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Found 2230 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase RIO2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337366
PNG
(2-(1H-indazol-5-yl)-3-phenylimidazo[1,2-a]pyrimidi...)
Show SMILES c1n[nH]c2ccc(cc12)-c1nc2ncccn2c1-c1ccccc1
Show InChI InChI=1S/C19H13N5/c1-2-5-13(6-3-1)18-17(22-19-20-9-4-10-24(18)19)14-7-8-16-15(11-14)12-21-23-16/h1-12H,(H,21,23)
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6n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM97666
PNG
(US8476295, 1.1.04)
Show SMILES Cc1ccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)cc1OCCO
Show InChI InChI=1S/C24H30N4O2/c1-16-2-3-17(10-24(16)30-9-8-29)15-28-21-5-6-22(28)13-20(12-21)26-19-4-7-23-18(11-19)14-25-27-23/h2-4,7,10-11,14,20-22,26,29H,5-6,8-9,12-13,15H2,1H3,(H,25,27)
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US Patent
10n/an/an/an/an/an/a7.2n/a



Inspire

US Patent


Assay Description
Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).


US Patent US8476295 (2013)

More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337322
PNG
(5-(1-(2,3-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)-1...)
Show SMILES Clc1cccc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)c1Cl
Show InChI InChI=1S/C16H11Cl2N5/c17-13-3-1-2-11(16(13)18)8-23-9-15(21-22-23)10-4-5-14-12(6-10)7-19-20-14/h1-7,9H,8H2,(H,19,20)
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15n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337325
PNG
(5-(3-benzylisoxazol-5-yl)-1H-indazol-3-amine | CHE...)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1cc(Cc2ccccc2)no1
Show InChI InChI=1S/C17H14N4O/c18-17-14-9-12(6-7-15(14)19-20-17)16-10-13(21-22-16)8-11-4-2-1-3-5-11/h1-7,9-10H,8H2,(H3,18,19,20)
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16n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337310
PNG
(5-(4-benzyl-1H-1,2,3-triazol-1-yl)-1H-indazole | C...)
Show SMILES C(c1cn(nn1)-c1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C16H13N5/c1-2-4-12(5-3-1)8-14-11-21(20-18-14)15-6-7-16-13(9-15)10-17-19-16/h1-7,9-11H,8H2,(H,17,19)
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18n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337329
PNG
(5-(1-(2,5-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)-1...)
Show SMILES Clc1ccc(Cl)c(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C16H11Cl2N5/c17-13-2-3-14(18)12(6-13)8-23-9-16(21-22-23)10-1-4-15-11(5-10)7-19-20-15/h1-7,9H,8H2,(H,19,20)
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18n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337311
PNG
(5-(4-phenethyl-1H-1,2,3-triazol-1-yl)-1H-indazole ...)
Show SMILES C(Cc1ccccc1)c1cn(nn1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C17H15N5/c1-2-4-13(5-3-1)6-7-15-12-22(21-19-15)16-8-9-17-14(10-16)11-18-20-17/h1-5,8-12H,6-7H2,(H,18,20)
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19n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM97664
PNG
(US8476295, 1.1.02)
Show SMILES Cc1ccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C22H26N4/c1-15-2-4-16(5-3-15)14-26-20-7-8-21(26)12-19(11-20)24-18-6-9-22-17(10-18)13-23-25-22/h2-6,9-10,13,19-21,24H,7-8,11-12,14H2,1H3,(H,23,25)
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US Patent
20n/an/an/an/an/an/a7.2n/a



Inspire

US Patent


Assay Description
Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).


US Patent US8476295 (2013)

More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM97665
PNG
(US8476295, 1.1.03)
Show SMILES OCCOc1cccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C23H28N4O2/c28-8-9-29-22-3-1-2-16(10-22)15-27-20-5-6-21(27)13-19(12-20)25-18-4-7-23-17(11-18)14-24-26-23/h1-4,7,10-11,14,19-21,25,28H,5-6,8-9,12-13,15H2,(H,24,26)
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US Patent
21n/an/an/an/an/an/a7.2n/a



Inspire

US Patent


Assay Description
Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).


