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Found 92 hits Enz. Inhib. hit(s) with Target = 'SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM50400044
PNG
(CHEMBL2177726 | US9169259, I-54)
Show SMILES COc1ccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(cc2)C(O)=O)nc1OC
Show InChI InChI=1S/C27H22N6O5/c1-37-22-10-11-23(31-26(22)38-2)30-21-15-20(32-33-13-12-28-24(21)33)17-4-3-5-18(14-17)25(34)29-19-8-6-16(7-9-19)27(35)36/h3-15H,1-2H3,(H,29,34)(H,30,31)(H,35,36)
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n/an/a 1n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188174
PNG
(US9169259, I-57)
Show SMILES COc1ccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(C(O)=O)c(OC)c2)nc1OC
Show InChI InChI=1S/C28H24N6O6/c1-38-22-9-10-24(32-27(22)40-3)31-21-15-20(33-34-12-11-29-25(21)34)16-5-4-6-17(13-16)26(35)30-18-7-8-19(28(36)37)23(14-18)39-2/h4-15H,1-3H3,(H,30,35)(H,31,32)(H,36,37)
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n/an/a 1.55n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188128
PNG
(US9169259, I-10)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(cc2)C(O)=O)n1
Show InChI InChI=1/C30H27N7O3/c1-19-5-4-15-36(19)27-9-3-8-26(34-27)33-25-18-24(35-37-16-14-31-28(25)37)21-6-2-7-22(17-21)29(38)32-23-12-10-20(11-13-23)30(39)40/h2-3,6-14,16-19H,4-5,15H2,1H3,(H,32,38)(H,33,34)(H,39,40)
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n/an/a 1.65n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188188
PNG
(US9169259, I-72)
Show SMILES COc1ccc(Nc2cc(nn3ccnc23)N2CCCC(C2)NC(=O)c2ccc(cc2)C(O)=O)nc1OC
Show InChI InChI=1/C26H27N7O5/c1-37-20-9-10-21(30-25(20)38-2)29-19-14-22(31-33-13-11-27-23(19)33)32-12-3-4-18(15-32)28-24(34)16-5-7-17(8-6-16)26(35)36/h5-11,13-14,18H,3-4,12,15H2,1-2H3,(H,28,34)(H,29,30)(H,35,36)
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n/an/a 2.20n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188172
PNG
(US9169259, I-55)
Show SMILES COc1ccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc3[nH]ncc3c2)nc1OC
Show InChI InChI=1S/C27H22N8O3/c1-37-23-8-9-24(32-27(23)38-2)31-22-14-21(34-35-11-10-28-25(22)35)16-4-3-5-17(12-16)26(36)30-19-6-7-20-18(13-19)15-29-33-20/h3-15H,1-2H3,(H,29,33)(H,30,36)(H,31,32)
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n/an/a 7.33n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188190
PNG
(US9169259, I-74)
Show SMILES COc1ccc(Nc2cc(nn3ccnc23)N2CCCC(C2)C(=O)Nc2ccc(cc2)C(O)=O)nc1OC
Show InChI InChI=1/C26H27N7O5/c1-37-20-9-10-21(30-25(20)38-2)29-19-14-22(31-33-13-11-27-23(19)33)32-12-3-4-17(15-32)24(34)28-18-7-5-16(6-8-18)26(35)36/h5-11,13-14,17H,3-4,12,15H2,1-2H3,(H,28,34)(H,29,30)(H,35,36)
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n/an/a 14.9n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM50400035
PNG
(CHEMBL2177735 | US9169259, I-84)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(CN)c2)n1
Show InChI InChI=1S/C23H25N7/c1-16-5-4-11-29(16)22-9-3-8-21(27-22)26-20-14-19(28-30-12-10-25-23(20)30)18-7-2-6-17(13-18)15-24/h2-3,6-10,12-14,16H,4-5,11,15,24H2,1H3,(H,26,27)
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n/an/a 15.6n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188169
PNG
(US9169259, I-51)
Show SMILES C[C@H]1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(N)=O)n1
Show InChI InChI=1/C23H23N7O/c1-15-5-4-11-29(15)21-9-3-8-20(27-21)26-19-14-18(28-30-12-10-25-23(19)30)16-6-2-7-17(13-16)22(24)31/h2-3,6-10,12-15H,4-5,11H2,1H3,(H2,24,31)(H,26,27)/t15-/s2
