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Found 647 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase RIPK2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303361
PNG
(US10138222, Example 76)
Show SMILES CN1CCC(CC1)Nc1cncc(c1)-n1cc(cn1)-c1cc(ccc1C)C(=O)NC1CC1
Show InChI InChI=1S/C25H30N6O/c1-17-3-4-18(25(32)29-20-5-6-20)11-24(17)19-13-27-31(16-19)23-12-22(14-26-15-23)28-21-7-9-30(2)10-8-21/h3-4,11-16,20-21,28H,5-10H2,1-2H3,(H,29,32)
PDB

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US Patent
n/an/a 0.610n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303364
PNG
(BDBM303369 | US10138222, Example 79)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCN(CC2)C2COC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C27H32N6O2/c1-18-2-3-19(27(34)31-21-4-5-21)10-26(18)20-12-29-33(15-20)24-11-23(13-28-14-24)30-22-6-8-32(9-7-22)25-16-35-17-25/h2-3,10-15,21-22,25,30H,4-9,16-17H2,1H3,(H,31,34)
PDB

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n/an/a 0.810n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303360
PNG
(US10138222, Example 75)
Show SMILES Cc1cc(F)c(cc1-c1cnn(c1)-c1cncc(NC2CC3CCC(C2)N3C2COC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C29H33FN6O2/c1-17-6-28(30)27(29(37)34-19-2-3-19)10-26(17)18-11-32-35(14-18)24-9-21(12-31-13-24)33-20-7-22-4-5-23(8-20)36(22)25-15-38-16-25/h6,9-14,19-20,22-23,25,33H,2-5,7-8,15-16H2,1H3,(H,34,37)
PDB

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US Patent
n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303438
PNG
(US10138222, Example 166)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCN(CC2)C2CCOC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C28H34N6O2/c1-19-2-3-20(28(35)32-22-4-5-22)12-27(19)21-14-30-34(17-21)26-13-24(15-29-16-26)31-23-6-9-33(10-7-23)25-8-11-36-18-25/h2-3,12-17,22-23,25,31H,4-11,18H2,1H3,(H,32,35)
PDB

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n/an/a 0.940n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303440
PNG
(US10138222, Example 168)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCN(CC3COCCO3)CC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C29H36N6O3/c1-20-2-3-21(29(36)33-23-4-5-23)12-28(20)22-14-31-35(17-22)26-13-25(15-30-16-26)32-24-6-8-34(9-7-24)18-27-19-37-10-11-38-27/h2-3,12-17,23-24,27,32H,4-11,18-19H2,1H3,(H,33,36)
PDB

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US Patent
n/an/a 0.950n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303823
PNG
(US10138241, Example 7)
Show SMILES CC(=O)Nc1ncc(s1)-n1cc(cn1)-c1cc(C(=O)NC2CC2)c(F)cc1Cl
Show InChI InChI=1S/C18H15ClFN5O2S/c1-9(26)23-18-21-7-16(28-18)25-8-10(6-22-25)12-4-13(15(20)5-14(12)19)17(27)24-11-2-3-11/h4-8,11H,2-3H2,1H3,(H,24,27)(H,21,23,26)
PDB

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n/an/a 0.990n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303359
PNG
(US10138222, Example 74)
Show SMILES COCCN1CCC(CC1)Nc1cncc(c1)-n1cc(cn1)-c1cc(C(=O)NC2CC2)c(F)cc1C
Show InChI InChI=1S/C27H33FN6O2/c1-18-11-26(28)25(27(35)32-20-3-4-20)13-24(18)19-14-30-34(17-19)23-12-22(15-29-16-23)31-21-5-7-33(8-6-21)9-10-36-2/h11-17,20-21,31H,3-10H2,1-2H3,(H,32,35)
PDB

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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303380
PNG
(US10138222, Example 105)
Show SMILES Cc1cc(F)c(cc1-c1cnn(c1)-c1cncc(c1)C1CC1)C(=O)NC1CC1
Show InChI InChI=1S/C22H21FN4O/c1-13-6-21(23)20(22(28)26-17-4-5-17)8-19(13)16-10-25-27(12-16)18-7-15(9-24-11-18)14-2-3-14/h6-12,14,17H,2-5H2,1H3,(H,26,28)
PDB

