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Compile Data Set for Download or QSAR

Found 50 hits Enz. Inhib. hit(s) with Target = 'S-adenosylmethionine decarboxylase 1' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50369827
PNG
(CHEMBL611536)
Show SMILES NCCC=NC[C@@H]1OC([C@@H](O)[C@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H19N7O3/c14-2-1-3-16-4-7-9(21)10(22)13(23-7)20-6-19-8-11(15)17-5-18-12(8)20/h3,5-7,9-10,13,21-22H,1-2,4,14H2,(H2,15,17,18)/t7-,9-,10-,13?/m0/s1
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560n/an/an/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibition of rat liver form of S-adenosyl-methionine decarboxylase enzyme


J Med Chem 44: 1-26 (2001)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50366942
PNG
(CHEMBL540135)
Show SMILES C[S+](C)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H18N5O3S/c1-21(2)3-6-8(18)9(19)12(20-6)17-5-16-7-10(13)14-4-15-11(7)17/h4-6,8-9,12,18-19H,3H2,1-2H3,(H2,13,14,15)/q+1/t6-,8-,9-,12-/m1/s1
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2.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in presence of 1 mM putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50291721
PNG
((3-Amino-propyl)-[5-(6-amino-purin-9-yl)-3,4-dihyd...)
Show SMILES C[S+](CCCN)C[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H23N6O3S/c1-24(4-2-3-15)5-8-10(21)11(22)14(23-8)20-7-19-9-12(16)17-6-18-13(9)20/h6-8,10-11,14,21-22H,2-5,15H2,1H3,(H2,16,17,18)/q+1/t8-,10-,11-,14?,24?/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in presence of 1 mM putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50366942
PNG
(CHEMBL540135)
Show SMILES C[S+](C)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H18N5O3S/c1-21(2)3-6-8(18)9(19)12(20-6)17-5-16-7-10(13)14-4-15-11(7)17/h4-6,8-9,12,18-19H,3H2,1-2H3,(H2,13,14,15)/q+1/t6-,8-,9-,12-/m1/s1
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2.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in absence of putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50291721
PNG
((3-Amino-propyl)-[5-(6-amino-purin-9-yl)-3,4-dihyd...)
Show SMILES C[S+](CCCN)C[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H23N6O3S/c1-24(4-2-3-15)5-8-10(21)11(22)14(23-8)20-7-19-9-12(16)17-6-18-13(9)20/h6-8,10-11,14,21-22H,2-5,15H2,1H3,(H2,16,17,18)/q+1/t8-,10-,11-,14?,24?/m1/s1
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4.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in absence of putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50367078
PNG
(CHEMBL610704)
Show SMILES NCCCNC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H21N7O3/c14-2-1-3-16-4-7-9(21)10(22)13(23-7)20-6-19-8-11(15)17-5-18-12(8)20/h5-7,9-10,13,16,21-22H,1-4,14H2,(H2,15,17,18)/t7-,9-,10-,13?/m1/s1
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5.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in presence of 1 mM putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM28422
PNG
((2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-puri...)
Show SMILES C[S+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27?/m0/s1
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6.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in presence of 1 mM putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM28441
PNG
((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-{[(3-ami...)
Show SMILES CN(CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H23N7O3/c1-20(4-2-3-15)5-8-10(22)11(23)14(24-8)21-7-19-9-12(16)17-6-18-13(9)21/h6-8,10-11,14,22-23H,2-5,15H2,1H3,(H2,16,17,18)/t8-,10-,11-,14-/m1/s1
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6.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in presence of 1 mM putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50367079
PNG
(CHEMBL610141)
Show SMILES NCCNC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H19N7O3/c13-1-2-15-3-6-8(20)9(21)12(22-6)19-5-18-7-10(14)16-4-17-11(7)19/h4-6,8-9,12,15,20-21H,1-3,13H2,(H2,14,16,17)/t6-,8-,9-,12?/m1/s1
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7.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in presence of 1 mM putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50367076
PNG
(CHEMBL611588)
Show SMILES NC(N)=NC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H16N8O3/c12-8-5-9(17-2-16-8)19(3-18-5)10-7(21)6(20)4(22-10)1-15-11(13)14/h2-4,6-7,10,20-21H,1H2,(H2,12,16,17)(H4,13,14,15)/t4-,6-,7-,10?/m1/s1
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8.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in presence of 1 mM putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50366974
PNG
(CHEMBL1204407)
Show SMILES CN(CCCN)C[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H23N7O3/c1-20(4-2-3-15)5-8-10(22)11(23)14(24-8)21-7-19-9-12(16)17-6-18-13(9)21/h6-8,10-11,14,22-23H,2-5,15H2,1H3,(H2,16,17,18)/t8-,10-,11-,14?/m1/s1
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1.10E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition against S-adenosyl-L-methionine decarboxylase from rat liver


