILES CCCc1cc2c(OC(=O)CC)c(-c3ccc(o3)C(=O)OCC)c(=O)oc2cc1OC
Show InChI InChI=1S/C23H24O8/c1-5-8-13-11-14-18(12-17(13)27-4)30-23(26)20(21(14)31-19(24)6-2)15-9-10-16(29-15)22(25)28-7-3/h9-12H,5-8H2,1-4H3
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n/an/a 7.94E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


Article DOI: 10.1038/42506
BindingDB Entry DOI: 10.7270/Q2T72FSX
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29643
PNG
((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Show SMILES CN1CCc2cccc-3c2[C@@H]1Cc1ccc(O)c(O)c-31
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m0/s1
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n/an/a 8.48E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q25D8Q6Q
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29632
PNG
(2-[2-(3-keto-1,2-benzothiazol-2-yl)thiazol-4-yl]ac...)
Show SMILES CCOC(=O)Cc1csc(n1)-n1sc2ccccc2c1=O
Show InChI InChI=1S/C14H12N2O3S2/c1-2-19-12(17)7-9-8-20-14(15-9)16-13(18)10-5-3-4-6-11(10)21-16/h3-6,8H,2,7H2,1H3
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n/an/a 8.58E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2DV1H7P
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29632
PNG
(2-[2-(3-keto-1,2-benzothiazol-2-yl)thiazol-4-yl]ac...)
Show SMILES CCOC(=O)Cc1csc(n1)-n1sc2ccccc2c1=O
Show InChI InChI=1S/C14H12N2O3S2/c1-2-19-12(17)7-9-8-20-14(15-9)16-13(18)10-5-3-4-6-11(10)21-16/h3-6,8H,2,7H2,1H3
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n/an/a 8.58E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


Article DOI: 10.1038/42506
BindingDB Entry DOI: 10.7270/Q2T72FSX
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434073
PNG
(US10562890, Compound Al-12-126)
Show SMILES FC(F)(F)Oc1ccc2[nH]c(nc2c1)-c1ccc(OCCN2CCOCC2)cn1
Show InChI InChI=1S/C19H19F3N4O3/c20-19(21,22)29-13-1-3-15-17(11-13)25-18(24-15)16-4-2-14(12-23-16)28-10-7-26-5-8-27-9-6-26/h1-4,11-12H,5-10H2,(H,24,25)
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US Patent
n/an/a 8.91E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31178
PNG
(thiazol-2-amine, 8)
Show SMILES Nc1nc(cs1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C10H8N2O2S/c11-10-12-7(4-15-10)6-1-2-8-9(3-6)14-5-13-8/h1-4H,5H2,(H2,11,12)
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n/an/a 9.00E+3n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31175
PNG
(thiazol-2-amine, 5)
Show SMILES Nc1nc(cs1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C10H7F3N2S/c11-10(12,13)7-3-1-6(2-4-7)8-5-16-9(14)15-8/h1-5H,(H2,14,15)
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n/an/a 9.00E+3n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29644
PNG
((6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
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n/an/a 9.81E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2DV1H7P
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29644
PNG
((6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
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n/an/a 9.81E+3n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


Article DOI: 10.1038/42506
BindingDB Entry DOI: 10.7270/Q2T72FSX
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29668
PNG
(2-(1-{[4-(2,5-Dimethyl-phenyl)-thiazol-2-yl]-hydra...)
Show SMILES CC(N=Nc1nc(cs1)-c1cc(C)ccc1C)c1cc2c(ccc3ccccc23)oc1=O
Show InChI InChI=1S/C26H21N3O2S/c1-15-8-9-16(2)20(12-15)23-14-32-26(27-23)29-28-17(3)21-13-22-19-7-5-4-6-18(19)10-11-24(22)31-25(21)30/h4-14,17H,1-3H3
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n/an/a 1.01E+4n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2DV1H7P
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29668
PNG
(2-(1-{[4-(2,5-Dimethyl-phenyl)-thiazol-2-yl]-hydra...)
Show SMILES CC(N=Nc1nc(cs1)-c1cc(C)ccc1C)c1cc2c(ccc3ccccc23)oc1=O
Show InChI InChI=1S/C26H21N3O2S/c1-15-8-9-16(2)20(12-15)23-14-32-26(27-23)29-28-17(3)21-13-22-19-7-5-4-6-18(19)10-11-24(22)31-25(21)30/h4-14,17H,1-3H3
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n/an/a 1.01E+4n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