US Patent US8476295 (2013)

More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337324
PNG
(3-benzyl-5-(1H-indazol-5-yl)isoxazole | CHEMBL1682...)
Show SMILES C(c1cc(on1)-c1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C17H13N3O/c1-2-4-12(5-3-1)8-15-10-17(21-20-15)13-6-7-16-14(9-13)11-18-19-16/h1-7,9-11H,8H2,(H,18,19)
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28n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM97663
PNG
(US8476295, 1.1.01)
Show SMILES C(N1C2CCC1CC(C2)Nc1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C21H24N4/c1-2-4-15(5-3-1)14-25-19-7-8-20(25)12-18(11-19)23-17-6-9-21-16(10-17)13-22-24-21/h1-6,9-10,13,18-20,23H,7-8,11-12,14H2,(H,22,24)
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US Patent
29n/an/an/an/an/an/a7.2n/a



Inspire

US Patent


Assay Description
Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).


US Patent US8476295 (2013)

More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337317
PNG
(5-(1-(3-chlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-in...)
Show SMILES Clc1cccc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C16H12ClN5/c17-14-3-1-2-11(6-14)9-22-10-16(20-21-22)12-4-5-15-13(7-12)8-18-19-15/h1-8,10H,9H2,(H,18,19)
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39n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337323
PNG
(5-(1-(3,5-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)-1...)
Show SMILES Clc1cc(Cl)cc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C16H11Cl2N5/c17-13-3-10(4-14(18)6-13)8-23-9-16(21-22-23)11-1-2-15-12(5-11)7-19-20-15/h1-7,9H,8H2,(H,19,20)
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41n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337308
PNG
(5-(4-cyclopentyl-1H-1,2,3-triazol-1-yl)-1H-indazol...)
Show SMILES C1CCC(C1)c1cn(nn1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C14H15N5/c1-2-4-10(3-1)14-9-19(18-17-14)12-5-6-13-11(7-12)8-15-16-13/h5-10H,1-4H2,(H,15,16)
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44n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337312
PNG
(5-(4-(3-phenylpropyl)-1H-1,2,3-triazol-1-yl)-1H-in...)
Show SMILES C(Cc1cn(nn1)-c1ccc2[nH]ncc2c1)Cc1ccccc1
Show InChI InChI=1S/C18H17N5/c1-2-5-14(6-3-1)7-4-8-16-13-23(22-20-16)17-9-10-18-15(11-17)12-19-21-18/h1-3,5-6,9-13H,4,7-8H2,(H,19,21)
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62n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337315
PNG
(5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C16H14N6/c17-16-13-8-12(6-7-14(13)18-20-16)15-10-22(21-19-15)9-11-4-2-1-3-5-11/h1-8,10H,9H2,(H3,17,18,20)
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64n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337378
PNG
(2-(1H-indazol-5-yl)-N-isopropylimidazo[1,2-a]pyrim...)
Show SMILES CC(C)Nc1c(nc2ncccn12)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H16N6/c1-10(2)19-15-14(20-16-17-6-3-7-22(15)16)11-4-5-13-12(8-11)9-18-21-13/h3-10,19H,1-2H3,(H,18,21)
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65n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337318
PNG
(5-(1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-in...)
Show SMILES Clc1ccc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C16H12ClN5/c17-14-4-1-11(2-5-14)9-22-10-16(20-21-22)12-3-6-15-13(7-12)8-18-19-15/h1-8,10H,9H2,(H,18,19)
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68n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337316
PNG
(5-(1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-in...)