J Med Chem 23: 121-7 (1980)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50366972
PNG
(CHEMBL541665)
Show SMILES CC(N)CC[S+](C)C[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C15H25N6O3S/c1-8(16)3-4-25(2)5-9-11(22)12(23)15(24-9)21-7-20-10-13(17)18-6-19-14(10)21/h6-9,11-12,15,22-23H,3-5,16H2,1-2H3,(H2,17,18,19)/q+1/t8?,9-,11-,12-,15?,25?/m1/s1
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1.20E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition against S-adenosyl-L-methionine decarboxylase from rat liver


J Med Chem 23: 121-7 (1980)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50366973
PNG
(CHEMBL539876)
Show SMILES C[S+](CCC(C)(N)C(O)=O)C[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C16H24N6O5S/c1-16(18,15(25)26)3-4-28(2)5-8-10(23)11(24)14(27-8)22-7-21-9-12(17)19-6-20-13(9)22/h6-8,10-11,14,23-24H,3-5,18H2,1-2H3,(H2-,17,19,20,25,26)/p+1/t8-,10-,11-,14?,16?,28?/m1/s1
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1.80E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition against S-adenosyl-L-methionine decarboxylase from rat liver


J Med Chem 23: 121-7 (1980)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50090850
PNG
((2R,3S,4R,5R)-2-Aminomethyl-5-(6-amino-purin-9-yl)...)
Show SMILES NC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C10H14N6O3/c11-1-4-6(17)7(18)10(19-4)16-3-15-5-8(12)13-2-14-9(5)16/h2-4,6-7,10,17-18H,1,11H2,(H2,12,13,14)/t4-,6-,7-,10-/m1/s1
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2.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in presence of 1 mM putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM28422
PNG
((2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-puri...)
Show SMILES C[S+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27?/m0/s1
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3.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in absence of putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50367077
PNG
(CHEMBL611902)
Show SMILES CN(CCC#N)C[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H19N7O3/c1-20(4-2-3-15)5-8-10(22)11(23)14(24-8)21-7-19-9-12(16)17-6-18-13(9)21/h6-8,10-11,14,22-23H,2,4-5H2,1H3,(H2,16,17,18)/t8-,10-,11-,14?/m1/s1
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3.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in presence of 1 mM putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM28441
PNG
((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-{[(3-ami...)
Show SMILES CN(CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H23N7O3/c1-20(4-2-3-15)5-8-10(22)11(23)14(24-8)21-7-19-9-12(16)17-6-18-13(9)21/h6-8,10-11,14,22-23H,2-5,15H2,1H3,(H2,16,17,18)/t8-,10-,11-,14-/m1/s1
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3.80E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in absence of putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50367079
PNG
(CHEMBL610141)
Show SMILES NCCNC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H19N7O3/c13-1-2-15-3-6-8(20)9(21)12(22-6)19-5-18-7-10(14)16-4-17-11(7)19/h4-6,8-9,12,15,20-21H,1-3,13H2,(H2,14,16,17)/t6-,8-,9-,12?/m1/s1
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5.40E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in absence of putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50367080
PNG
(CHEMBL610142)
Show SMILES CNCCCNC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H23N7O3/c1-16-3-2-4-17-5-8-10(22)11(23)14(24-8)21-7-20-9-12(15)18-6-19-13(9)21/h6-8,10-11,14,16-17,22-23H,2-5H2,1H3,(H2,15,18,19)/t8-,10-,11-,14?/m1/s1
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6.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in presence of 1 mM putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50367076
PNG
(CHEMBL611588)
Show SMILES NC(N)=NC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H16N8O3/c12-8-5-9(17-2-16-8)19(3-18-5)10-7(21)6(20)4(22-10)1-15-11(13)14/h2-4,6-7,10,20-21H,1H2,(H2,12,16,17)(H4,13,14,15)/t4-,6-,7-,10?/m1/s1
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1.00E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in absence of putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50090850
PNG
((2R,3S,4R,5R)-2-Aminomethyl-5-(6-amino-purin-9-yl)...)
Show SMILES NC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C10H14N6O3/c11-1-4-6(17)7(18)10(19-4)16-3-15-5-8(12)13-2-14-9(5)16/h2-4,6-7,10,17-18H,1,11H2,(H2,12,13,14)/t4-,6-,7-,10-/m1/s1
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1.70E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in absence of putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50367077
PNG
(CHEMBL611902)
Show SMILES CN(CCC#N)C[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H19N7O3/c1-20(4-2-3-15)5-8-10(22)11(23)14(24-8)21-7-19-9-12(16)17-6-18-13(9)21/h6-8,10-11,14,22-23H,2,4-5H2,1H3,(H2,16,17,18)/t8-,10-,11-,14?/m1/s1
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2.80E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in absence of putrescine