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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303439
PNG
(US10138222, Example 167)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCN(CC3C4COCC34)CC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C30H36N6O2/c1-19-2-3-20(30(37)34-22-4-5-22)10-26(19)21-12-32-36(15-21)25-11-24(13-31-14-25)33-23-6-8-35(9-7-23)16-27-28-17-38-18-29(27)28/h2-3,10-15,22-23,27-29,33H,4-9,16-18H2,1H3,(H,34,37)
PDB

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US Patent
n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303909
PNG
(N-Cyclopropyl-5-{1-[7-ethoxy-6-(4-fluoro-1-methyl-...)
Show SMILES CCOc1cc2ncc(-n3cc(cn3)-c3cc(C(=O)NC4CC4)c(F)cc3C)n2cc1C1(F)CCN(C)CC1
Show InChI InChI=1S/C29H32F2N6O2/c1-4-39-25-13-26-32-15-27(36(26)17-23(25)29(31)7-9-35(3)10-8-29)37-16-19(14-33-37)21-12-22(24(30)11-18(21)2)28(38)34-20-5-6-20/h11-17,20H,4-10H2,1-3H3,(H,34,38)
PDB

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PC sid
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US Patent
n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303435
PNG
(US10138222, Example 163)
Show SMILES COC1COCCC1N1CCC(CC1)Nc1cncc(c1)-n1cc(cn1)-c1cc(ccc1C)C(=O)NC1CC1
Show InChI InChI=1S/C30H38N6O3/c1-20-3-4-21(30(37)34-23-5-6-23)13-27(20)22-15-32-36(18-22)26-14-25(16-31-17-26)33-24-7-10-35(11-8-24)28-9-12-39-19-29(28)38-2/h3-4,13-18,23-24,28-29,33H,5-12,19H2,1-2H3,(H,34,37)
PDB

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PC cid
PC sid
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US Patent
n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303362
PNG
(US10138222, Example 77)
Show SMILES CN1CCC(CC1)Nc1cncc(c1)-n1cc(cn1)-c1cc(C(=O)NC2CC2)c(F)cc1C
Show InChI InChI=1S/C25H29FN6O/c1-16-9-24(26)23(25(33)30-18-3-4-18)11-22(16)17-12-28-32(15-17)21-10-20(13-27-14-21)29-19-5-7-31(2)8-6-19/h9-15,18-19,29H,3-8H2,1-2H3,(H,30,33)
PDB

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n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303432
PNG
(US10138222, Example 160)
Show SMILES COC1CCC(CC1)N1CCC(CC1)Nc1cncc(c1)-n1cc(cn1)-c1cc(ccc1C)C(=O)NC1CC1
Show InChI InChI=1S/C31H40N6O2/c1-21-3-4-22(31(38)35-24-5-6-24)15-30(21)23-17-33-37(20-23)28-16-26(18-32-19-28)34-25-11-13-36(14-12-25)27-7-9-29(39-2)10-8-27/h3-4,15-20,24-25,27,29,34H,5-14H2,1-2H3,(H,35,38)
PDB

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n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303355
PNG
(US10138222, Example 68)
Show SMILES Cc1cc(F)c(cc1-c1cnn(c1)-c1cncc(NC2CCN(CC2)C2COC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C27H31FN6O2/c1-17-8-26(28)25(27(35)32-19-2-3-19)10-24(17)18-11-30-34(14-18)22-9-21(12-29-13-22)31-20-4-6-33(7-5-20)23-15-36-16-23/h8-14,19-20,23,31H,2-7,15-16H2,1H3,(H,32,35)
PDB

