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Compile Data Set for Download or QSAR

Found 64 hits Enz. Inhib. hit(s) with Target = 'Secretory phospholipase A2, group V (sPLA2-V)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50263002
PNG
((2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-6,7-benz...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3ccccc3c2n1Cc1ccccc1
Show InChI InChI=1S/C25H22N2O5/c1-2-18-21(24(30)25(26)31)22-19(32-14-20(28)29)12-16-10-6-7-11-17(16)23(22)27(18)13-15-8-4-3-5-9-15/h3-12H,2,13-14H2,1H3,(H2,26,31)(H,28,29)
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n/an/a 35n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50055391
PNG
(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-ind...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OC(C)C(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C22H22N2O5/c1-3-15-19(20(25)21(23)26)18-16(24(15)12-14-8-5-4-6-9-14)10-7-11-17(18)29-13(2)22(27)28/h4-11,13H,3,12H2,1-2H3,(H2,23,26)(H,27,28)
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n/an/a 44n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50262842
PNG
(Benzenesulfonyl-2-(3-(2-amino-2-oxoacetyl)-1-benzy...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C27H25N3O6S/c1-2-20-25(26(32)27(28)33)24-21(30(20)16-18-10-5-3-6-11-18)14-9-15-22(24)36-17-23(31)29-37(34,35)19-12-7-4-8-13-19/h3-15H,2,16-17H2,1H3,(H2,28,33)(H,29,31)
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n/an/a 100n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50053137
PNG
((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-ethyl-indol...)
Show SMILES CCc1c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C27H24N2O5/c1-2-19-21(15-18-11-6-7-12-20(18)17-9-4-3-5-10-17)29-14-8-13-22(34-16-23(30)31)25(29)24(19)26(32)27(28)33/h3-14H,2,15-16H2,1H3,(H2,28,33)(H,30,31)
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n/an/a 100n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50274336
PNG
(1-{3-Dodecanoyl-2,4,6-trihydroxy-5-[7-hydroxy-2-(4...)
Show SMILES CCCCCCCCCCCC(=O)c1c(O)c(C2CC(Oc3cc(O)ccc23)c2ccc(O)cc2)c(O)c(C(=O)CCCCCCCCCCC)c1O
Show InChI InChI=1S/C45H62O8/c1-3-5-7-9-11-13-15-17-19-21-36(48)41-43(50)40(44(51)42(45(41)52)37(49)22-20-18-16-14-12-10-8-6-4-2)35-30-38(31-23-25-32(46)26-24-31)53-39-29-33(47)27-28-34(35)39/h23-29,35,38,46-47,50-52H,3-22,30H2,1-2H3
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n/an/a 110n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human sPLA2 group 5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50263000
PNG
(2-(1-benzyl-2-ethyl-1H-6,7-benzoindol-4-yloxy)-N-(...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3ccccc3c2n1Cc1ccccc1
Show InChI InChI=1S/C31H27N3O6S/c1-2-24-27(30(36)31(32)37)28-25(40-19-26(35)33-41(38,39)22-14-7-4-8-15-22)17-21-13-9-10-16-23(21)29(28)34(24)18-20-11-5-3-6-12-20/h3-17H,2,18-19H2,1H3,(H2,32,37)(H,33,35)
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n/an/a 140n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50055371
PNG
((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1-c1ccccc1
Show InChI InChI=1S/C26H22N2O5/c1-16-23(25(31)26(27)32)24-20(12-7-13-21(24)33-15-22(29)30)28(16)14-18-10-5-6-11-19(18)17-8-3-2-4-9-17/h2-13H,14-15H2,1H3,(H2,27,32)(H,29,30)
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n/an/a 270n/an/an/an/an/an/a



