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Compile Data Set for Download or QSAR

Found 32 hits Enz. Inhib. hit(s) with Target = 'Segment polarity protein dishevelled homolog DVL-1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373848
PNG
(CHEMBL255779)
Show SMILES Cc1cc2[nH]c(C(=O)NC3CCCCC3)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C25H28N2O3/c1-16-14-22-21(15-20(16)25(29)30)19(13-12-17-8-4-2-5-9-17)23(27-22)24(28)26-18-10-6-3-7-11-18/h2,4-5,8-9,14-15,18,27H,3,6-7,10-13H2,1H3,(H,26,28)(H,29,30)
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n/an/a 4.90E+4n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Bioorg Med Chem Lett 18: 946-9 (2008)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373845
PNG
(CHEMBL402939)
Show SMILES Cc1cc2n(C)c(C(=O)NC3CCCCC3)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C26H30N2O3/c1-17-15-23-22(16-21(17)26(30)31)20(14-13-18-9-5-3-6-10-18)24(28(23)2)25(29)27-19-11-7-4-8-12-19/h3,5-6,9-10,15-16,19H,4,7-8,11-14H2,1-2H3,(H,27,29)(H,30,31)
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n/an/a 7.80E+4n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Bioorg Med Chem Lett 18: 946-9 (2008)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373844
PNG
(CHEMBL272948)
Show SMILES COC(=O)c1cc2c(CCc3ccccc3)c([nH]c2cc1C)C(=O)NC1CCCCC1
Show InChI InChI=1S/C26H30N2O3/c1-17-15-23-22(16-21(17)26(30)31-2)20(14-13-18-9-5-3-6-10-18)24(28-23)25(29)27-19-11-7-4-8-12-19/h3,5-6,9-10,15-16,19,28H,4,7-8,11-14H2,1-2H3,(H,27,29)
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n/an/a 9.70E+4n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Bioorg Med Chem Lett 18: 946-9 (2008)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373847
PNG
(CHEMBL256605)
Show SMILES Cc1cc2[nH]c(C(=O)NCC3CCCCC3)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C26H30N2O3/c1-17-14-23-22(15-21(17)26(30)31)20(13-12-18-8-4-2-5-9-18)24(28-23)25(29)27-16-19-10-6-3-7-11-19/h2,4-5,8-9,14-15,19,28H,3,6-7,10-13,16H2,1H3,(H,27,29)(H,30,31)
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n/an/a 1.57E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Bioorg Med Chem Lett 18: 946-9 (2008)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373851
PNG
(CHEMBL256431)
Show SMILES CCC(C)CNC(=O)c1[nH]c2cc(C)c(cc2c1CCc1ccccc1)C(O)=O
Show InChI InChI=1S/C24H28N2O3/c1-4-15(2)14-25-23(27)22-18(11-10-17-8-6-5-7-9-17)20-13-19(24(28)29)16(3)12-21(20)26-22/h5-9,12-13,15,26H,4,10-11,14H2,1-3H3,(H,25,27)(H,28,29)
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n/an/a 1.59E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Bioorg Med Chem Lett 18: 946-9 (2008)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373846
PNG
(CHEMBL401537)
Show SMILES Cc1cc2[nH]c(C(=O)NCc3ccccc3)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C26H24N2O3/c1-17-14-23-22(15-21(17)26(30)31)20(13-12-18-8-4-2-5-9-18)24(28-23)25(29)27-16-19-10-6-3-7-11-19/h2-11,14-15,28H,12-13,16H2,1H3,(H,27,29)(H,30,31)
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n/an/a 1.97E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Bioorg Med Chem Lett 18: 946-9 (2008)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373850
PNG
(CHEMBL404331)
Show SMILES Cc1cc2[nH]c(C(=O)NC(C)(C)C)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C23H26N2O3/c1-14-12-19-18(13-17(14)22(27)28)16(11-10-15-8-6-5-7-9-15)20(24-19)21(26)25-23(2,3)4/h5-9,12-13,24H,10-11H2,1-4H3,(H,25,26)(H,27,28)
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n/an/a>5.00E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Bioorg Med Chem Lett 18: 946-9 (2008)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373843
PNG
(CHEMBL410400)
Show SMILES CCCNC(=O)c1[nH]c2cc(C)c(cc2c1CCc1ccccc1)C(O)=O
Show InChI InChI=1S/C22H24N2O3/c1-3-11-23-21(25)20-16(10-9-15-7-5-4-6-8-15)18-13-17(22(26)27)14(2)12-19(18)24-20/h4-8,12-13,24H,3,9-11H2,1-2H3,(H,23,25)(H,26,27)
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n/an/a>5.00E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Bioorg Med Chem Lett 18: 946-9 (2008)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50231890
PNG
(2-((2-carboxyethyl)carbamoyl)-6-methyl-3-phenethyl...)
