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Found 68 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PIM-3' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 0.900n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104169
PNG
(US8575145, 46/47/48/49/50 | US8575145, 77 | US8575...)
Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H20FN5O/c22-15-9-11-23-12-10-17(15)28-18-5-3-4-14-7-8-16(24-20(14)18)21-26-25-19-6-1-2-13-27(19)21/h1-8,13,15,17,23H,9-12H2
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n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104141
PNG
(US8575145, 18)
Show SMILES CC(C)(CN)COc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H21N5O/c1-20(2,12-21)13-26-16-7-5-6-14-9-10-15(22-18(14)16)19-24-23-17-8-3-4-11-25(17)19/h3-11H,12-13,21H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104142
PNG
(US8575145, 19)
Show SMILES CC(C)(CO)COc1cccc2ccc(nc12)-c1nnc2cc(CN)ccn12
Show InChI InChI=1S/C21H23N5O2/c1-21(2,12-27)13-28-17-5-3-4-15-6-7-16(23-19(15)17)20-25-24-18-10-14(11-22)8-9-26(18)20/h3-10,27H,11-13,22H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104222
PNG
(US8575145, 130 | US8575145, 99/100)
Show SMILES Cc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1
Show InChI InChI=1S/C22H22FN5O/c1-14-5-8-20-26-27-22(28(20)13-14)17-7-6-15-3-2-4-19(21(15)25-17)29-18-10-12-24-11-9-16(18)23/h2-8,13,16,18,24H,9-12H2,1H3
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n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104140
PNG
(US8575145, 17)
Show SMILES NC1CCC(CC1)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H21N5O/c22-15-8-10-16(11-9-15)27-18-5-3-4-14-7-12-17(23-20(14)18)21-25-24-19-6-1-2-13-26(19)21/h1-7,12-13,15-16H,8-11,22H2
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n/an/a 3n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104215
PNG
(US8575145, 152 | US8575145, 92 | US8575145, 92/122)
Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1
Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3
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n/an/a 3n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM41535
PNG
(US8575145, 106 | US8575145, 66)
Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C21H26N6O5/c1-5-31-18-8-7-15(9-19(18)32-6-2)12-25-13-16(10-22-25)24-20(28)21(3,4)26-14-17(11-23-26)27(29)30/h7-11,13-14H,5-6,12H2,1-4H3,(H,24,28)
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n/an/a 3n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104190
PNG
(US8575145, 67)
Show SMILES CC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C22H23N5O/c1-22(10-12-23-13-11-22)15-28-18-6-4-5-16-8-9-17(24-20(16)18)21-26-25-19-7-2-3-14-27(19)21/h2-9,14,23H,10-13,15H2,1H3
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n/an/a 3n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104139
PNG
(US8575145, 16)
Show SMILES C(Oc1cccc2ccc(nc12)-c1nnc2ccccn12)C1CCCNC1
Show InChI InChI=1S/C21H21N5O/c1-2-12-26-19(8-1)24-25-21(26)17-10-9-16-6-3-7-18(20(16)23-17)27-14-15-5-4-11-22-13-15/h1-3,6-10,12,15,22H,4-5,11,13-14H2
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n/an/a 4n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104151
PNG
(US8575145, 28)
Show SMILES CNCC(C)(C)COc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H23N5O/c1-21(2,13-22-3)14-27-17-8-6-7-15-10-11-16(23-19(15)17)20-25-24-18-9-4-5-12-26(18)20/h4-12,22H,13-14H2,1-3H3
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n/an/a 4n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104175
PNG
(US8575145, 157 | US8575145, 158 | US8575145, 52/12...)
Show SMILES C1CNCCC(C1)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H21N5O/c1-2-14-26-19(8-1)24-25-21(26)17-10-9-15-5-3-7-18(20(15)23-17)27-16-6-4-12-22-13-11-16/h1-3,5,7-10,14,16,22H,4,6,11-13H2
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Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104169
PNG
(US8575145, 46/47/48/49/50 | US8575145, 77 | US8575...)
Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H20FN5O/c22-15-9-11-23-12-10-17(15)28-18-5-3-4-14-7-8-16(24-20(14)18)21-26-25-19-6-1-2-13-27(19)21/h1-8,13,15,17,23H,9-12H2
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n/an/a 4n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104147
PNG
(US8575145, 24)
Show SMILES CC(C)(CO)COc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H20N4O2/c1-20(2,12-25)13-26-16-7-5-6-14-9-10-15(21-18(14)16)19-23-22-17-8-3-4-11-24(17)19/h3-11,25H,12-13H2,1-2H3
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n/an/a 4n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104124
PNG
(US8575145, 1)
Show SMILES C1CC(CCN1)Nc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H20N6/c1-2-13-26-18(6-1)24-25-20(26)17-8-7-14-4-3-5-16(19(14)23-17)22-15-9-11-21-12-10-15/h1-8,13,15,21-22H,9-12H2
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n/an/a 4.40n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104196
PNG
(US8575145, 73)
Show SMILES COC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C22H23N5O2/c1-28-22(10-12-23-13-11-22)15-29-18-6-4-5-16-8-9-17(24-20(16)18)21-26-25-19-7-2-3-14-27(19)21/h2-9,14,23H,10-13,15H2,1H3
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n/an/a 5n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104143
PNG
(US8575145, 20)
Show SMILES CC(C)COc1cccc2ccc(nc12)-c1nnc2cc(CN)ccn12
Show InChI InChI=1S/C20H21N5O/c1-13(2)12-26-17-5-3-4-15-6-7-16(22-19(15)17)20-24-23-18-10-14(11-21)8-9-25(18)20/h3-10,13H,11-12,21H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104187
PNG
(US8575145, 64)
Show SMILES CC(C)(CN)COc1cccc2ccc(nc12)-c1nnc2ccc(cn12)C1CC1
Show InChI InChI=1S/C23H25N5O/c1-23(2,13-24)14-29-19-5-3-4-16-8-10-18(25-21(16)19)22-27-26-20-11-9-17(12-28(20)22)15-6-7-15/h3-5,8-12,15H,6-7,13-14,24H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104146
PNG
(US8575145, 23)
Show SMILES CC(C)(C)COc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H20N4O/c1-20(2,3)13-25-16-8-6-7-14-10-11-15(21-18(14)16)19-23-22-17-9-4-5-12-24(17)19/h4-12H,13H2,1-3H3
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n/an/a 6n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104175
PNG
(US8575145, 157 | US8575145, 158 | US8575145, 52/12...)
Show SMILES C1CNCCC(C1)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H21N5O/c1-2-14-26-19(8-1)24-25-21(26)17-10-9-15-5-3-7-18(20(15)23-17)27-16-6-4-12-22-13-11-16/h1-3,5,7-10,14,16,22H,4,6,11-13H2
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n/an/a 6.80n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104169
PNG
(US8575145, 46/47/48/49/50 | US8575145, 77 | US8575...)
Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H20FN5O/c22-15-9-11-23-12-10-17(15)28-18-5-3-4-14-7-8-16(24-20(14)18)21-26-25-19-6-1-2-13-27(19)21/h1-8,13,15,17,23H,9-12H2
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n/an/a 8n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104236
PNG
(US8575145, 113)
Show SMILES CC(C)(COc1cccc2ccc(nc12)-c1nnc2ccccn12)[C@@H](O)CO
Show InChI InChI=1S/C21H22N4O3/c1-21(2,17(27)12-26)13-28-16-7-5-6-14-9-10-15(22-19(14)16)20-24-23-18-8-3-4-11-25(18)20/h3-11,17,26-27H,12-13H2,1-2H3/t17-/m0/s1
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n/an/a 8.80n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104149
PNG
(US8575145, 26)
Show SMILES F[C@@H]1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H18FN5O/c21-14-12-22-10-9-16(14)27-17-5-3-4-13-7-8-15(23-19(13)17)20-25-24-18-6-1-2-11-26(18)20/h1-8,11,14,16,22H,9-10,12H2/t14-,16?/m1/s1
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n/an/a 9n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104136
PNG
(US8575145, 13)
Show SMILES COC(=O)[C@@H]1C[C@H](CCN1)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C22H21N5O3/c1-29-22(28)17-13-15(10-11-23-17)30-18-6-4-5-14-8-9-16(24-20(14)18)21-26-25-19-7-2-3-12-27(19)21/h2-9,12,15,17,23H,10-11,13H2,1H3/t15-,17-/m0/s1
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n/an/a 9n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104191
PNG
(US8575145, 68)