Show SMILES Clc1ccccc1Cn1cc(nn1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H12ClN5/c17-14-4-2-1-3-12(14)9-22-10-16(20-21-22)11-5-6-15-13(7-11)8-18-19-15/h1-8,10H,9H2,(H,18,19)
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97n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337314
PNG
(5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazole | C...)
Show SMILES C(c1ccccc1)n1cc(nn1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H13N5/c1-2-4-12(5-3-1)10-21-11-16(19-20-21)13-6-7-15-14(8-13)9-17-18-15/h1-9,11H,10H2,(H,17,18)
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97n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337309
PNG
(5-(4-(cyclohexylmethyl)-1H-1,2,3-triazol-1-yl)-1H-...)
Show SMILES C(C1CCCCC1)c1cn(nn1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H19N5/c1-2-4-12(5-3-1)8-14-11-21(20-18-14)15-6-7-16-13(9-15)10-17-19-16/h6-7,9-12H,1-5,8H2,(H,17,19)
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100n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337304
PNG
(5-(4-propyl-1H-1,2,3-triazol-1-yl)-1H-indazole | C...)
Show SMILES CCCc1cn(nn1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C12H13N5/c1-2-3-10-8-17(16-14-10)11-4-5-12-9(6-11)7-13-15-12/h4-8H,2-3H2,1H3,(H,13,15)
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108n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337326
PNG
(5-(1H-indazol-5-yl)-3-propylisoxazole | CHEMBL1682...)
Show SMILES CCCc1cc(on1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C13H13N3O/c1-2-3-11-7-13(17-16-11)9-4-5-12-10(6-9)8-14-15-12/h4-8H,2-3H2,1H3,(H,14,15)
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113n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337379
PNG
(CHEMBL1682554 | N-butyl-2-(1H-indazol-5-yl)imidazo...)
Show SMILES CCCCNc1c(nc2ncccn12)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C17H18N6/c1-2-3-7-18-16-15(21-17-19-8-4-9-23(16)17)12-5-6-14-13(10-12)11-20-22-14/h4-6,8-11,18H,2-3,7H2,1H3,(H,20,22)
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116n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337371
PNG
(CHEMBL1682546 | N-benzyl-4-(1H-indazol-5-yl)thiazo...)
Show SMILES C(Nc1nc(cs1)-c1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C17H14N4S/c1-2-4-12(5-3-1)9-18-17-20-16(11-22-17)13-6-7-15-14(8-13)10-19-21-15/h1-8,10-11H,9H2,(H,18,20)(H,19,21)
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136n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337320
PNG
(5-(1-(3-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-in...)
Show SMILES Fc1cccc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C16H12FN5/c17-14-3-1-2-11(6-14)9-22-10-16(20-21-22)12-4-5-15-13(7-12)8-18-19-15/h1-8,10H,9H2,(H,18,19)
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180n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337313
PNG
(5-(1H-1,2,3-triazol-4-yl)-1H-indazole | CHEMBL1682...)
Show SMILES c1[nH]nnc1-c1ccc2n[nH]cc2c1
Show InChI InChI=1S/C9H7N5/c1-2-8-7(4-10-12-8)3-6(1)9-5-11-14-13-9/h1-5H,(H,10,12)(H,11,13,14)
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209n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM97667
PNG
(US8476295, 2.1.01)
Show SMILES C(N1C2CCC1CC(C2)Nc1cccc2cnccc12)c1ccccc1
Show InChI InChI=1S/C23H25N3/c1-2-5-17(6-3-1)16-26-20-9-10-21(26)14-19(13-20)25-23-8-4-7-18-15-24-12-11-22(18)23/h1-8,11-12,15,19-21,25H,9-10,13-14,16H2
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US Patent
220n/an/an/an/an/an/a7.2n/a



Inspire

US Patent


Assay Description
Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).