Université Paris7-Denis Diderot

Curated by ChEMBL


Assay Description
Inhibition of human group V PLA2 in [3H]oleate-labeled Escherichia coli membrane by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50333788
PNG
((S)-4-Methyl-2-(2-oxohexadecanamido)pentanoic acid...)
Show SMILES CCCCCCCCCCCCCCC(=O)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C22H41NO4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)21(25)23-19(22(26)27)17-18(2)3/h18-19H,4-17H2,1-3H3,(H,23,25)(H,26,27)/t19-/m0/s1
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n/an/a 440n/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human group 5 sPLA2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50055366
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)
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n/an/a 500n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50055366
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)
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n/an/a 500n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sPLA2 G5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50186585
PNG
(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-meth...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc(C)cc2n1Cc1ccccc1
Show InChI InChI=1S/C22H22N2O5/c1-3-15-20(21(27)22(23)28)19-16(24(15)11-14-7-5-4-6-8-14)9-13(2)10-17(19)29-12-18(25)26/h4-10H,3,11-12H2,1-2H3,(H2,23,28)(H,25,26)
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n/an/a 500n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sPLA2 G5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50274337
PNG
(1-(3-Dodecanoyl-2,4,6-trihydroxy-5-methyl-phenyl)-...)
Show SMILES CCCCCCCCCCCC(=O)c1c(O)c(C)c(O)c(C(=O)CCCCCCCCCCC)c1O
Show InChI InChI=1S/C31H52O5/c1-4-6-8-10-12-14-16-18-20-22-25(32)27-29(34)24(3)30(35)28(31(27)36)26(33)23-21-19-17-15-13-11-9-7-5-2/h34-36H,4-23H2,1-3H3
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n/an/a 530n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human sPLA2 group 5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50206911
PNG
((+/+)-1-O-decyl-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H...)
Show SMILES CCCCCCCCCCCCCCOC(COCCCCCCCCCC)COc1ccc(cc1)-c1nc(=O)o[nH]1
Show InChI InChI=1S/C35H60N2O5/c1-3-5-7-9-11-13-14-15-16-18-20-22-28-40-33(29-39-27-21-19-17-12-10-8-6-4-2)30-41-32-25-23-31(24-26-32)34-36-35(38)42-37-34/h23-26,33H,3-22,27-30H2,1-2H3,(H,36,37,38)
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n/an/a 550n/an/an/an/an/an/a



Université Paris7-Denis Diderot

Curated by ChEMBL


Assay Description
Inhibition of human group V PLA2 in [3H]oleate-labeled Escherichia coli membrane by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM18207
PNG
((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
Show InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
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n/an/a 620n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz



Assay Description
Briefly, sn-2ester bond of the substrate 1,2-bis(heptanoylthio)-glycerophosphocholine was hydrolyzed by PLA2-V followed by the exposure of free thiol...


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50206920
PNG
((+/-)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol...)
Show SMILES CCCCCCCCCCCCCCOC(COc1ccc(cc1)-c1nc(=O)o[nH]1)COC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C44H54N2O5/c1-2-3-4-5-6-7-8-9-10-11-12-22-33-48-41(34-49-40-31-29-36(30-32-40)42-45-43(47)51-46-42)35-50-44(37-23-16-13-17-24-37,38-25-18-14-19-26-38)39-27-20-15-21-28-39/h13-21,23-32,41H,2-12,22,33-35H2,1H3,(H,45,46,47)
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n/an/a 660n/an/an/an/an/an/a



Université Paris7-Denis Diderot

Curated by ChEMBL


Assay Description
Inhibition of human group V PLA2 in [3H]oleate-labeled Escherichia coli membrane by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50055383
PNG
((3-Aminooxalyl-1-benzyl-2-methyl-1H-indol-4-yloxy)...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C20H18N2O5/c1-12-17(19(25)20(21)26)18-14(8-5-9-15(18)27-11-16(23)24)22(12)10-13-6-3-2-4-7-13/h2-9H,10-11H2,1H3,(H2,21,26)(H,23,24)
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n/an/a 800n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sPLA2 G5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50186586
PNG
(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2,6-dimethyl-1...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc(C)cc2n1Cc1ccccc1
Show InChI InChI=1S/C21H20N2O5/c1-12-8-15-19(16(9-12)28-11-17(24)25)18(20(26)21(22)27)13(2)23(15)10-14-6-4-3-5-7-14/h3-9H,10-11H2,1-2H3,(H2,22,27)(H,24,25)
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n/an/a 800n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sPLA2 G5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50206910
PNG
((+/-)-1-O-(4-cyanomethylphenyl)-3-O-[4-(4,5-dihydr...)
Show SMILES CCCCCCCCCCCCCCCCCCOC(COCc1ccc(cc1)C#N)COc1ccc(Cc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C38H55N3O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-26-44-36(30-43-29-34-20-18-33(28-39)19-21-34)31-45-35-24-22-32(23-25-35)27-37-40-38(42)46-41-37/h18-25,36H,2-17,26-27,29-31H2,1H3,(H,40,41,42)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Université Paris7-Denis Diderot