Show SMILES CCC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C23H25N5O/c1-2-23(11-13-24-14-12-23)16-29-19-7-5-6-17-9-10-18(25-21(17)19)22-27-26-20-8-3-4-15-28(20)22/h3-10,15,24H,2,11-14,16H2,1H3
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n/an/a 10n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104209
PNG
(US8575145, 86)
Show SMILES CC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCN(CCO)CC1
Show InChI InChI=1S/C24H27N5O2/c1-24(10-13-28(14-11-24)15-16-30)17-31-20-6-4-5-18-8-9-19(25-22(18)20)23-27-26-21-7-2-3-12-29(21)23/h2-9,12,30H,10-11,13-17H2,1H3
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n/an/a 10n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104174
PNG
(US8575145, 51)
Show SMILES FC1CNCCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H20FN5O/c22-15-13-23-11-4-7-17(15)28-18-6-3-5-14-9-10-16(24-20(14)18)21-26-25-19-8-1-2-12-27(19)21/h1-3,5-6,8-10,12,15,17,23H,4,7,11,13H2
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n/an/a 10n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104235
PNG
(US8575145, 112)
Show SMILES CC(C)(COc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12)[C@@H](O)CO
Show InChI InChI=1S/C21H21FN4O3/c1-21(2,17(28)11-27)12-29-16-10-14(22)9-13-6-7-15(23-19(13)16)20-25-24-18-5-3-4-8-26(18)20/h3-10,17,27-28H,11-12H2,1-2H3/t17-/m0/s1
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n/an/a 10.1n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 10.9n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104137
PNG
(US8575145, 14)
Show SMILES C(Oc1cccc2ccc(nc12)-c1nnc2ccccn12)C1CCNCC1
Show InChI InChI=1S/C21H21N5O/c1-2-13-26-19(6-1)24-25-21(26)17-8-7-16-4-3-5-18(20(16)23-17)27-14-15-9-11-22-12-10-15/h1-8,13,15,22H,9-12,14H2
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n/an/a 11n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104153
PNG
(US8575145, 30)
Show SMILES CC[C@@H](CN)C(CC)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C22H25N5O/c1-3-15(14-23)18(4-2)28-19-9-7-8-16-11-12-17(24-21(16)19)22-26-25-20-10-5-6-13-27(20)22/h5-13,15,18H,3-4,14,23H2,1-2H3/t15-,18?/m0/s1
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n/an/a 13n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104133
PNG
(US8575145, 10)
Show SMILES NCCCOc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C18H17N5O/c19-10-4-12-24-15-6-3-5-13-8-9-14(20-17(13)15)18-22-21-16-7-1-2-11-23(16)18/h1-3,5-9,11H,4,10,12,19H2
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n/an/a 13n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104150
PNG
(US8575145, 27)
Show SMILES CCNCC(C)(C)COc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C22H25N5O/c1-4-23-14-22(2,3)15-28-18-9-7-8-16-11-12-17(24-20(16)18)21-26-25-19-10-5-6-13-27(19)21/h5-13,23H,4,14-15H2,1-3H3
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n/an/a 13n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 16.1n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104132
PNG
(US8575145, 9)
Show SMILES C1CC(CCN1)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H19N5O/c1-2-13-25-18(6-1)23-24-20(25)16-8-7-14-4-3-5-17(19(14)22-16)26-15-9-11-21-12-10-15/h1-8,13,15,21H,9-12H2
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n/an/a 17n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104155
PNG
(US8575145, 32)
Show SMILES CC[C@@H](CN)C(C)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H23N5O/c1-3-15(13-22)14(2)27-18-8-6-7-16-10-11-17(23-20(16)18)21-25-24-19-9-4-5-12-26(19)21/h4-12,14-15H,3,13,22H2,1-2H3/t14?,15-/m0/s1
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n/an/a 17n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104156
PNG
(US8575145, 33)
Show SMILES CC[C@H](CN)C(C)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H23N5O/c1-3-15(13-22)14(2)27-18-8-6-7-16-10-11-17(23-20(16)18)21-25-24-19-9-4-5-12-26(19)21/h4-12,14-15H,3,13,22H2,1-2H3/t14?,15-/m1/s1
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n/an/a 19n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104154
PNG
(US8575145, 31)
Show SMILES CC[C@H](CN)C(CC)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C22H25N5O/c1-3-15(14-23)18(4-2)28-19-9-7-8-16-11-12-17(24-21(16)19)22-26-25-20-10-5-6-13-27(20)22/h5-13,15,18H,3-4,14,23H2,1-2H3/t15-,18?/m1/s1