J Med Chem 25: 550-6 (1982)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50368644
PNG
(CHEMBL1202793 | Sardomozide chloride)
Show SMILES NC(=N)NN=C1CCc2c1cccc2C(N)=N
Show InChI InChI=1S/C11H14N6/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17)
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n/an/a 5n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory activity against S- adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 2168-71 (1993)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046206
PNG
(2,2'-bipyridine-6,6'-dicarboximidamide | CHEMBL151...)
Show SMILES NC(=N)c1cccc(n1)-c1cccc(n1)C(N)=N
Show InChI InChI=1S/C12H12N6/c13-11(14)9-5-1-3-7(17-9)8-4-2-6-10(18-8)12(15)16/h1-6H,(H3,13,14)(H3,15,16)
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n/an/a 6n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046197
PNG
(4-{3-[(Z)-amino(imino)methyl]phenyl}pyrimidine-2-c...)
Show SMILES NC(=N)c1cccc(c1)-c1ccnc(n1)C(N)=N
Show InChI InChI=1S/C12H12N6/c13-10(14)8-3-1-2-7(6-8)9-4-5-17-12(18-9)11(15)16/h1-6H,(H3,13,14)(H3,15,16)
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n/an/a 6n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50368645
PNG
(CHEMBL1202792)
Show SMILES CC(=NN=C(N)N)c1cccc(n1)C(N)=N
Show InChI InChI=1S/C9H13N7/c1-5(15-16-9(12)13)6-3-2-4-7(14-6)8(10)11/h2-4H,1H3,(H3,10,11)(H4,12,13,16)
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n/an/a 10n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory activity against S- adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 2168-71 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046189
PNG
((2E)-2-{3-[(Z)-amino(imino)methyl]benzylidene}hydr...)
Show SMILES NC(=N)NN=Cc1cccc(c1)C(N)=N
Show InChI InChI=1S/C9H12N6/c10-8(11)7-3-1-2-6(4-7)5-14-15-9(12)13/h1-5H,(H3,10,11)(H4,12,13,15)
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n/an/a 36n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046196
PNG
(3-((E)-{[(Z)-((2E)-2-{3-[(E)-amino(imino)methyl]be...)
Show SMILES NC(NN=Cc1cccc(c1)C(N)=N)=NN=Cc1cccc(c1)C(N)=N
Show InChI InChI=1S/C17H19N9/c18-15(19)13-5-1-3-11(7-13)9-23-25-17(22)26-24-10-12-4-2-6-14(8-12)16(20)21/h1-10H,(H3,18,19)(H3,20,21)(H3,22,25,26)
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n/an/a 61n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046200
PNG
((2E)-2-(1-{3-[(E)-amino(imino)methyl]phenyl}ethyli...)
Show SMILES CC(=NN=C(N)N)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C10H14N6/c1-6(15-16-10(13)14)7-3-2-4-8(5-7)9(11)12/h2-5H,1H3,(H3,11,12)(H4,13,14,16)
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n/an/a 66n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046190
PNG
(6-((E)-{[(E)-amino(hydrazono)methyl]hydrazono}meth...)
Show SMILES NN=C(N)c1cccc(C=NNC(N)=N)n1
Show InChI InChI=1S/C8H12N8/c9-7(15-12)6-3-1-2-5(14-6)4-13-16-8(10)11/h1-4H,12H2,(H2,9,15)(H4,10,11,16)
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n/an/a 84n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046193
PNG
((2E)-2-(1-{3-[(E)-amino(imino)methyl]phenyl}propyl...)