Curated by ChEMBL


Assay Description
Inhibition of human group V PLA2 in [3H]oleate-labeled Escherichia coli membrane by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50149981
PNG
(CHEMBL3769794)
Show SMILES CNC(=O)C(CC(=O)Nc1ccc(Br)cn1)NC(=O)c1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C23H22BrN5O5S/c1-26-23(32)18(12-21(30)29-20-11-10-16(24)13-27-20)28-22(31)15-8-6-14(7-9-15)17-4-2-3-5-19(17)35(25,33)34/h2-11,13,18H,12H2,1H3,(H,26,32)(H,28,31)(H2,25,33,34)(H,27,29,30)
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n/an/a 1.20E+3n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human group 5 secreted phospholipase A2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50333789
PNG
((R)-4-Methyl-2-(2-oxohexadecanamido)pentanoic acid...)
Show SMILES CCCCCCCCCCCCCCC(=O)C(=O)N[C@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C22H41NO4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)21(25)23-19(22(26)27)17-18(2)3/h18-19H,4-17H2,1-3H3,(H,23,25)(H,26,27)/t19-/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human group 5 sPLA2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50263052
PNG
(2-[3-Biphenyl-2-ylmethyl-2-ethyl-8-(2-oxo-propoxy)...)
Show SMILES CCc1c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(C)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C28H26N2O4/c1-3-21-23(16-20-12-7-8-13-22(20)19-10-5-4-6-11-19)30-15-9-14-24(34-17-18(2)31)26(30)25(21)27(32)28(29)33/h4-15H,3,16-17H2,1-2H3,(H2,29,33)
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50263053
PNG
(2-(3-Biphenyl-2-ylmethyl-2-ethyl-8-methoxy-indoliz...)
Show SMILES CCc1c(Cc2ccccc2-c2ccccc2)n2cccc(OC)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C26H24N2O3/c1-3-19-21(16-18-12-7-8-13-20(18)17-10-5-4-6-11-17)28-15-9-14-22(31-2)24(28)23(19)25(29)26(27)30/h4-15H,3,16H2,1-2H3,(H2,27,30)
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50263003
PNG
(2-(2-ethyl-3-(o-phenylbenzyl)-8-(2-oxopropoxy)indo...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OC)cc3ccccc3c2n1Cc1ccccc1
Show InChI InChI=1S/C24H22N2O3/c1-3-18-20(23(27)24(25)28)21-19(29-2)13-16-11-7-8-12-17(16)22(21)26(18)14-15-9-5-4-6-10-15/h4-13H,3,14H2,1-2H3,(H2,25,28)
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50274442
PNG
(1-(3-Dodecanoyl-2-hydroxy-5-methyl-phenyl)-dodecan...)
Show SMILES CCCCCCCCCCCC(=O)c1cc(C)cc(C(=O)CCCCCCCCCCC)c1O
Show InChI InChI=1S/C31H52O3/c1-4-6-8-10-12-14-16-18-20-22-29(32)27-24-26(3)25-28(31(27)34)30(33)23-21-19-17-15-13-11-9-7-5-2/h24-25,34H,4-23H2,1-3H3
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human sPLA2 group 5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50274387
PNG
(1-(3-Acetyl-2,4,6-trihydroxy-5-methyl-phenyl)-etha...)
Show SMILES CC(=O)c1c(O)c(C)c(O)c(C(C)=O)c1O
Show InChI InChI=1S/C11H12O5/c1-4-9(14)7(5(2)12)11(16)8(6(3)13)10(4)15/h14-16H,1-3H3
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human sPLA2 group 5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50274391
PNG
(1-(3-dodecyl-2,4,6-trihydroxyphenyl)dodecan-1-one ...)