US Patent US8476295 (2013)

More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337365
PNG
(2-(1H-indazol-5-yl)imidazo[1,2-a]pyrimidine | CHEM...)
Show SMILES c1n[nH]c2ccc(cc12)-c1cn2cccnc2n1
Show InChI InChI=1S/C13H9N5/c1-4-14-13-16-12(8-18(13)5-1)9-2-3-11-10(6-9)7-15-17-11/h1-8H,(H,15,17)
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226n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337306
PNG
(3-(1-(1H-indazol-5-yl)-1H-1,2,3-triazol-4-yl)propa...)
Show SMILES OCCCc1cn(nn1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C12H13N5O/c18-5-1-2-10-8-17(16-14-10)11-3-4-12-9(6-11)7-13-15-12/h3-4,6-8,18H,1-2,5H2,(H,13,15)
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230n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337377
PNG
(CHEMBL1682552 | N-cyclohexyl-2-(1H-indazol-5-yl)im...)
Show SMILES C1CCC(CC1)Nc1c(nc2ncccn12)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C19H20N6/c1-2-5-15(6-3-1)22-18-17(23-19-20-9-4-10-25(18)19)13-7-8-16-14(11-13)12-21-24-16/h4,7-12,15,22H,1-3,5-6H2,(H,21,24)
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245n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337330
PNG
(5-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-in...)
Show SMILES Fc1ccc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C16H12FN5/c17-14-4-1-11(2-5-14)9-22-10-16(20-21-22)12-3-6-15-13(7-12)8-18-19-15/h1-8,10H,9H2,(H,18,19)
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285n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337319
PNG
(5-(1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-in...)
Show SMILES Fc1ccccc1Cn1cc(nn1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H12FN5/c17-14-4-2-1-3-12(14)9-22-10-16(20-21-22)11-5-6-15-13(7-11)8-18-19-15/h1-8,10H,9H2,(H,18,19)
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285n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM14029
PNG
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Show SMILES C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1
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300n/an/an/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human ROCK2 by homogenous luciferase assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337328
PNG
(5-(1H-indazol-5-yl)-3-(piperidin-1-ylmethyl)isoxaz...)
Show SMILES C(N1CCCCC1)c1cc(on1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H18N4O/c1-2-6-20(7-3-1)11-14-9-16(21-19-14)12-4-5-15-13(8-12)10-17-18-15/h4-5,8-10H,1-3,6-7,11H2,(H,17,18)
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315n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337307
PNG
(5-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-1H-indazol...)
Show SMILES C1CC1c1cn(nn1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C12H11N5/c1-2-8(1)12-7-17(16-15-12)10-3-4-11-9(5-10)6-13-14-11/h3-8H,1-2H2,(H,13,14)
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356n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337372
PNG
(4-(1H-indazol-5-yl)-N-phenethylthiazol-2-amine | C...)
Show SMILES C(Cc1ccccc1)Nc1nc(cs1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C18H16N4S/c1-2-4-13(5-3-1)8-9-19-18-21-17(12-23-18)14-6-7-16-15(10-14)11-20-22-16/h1-7,10-12H,8-9H2,(H,19,21)(H,20,22)
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364n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337321
PNG
(5-(1-(3-methylbenzyl)-1H-1,2,3-triazol-4-yl)-1H-in...)
Show SMILES Cc1cccc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C17H15N5/c1-12-3-2-4-13(7-12)10-22-11-17(20-21-22)14-5-6-16-15(8-14)9-18-19-16/h2-9,11H,10H2,1H3,(H,18,19)
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375n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337327
PNG
(5-(1H-indazol-5-yl)-N-methylisoxazole-3-carboxamid...)
Show SMILES CNC(=O)c1cc(on1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C12H10N4O2/c1-13-12(17)10-5-11(18-16-10)7-2-3-9-8(4-7)6-14-15-9/h2-6H,1H3,(H,13,17)(H,14,15)
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402n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50402020
PNG
(CHEMBL2205426)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28)
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430n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant ROCK2 after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM97668
PNG
(US8476295, 3.1.01)
Show SMILES C(N1CC2CCC1C2Nc1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-2-4-14(5-3-1)12-24-13-15-6-9-19(24)20(15)22-17-7-8-18-16(10-17)11-21-23-18/h1-5,7-8,10-11,15,19-20,22H,6,9,12-13H2,(H,21,23)
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US Patent
464n/an/an/an/an/an/a7.2n/a



Inspire

US Patent


Assay Description
Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).