Show SMILES CCC(=NN=C(N)N)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C11H16N6/c1-2-9(16-17-11(14)15)7-4-3-5-8(6-7)10(12)13/h3-6H,2H2,1H3,(H3,12,13)(H4,14,15,17)
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n/an/a 88n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046210
PNG
(6-((E)-{[(E)-amino(imino)methyl]hydrazono}methyl)p...)
Show SMILES NC(=N)NN=Cc1cccc(n1)C(N)=N
Show InChI InChI=1S/C8H11N7/c9-7(10)6-3-1-2-5(14-6)4-13-15-8(11)12/h1-4H,(H3,9,10)(H4,11,12,15)
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n/an/a 90n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046209
PNG
((2E)-2-{3-[(E)-amino(imino)methyl]benzylidene}-N'-...)
Show SMILES NC(NO)=NN=Cc1cccc(c1)C(N)=N
Show InChI InChI=1S/C9H12N6O/c10-8(11)7-3-1-2-6(4-7)5-13-14-9(12)15-16/h1-5,16H,(H3,10,11)(H3,12,14,15)
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n/an/a 92n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046207
PNG
(6-((E)-{[(E)-[(2E)-2-({6-[(E)-amino(imino)methyl]p...)
Show SMILES NC(=N)c1cccc(C=NNC(=N)NN=Cc2cccc(n2)C(N)=N)n1
Show InChI InChI=1S/C15H17N11/c16-13(17)11-5-1-3-9(23-11)7-21-25-15(20)26-22-8-10-4-2-6-12(24-10)14(18)19/h1-8H,(H3,16,17)(H3,18,19)(H3,20,25,26)
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n/an/a 120n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046191
PNG
((2E)-2-{3-[(E)-amino(imino)methyl]benzylidene}-N'-...)
Show SMILES CCCCN=C(N)NN=Cc1cccc(c1)C(N)=N
Show InChI InChI=1S/C13H20N6/c1-2-3-7-17-13(16)19-18-9-10-5-4-6-11(8-10)12(14)15/h4-6,8-9H,2-3,7H2,1H3,(H3,14,15)(H3,16,17,19)
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n/an/a 160n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046204
PNG
(4,4'-bipyridine-2,2'-dicarboximidamide | CHEMBL433...)
Show SMILES NC(=N)c1cc(ccn1)-c1ccnc(c1)C(N)=N
Show InChI InChI=1S/C12H12N6/c13-11(14)9-5-7(1-3-17-9)8-2-4-18-10(6-8)12(15)16/h1-6H,(H3,13,14)(H3,15,16)
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n/an/a 180n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046203
PNG
(3-((E)-{[(E)-amino(hydrazono)methyl]hydrazono}meth...)
Show SMILES NC(=N)c1cccc(CNN=C(N)N=N)c1
Show InChI InChI=1S/C9H13N7/c10-8(11)7-3-1-2-6(4-7)5-14-16-9(12)15-13/h1-4,13-14H,5H2,(H3,10,11)(H2,12,16)
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n/an/a 210n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046202
PNG
(6-((E)-{[(E)-amino(hydroxyimino)methyl]hydrazono}m...)
Show SMILES NC(NO)=NN=Cc1cccc(n1)C(N)=N
Show InChI InChI=1S/C8H11N7O/c9-7(10)6-3-1-2-5(13-6)4-12-14-8(11)15-16/h1-4,16H,(H3,9,10)(H3,11,14,15)
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n/an/a 240n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046195
PNG
(4-((E)-{[(E)-amino(imino)methyl]hydrazono}methyl)p...)
Show SMILES NC(=N)NN=Cc1ccnc(c1)C(N)=N
Show InChI InChI=1S/C8H11N7/c9-7(10)6-3-5(1-2-13-6)4-14-15-8(11)12/h1-4H,(H3,9,10)(H4,11,12,15)
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n/an/a 330n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046194
PNG
(4-((E)-{[(E)-amino(imino)methyl]hydrazono}methyl)p...)
Show SMILES NC(=N)NN=Cc1ccnc(n1)C(N)=N
Show InChI InChI=1S/C7H10N8/c8-5(9)6-12-2-1-4(14-6)3-13-15-7(10)11/h1-3H,(H3,8,9)(H4,10,11,15)