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n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303430
PNG
(US10138222, Example 158)
Show SMILES CC(=O)N1CCC(CC1)N1CCC(CC1)Nc1cncc(c1)-n1cc(cn1)-c1cc(ccc1C)C(=O)NC1CC1
Show InChI InChI=1S/C31H39N7O2/c1-21-3-4-23(31(40)35-25-5-6-25)15-30(21)24-17-33-38(20-24)29-16-27(18-32-19-29)34-26-7-11-37(12-8-26)28-9-13-36(14-10-28)22(2)39/h3-4,15-20,25-26,28,34H,5-14H2,1-2H3,(H,35,40)
PDB

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US Patent
n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303437
PNG
(US10138222, Example 165)
Show SMILES CC1CC(CCO1)N1CCC(CC1)Nc1cncc(c1)-n1cc(cn1)-c1cc(ccc1C)C(=O)NC1CC1
Show InChI InChI=1S/C30H38N6O2/c1-20-3-4-22(30(37)34-24-5-6-24)14-29(20)23-16-32-36(19-23)28-15-26(17-31-18-28)33-25-7-10-35(11-8-25)27-9-12-38-21(2)13-27/h3-4,14-19,21,24-25,27,33H,5-13H2,1-2H3,(H,34,37)
PDB

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US Patent
n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303849
PNG
(US10138241, Example 35)
Show SMILES COc1cc2ncc(-n3cc(cn3)-c3cc(ccc3C)C(=O)NC3CC3)n2cc1S(=O)(=O)C(C)(C)C
Show InChI InChI=1S/C26H29N5O4S/c1-16-6-7-17(25(32)29-19-8-9-19)10-20(16)18-12-28-31(14-18)24-13-27-23-11-21(35-5)22(15-30(23)24)36(33,34)26(2,3)4/h6-7,10-15,19H,8-9H2,1-5H3,(H,29,32)
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n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303859
PNG
(US10138241, Example 45)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cnc(NC(=O)C2CC2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C21H21N5O2S/c1-12-2-3-14(20(28)24-16-6-7-16)8-17(12)15-9-23-26(11-15)18-10-22-21(29-18)25-19(27)13-4-5-13/h2-3,8-11,13,16H,4-7H2,1H3,(H,24,28)(H,22,25,27)
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n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303441
PNG
(US10138222, Example 169)
Show SMILES CN1CC[C@H](Nc2cncc(c2)-n2cc(cn2)-c2cc(C(=O)NC3CC3)c(F)cc2C)[C@H](F)C1
Show InChI InChI=1S/C25H28F2N6O/c1-15-7-22(26)21(25(34)31-17-3-4-17)9-20(15)16-10-29-33(13-16)19-8-18(11-28-12-19)30-24-5-6-32(2)14-23(24)27/h7-13,17,23-24,30H,3-6,14H2,1-2H3,(H,31,34)/t23-,24+/m1/s1
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n/an/a 1.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303363
PNG
(US10138222, Example 78)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCOCC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C24H27N5O2/c1-16-2-3-17(24(30)28-19-4-5-19)10-23(16)18-12-26-29(15-18)22-11-21(13-25-14-22)27-20-6-8-31-9-7-20/h2-3,10-15,19-20,27H,4-9H2,1H3,(H,28,30)
PDB