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n/an/a 16.1n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188168
PNG
(US9169259, I-50)
Show SMILES C[C@H]1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc(cc2)C(N)=O)n1
Show InChI InChI=1/C23H23N7O/c1-15-4-3-12-29(15)21-6-2-5-20(27-21)26-19-14-18(28-30-13-11-25-23(19)30)16-7-9-17(10-8-16)22(24)31/h2,5-11,13-15H,3-4,12H2,1H3,(H2,24,31)(H,26,27)/t15-/s2
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n/an/a 18.9n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188208
PNG
(US9169259, I-93)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(CNC3CCNCC3)c2)n1
Show InChI InChI=1/C28H34N8/c1-20-5-4-15-35(20)27-9-3-8-26(33-27)32-25-18-24(34-36-16-14-30-28(25)36)22-7-2-6-21(17-22)19-31-23-10-12-29-13-11-23/h2-3,6-9,14,16-18,20,23,29,31H,4-5,10-13,15,19H2,1H3,(H,32,33)
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n/an/a 24.4n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM50400036
PNG
(CHEMBL2177734 | US9169259, I-68)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(CO)c2)n1
Show InChI InChI=1S/C23H24N6O/c1-16-5-4-11-28(16)22-9-3-8-21(26-22)25-20-14-19(27-29-12-10-24-23(20)29)18-7-2-6-17(13-18)15-30/h2-3,6-10,12-14,16,30H,4-5,11,15H2,1H3,(H,25,26)
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n/an/a 24.7n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188135
PNG
(US9169259, I-17)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc(cc2)C(N)=O)n1
Show InChI InChI=1/C23H23N7O/c1-15-4-3-12-29(15)21-6-2-5-20(27-21)26-19-14-18(28-30-13-11-25-23(19)30)16-7-9-17(10-8-16)22(24)31/h2,5-11,13-15H,3-4,12H2,1H3,(H2,24,31)(H,26,27)
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n/an/a 33.1n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188170
PNG
(US9169259, I-52)
Show SMILES C[C@H]1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc3ncsc3c2)n1
Show InChI InChI=1/C23H21N7S/c1-15-4-3-10-29(15)22-6-2-5-21(27-22)26-19-13-18(28-30-11-9-24-23(19)30)16-7-8-17-20(12-16)31-14-25-17/h2,5-9,11-15H,3-4,10H2,1H3,(H,26,27)/t15-/s2
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n/an/a 36.1n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188192
PNG
(US9169259, I-76)
Show SMILES COc1ccc(Nc2cc(nn3ccnc23)N2CCC(C2)NC(=O)c2ccc(cc2)C(O)=O)nc1OC
Show InChI InChI=1/C25H25N7O5/c1-36-19-7-8-20(29-24(19)37-2)28-18-13-21(30-32-12-10-26-22(18)32)31-11-9-17(14-31)27-23(33)15-3-5-16(6-4-15)25(34)35/h3-8,10,12-13,17H,9,11,14H2,1-2H3,(H,27,33)(H,28,29)(H,34,35)
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n/an/a 42.1n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188158
PNG
(US9169259, I-40)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(=O)NCCO)n1
Show InChI InChI=1/C25H27N7O2/c1-17-5-4-12-31(17)23-9-3-8-22(29-23)28-21-16-20(30-32-13-10-26-24(21)32)18-6-2-7-19(15-18)25(34)27-11-14-33/h2-3,6-10,13,15-17,33H,4-5,11-12,14H2,1H3,(H,27,34)(H,28,29)
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n/an/a 42.5n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188199
PNG
(US9169259, I-83)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc(OCCN3CCCC3)cc2)n1
Show InChI InChI=1/C28H33N7O/c1-21-6-5-16-34(21)27-8-4-7-26(31-27)30-25-20-24(32-35-17-13-29-28(25)35)22-9-11-23(12-10-22)36-19-18-33-14-2-3-15-33/h4,7-13,17,20-21H,2-3,5-6,14-16,18-19H2,1H3,(H,30,31)