Show SMILES Cc1cc2[nH]c(C(=O)NCCC(O)=O)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C22H22N2O5/c1-13-11-18-17(12-16(13)22(28)29)15(8-7-14-5-3-2-4-6-14)20(24-18)21(27)23-10-9-19(25)26/h2-6,11-12,24H,7-10H2,1H3,(H,23,27)(H,25,26)(H,28,29)
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n/an/a>5.00E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Bioorg Med Chem Lett 18: 946-9 (2008)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50373849
PNG
(CHEMBL255988)
Show SMILES Cc1cc2[nH]c(C(=O)NCC3CC3)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C23H24N2O3/c1-14-11-20-19(12-18(14)23(27)28)17(10-9-15-5-3-2-4-6-15)21(25-20)22(26)24-13-16-7-8-16/h2-6,11-12,16,25H,7-10,13H2,1H3,(H,24,26)(H,27,28)
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n/an/a>5.00E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Bioorg Med Chem Lett 18: 946-9 (2008)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177677
PNG
(CHEMBL3814692)
Show SMILES CCOc1cc(\C=C2/Sc3ccccc3C2=O)cc(Br)c1OCC(O)=O
Show InChI InChI=1S/C19H15BrO5S/c1-2-24-14-8-11(7-13(20)19(14)25-10-17(21)22)9-16-18(23)12-5-3-4-6-15(12)26-16/h3-9H,2,10H2,1H3,(H,21,22)/b16-9-
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n/an/an/a 5.80n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177714
PNG
(CHEMBL3813775)
Show SMILES COc1cc(\C=C2/Sc3ccccc3C2=O)ccc1OCC(O)=O
Show InChI InChI=1S/C18H14O5S/c1-22-14-8-11(6-7-13(14)23-10-17(19)20)9-16-18(21)12-4-2-3-5-15(12)24-16/h2-9H,10H2,1H3,(H,19,20)/b16-9-
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n/an/an/a 6.20n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177676
PNG
(CHEMBL3814041)
Show SMILES COC(=O)COc1ccc(\C=C2/Sc3ccccc3C2=O)cc1
Show InChI InChI=1S/C18H14O4S/c1-21-17(19)11-22-13-8-6-12(7-9-13)10-16-18(20)14-4-2-3-5-15(14)23-16/h2-10H,11H2,1H3/b16-10-
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n/an/an/a 2.5n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177677
PNG
(CHEMBL3814692)
Show SMILES CCOc1cc(\C=C2/Sc3ccccc3C2=O)cc(Br)c1OCC(O)=O
Show InChI InChI=1S/C19H15BrO5S/c1-2-24-14-8-11(7-13(20)19(14)25-10-17(21)22)9-16-18(23)12-5-3-4-6-15(12)26-16/h3-9H,2,10H2,1H3,(H,21,22)/b16-9-
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n/an/an/a 1.12E+4n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177709
PNG
(CHEMBL3814864)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccccc3Cl)C2=O)cc(Cl)c1OCC(O)=O
Show InChI InChI=1S/C20H15Cl2NO6S/c1-28-15-7-11(6-14(22)18(15)29-10-17(24)25)8-16-19(26)23(20(27)30-16)9-12-4-2-3-5-13(12)21/h2-8H,9-10H2,1H3,(H,24,25)/b16-8-
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n/an/an/a 6.84E+4n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177708
PNG
(CHEMBL3814619)
Show SMILES CCOc1cc(\C=C2/SC(=S)N(Cc3ccccc3)C2=O)ccc1OCC(O)=O
Show InChI InChI=1S/C21H19NO5S2/c1-2-26-17-10-15(8-9-16(17)27-13-19(23)24)11-18-20(25)22(21(28)29-18)12-14-6-4-3-5-7-14/h3-11H,2,12-13H2,1H3,(H,23,24)/b18-11-
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n/an/an/a 3.83E+4n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177707