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n/an/a 1.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303826
PNG
(US10138241, Example 10)
Show SMILES CC(C)(C)S(=O)(=O)c1ccc2ncc(-n3cc(cn3)-c3cc(C(=O)NC4CC4)c(F)cc3Cl)n2c1
Show InChI InChI=1S/C24H23ClFN5O3S/c1-24(2,3)35(33,34)16-6-7-21-27-11-22(30(21)13-16)31-12-14(10-28-31)17-8-18(20(26)9-19(17)25)23(32)29-15-4-5-15/h6-13,15H,4-5H2,1-3H3,(H,29,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303914
PNG
(N-Cyclopropyl-5-{1-[6-(1-ethyl-4-fluoro-piperidin-...)
Show SMILES CCN1CCC(F)(CC1)c1cn2c(cnc2cc1OC)-n1cc(cn1)-c1cc(C(=O)NC2CC2)c(F)cc1C
Show InChI InChI=1S/C29H32F2N6O2/c1-4-35-9-7-29(31,8-10-35)23-17-36-26(13-25(23)39-3)32-15-27(36)37-16-19(14-33-37)21-12-22(24(30)11-18(21)2)28(38)34-20-5-6-20/h11-17,20H,4-10H2,1-3H3,(H,34,38)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303911
PNG
(N-Cyclopropyl-2-fluoro-4-methyl-5-{1-[6-((R)-1-met...)
Show SMILES CN1CC[C@@H](C1)c1ccc2ncc(-n3cc(cn3)-c3cc(C(=O)NC4CC4)c(F)cc3C)n2c1
Show InChI InChI=1S/C26H27FN6O/c1-16-9-23(27)22(26(34)30-20-4-5-20)10-21(16)19-11-29-33(15-19)25-12-28-24-6-3-17(14-32(24)25)18-7-8-31(2)13-18/h3,6,9-12,14-15,18,20H,4-5,7-8,13H2,1-2H3,(H,30,34)/t18-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303443
PNG
(US10138222, Example 171)
Show SMILES CN(C)C1CCN(CC1)c1cncc(c1)-n1cc(cn1)-c1cc(C(=O)NC2CC2)c(F)cc1C
Show InChI InChI=1S/C26H31FN6O/c1-17-10-25(27)24(26(34)30-19-4-5-19)12-23(17)18-13-29-33(16-18)22-11-21(14-28-15-22)32-8-6-20(7-9-32)31(2)3/h10-16,19-20H,4-9H2,1-3H3,(H,30,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303887
PNG
(US10138241, Example 75)
Show SMILES Cc1cc(F)c(cc1-c1cnn(c1)-c1cnc2ccc(cn12)C(C)(C)O)C(=O)NC1CC1
Show InChI InChI=1S/C24H24FN5O2/c1-14-8-20(25)19(23(31)28-17-5-6-17)9-18(14)15-10-27-30(12-15)22-11-26-21-7-4-16(13-29(21)22)24(2,3)32/h4,7-13,17,32H,5-6H2,1-3H3,(H,28,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303907
PNG
(N-Cyclopropyl-2-fluoro-5-{1-[6-(4-fluoro-1-methylp...)
Show SMILES COc1cc2ncc(-n3cc(cn3)-c3cc(C(=O)NC4CC4)c(F)cc3C)n2cc1C1(F)CCN(C)CC1
Show InChI InChI=1S/C28H30F2N6O2/c1-17-10-23(29)21(27(37)33-19-4-5-19)11-20(17)18-13-32-36(15-18)26-14-31-25-12-24(38-3)22(16-35(25)26)28(30)6-8-34(2)9-7-28/h10-16,19H,4-9H2,1-3H3,(H,33,37)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303364
PNG
(BDBM303369 | US10138222, Example 79)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCN(CC2)C2COC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C27H32N6O2/c1-18-2-3-19(27(34)31-21-4-5-21)10-26(18)20-12-29-33(15-20)24-11-23(13-28-14-24)30-22-6-8-32(9-7-22)25-16-35-17-25/h2-3,10-15,21-22,25,30H,4-9,16-17H2,1H3,(H,31,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303368
PNG