Show SMILES CCCCCCCCCCCCc1c(O)cc(O)c(C(=O)CCCCCCCCCCC)c1O
Show InChI InChI=1S/C30H52O4/c1-3-5-7-9-11-13-15-16-18-20-22-25-27(32)24-28(33)29(30(25)34)26(31)23-21-19-17-14-12-10-8-6-4-2/h24,32-34H,3-23H2,1-2H3
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human sPLA2 group 5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50274388
PNG
(2-Phenyl-1-(2,4,6-trihydroxy-3-methyl-5-phenylacet...)
Show SMILES Cc1c(O)c(C(=O)Cc2ccccc2)c(O)c(C(=O)Cc2ccccc2)c1O
Show InChI InChI=1S/C23H20O5/c1-14-21(26)19(17(24)12-15-8-4-2-5-9-15)23(28)20(22(14)27)18(25)13-16-10-6-3-7-11-16/h2-11,26-28H,12-13H2,1H3
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human sPLA2 group 5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50262844
PNG
(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-isobutyl-1H-...)
Show SMILES CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C23H24N2O5/c1-14(2)11-17-21(22(28)23(24)29)20-16(9-6-10-18(20)30-13-19(26)27)25(17)12-15-7-4-3-5-8-15/h3-10,14H,11-13H2,1-2H3,(H2,24,29)(H,26,27)
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50274390
PNG
(1-(5-Dodecanoyl-2,4-dihydroxy-phenyl)-dodecan-1-on...)
Show SMILES CCCCCCCCCCCC(=O)c1cc(C(=O)CCCCCCCCCCC)c(O)cc1O
Show InChI InChI=1S/C30H50O4/c1-3-5-7-9-11-13-15-17-19-21-27(31)25-23-26(30(34)24-29(25)33)28(32)22-20-18-16-14-12-10-8-6-4-2/h23-24,33-34H,3-22H2,1-2H3
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human sPLA2 group 5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50274389
PNG
(1-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)dodeca...)
Show SMILES CCCCCCCCCCCC(=O)c1c(O)c(C)c(O)c(C(C)=O)c1O
Show InChI InChI=1S/C21H32O5/c1-4-5-6-7-8-9-10-11-12-13-16(23)18-20(25)14(2)19(24)17(15(3)22)21(18)26/h24-26H,4-13H2,1-3H3
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human sPLA2 group 5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50256011
PNG
(1,1'-(2,4,6-trihydroxy-1,3-phenylene)didodecan-1-o...)
Show SMILES CCCCCCCCCCCC(=O)c1c(O)cc(O)c(C(=O)CCCCCCCCCCC)c1O
Show InChI InChI=1S/C30H50O5/c1-3-5-7-9-11-13-15-17-19-21-24(31)28-26(33)23-27(34)29(30(28)35)25(32)22-20-18-16-14-12-10-8-6-4-2/h23,33-35H,3-22H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human sPLA2 group 5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50263001
PNG
(2-(1-benzyl-2-isobutyl-1H-6,7-benzoindol-4-yloxy)-...)
Show SMILES CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3ccccc3c2n1Cc1ccccc1
Show InChI InChI=1S/C33H31N3O6S/c1-21(2)17-26-29(32(38)33(34)39)30-27(42-20-28(37)35-43(40,41)24-14-7-4-8-15-24)18-23-13-9-10-16-25(23)31(30)36(26)19-22-11-5-3-6-12-22/h3-16,18,21H,17,19-20H2,1-2H3,(H2,34,39)(H,35,37)
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50274441
PNG
(1-(3-Acetyl-5-dodecyl-2,4,6-trihydroxy-phenyl)-eth...)
Show SMILES CCCCCCCCCCCCc1c(O)c(C(C)=O)c(O)c(C(C)=O)c1O
Show InChI InChI=1S/C22H34O5/c1-4-5-6-7-8-9-10-11-12-13-14-17-20(25)18(15(2)23)22(27)19(16(3)24)21(17)26/h25-27H,4-14H2,1-3H3
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human sPLA2 group 5