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n/an/a 47.5n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188162
PNG
(US9169259, I-44)
Show SMILES COc1ccc(Nc2cc(nn3ccnc23)-c2ccccc2)nc1OC
Show InChI InChI=1S/C19H17N5O2/c1-25-16-8-9-17(22-19(16)26-2)21-15-12-14(13-6-4-3-5-7-13)23-24-11-10-20-18(15)24/h3-12H,1-2H3,(H,21,22)
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n/an/a 47.6n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188130
PNG
(US9169259, I-12)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(N)=O)n1
Show InChI InChI=1/C23H23N7O/c1-15-5-4-11-29(15)21-9-3-8-20(27-21)26-19-14-18(28-30-12-10-25-23(19)30)16-6-2-7-17(13-16)22(24)31/h2-3,6-10,12-15H,4-5,11H2,1H3,(H2,24,31)(H,26,27)
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n/an/a 48.6n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188203
PNG
(US9169259, I-88)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(OCCN3CCOCC3)c2)n1
Show InChI InChI=1/C28H33N7O2/c1-21-5-4-11-34(21)27-9-3-8-26(31-27)30-25-20-24(32-35-12-10-29-28(25)35)22-6-2-7-23(19-22)37-18-15-33-13-16-36-17-14-33/h2-3,6-10,12,19-21H,4-5,11,13-18H2,1H3,(H,30,31)
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n/an/a 51.0n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188181
PNG
(US9169259, I-64)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc3CCN(Cc3c2)C(C)=O)n1
Show InChI InChI=1/C27H29N7O/c1-18-5-4-12-33(18)26-7-3-6-25(30-26)29-24-16-23(31-34-14-11-28-27(24)34)21-9-8-20-10-13-32(19(2)35)17-22(20)15-21/h3,6-9,11,14-16,18H,4-5,10,12-13,17H2,1-2H3,(H,29,30)
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n/an/a 56.6n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188198
PNG
(US9169259, I-82)
Show SMILES COc1cncc(c1)-c1cc(Nc2cccc(n2)N2CCCC2C)c2nccn2n1
Show InChI InChI=1/C22H23N7O/c1-15-5-4-9-28(15)21-7-3-6-20(26-21)25-19-12-18(27-29-10-8-24-22(19)29)16-11-17(30-2)14-23-13-16/h3,6-8,10-15H,4-5,9H2,1-2H3,(H,25,26)
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n/an/a 59.9n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188207
PNG
(US9169259, I-92)
Show SMILES CCN(CC)CCOc1ccc(cc1)-c1cc(Nc2cccc(n2)N2CCCC2C)c2nccn2n1
Show InChI InChI=1/C28H35N7O/c1-4-33(5-2)18-19-36-23-13-11-22(12-14-23)24-20-25(28-29-15-17-35(28)32-24)30-26-9-6-10-27(31-26)34-16-7-8-21(34)3/h6,9-15,17,20-21H,4-5,7-8,16,18-19H2,1-3H3,(H,30,31)
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n/an/a 60.6n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188186
PNG
(US9169259, I-70)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(CN3CCCC3)c2)n1
Show InChI InChI=1/C27H31N7/c1-20-7-6-15-33(20)26-11-5-10-25(30-26)29-24-18-23(31-34-16-12-28-27(24)34)22-9-4-8-21(17-22)19-32-13-2-3-14-32/h4-5,8-12,16-18,20H,2-3,6-7,13-15,19H2,1H3,(H,29,30)
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n/an/a 60.8n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188193
PNG
(US9169259, I-77)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc(O)cc2)n1
Show InChI InChI=1/C22H22N6O/c1-15-4-3-12-27(15)21-6-2-5-20(25-21)24-19-14-18(16-7-9-17(29)10-8-16)26-28-13-11-23-22(19)28/h2,5-11,13-15,29H,3-4,12H2,1H3,(H,24,25)
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n/an/a 63.9n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188194
PNG
(US9169259, I-78)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccnc2)n1
Show InChI InChI=1/C21H21N7/c1-15-5-4-11-27(15)20-8-2-7-19(25-20)24-18-13-17(16-6-3-9-22-14-16)26-28-12-10-23-21(18)28/h2-3,6-10,12-15H,4-5,11H2,1H3,(H,24,25)