(US10138222, Example 93)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCN(CC2)C2CCC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C28H34N6O/c1-19-5-6-20(28(35)32-22-7-8-22)13-27(19)21-15-30-34(18-21)26-14-24(16-29-17-26)31-23-9-11-33(12-10-23)25-3-2-4-25/h5-6,13-18,22-23,25,31H,2-4,7-12H2,1H3,(H,32,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303446
PNG
(US10138222, Example 174)
Show SMILES Cc1cc(F)c(cc1-c1cnn(c1)-c1cncc(NC2CCN(CCF)CC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C26H30F2N6O/c1-17-10-25(28)24(26(35)32-19-2-3-19)12-23(17)18-13-30-34(16-18)22-11-21(14-29-15-22)31-20-4-7-33(8-5-20)9-6-27/h10-16,19-20,31H,2-9H2,1H3,(H,32,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303433
PNG
(US10138222, Example 161)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCN(CC2)C2CCCOC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C29H36N6O2/c1-20-4-5-21(29(36)33-23-6-7-23)13-28(20)22-15-31-35(18-22)27-14-25(16-30-17-27)32-24-8-10-34(11-9-24)26-3-2-12-37-19-26/h4-5,13-18,23-24,26,32H,2-3,6-12,19H2,1H3,(H,33,36)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303367
PNG
(US10138222, Example 92)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCNCC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C24H28N6O/c1-16-2-3-17(24(31)29-19-4-5-19)10-23(16)18-12-27-30(15-18)22-11-21(13-26-14-22)28-20-6-8-25-9-7-20/h2-3,10-15,19-20,25,28H,4-9H2,1H3,(H,29,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303906
PNG
(N-Cyclopropyl-5-{1-[6-(1-dimethylcarbamoylmethyl-p...)
Show SMILES CN(C)C(=O)CN1CCC(CC1)c1ccc2ncc(-n3cc(cn3)-c3cc(C(=O)NC4CC4)c(F)cc3C)n2c1
Show InChI InChI=1S/C30H34FN7O2/c1-19-12-26(31)25(30(40)34-23-5-6-23)13-24(19)22-14-33-38(17-22)28-15-32-27-7-4-21(16-37(27)28)20-8-10-36(11-9-20)18-29(39)35(2)3/h4,7,12-17,20,23H,5-6,8-11,18H2,1-3H3,(H,34,40)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303448
PNG
(US10138222, Example 176)
Show SMILES CN1CC[C@@H](Nc2cncc(c2)-n2cc(cn2)-c2cc(C(=O)NC3CC3)c(F)cc2C)C(F)(F)C1
Show InChI InChI=1S/C25H27F3N6O/c1-15-7-22(26)21(24(35)32-17-3-4-17)9-20(15)16-10-30-34(13-16)19-8-18(11-29-12-19)31-23-5-6-33(2)14-25(23,27)28/h7-13,17,23,31H,3-6,14H2,1-2H3,(H,32,35)/t23-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303428
PNG
(US10138222, Example 156)
Show SMILES COCC(C)N1CCC(CC1)Nc1cncc(c1)-n1cc(cn1)-c1cc(ccc1C)C(=O)NC1CC1
Show InChI InChI=1S/C28H36N6O2/c1-19-4-5-21(28(35)32-23-6-7-23)12-27(19)22-14-30-34(17-22)26-13-25(15-29-16-26)31-24-8-10-33(11-9-24)20(2)18-36-3/h4-5,12-17,20,23-24,31H,6-11,18H2,1-3H3,(H,32,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303425
PNG
(US10138222, Example 153)
Show SMILES CC(CCO)N1CCC(CC1)Nc1cncc(c1)-n1cc(cn1)-c1cc(ccc1C)C(=O)NC1CC1