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n/an/a 19n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104128
PNG
(US8575145, 5)
Show SMILES C1C[C@H](CN1)Nc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C19H18N6/c1-2-11-25-17(6-1)23-24-19(25)16-8-7-13-4-3-5-15(18(13)22-16)21-14-9-10-20-12-14/h1-8,11,14,20-21H,9-10,12H2/t14-/m1/s1
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n/an/a 20n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104148
PNG
(US8575145, 25)
Show SMILES F[C@H]1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H18FN5O/c21-14-12-22-10-9-16(14)27-17-5-3-4-13-7-8-15(23-19(13)17)20-25-24-18-6-1-2-11-26(18)20/h1-8,11,14,16,22H,9-10,12H2/t14-,16?/m0/s1
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n/an/a 20n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104215
PNG
(US8575145, 152 | US8575145, 92 | US8575145, 92/122)
Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1
Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3
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n/an/a 23.5n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104179
PNG
(US8575145, 56)
Show SMILES OC[C@@H]1CC(CCN1)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H21N5O2/c27-13-15-12-16(9-10-22-15)28-18-5-3-4-14-7-8-17(23-20(14)18)21-25-24-19-6-1-2-11-26(19)21/h1-8,11,15-16,22,27H,9-10,12-13H2/t15-,16?/m0/s1
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n/an/a 24n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104211
PNG
(US8575145, 88)
Show SMILES FC1CNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H17F2N5O/c21-13-9-12-4-5-15(20-26-25-18-3-1-2-8-27(18)20)24-19(12)17(10-13)28-16-6-7-23-11-14(16)22/h1-5,8-10,14,16,23H,6-7,11H2
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n/an/a 24n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104145
PNG
(US8575145, 22)
Show SMILES OCC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C20H18N4O2/c25-12-20(9-10-20)13-26-16-5-3-4-14-7-8-15(21-18(14)16)19-23-22-17-6-1-2-11-24(17)19/h1-8,11,25H,9-10,12-13H2
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n/an/a 25n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104126
PNG
(US8575145, 3)
Show SMILES OC1CCC(CC1)Nc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H21N5O/c27-16-10-8-15(9-11-16)22-17-5-3-4-14-7-12-18(23-20(14)17)21-25-24-19-6-1-2-13-26(19)21/h1-7,12-13,15-16,22,27H,8-11H2
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n/an/a 25n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104152
PNG
(US8575145, 29)
Show SMILES C1CC2CC(CC1N2)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C22H21N5O/c1-2-11-27-20(6-1)25-26-22(27)18-10-7-14-4-3-5-19(21(14)24-18)28-17-12-15-8-9-16(13-17)23-15/h1-7,10-11,15-17,23H,8-9,12-13H2
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n/an/a 30n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104134
PNG
(US8575145, 11)
Show SMILES C1C[C@H](CN1)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C19H17N5O/c1-2-11-24-17(6-1)22-23-19(24)15-8-7-13-4-3-5-16(18(13)21-15)25-14-9-10-20-12-14/h1-8,11,14,20H,9-10,12H2/t14-/m1/s1
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n/an/a 33n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104130
PNG
(US8575145, 7)
Show SMILES NCCCNc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C18H18N6/c19-10-4-11-20-14-6-3-5-13-8-9-15(21-17(13)14)18-23-22-16-7-1-2-12-24(16)18/h1-3,5-9,12,20H,4,10-11,19H2
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n/an/a 35n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104222
PNG
(US8575145, 130 | US8575145, 99/100)
Show SMILES Cc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1
Show InChI InChI=1S/C22H22FN5O/c1-14-5-8-20-26-27-22(28(20)13-14)17-7-6-15-3-2-4-19(21(15)25-17)29-18-10-12-24-11-9-16(18)23/h2-8,13,16,18,24H,9-12H2,1H3
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n/an/a 39.7n/an/an/an/a7.422



Array BioPharma Inc.

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)

More data for this
Ligand-Target Pair
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