US Patent US8476295 (2013)

More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337367
PNG
(4-(1H-indazol-5-yl)-2-methylthiazole | CHEMBL16825...)
Show SMILES Cc1nc(cs1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C11H9N3S/c1-7-13-11(6-15-7)8-2-3-10-9(4-8)5-12-14-10/h2-6H,1H3,(H,12,14)
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513n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337381
PNG
(CHEMBL1682556 | N-cyclohexyl-6-(1H-indazol-5-yl)im...)
Show SMILES C1CCC(CC1)Nc1c(nc2sccn12)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C18H19N5S/c1-2-4-14(5-3-1)20-17-16(21-18-23(17)8-9-24-18)12-6-7-15-13(10-12)11-19-22-15/h6-11,14,20H,1-5H2,(H,19,22)
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622n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337305
PNG
(5-(4-(methoxymethyl)-1H-1,2,3-triazol-1-yl)-1H-ind...)
Show SMILES COCc1cn(nn1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C11H11N5O/c1-17-7-9-6-16(15-13-9)10-2-3-11-8(4-10)5-12-14-11/h2-6H,7H2,1H3,(H,12,14)
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635n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337374
PNG
(CHEMBL1682549 | N-benzyl-4-(1H-indazol-5-yl)-5-phe...)
Show SMILES C(Nc1nc(c(s1)-c1ccccc1)-c1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C23H18N4S/c1-3-7-16(8-4-1)14-24-23-26-21(22(28-23)17-9-5-2-6-10-17)18-11-12-20-19(13-18)15-25-27-20/h1-13,15H,14H2,(H,24,26)(H,25,27)
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822n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337370
PNG
(4-(1H-indazol-5-yl)-N-phenylthiazol-2-amine | CHEM...)
Show SMILES N(c1nc(cs1)-c1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C16H12N4S/c1-2-4-13(5-3-1)18-16-19-15(10-21-16)11-6-7-14-12(8-11)9-17-20-14/h1-10H,(H,17,20)(H,18,19)
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864n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337369
PNG
(CHEMBL1682544 | N-ethyl-4-(1H-indazol-5-yl)thiazol...)
Show SMILES CCNc1nc(cs1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C12H12N4S/c1-2-13-12-15-11(7-17-12)8-3-4-10-9(5-8)6-14-16-10/h3-7H,2H2,1H3,(H,13,15)(H,14,16)
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888n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337368
PNG
(4-(1H-indazol-5-yl)thiazol-2-amine | CHEMBL1682543)
Show SMILES Nc1nc(cs1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C10H8N4S/c11-10-13-9(5-15-10)6-1-2-8-7(3-6)4-12-14-8/h1-5H,(H2,11,13)(H,12,14)
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909n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50341519
PNG
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1
Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of ROCK2


Citation and Details
More data for this
Ligand-Target Pair
Rho Kinase 2


(Homo sapiens (Human))
BDBM50337373
PNG
(4-(1H-indazol-5-yl)-N,5-diphenylthiazol-2-amine | ...)
Show SMILES N(c1nc(c(s1)-c1ccccc1)-c1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C22H16N4S/c1-3-7-15(8-4-1)21-20(16-11-12-19-17(13-16)14-23-26-19)25-22(27-21)24-18-9-5-2-6-10-18/h1-14H,(H,23,26)(H,24,25)
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1.41E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2


Citation and Details
More data for this
Ligand-Target Pair
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