Article DOI: 10.1038/42506
BindingDB Entry DOI: 10.7270/Q2T72FSX
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM576
PNG
(1-Diphenylamino-pyrrole-2,5-dione | MLS000590474 |...)
Show SMILES O=C1C=CC(=O)N1N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C16H12N2O2/c19-15-11-12-16(20)18(15)17(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-12H
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n/an/a 1.03E+4n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q25D8Q6Q
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29685
PNG
((3E)-3-(2-furanylmethylidene)-1,2-dihydrocyclopent...)
Show SMILES O=C(COC(=O)c1c2CC\C(=C/c3ccco3)c2nc2ccccc12)NC1CCCC1
Show InChI InChI=1S/C25H24N2O4/c28-22(26-17-6-1-2-7-17)15-31-25(29)23-19-9-3-4-10-21(19)27-24-16(11-12-20(23)24)14-18-8-5-13-30-18/h3-5,8-10,13-14,17H,1-2,6-7,11-12,15H2,(H,26,28)/b16-14+
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n/an/a 1.04E+4n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2DV1H7P
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29685
PNG
((3E)-3-(2-furanylmethylidene)-1,2-dihydrocyclopent...)
Show SMILES O=C(COC(=O)c1c2CC\C(=C/c3ccco3)c2nc2ccccc12)NC1CCCC1
Show InChI InChI=1S/C25H24N2O4/c28-22(26-17-6-1-2-7-17)15-31-25(29)23-19-9-3-4-10-21(19)27-24-16(11-12-20(23)24)14-18-8-5-13-30-18/h3-5,8-10,13-14,17H,1-2,6-7,11-12,15H2,(H,26,28)/b16-14+
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n/an/a 1.04E+4n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


Article DOI: 10.1038/42506
BindingDB Entry DOI: 10.7270/Q2T72FSX
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29684
PNG
((3E)-3-(2-furanylmethylidene)-1,2-dihydrocyclopent...)
Show SMILES CC1CCCCC1NC(=O)COC(=O)c1c2CC\C(=C/c3ccco3)c2nc2ccccc12
Show InChI InChI=1S/C27H28N2O4/c1-17-7-2-4-10-22(17)28-24(30)16-33-27(31)25-20-9-3-5-11-23(20)29-26-18(12-13-21(25)26)15-19-8-6-14-32-19/h3,5-6,8-9,11,14-15,17,22H,2,4,7,10,12-13,16H2,1H3,(H,28,30)/b18-15+
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n/an/a 1.06E+4n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2DV1H7P
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29684
PNG
((3E)-3-(2-furanylmethylidene)-1,2-dihydrocyclopent...)
Show SMILES CC1CCCCC1NC(=O)COC(=O)c1c2CC\C(=C/c3ccco3)c2nc2ccccc12
Show InChI InChI=1S/C27H28N2O4/c1-17-7-2-4-10-22(17)28-24(30)16-33-27(31)25-20-9-3-5-11-23(20)29-26-18(12-13-21(25)26)15-19-8-6-14-32-19/h3,5-6,8-9,11,14-15,17,22H,2,4,7,10,12-13,16H2,1H3,(H,28,30)/b18-15+
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n/an/a 1.06E+4n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


Article DOI: 10.1038/42506
BindingDB Entry DOI: 10.7270/Q2T72FSX
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29666
PNG
((9-Oxo-9H-acridin-10-yl)-acetic acid [1-(4-chloro-...)
Show SMILES Cc1cc(C=NNC(=O)Cn2c3ccccc3c(=O)c3ccccc23)c(C)n1-c1ccc(Cl)cc1
Show InChI InChI=1S/C28H23ClN4O2/c1-18-15-20(19(2)33(18)22-13-11-21(29)12-14-22)16-30-31-27(34)17-32-25-9-5-3-7-23(25)28(35)24-8-4-6-10-26(24)32/h3-16H,17H2,1-2H3,(H,31,34)
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n/an/a 1.16E+4n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2DV1H7P
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29666
PNG
((9-Oxo-9H-acridin-10-yl)-acetic acid [1-(4-chloro-...)
Show SMILES Cc1cc(C=NNC(=O)Cn2c3ccccc3c(=O)c3ccccc23)c(C)n1-c1ccc(Cl)cc1
Show InChI InChI=1S/C28H23ClN4O2/c1-18-15-20(19(2)33(18)22-13-11-21(29)12-14-22)16-30-31-27(34)17-32-25-9-5-3-7-23(25)28(35)24-8-4-6-10-26(24)32/h3-16H,17H2,1-2H3,(H,31,34)
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n/an/a 1.16E+4n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


Article DOI: 10.1038/42506
BindingDB Entry DOI: 10.7270/Q2T72FSX
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29661
PNG
(2-Amino-1-furan-2-ylmethyl-1H-pyrrolo[2,3-b]quinox...)
Show SMILES CC(C)CNC(=O)c1c(N)n(Cc2ccco2)c2nc3ccccc3nc12
Show InChI InChI=1S/C20H21N5O2/c1-12(2)10-22-20(26)16-17-19(24-15-8-4-3-7-14(15)23-17)25(18(16)21)11-13-6-5-9-27-13/h3-9,12H,10-11,21H2,1-2H3,(H,22,26)
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n/an/a 1.17E+4n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


Article DOI: 10.1038/42506
BindingDB Entry DOI: 10.7270/Q2T72FSX
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM29661
PNG
(2-Amino-1-furan-2-ylmethyl-1H-pyrrolo[2,3-b]quinox...)
Show SMILES CC(C)CNC(=O)c1c(N)n(Cc2ccco2)c2nc3ccccc3nc12
Show InChI InChI=1S/C20H21N5O2/c1-12(2)10-22-20(26)16-17-19(24-15-8-4-3-7-14(15)23-17)25(18(16)21)11-13-6-5-9-27-13/h3-9,12H,10-11,21H2,1-2H3,(H,22,26)
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n/an/a 1.17E+4n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2DV1H7P
More data for this
Ligand-Target Pair
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