Show InChI InChI=1S/C28H36N6O2/c1-19-3-4-21(28(36)32-23-5-6-23)13-27(19)22-15-30-34(18-22)26-14-25(16-29-17-26)31-24-7-10-33(11-8-24)20(2)9-12-35/h3-4,13-18,20,23-24,31,35H,5-12H2,1-2H3,(H,32,36)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303353
PNG
(US10138222, Example 67)
Show SMILES CC(Nc1cncc(c1)-n1cc(cn1)-c1cc(ccc1C)C(=O)NC1CC1)C1CCOC1
Show InChI InChI=1S/C25H29N5O2/c1-16-3-4-18(25(31)29-21-5-6-21)9-24(16)20-11-27-30(14-20)23-10-22(12-26-13-23)28-17(2)19-7-8-32-15-19/h3-4,9-14,17,19,21,28H,5-8,15H2,1-2H3,(H,29,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303850
PNG
(US10138241, Example 36)
Show SMILES Cc1cc(F)c(cc1-c1cnn(c1)-c1cnc2ccc(cn12)S(=O)(=O)N1CCOCC1)C(=O)NC1CC1
Show InChI InChI=1S/C25H25FN6O4S/c1-16-10-22(26)21(25(33)29-18-2-3-18)11-20(16)17-12-28-32(14-17)24-13-27-23-5-4-19(15-31(23)24)37(34,35)30-6-8-36-9-7-30/h4-5,10-15,18H,2-3,6-9H2,1H3,(H,29,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303843
PNG
(US10138241, Example 29)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cnn2ccc(cc12)S(=O)(=O)C(C)(C)C)C(=O)NC1CC1
Show InChI InChI=1S/C25H27N5O3S/c1-16-5-6-17(24(31)28-19-7-8-19)11-21(16)18-13-26-30(15-18)23-14-27-29-10-9-20(12-22(23)29)34(32,33)25(2,3)4/h5-6,9-15,19H,7-8H2,1-4H3,(H,28,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303912
PNG
(US10138241, Example 99)
Show SMILES CN1CC[C@H](C1)c1ccc2ncc(-n3cc(cn3)-c3cc(C(=O)NC4CC4)c(F)cc3C)n2c1
Show InChI InChI=1S/C26H27FN6O/c1-16-9-23(27)22(26(34)30-20-4-5-20)10-21(16)19-11-29-33(15-19)25-12-28-24-6-3-17(14-32(24)25)18-7-8-31(2)13-18/h3,6,9-12,14-15,18,20H,4-5,7-8,13H2,1-2H3,(H,30,34)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303427
PNG
(US10138222, Example 155)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCN(CC3CCOCC3)CC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C30H38N6O2/c1-21-2-3-23(30(37)34-25-4-5-25)14-29(21)24-16-32-36(20-24)28-15-27(17-31-18-28)33-26-6-10-35(11-7-26)19-22-8-12-38-13-9-22/h2-3,14-18,20,22,25-26,33H,4-13,19H2,1H3,(H,34,37)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303447
PNG
(US10138222, Example 175)
Show SMILES CN1CC[C@H](Nc2cncc(c2)-n2cc(cn2)-c2cc(C(=O)NC3CC3)c(F)cc2C)C(F)(F)C1
Show InChI InChI=1S/C25H27F3N6O/c1-15-7-22(26)21(24(35)32-17-3-4-17)9-20(15)16-10-30-34(13-16)19-8-18(11-29-12-19)31-23-5-6-33(2)14-25(23,27)28/h7-13,17,23,31H,3-6,14H2,1-2H3,(H,32,35)/t23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303905
PNG
(N-Cyclopropyl-2-fluoro-4-methyl-5-{1-[6-(1-oxetan-...)
Show SMILES Cc1cc(F)c(cc1-c1cnn(c1)-c1cnc2ccc(cn12)C1CCN(CC1)C1COC1)C(=O)NC1CC1
Show InChI InChI=1S/C29H31FN6O2/c1-18-10-26(30)25(29(37)33-22-3-4-22)11-24(18)21-12-32-36(15-21)28-13-31-27-5-2-20(14-35(27)28)19-6-8-34(9-7-19)23-16-38-17-23/h2,5,10-15,19,22-23H,3-4,6-9,16-17H2,1H3,(H,33,37)
PDB