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50263051
PNG
(2-(1-(2-amino-2-oxoacetyl)-2-(isobutyl)-3-(ophenyl...)
Show SMILES CC(C)Cc1c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C29H28N2O5/c1-18(2)15-22-23(16-20-11-6-7-12-21(20)19-9-4-3-5-10-19)31-14-8-13-24(36-17-25(32)33)27(31)26(22)28(34)29(30)35/h3-14,18H,15-17H2,1-2H3,(H2,30,35)(H,32,33)
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50262843
PNG
(Benzenesulfonyl-2-(3-(2-amino-2-oxoacetyl)-1-benzy...)
Show SMILES CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C29H29N3O6S/c1-19(2)16-23-27(28(34)29(30)35)26-22(32(23)17-20-10-5-3-6-11-20)14-9-15-24(26)38-18-25(33)31-39(36,37)21-12-7-4-8-13-21/h3-15,19H,16-18H2,1-2H3,(H2,30,35)(H,31,33)
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50262804
PNG
(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-isobutyl-1H-...)
Show SMILES CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3ccccc3c2n1Cc1ccccc1
Show InChI InChI=1S/C27H26N2O5/c1-16(2)12-20-23(26(32)27(28)33)24-21(34-15-22(30)31)13-18-10-6-7-11-19(18)25(24)29(20)14-17-8-4-3-5-9-17/h3-11,13,16H,12,14-15H2,1-2H3,(H2,28,33)(H,30,31)
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2V phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50333790
PNG
((S)-4-Methyl-2-palmitamidopentanoic acid | CHEMBL1...)
Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C22H43NO3/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)23-20(22(25)26)18-19(2)3/h19-20H,4-18H2,1-3H3,(H,23,24)(H,25,26)/t20-/m0/s1
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n/an/a>1.66E+3n/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human group 5 sPLA2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50333791
PNG
((S)-2-(2-Oxohexadecanamido)-3-phenylpropanoic acid...)
Show SMILES CCCCCCCCCCCCCCC(=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C25H39NO4/c1-2-3-4-5-6-7-8-9-10-11-12-16-19-23(27)24(28)26-22(25(29)30)20-21-17-14-13-15-18-21/h13-15,17-18,22H,2-12,16,19-20H2,1H3,(H,26,28)(H,29,30)/t22-/m0/s1
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n/an/a>1.66E+3n/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human group 5 sPLA2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50206908
PNG
((+/-)-1-O-(4-cyanomethylphenyl)-3-O-[4-(4,5-dihydr...)
Show SMILES CCCCCCCCCCCCCCOC(COCc1ccc(cc1)C#N)COc1ccc(Cc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C34H47N3O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-22-40-32(26-39-25-30-16-14-29(24-35)15-17-30)27-41-31-20-18-28(19-21-31)23-33-36-34(38)42-37-33/h14-21,32H,2-13,22-23,25-27H2,1H3,(H,36,37,38)
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n/an/a 1.73E+3n/an/an/an/an/an/a



Université Paris7-Denis Diderot

Curated by ChEMBL


Assay Description
Inhibition of human group V PLA2 in [3H]oleate-labeled Escherichia coli membrane by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50206913
PNG
((+/-)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol...)
Show SMILES CCCCCCCCCCCCCCOC(COC(c1ccccc1)c1ccccc1)COc1ccc(cc1)-c1nc(=O)o[nH]1
Show InChI InChI=1S/C38H50N2O5/c1-2-3-4-5-6-7-8-9-10-11-12-19-28-42-35(29-43-34-26-24-33(25-27-34)37-39-38(41)45-40-37)30-44-36(31-20-15-13-16-21-31)32-22-17-14-18-23-32/h13-18,20-27,35-36H,2-12,19,28-30H2,1H3,(H,39,40,41)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Université Paris7-Denis Diderot