PNG
(CHEMBL3814506)
Show SMILES CCCN1C(=S)N\C(=C/c2ccc(OCC(O)=O)c(Cl)c2)C1=O
Show InChI InChI=1S/C15H15ClN2O4S/c1-2-5-18-14(21)11(17-15(18)23)7-9-3-4-12(10(16)6-9)22-8-13(19)20/h3-4,6-7H,2,5,8H2,1H3,(H,17,23)(H,19,20)/b11-7-
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n/an/an/a 1.52E+5n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177706
PNG
(CHEMBL3814441)
Show SMILES COC(=O)CN1C(=O)S\C(=C\c2ccc(o2)-c2cccc(C(O)=O)c2C)C1=O
Show InChI InChI=1S/C19H15NO7S/c1-10-12(4-3-5-13(10)18(23)24)14-7-6-11(27-14)8-15-17(22)20(19(25)28-15)9-16(21)26-2/h3-8H,9H2,1-2H3,(H,23,24)/b15-8+
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n/an/an/a 2.51E+5n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177705
PNG
(CHEMBL3815146)
Show SMILES OC(=O)C1CCN(CC1)C(=O)c1cc(nc2ccccc12)-c1ccc(Cl)s1
Show InChI InChI=1S/C20H17ClN2O3S/c21-18-6-5-17(27-18)16-11-14(13-3-1-2-4-15(13)22-16)19(24)23-9-7-12(8-10-23)20(25)26/h1-6,11-12H,7-10H2,(H,25,26)
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n/an/an/a 3.11E+5n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177704
PNG
(CHEMBL3814273)
Show SMILES OC(=O)Cc1coc2cc(OS(=O)(=O)c3ccc(Cl)cc3F)ccc12
Show InChI InChI=1S/C16H10ClFO6S/c17-10-1-4-15(13(18)6-10)25(21,22)24-11-2-3-12-9(5-16(19)20)8-23-14(12)7-11/h1-4,6-8H,5H2,(H,19,20)
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n/an/an/a 1.39E+5n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177703
PNG
(CHEMBL3814879)
Show SMILES Cc1nc(cs1)-c1ccc2N(CCc2c1)S(=O)(=O)c1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C21H20N2O4S2/c1-14-22-19(13-28-14)16-5-8-20-17(12-16)10-11-23(20)29(26,27)18-6-2-15(3-7-18)4-9-21(24)25/h2-3,5-8,12-13H,4,9-11H2,1H3,(H,24,25)
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n/an/an/a 6.24E+4n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177709
PNG
(CHEMBL3814864)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccccc3Cl)C2=O)cc(Cl)c1OCC(O)=O
Show InChI InChI=1S/C20H15Cl2NO6S/c1-28-15-7-11(6-14(22)18(15)29-10-17(24)25)8-16-19(26)23(20(27)30-16)9-12-4-2-3-5-13(12)21/h2-8H,9-10H2,1H3,(H,24,25)/b16-8-
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n/an/an/a 1.30n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177708
PNG
(CHEMBL3814619)
Show SMILES CCOc1cc(\C=C2/SC(=S)N(Cc3ccccc3)C2=O)ccc1OCC(O)=O
Show InChI InChI=1S/C21H19NO5S2/c1-2-26-17-10-15(8-9-16(17)27-13-19(23)24)11-18-20(25)22(21(28)29-18)12-14-6-4-3-5-7-14/h3-11H,2,12-13H2,1H3,(H,23,24)/b18-11-
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n/an/an/a 2n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177707
PNG
(CHEMBL3814506)
Show SMILES CCCN1C(=S)N\C(=C/c2ccc(OCC(O)=O)c(Cl)c2)C1=O
Show InChI InChI=1S/C15H15ClN2O4S/c1-2-5-18-14(21)11(17-15(18)23)7-9-3-4-12(10(16)6-9)22-8-13(19)20/h3-4,6-7H,2,5,8H2,1H3,(H,17,23)(H,19,20)/b11-7-
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n/an/an/a 3.80n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177706
PNG
(CHEMBL3814441)
Show SMILES COC(=O)CN1C(=O)S\C(=C\c2ccc(o2)-c2cccc(C(O)=O)c2C)C1=O