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US Patent
n/an/a 1.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303442
PNG
(US10138222, Example 170)
Show SMILES CN1CC[C@@H](Nc2cncc(c2)-n2cc(cn2)-c2cc(C(=O)NC3CC3)c(F)cc2C)[C@@H](F)C1
Show InChI InChI=1S/C25H28F2N6O/c1-15-7-22(26)21(25(34)31-17-3-4-17)9-20(15)16-10-29-33(13-16)19-8-18(11-28-12-19)30-24-5-6-32(2)14-23(24)27/h7-13,17,23-24,30H,3-6,14H2,1-2H3,(H,31,34)/t23-,24+/m0/s1
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US Patent
n/an/a 1.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303426
PNG
(US10138222, Example 154)
Show SMILES Cc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCN(CC3CCOC3)CC2)c1)C(=O)NC1CC1
Show InChI InChI=1S/C29H36N6O2/c1-20-2-3-22(29(36)33-24-4-5-24)12-28(20)23-14-31-35(18-23)27-13-26(15-30-16-27)32-25-6-9-34(10-7-25)17-21-8-11-37-19-21/h2-3,12-16,18,21,24-25,32H,4-11,17,19H2,1H3,(H,33,36)
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US Patent
n/an/a 1.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303445
PNG
(US10138222, Example 173)
Show SMILES CO[C@@H]1CN(C)CC[C@@H]1Nc1cncc(c1)-n1cc(cn1)-c1cc(C(=O)NC2CC2)c(F)cc1Cl
Show InChI InChI=1S/C25H28ClFN6O2/c1-32-6-5-23(24(14-32)35-2)30-17-7-18(12-28-11-17)33-13-15(10-29-33)19-8-20(22(27)9-21(19)26)25(34)31-16-3-4-16/h7-13,16,23-24,30H,3-6,14H2,1-2H3,(H,31,34)/t23-,24+/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303431
PNG
(US10138222, Example 159)
Show SMILES CC1OCCC1N1CCC(CC1)Nc1cncc(c1)-n1cc(cn1)-c1cc(ccc1C)C(=O)NC1CC1
Show InChI InChI=1S/C29H36N6O2/c1-19-3-4-21(29(36)33-23-5-6-23)13-27(19)22-15-31-35(18-22)26-14-25(16-30-17-26)32-24-7-10-34(11-8-24)28-9-12-37-20(28)2/h3-4,13-18,20,23-24,28,32H,5-12H2,1-2H3,(H,33,36)
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n/an/a 1.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303444
PNG
(US10138222, Example 172)
Show SMILES CN1CCC(COc2cncc(c2)-n2cc(cn2)-c2cc(C(=O)NC3CC3)c(F)cc2C)C1
Show InChI InChI=1S/C25H28FN5O2/c1-16-7-24(26)23(25(32)29-19-3-4-19)9-22(16)18-10-28-31(14-18)20-8-21(12-27-11-20)33-15-17-5-6-30(2)13-17/h7-12,14,17,19H,3-6,13,15H2,1-2H3,(H,29,32)
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n/an/a 1.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303894
PNG
(US10138241, Example 81-2)
Show SMILES C[C@H](O)c1ccc2ncc(-n3cc(cn3)-c3cc(C(=O)NC4CC4)c(F)cc3C)n2c1
Show InChI InChI=1S/C23H22FN5O2/c1-13-7-20(24)19(23(31)27-17-4-5-17)8-18(13)16-9-26-29(12-16)22-10-25-21-6-3-15(14(2)30)11-28(21)22/h3,6-12,14,17,30H,4-5H2,1-2H3,(H,27,31)/t14-/m0/s1
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US Patent
n/an/a 1.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138241 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303379
PNG
(US10138222, Example 104)
Show SMILES Fc1cc(Cl)c(cc1C(=O)NC1CC1)-c1cnn(c1)-c1cncc(c1)C1CC1
Show InChI InChI=1S/C21H18ClFN4O/c22-19-7-20(23)18(21(28)26-15-3-4-15)6-17(19)14-9-25-27(11-14)16-5-13(8-24-10-16)12-1-2-12/h5-12,15H,1-4H2,(H,26,28)
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n/an/a 1.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM303345
PNG
(US10138222, Example 63)
Show SMILES CC(=O)N1CCC(CC1)Nc1cncc(c1)-n1cc(cn1)-c1cc(ccc1C)C(=O)NC1CC1
Show InChI InChI=1S/C26H30N6O2/c1-17-3-4-19(26(34)30-21-5-6-21)11-25(17)20-13-28-32(16-20)24-12-23(14-27-15-24)29-22-7-9-31(10-8-22)18(2)33/h3-4,11-16,21-22,29H,5-10H2,1-2H3,(H,30,34)
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US Patent
n/an/a 1.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...


US Patent US10138222 (2018)

More data for this
Ligand-Target Pair
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