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Compile Data Set for Download or QSAR

Found 10 hits Enz. Inhib. hit(s) with Target = 'Segment polarity protein dishevelled homolog DVL-1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373848
PNG
(CHEMBL255779)
Show SMILES Cc1cc2[nH]c(C(=O)NC3CCCCC3)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C25H28N2O3/c1-16-14-22-21(15-20(16)25(29)30)19(13-12-17-8-4-2-5-9-17)23(27-22)24(28)26-18-10-6-3-7-11-18/h2,4-5,8-9,14-15,18,27H,3,6-7,10-13H2,1H3,(H,26,28)(H,29,30)
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n/an/a 4.90E+4n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373845
PNG
(CHEMBL402939)
Show SMILES Cc1cc2n(C)c(C(=O)NC3CCCCC3)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C26H30N2O3/c1-17-15-23-22(16-21(17)26(30)31)20(14-13-18-9-5-3-6-10-18)24(28(23)2)25(29)27-19-11-7-4-8-12-19/h3,5-6,9-10,15-16,19H,4,7-8,11-14H2,1-2H3,(H,27,29)(H,30,31)
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n/an/a 7.80E+4n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373844
PNG
(CHEMBL272948)
Show SMILES COC(=O)c1cc2c(CCc3ccccc3)c([nH]c2cc1C)C(=O)NC1CCCCC1
Show InChI InChI=1S/C26H30N2O3/c1-17-15-23-22(16-21(17)26(30)31-2)20(14-13-18-9-5-3-6-10-18)24(28-23)25(29)27-19-11-7-4-8-12-19/h3,5-6,9-10,15-16,19,28H,4,7-8,11-14H2,1-2H3,(H,27,29)
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n/an/a 9.70E+4n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373847
PNG
(CHEMBL256605)
Show SMILES Cc1cc2[nH]c(C(=O)NCC3CCCCC3)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C26H30N2O3/c1-17-14-23-22(15-21(17)26(30)31)20(13-12-18-8-4-2-5-9-18)24(28-23)25(29)27-16-19-10-6-3-7-11-19/h2,4-5,8-9,14-15,19,28H,3,6-7,10-13,16H2,1H3,(H,27,29)(H,30,31)
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n/an/a 1.57E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373851
PNG
(CHEMBL256431)
Show SMILES CCC(C)CNC(=O)c1[nH]c2cc(C)c(cc2c1CCc1ccccc1)C(O)=O
Show InChI InChI=1S/C24H28N2O3/c1-4-15(2)14-25-23(27)22-18(11-10-17-8-6-5-7-9-17)20-13-19(24(28)29)16(3)12-21(20)26-22/h5-9,12-13,15,26H,4,10-11,14H2,1-3H3,(H,25,27)(H,28,29)
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n/an/a 1.59E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373846
PNG
(CHEMBL401537)
Show SMILES Cc1cc2[nH]c(C(=O)NCc3ccccc3)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C26H24N2O3/c1-17-14-23-22(15-21(17)26(30)31)20(13-12-18-8-4-2-5-9-18)24(28-23)25(29)27-16-19-10-6-3-7-11-19/h2-11,14-15,28H,12-13,16H2,1H3,(H,27,29)(H,30,31)
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n/an/a 1.97E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373843
PNG
(CHEMBL410400)
Show SMILES CCCNC(=O)c1[nH]c2cc(C)c(cc2c1CCc1ccccc1)C(O)=O
Show InChI InChI=1S/C22H24N2O3/c1-3-11-23-21(25)20-16(10-9-15-7-5-4-6-8-15)18-13-17(22(26)27)14(2)12-19(18)24-20/h4-8,12-13,24H,3,9-11H2,1-2H3,(H,23,25)(H,26,27)
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n/an/a>5.00E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373849
PNG
(CHEMBL255988)
Show SMILES Cc1cc2[nH]c(C(=O)NCC3CC3)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C23H24N2O3/c1-14-11-20-19(12-18(14)23(27)28)17(10-9-15-5-3-2-4-6-15)21(25-20)22(26)24-13-16-7-8-16/h2-6,11-12,16,25H,7-10,13H2,1H3,(H,24,26)(H,27,28)
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n/an/a>5.00E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373850
PNG
(CHEMBL404331)
Show SMILES Cc1cc2[nH]c(C(=O)NC(C)(C)C)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C23H26N2O3/c1-14-12-19-18(13-17(14)22(27)28)16(11-10-15-8-6-5-7-9-15)20(24-19)21(26)25-23(2,3)4/h5-9,12-13,24H,10-11H2,1-4H3,(H,25,26)(H,27,28)
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n/an/a>5.00E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50231890
PNG
(2-((2-carboxyethyl)carbamoyl)-6-methyl-3-phenethyl...)
Show SMILES Cc1cc2[nH]c(C(=O)NCCC(O)=O)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C22H22N2O5/c1-13-11-18-17(12-16(13)22(28)29)15(8-7-14-5-3-2-4-6-14)20(24-18)21(27)23-10-9-19(25)26/h2-6,11-12,24H,7-10H2,1H3,(H,23,27)(H,25,26)(H,28,29)
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n/an/a>5.00E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair