BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 24 hits Enz. Inhib. hit(s) with Target = 'Sepiapterin reductase (SPR)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187258
PNG
(US9169234, 23)
Show SMILES COCC(=O)NCCc1c(C)[nH]c2ccc(O)cc12
Show InChI InChI=1S/C14H18N2O3/c1-9-11(5-6-15-14(18)8-19-2)12-7-10(17)3-4-13(12)16-9/h3-4,7,16-17H,5-6,8H2,1-2H3,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
US Patent
n/an/a 11n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the produc...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187257
PNG
(US9169234, 22)
Show SMILES COCC(=O)NCCc1c(C)n(C)c2ccc(O)cc12
Show InChI InChI=1S/C15H20N2O3/c1-10-12(6-7-16-15(19)9-20-3)13-8-11(18)4-5-14(13)17(10)2/h4-5,8,18H,6-7,9H2,1-3H3,(H,16,19)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 11n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the produc...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187258
PNG
(US9169234, 23)
Show SMILES COCC(=O)NCCc1c(C)[nH]c2ccc(O)cc12
Show InChI InChI=1S/C14H18N2O3/c1-9-11(5-6-15-14(18)8-19-2)12-7-10(17)3-4-13(12)16-9/h3-4,7,16-17H,5-6,8H2,1-2H3,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
US Patent
n/an/a 12n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the product ...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187257
PNG
(US9169234, 22)
Show SMILES COCC(=O)NCCc1c(C)n(C)c2ccc(O)cc12
Show InChI InChI=1S/C15H20N2O3/c1-10-12(6-7-16-15(19)9-20-3)13-8-11(18)4-5-14(13)17(10)2/h4-5,8,18H,6-7,9H2,1-3H3,(H,16,19)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 19n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the product ...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187260
PNG
(US9169234, 32)
Show SMILES COCC(=O)NCCc1cccc(O)c1
Show InChI InChI=1S/C11H15NO3/c1-15-8-11(14)12-6-5-9-3-2-4-10(13)7-9/h2-4,7,13H,5-6,8H2,1H3,(H,12,14)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 64n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the produc...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187260
PNG
(US9169234, 32)
Show SMILES COCC(=O)NCCc1cccc(O)c1
Show InChI InChI=1S/C11H15NO3/c1-15-8-11(14)12-6-5-9-3-2-4-10(13)7-9/h2-4,7,13H,5-6,8H2,1H3,(H,12,14)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 69n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the product ...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187256
PNG
(US9169234, 21)
Show SMILES COCC(=O)NCCc1cn(C)c2ccc(O)cc12
Show InChI InChI=1S/C14H18N2O3/c1-16-8-10(5-6-15-14(18)9-19-2)12-7-11(17)3-4-13(12)16/h3-4,7-8,17H,5-6,9H2,1-2H3,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 84n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the produc...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187256
PNG
(US9169234, 21)
Show SMILES COCC(=O)NCCc1cn(C)c2ccc(O)cc12
Show InChI InChI=1S/C14H18N2O3/c1-16-8-10(5-6-15-14(18)9-19-2)12-7-11(17)3-4-13(12)16/h3-4,7-8,17H,5-6,9H2,1-2H3,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 86n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the product ...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187259
PNG
(US9169234, 24)
Show SMILES COCC(=O)NCC(=O)c1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C13H14N2O4/c1-19-7-13(18)15-6-12(17)10-5-14-11-3-2-8(16)4-9(10)11/h2-5,14,16H,6-7H2,1H3,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 310n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the product ...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187259
PNG
(US9169234, 24)
Show SMILES COCC(=O)NCC(=O)c1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C13H14N2O4/c1-19-7-13(18)15-6-12(17)10-5-14-11-3-2-8(16)4-9(10)11/h2-5,14,16H,6-7H2,1H3,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 310n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the produc...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187250
PNG
(US9169234, 1)
Show SMILES CC(C)C(=O)NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C14H18N2O2/c1-9(2)14(18)15-6-5-10-8-16-13-4-3-11(17)7-12(10)13/h3-4,7-9,16-17H,5-6H2,1-2H3,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 330n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the product ...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187251
PNG
(US9169234, 2)
Show SMILES Oc1ccc2[nH]cc(CCNC(=O)C3CC3)c2c1
Show InChI InChI=1S/C14H16N2O2/c17-11-3-4-13-12(7-11)10(8-16-13)5-6-15-14(18)9-1-2-9/h3-4,7-9,16-17H,1-2,5-6H2,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 340n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the product ...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187251
PNG
(US9169234, 2)
Show SMILES Oc1ccc2[nH]cc(CCNC(=O)C3CC3)c2c1
Show InChI InChI=1S/C14H16N2O2/c17-11-3-4-13-12(7-11)10(8-16-13)5-6-15-14(18)9-1-2-9/h3-4,7-9,16-17H,1-2,5-6H2,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 360n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the produc...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187250
PNG
(US9169234, 1)
Show SMILES CC(C)C(=O)NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C14H18N2O2/c1-9(2)14(18)15-6-5-10-8-16-13-4-3-11(17)7-12(10)13/h3-4,7-9,16-17H,5-6H2,1-2H3,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 400n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the produc...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187255
PNG
(US9169234, 18)
Show SMILES COCC(=O)NCCc1c[nH]c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C14H19N3O4S/c1-21-9-14(18)15-6-5-10-8-16-13-4-3-11(7-12(10)13)17-22(2,19)20/h3-4,7-8,16-17H,5-6,9H2,1-2H3,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.00E+3n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the product ...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187255
PNG
(US9169234, 18)
Show SMILES COCC(=O)NCCc1c[nH]c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C14H19N3O4S/c1-21-9-14(18)15-6-5-10-8-16-13-4-3-11(7-12(10)13)17-22(2,19)20/h3-4,7-8,16-17H,5-6,9H2,1-2H3,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the produc...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187261
PNG
(US9169234, 12)
Show SMILES Oc1ccc2[nH]cc(CCNc3cccnc3)c2c1
Show InChI InChI=1S/C15H15N3O/c19-13-3-4-15-14(8-13)11(9-18-15)5-7-17-12-2-1-6-16-10-12/h1-4,6,8-10,17-19H,5,7H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the product ...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187261
PNG
(US9169234, 12)
Show SMILES Oc1ccc2[nH]cc(CCNc3cccnc3)c2c1
Show InChI InChI=1S/C15H15N3O/c19-13-3-4-15-14(8-13)11(9-18-15)5-7-17-12-2-1-6-16-10-12/h1-4,6,8-10,17-19H,5,7H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.10E+3n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the produc...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187252
PNG
(US9169234, 3)
Show SMILES CCOCC(=O)NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C14H18N2O3/c1-2-19-9-14(18)15-6-5-10-8-16-13-4-3-11(17)7-12(10)13/h3-4,7-8,16-17H,2,5-6,9H2,1H3,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 2.20E+3n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the product ...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187253
PNG
(US9169234, 16)
Show SMILES COCC(=O)NCCc1c[nH]c2ccc(F)cc12
Show InChI InChI=1S/C13H15FN2O2/c1-18-8-13(17)15-5-4-9-7-16-12-3-2-10(14)6-11(9)12/h2-3,6-7,16H,4-5,8H2,1H3,(H,15,17)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 2.80E+3n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the product ...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187252
PNG
(US9169234, 3)
Show SMILES CCOCC(=O)NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C14H18N2O3/c1-2-19-9-14(18)15-6-5-10-8-16-13-4-3-11(17)7-12(10)13/h3-4,7-8,16-17H,2,5-6,9H2,1H3,(H,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 2.80E+3n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the produc...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187254
PNG
(US9169234, 17)
Show SMILES COCC(=O)NCCc1c[nH]c2ccc(cc12)S(C)(=O)=O
Show InChI InChI=1S/C14H18N2O4S/c1-20-9-14(17)15-6-5-10-8-16-13-4-3-11(7-12(10)13)21(2,18)19/h3-4,7-8,16H,5-6,9H2,1-2H3,(H,15,17)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 3.20E+3n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the product ...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187253
PNG
(US9169234, 16)
Show SMILES COCC(=O)NCCc1c[nH]c2ccc(F)cc12
Show InChI InChI=1S/C13H15FN2O2/c1-18-8-13(17)15-5-4-9-7-16-12-3-2-10(14)6-11(9)12/h2-3,6-7,16H,4-5,8H2,1H3,(H,15,17)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 3.40E+3n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the produc...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair
Sepiapterin reductase (SPR)


(Homo sapiens (Human))
BDBM187254
PNG
(US9169234, 17)
Show SMILES COCC(=O)NCCc1c[nH]c2ccc(cc12)S(C)(=O)=O
Show InChI InChI=1S/C14H18N2O4S/c1-20-9-14(17)15-6-5-10-8-16-13-4-3-11(7-12(10)13)21(2,18)19/h3-4,7-8,16H,5-6,9H2,1-2H3,(H,15,17)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 4.50E+3n/an/an/an/an/an/a



Children's Medical Center Corporation

US Patent


Assay Description
To screen for SPR inhibition, a biochemical assay based on LC/MS (and chromogenic) read-out has been developed. The LC/MS assay monitors the produc...


US Patent US9169234 (2015)

More data for this
Ligand-Target Pair