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n/an/a 65.2n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188163
PNG
(US9169259, I-45)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccccc2Cl)n1
Show InChI InChI=1/C22H21ClN6/c1-15-6-5-12-28(15)21-10-4-9-20(26-21)25-19-14-18(16-7-2-3-8-17(16)23)27-29-13-11-24-22(19)29/h2-4,7-11,13-15H,5-6,12H2,1H3,(H,25,26)
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n/an/a 71.2n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188137
PNG
(US9169259, I-19)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc3cn[nH]c3c2)n1
Show InChI InChI=1/C23H22N8/c1-15-4-3-10-30(15)22-6-2-5-21(27-22)26-20-13-19(29-31-11-9-24-23(20)31)16-7-8-17-14-25-28-18(17)12-16/h2,5-9,11-15H,3-4,10H2,1H3,(H,25,28)(H,26,27)
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n/an/a 75n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188151
PNG
(US9169259, I-33)
Show SMILES COc1ccc(Nc2cc(nn3ccnc23)-c2ccc(cc2)C(=O)NCCc2ccn(C)c(=O)c2)nc1OC
Show InChI InChI=1S/C28H27N7O4/c1-34-14-11-18(16-25(34)36)10-12-30-27(37)20-6-4-19(5-7-20)21-17-22(26-29-13-15-35(26)33-21)31-24-9-8-23(38-2)28(32-24)39-3/h4-9,11,13-17H,10,12H2,1-3H3,(H,30,37)(H,31,32)
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n/an/a 79.0n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188133
PNG
(US9169259, I-15)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc(cc2)C(O)=O)n1
Show InChI InChI=1/C23H22N6O2/c1-15-4-3-12-28(15)21-6-2-5-20(26-21)25-19-14-18(27-29-13-11-24-22(19)29)16-7-9-17(10-8-16)23(30)31/h2,5-11,13-15H,3-4,12H2,1H3,(H,25,26)(H,30,31)
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n/an/a 84.2n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188134
PNG
(US9169259, I-16)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc(cc2)C(=O)NCCc2ccncc2)n1
Show InChI InChI=1/C30H30N8O/c1-21-4-3-18-37(21)28-6-2-5-27(35-28)34-26-20-25(36-38-19-17-32-29(26)38)23-7-9-24(10-8-23)30(39)33-16-13-22-11-14-31-15-12-22/h2,5-12,14-15,17,19-21H,3-4,13,16,18H2,1H3,(H,33,39)(H,34,35)
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n/an/a 87.6n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188143
PNG
(US9169259, I-25)
Show SMILES CC1CCN(C1)c1cccc(Nc2cc(nn3ccnc23)-c2ccccc2)n1
Show InChI InChI=1/C22H22N6/c1-16-10-12-27(15-16)21-9-5-8-20(25-21)24-19-14-18(17-6-3-2-4-7-17)26-28-13-11-23-22(19)28/h2-9,11,13-14,16H,10,12,15H2,1H3,(H,24,25)
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n/an/a 88.5n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188204
PNG
(US9169259, I-89)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc(OCCN3CCCCC3)cc2)n1
Show InChI InChI=1/C29H35N7O/c1-22-7-6-17-35(22)28-9-5-8-27(32-28)31-26-21-25(33-36-18-14-30-29(26)36)23-10-12-24(13-11-23)37-20-19-34-15-3-2-4-16-34/h5,8-14,18,21-22H,2-4,6-7,15-17,19-20H2,1H3,(H,31,32)
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n/an/a 89.5n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188155
PNG
(US9169259, I-37)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc3[nH]ncc3c2)n1
Show InChI InChI=1/C23H22N8/c1-15-4-3-10-30(15)22-6-2-5-21(27-22)26-20-13-19(29-31-11-9-24-23(20)31)16-7-8-18-17(12-16)14-25-28-18/h2,5-9,11-15H,3-4,10H2,1H3,(H,25,28)(H,26,27)
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n/an/a 98.1n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188201
PNG
(US9169259, I-86)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(O)c2)n1