Curated by ChEMBL


Assay Description
Inhibition of human group V PLA2 in [3H]oleate-labeled Escherichia coli membrane by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM153297
PNG
(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-5-(4,7- dime...)
Show SMILES COc1ccc2c(OC)ccc(C3CC(=NN3C(=O)Nc3ccc(Cl)cc3)c3ccc4OCCOc4c3)c2c1
Show InChI InChI=1/C30H26ClN3O5/c1-36-21-8-9-23-24(16-21)22(10-12-27(23)37-2)26-17-25(18-3-11-28-29(15-18)39-14-13-38-28)33-34(26)30(35)32-20-6-4-19(31)5-7-20/h3-12,15-16,26H,13-14,17H2,1-2H3,(H,32,35)
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n/an/a 5.12E+3n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz



Assay Description
Briefly, sn-2ester bond of the substrate 1,2-bis(heptanoylthio)-glycerophosphocholine was hydrolyzed by PLA2-V followed by the exposure of free thiol...


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM153291
PNG
(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-5-(4,7- dime...)
Show SMILES COc1ccc2c(OC)ccc(C3CC(=NN3C(N)=S)c3ccc4OCCOc4c3)c2c1
Show InChI InChI=1/C24H23N3O4S/c1-28-15-4-5-17-18(12-15)16(6-8-21(17)29-2)20-13-19(26-27(20)24(25)32)14-3-7-22-23(11-14)31-10-9-30-22/h3-8,11-12,20H,9-10,13H2,1-2H3,(H2,25,32)
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n/an/a 7.12E+3n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz



Assay Description
Briefly, sn-2ester bond of the substrate 1,2-bis(heptanoylthio)-glycerophosphocholine was hydrolyzed by PLA2-V followed by the exposure of free thiol...


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM153294
PNG
(3-Benzofuran-2-yl-5-(2,3-dimethoxy-naphthalen-1-yl...)
Show SMILES COc1cc2ccccc2c(C2CC(=NN2C(=O)Nc2ccc(Cl)cc2)c2cc3ccccc3o2)c1OC
Show InChI InChI=1/C30H24ClN3O4/c1-36-27-15-18-7-3-5-9-22(18)28(29(27)37-2)24-17-23(26-16-19-8-4-6-10-25(19)38-26)33-34(24)30(35)32-21-13-11-20(31)12-14-21/h3-16,24H,17H2,1-2H3,(H,32,35)
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n/an/a 8.46E+3n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz



Assay Description
Briefly, sn-2ester bond of the substrate 1,2-bis(heptanoylthio)-glycerophosphocholine was hydrolyzed by PLA2-V followed by the exposure of free thiol...


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM153288
PNG
(3-Benzofuran-2-yl-5-(2,3-dimethoxy-naphthalen-1-yl...)
Show SMILES COc1cc2ccccc2c(C2CC(=NN2C(N)=S)c2cc3ccccc3o2)c1OC
Show InChI InChI=1/C24H21N3O3S/c1-28-21-11-14-7-3-5-9-16(14)22(23(21)29-2)18-13-17(26-27(18)24(25)31)20-12-15-8-4-6-10-19(15)30-20/h3-12,18H,13H2,1-2H3,(H2,25,31)
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n/an/a 9.17E+3n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz



Assay Description
Briefly, sn-2ester bond of the substrate 1,2-bis(heptanoylthio)-glycerophosphocholine was hydrolyzed by PLA2-V followed by the exposure of free thiol...