Show InChI InChI=1S/C19H15NO7S/c1-10-12(4-3-5-13(10)18(23)24)14-7-6-11(27-14)8-15-17(22)20(19(25)28-15)9-16(21)26-2/h3-8H,9H2,1-2H3,(H,23,24)/b15-8+
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n/an/an/a 1.20n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177714
PNG
(CHEMBL3813775)
Show SMILES COc1cc(\C=C2/Sc3ccccc3C2=O)ccc1OCC(O)=O
Show InChI InChI=1S/C18H14O5S/c1-22-14-8-11(6-7-13(14)23-10-17(19)20)9-16-18(21)12-4-2-3-5-15(12)24-16/h2-9H,10H2,1H3,(H,19,20)/b16-9-
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n/an/an/a 2.68E+5n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177704
PNG
(CHEMBL3814273)
Show SMILES OC(=O)Cc1coc2cc(OS(=O)(=O)c3ccc(Cl)cc3F)ccc12
Show InChI InChI=1S/C16H10ClFO6S/c17-10-1-4-15(13(18)6-10)25(21,22)24-11-2-3-12-9(5-16(19)20)8-23-14(12)7-11/h1-4,6-8H,5H2,(H,19,20)
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n/an/an/a 1.5n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177703
PNG
(CHEMBL3814879)
Show SMILES Cc1nc(cs1)-c1ccc2N(CCc2c1)S(=O)(=O)c1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C21H20N2O4S2/c1-14-22-19(13-28-14)16-5-8-20-17(12-16)10-11-23(20)29(26,27)18-6-2-15(3-7-18)4-9-21(24)25/h2-3,5-8,12-13H,4,9-11H2,1H3,(H,24,25)
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n/an/an/a 3.20n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177679
PNG
(CHEMBL3814761)
Show SMILES OC(=O)c1ccccc1NC(=O)c1cccc(NC(=O)Cc2ccccc2)c1
Show InChI InChI=1S/C22H18N2O4/c25-20(13-15-7-2-1-3-8-15)23-17-10-6-9-16(14-17)21(26)24-19-12-5-4-11-18(19)22(27)28/h1-12,14H,13H2,(H,23,25)(H,24,26)(H,27,28)
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n/an/an/a 1.06E+4n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to TMR-labeled Dvl-1 PDZ domain (unknown origin) expressed in Escherichia coli by fluorescence spectroscopy


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177677
PNG
(CHEMBL3814692)
Show SMILES CCOc1cc(\C=C2/Sc3ccccc3C2=O)cc(Br)c1OCC(O)=O
Show InChI InChI=1S/C19H15BrO5S/c1-2-24-14-8-11(7-13(20)19(14)25-10-17(21)22)9-16-18(23)12-5-3-4-6-15(12)26-16/h3-9H,2,10H2,1H3,(H,21,22)/b16-9-
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n/an/an/a 186n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by fluorescence spect...


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177676
PNG
(CHEMBL3814041)
Show SMILES COC(=O)COc1ccc(\C=C2/Sc3ccccc3C2=O)cc1
Show InChI InChI=1S/C18H14O4S/c1-21-17(19)11-22-13-8-6-12(7-9-13)10-16-18(20)14-4-2-3-5-15(14)23-16/h2-10H,11H2,1H3/b16-10-
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n/an/an/a 7.83E+5n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens)
BDBM50177705
PNG
(CHEMBL3815146)
Show SMILES OC(=O)C1CCN(CC1)C(=O)c1cc(nc2ccccc12)-c1ccc(Cl)s1
Show InChI InChI=1S/C20H17ClN2O3S/c21-18-6-5-17(27-18)16-11-14(13-3-1-2-4-15(13)22-16)19(24)23-9-7-12(8-10-23)20(25)26/h1-6,11-12H,7-10H2,(H,25,26)
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n/an/an/a 1.70n/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...


Bioorg Med Chem 24: 3259-66 (2016)

More data for this
Ligand-Target Pair