Show InChI InChI=1/C22H22N6O/c1-15-5-4-11-27(15)21-9-3-8-20(25-21)24-19-14-18(16-6-2-7-17(29)13-16)26-28-12-10-23-22(19)28/h2-3,6-10,12-15,29H,4-5,11H2,1H3,(H,24,25)
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n/an/a 102n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188211
PNG
(US9169259, I-96)
Show SMILES CNC(=O)c1ccc(NC(=O)c2cccc(c2)-c2cc(Nc3ccc(OC)c(OC)n3)c3nccn3n2)cc1
Show InChI InChI=1S/C28H25N7O4/c1-29-26(36)17-7-9-20(10-8-17)31-27(37)19-6-4-5-18(15-19)21-16-22(25-30-13-14-35(25)34-21)32-24-12-11-23(38-2)28(33-24)39-3/h4-16H,1-3H3,(H,29,36)(H,31,37)(H,32,33)
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n/an/a 103n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188161
PNG
(US9169259, I-43)
Show SMILES C[C@H]1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccccc2)n1
Show InChI InChI=1/C22H22N6/c1-16-7-6-13-27(16)21-11-5-10-20(25-21)24-19-15-18(17-8-3-2-4-9-17)26-28-14-12-23-22(19)28/h2-5,8-12,14-16H,6-7,13H2,1H3,(H,24,25)/t16-/s2
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n/an/a 107n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188167
PNG
(US9169259, I-49)
Show SMILES C[C@H]1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(O)=O)n1
Show InChI InChI=1/C23H22N6O2/c1-15-5-4-11-28(15)21-9-3-8-20(26-21)25-19-14-18(27-29-12-10-24-22(19)29)16-6-2-7-17(13-16)23(30)31/h2-3,6-10,12-15H,4-5,11H2,1H3,(H,25,26)(H,30,31)/t15-/s2
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n/an/a 108n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188136
PNG
(US9169259, I-18)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc3OCOc3c2)n1
Show InChI InChI=1/C23H22N6O2/c1-15-4-3-10-28(15)22-6-2-5-21(26-22)25-18-13-17(27-29-11-9-24-23(18)29)16-7-8-19-20(12-16)31-14-30-19/h2,5-9,11-13,15H,3-4,10,14H2,1H3,(H,25,26)
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n/an/a 115n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188127
PNG
(US9169259, I-9)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(O)=O)n1
Show InChI InChI=1/C23H22N6O2/c1-15-5-4-11-28(15)21-9-3-8-20(26-21)25-19-14-18(27-29-12-10-24-22(19)29)16-6-2-7-17(13-16)23(30)31/h2-3,6-10,12-15H,4-5,11H2,1H3,(H,25,26)(H,30,31)
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n/an/a 117n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM50400037
PNG
(CHEMBL2177733 | US9169259, I-5)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccccc2)n1
Show InChI InChI=1S/C22H22N6/c1-16-7-6-13-27(16)21-11-5-10-20(25-21)24-19-15-18(17-8-3-2-4-9-17)26-28-14-12-23-22(19)28/h2-5,8-12,14-16H,6-7,13H2,1H3,(H,24,25)
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n/an/a 127n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188159
PNG
(US9169259, I-41)
Show SMILES CC(CO)NC(=O)c1cccc(c1)-c1cc(Nc2cccc(n2)N2CCCC2C)c2nccn2n1
Show InChI InChI=1/C26H29N7O2/c1-17(16-34)28-26(35)20-8-3-7-19(14-20)21-15-22(25-27-11-13-33(25)31-21)29-23-9-4-10-24(30-23)32-12-5-6-18(32)2/h3-4,7-11,13-15,17-18,34H,5-6,12,16H2,1-2H3,(H,28,35)(H,29,30)
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n/an/a 130n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188164
PNG
(US9169259, I-46)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(=O)NCCN(C)C)n1
Show InChI InChI=1/C27H32N8O/c1-19-7-6-14-34(19)25-11-5-10-24(31-25)30-23-18-22(32-35-16-13-28-26(23)35)20-8-4-9-21(17-20)27(36)29-12-15-33(2)3/h4-5,8-11,13,16-19H,6-7,12,14-15H2,1-3H3,(H,29,36)(H,30,31)