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50200326
PNG
(((S)-7-benzyl-3-tert-butoxycarbonylmethyl-5-methyl...)
Show SMILES CN1CN(CC(=O)OC(C)(C)C)C(=O)N(CC(=O)OC(C)(C)C)[C@@H](Cc2ccccc2)C1=O
Show InChI InChI=1S/C24H35N3O6/c1-23(2,3)32-19(28)14-26-16-25(7)21(30)18(13-17-11-9-8-10-12-17)27(22(26)31)15-20(29)33-24(4,5)6/h8-12,18H,13-16H2,1-7H3/t18-/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



CNRS UMR 7175

Curated by ChEMBL


Assay Description
Inhibition of human group 5 sPLA2


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50200324
PNG
((4S,7S)-4,7-dibenzyl-5-methyl-1,3,5-triazepane-2,6...)
Show SMILES CN1[C@@H](Cc2ccccc2)NC(=O)N[C@@H](Cc2ccccc2)C1=O
Show InChI InChI=1S/C19H21N3O2/c1-22-17(13-15-10-6-3-7-11-15)21-19(24)20-16(18(22)23)12-14-8-4-2-5-9-14/h2-11,16-17H,12-13H2,1H3,(H2,20,21,24)/t16-,17-/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



CNRS UMR 7175

Curated by ChEMBL


Assay Description
Inhibition of human group 5 sPLA2


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50200327
PNG
((E)-4-(6-Benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepa...)
Show SMILES CN1CN(C\C=C\C(O)=O)C(=O)N[C@@H](Cc2ccccc2)C1=O
Show InChI InChI=1S/C16H19N3O4/c1-18-11-19(9-5-8-14(20)21)16(23)17-13(15(18)22)10-12-6-3-2-4-7-12/h2-8,13H,9-11H2,1H3,(H,17,23)(H,20,21)/b8-5+/t13-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



CNRS UMR 7175

Curated by ChEMBL


Assay Description
Inhibition of human group 5 sPLA2


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM50200325
PNG
((S)-tert-butyl 2-(6-isopropyl-1-methyl-4,7-dioxo-1...)
Show SMILES CC(C)[C@@H]1NC(=O)N(CC(=O)OC(C)(C)C)CN(C)C1=O
Show InChI InChI=1S/C14H25N3O4/c1-9(2)11-12(19)16(6)8-17(13(20)15-11)7-10(18)21-14(3,4)5/h9,11H,7-8H2,1-6H3,(H,15,20)/t11-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



CNRS UMR 7175

Curated by ChEMBL


Assay Description
Inhibition of human group 5 sPLA2


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM153282
PNG
(1-Benzofuran-2-yl-3-(2,3-dimethoxy-naphthalen-1-yl...)
Show SMILES COc1cc2ccccc2c(\C=C\C(=O)c2cc3ccccc3o2)c1OC
Show InChI InChI=1S/C23H18O4/c1-25-22-13-15-7-3-5-9-17(15)18(23(22)26-2)11-12-19(24)21-14-16-8-4-6-10-20(16)27-21/h3-14H,1-2H3/b12-11+
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n/an/a 1.27E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz



Assay Description
Briefly, sn-2ester bond of the substrate 1,2-bis(heptanoylthio)-glycerophosphocholine was hydrolyzed by PLA2-V followed by the exposure of free thiol...


Citation and Details
More data for this
Ligand-Target Pair
Secretory phospholipase A2, group V (sPLA2-V)


(Homo sapiens (Human))
BDBM153293
PNG
(3-Benzofuran-2-yl-5-(4,7-dimethoxy-naphthalen-1-yl...)
Show SMILES COc1ccc2c(OC)ccc(C3CC(=NN3C(=O)Nc3ccc(Cl)cc3)c3cc4ccccc4o3)c2c1
Show InChI InChI=1/C30H24ClN3O4/c1-36-21-11-12-23-24(16-21)22(13-14-28(23)37-2)26-17-25(29-15-18-5-3-4-6-27(18)38-29)33-34(26)30(35)32-20-9-7-19(31)8-10-20/h3-16,26H,17H2,1-2H3,(H,32,35)
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n/an/a 1.46E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz



Assay Description
Briefly, sn-2ester bond of the substrate 1,2-bis(heptanoylthio)-glycerophosphocholine was hydrolyzed by PLA2-V followed by the exposure of free thiol...


Citation and Details
More data for this
Ligand-Target Pair
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