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Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046212
PNG
(1,1'-biphenyl-3,3'-dicarboximidamide | CHEMBL15062...)
Show SMILES NC(=N)c1cccc(c1)-c1cccc(c1)C(N)=N
Show InChI InChI=1S/C14H14N4/c15-13(16)11-5-1-3-9(7-11)10-4-2-6-12(8-10)14(17)18/h1-8H,(H3,15,16)(H3,17,18)
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n/an/a 600n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046192
PNG
(6-((E)-{[(E)-amino(hydrazono)methyl]hydrazono}meth...)
Show SMILES NC(=N)c1cccc(CNN=C(N)N=N)n1
Show InChI InChI=1S/C8H12N8/c9-7(10)6-3-1-2-5(14-6)4-13-16-8(11)15-12/h1-3,12-13H,4H2,(H3,9,10)(H2,11,16)
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n/an/a 670n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046201
PNG
((2E)-2-((2E)-2-{[(E)-amino(imino)methyl]hydrazono}...)
Show SMILES CC(C=NNC(N)=N)=NN=C(N)N
Show InChI InChI=1S/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50044330
PNG
((2Z)-2-((2E)-2-{[(E)-amino(imino)methyl]hydrazono}...)
Show SMILES CC(C=NNC(N)=N)=NN=C(N)N
Show InChI InChI=1S/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory activity against S- adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 2168-71 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046205
PNG
(2,2'-bipyridine-4,4'-dicarboximidamide | CHEMBL151...)
Show SMILES NC(=N)c1ccnc(c1)-c1cc(ccn1)C(N)=N
Show InChI InChI=1S/C12H12N6/c13-11(14)7-1-3-17-9(5-7)10-6-8(12(15)16)2-4-18-10/h1-6H,(H3,13,14)(H3,15,16)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50368643
PNG
(CHEMBL1202794)
Show SMILES CC(=NN=C(N)N)c1cc(ccn1)C(N)=N
Show InChI InChI=1S/C9H13N7/c1-5(15-16-9(12)13)7-4-6(8(10)11)2-3-14-7/h2-4H,1H3,(H3,10,11)(H4,12,13,16)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory activity against S- adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 2168-71 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046211
PNG
(2-((E)-{[(E)-amino(imino)methyl]hydrazono}methyl)p...)
Show SMILES NC(=N)NN=Cc1nccc(n1)C(N)=N
Show InChI InChI=1S/C7H10N8/c8-6(9)4-1-2-12-5(14-4)3-13-15-7(10)11/h1-3H,(H3,8,9)(H4,10,11,15)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046208
PNG
(3-((E)-{[(E)-amino(imino)methyl]hydrazono}methyl)b...)
Show SMILES NC(=N)NN=Cc1cccc(c1)C(N)=O
Show InChI InChI=1S/C9H11N5O/c10-8(15)7-3-1-2-6(4-7)5-13-14-9(11)12/h1-5H,(H2,10,15)(H4,11,12,14)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046198
PNG
(6-((E)-{[(E)-amino(imino)methyl]hydrazono}methyl)-...)
Show SMILES NC(=N)NN=Cc1cccc(n1)C(=N)NO
Show InChI InChI=1S/C8H11N7O/c9-7(15-16)6-3-1-2-5(13-6)4-12-14-8(10)11/h1-4,16H,(H2,9,15)(H4,10,11,14)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair
S-adenosylmethionine decarboxylase 1


(Rattus norvegicus)
BDBM50046199
PNG
((2E)-2-{3-[(E)-amino(butylimino)methyl]benzylidene...)
Show SMILES CCCCN=C(N)c1cccc(C=NNC(N)=N)c1
Show InChI InChI=1S/C13H20N6/c1-2-3-7-17-12(14)11-6-4-5-10(8-11)9-18-19-13(15)16/h4-6,8-9H,2-3,7H2,1H3,(H2,14,17)(H4,15,16,19)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Ciba-Geigy AG

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver


J Med Chem 36: 46-54 (1993)

More data for this
Ligand-Target Pair