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n/an/a 141n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188180
PNG
(US9169259, I-63)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc3CCCNc3c2)n1
Show InChI InChI=1/C25H27N7/c1-17-5-4-13-31(17)24-8-2-7-23(29-24)28-22-16-21(30-32-14-12-27-25(22)32)19-10-9-18-6-3-11-26-20(18)15-19/h2,7-10,12,14-17,26H,3-6,11,13H2,1H3,(H,28,29)
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n/an/a 151n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188205
PNG
(US9169259, I-90)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc(OCCN3CCOCC3)cc2)n1
Show InChI InChI=1/C28H33N7O2/c1-21-4-3-12-34(21)27-6-2-5-26(31-27)30-25-20-24(32-35-13-11-29-28(25)35)22-7-9-23(10-8-22)37-19-16-33-14-17-36-18-15-33/h2,5-11,13,20-21H,3-4,12,14-19H2,1H3,(H,30,31)
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n/an/a 157n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188165
PNG
(US9169259, I-47)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccccc2C)n1
Show InChI InChI=1/C23H24N6/c1-16-7-3-4-9-18(16)19-15-20(23-24-12-14-29(23)27-19)25-21-10-5-11-22(26-21)28-13-6-8-17(28)2/h3-5,7,9-12,14-15,17H,6,8,13H2,1-2H3,(H,25,26)
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n/an/a 159n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188209
PNG
(US9169259, I-94)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(OCCN3CCNCC3)c2)n1
Show InChI InChI=1/C28H34N8O/c1-21-5-4-13-35(21)27-9-3-8-26(32-27)31-25-20-24(33-36-16-12-30-28(25)36)22-6-2-7-23(19-22)37-18-17-34-14-10-29-11-15-34/h2-3,6-9,12,16,19-21,29H,4-5,10-11,13-15,17-18H2,1H3,(H,31,32)
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n/an/a 176n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188123
PNG
(US9169259, I-2)
Show SMILES CCc1ccc(Nc2cc(nn3ccnc23)-c2ccccc2)nc1
Show InChI InChI=1S/C19H17N5/c1-2-14-8-9-18(21-13-14)22-17-12-16(15-6-4-3-5-7-15)23-24-11-10-20-19(17)24/h3-13H,2H2,1H3,(H,21,22)
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n/an/a 186n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188146
PNG
(US9169259, I-28)
Show SMILES COc1ccc(Nc2cc(nn3ccnc23)-c2ccc(cc2)C(=O)NCCc2cc[nH]c(=O)c2)nc1OC
Show InChI InChI=1S/C27H25N7O4/c1-37-22-7-8-23(32-27(22)38-2)31-21-16-20(33-34-14-13-29-25(21)34)18-3-5-19(6-4-18)26(36)30-12-10-17-9-11-28-24(35)15-17/h3-9,11,13-16H,10,12H2,1-2H3,(H,28,35)(H,30,36)(H,31,32)
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n/an/a 187n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188197
PNG
(US9169259, I-81)
Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccncc2)n1
Show InChI InChI=1/C21H21N7/c1-15-4-3-12-27(15)20-6-2-5-19(25-20)24-18-14-17(16-7-9-22-10-8-16)26-28-13-11-23-21(18)28/h2,5-11,13-15H,3-4,12H2,1H3,(H,24,25)
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n/an/a 189n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM188142
PNG
(US9169259, I-24)
Show SMILES C[C@H]1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(C(O)=O)c2C)n1
Show InChI InChI=1/C24H24N6O2/c1-15-6-5-12-29(15)22-10-4-9-21(27-22)26-20-14-19(28-30-13-11-25-23(20)30)17-7-3-8-18(16(17)2)24(31)32/h3-4,7-11,13-15H,5-6,12H2,1-2H3,(H,26,27)(H,31,32)/t15-/s2
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n/an/a 194n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...


US Patent US9169259 (2015)

More data for this
Ligand-Target Pair
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