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Found 35 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase haspin' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50442760
PNG
(CHEMBL2443044)
Show SMILES CN1CCC(CC1)NC(=O)c1cc(on1)-c1c(O)cc(O)cc1Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C22H22N4O7/c1-25-8-6-13(7-9-25)23-22(29)17-12-20(33-24-17)21-18(28)10-15(27)11-19(21)32-16-4-2-14(3-5-16)26(30)31/h2-5,10-13,27-28H,6-9H2,1H3,(H,23,29)
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n/an/a>10n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of haspin (V473 to K798) (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50442759
PNG
(CHEMBL2443138)
Show SMILES CN(C)c1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(C)CC2)cc1
Show InChI InChI=1S/C24H28N4O5/c1-27(2)16-4-6-18(7-5-16)32-21-13-17(29)12-20(30)23(21)22-14-19(26-33-22)24(31)25-15-8-10-28(3)11-9-15/h4-7,12-15,29-30H,8-11H2,1-3H3,(H,25,31)
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of haspin (V473 to K798) (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50442758
PNG
(CHEMBL2443139)
Show SMILES CC(C)Nc1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(C)CC2)cc1
Show InChI InChI=1S/C25H30N4O5/c1-15(2)26-16-4-6-19(7-5-16)33-22-13-18(30)12-21(31)24(22)23-14-20(28-34-23)25(32)27-17-8-10-29(3)11-9-17/h4-7,12-15,17,26,30-31H,8-11H2,1-3H3,(H,27,32)
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of haspin (V473 to K798) (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50442757
PNG
(CHEMBL2443026)
Show SMILES CN(C)c1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(CC2)C2CCC3(CC2)OCCO3)cc1
Show InChI InChI=1S/C31H38N4O7/c1-34(2)21-3-5-24(6-4-21)41-27-18-23(36)17-26(37)29(27)28-19-25(33-42-28)30(38)32-20-9-13-35(14-10-20)22-7-11-31(12-8-22)39-15-16-40-31/h3-6,17-20,22,36-37H,7-16H2,1-2H3,(H,32,38)
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of haspin (V473 to K798) (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50364776
PNG
(CHEMBL1952141 | CHEMBL1952329)
Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)
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n/an/a 34n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of haspin


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379521
PNG
(CHEMBL2012574)
Show SMILES COc1ccc2c(c1)n(CCCCN)c1c(nccc21)C(F)(F)F
Show InChI InChI=1S/C17H18F3N3O/c1-24-11-4-5-12-13-6-8-22-16(17(18,19)20)15(13)23(14(12)10-11)9-3-2-7-21/h4-6,8,10H,2-3,7,9,21H2,1H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379526
PNG
(CHEMBL2012563)
Show SMILES Cc1nccc2c3ccc(O)cc3n(CCCCN)c12
Show InChI InChI=1S/C16H19N3O/c1-11-16-14(6-8-18-11)13-5-4-12(20)10-15(13)19(16)9-3-2-7-17/h4-6,8,10,20H,2-3,7,9,17H2,1H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379512
PNG
(CHEMBL2012559)
Show SMILES COc1ccc2c(c1)n(CCCCN)c1c(C)nccc21
Show InChI InChI=1S/C17H21N3O/c1-12-17-15(7-9-19-12)14-6-5-13(21-2)11-16(14)20(17)10-4-3-8-18/h5-7,9,11H,3-4,8,10,18H2,1-2H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379525
PNG
(CHEMBL2012562)
Show SMILES CCc1nccc2c3ccc(OC)cc3n(CCCCN)c12
Show InChI InChI=1S/C18H23N3O/c1-3-16-18-15(8-10-20-16)14-7-6-13(22-2)12-17(14)21(18)11-5-4-9-19/h6-8,10,12H,3-5,9,11,19H2,1-2H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379516
PNG
(CHEMBL2012569)
Show SMILES COc1cccc2c3ccnc(C)c3n(CCCCN)c12
Show InChI InChI=1S/C17H21N3O/c1-12-16-14(8-10-19-12)13-6-5-7-15(21-2)17(13)20(16)11-4-3-9-18/h5-8,10H,3-4,9,11,18H2,1-2H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379522
PNG
(CHEMBL2012575)
Show SMILES NCCCCn1c2cc(O)ccc2c2ccnc(c12)C(F)(F)F
Show InChI InChI=1S/C16H16F3N3O/c17-16(18,19)15-14-12(5-7-21-15)11-4-3-10(23)9-13(11)22(14)8-2-1-6-20/h3-5,7,9,23H,1-2,6,8,20H2
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379511
PNG
(CHEMBL2012560)
Show SMILES COc1ccc2c(c1)n(CCCCN)c1cnccc21
Show InChI InChI=1S/C16H19N3O/c1-20-12-4-5-13-14-6-8-18-11-16(14)19(15(13)10-12)9-3-2-7-17/h4-6,8,10-11H,2-3,7,9,17H2,1H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379519
PNG
(CHEMBL2012572)
Show SMILES CNCCCCn1c2cc(OC)ccc2c2ccnc(C)c12
Show InChI InChI=1S/C18H23N3O/c1-13-18-16(8-10-20-13)15-7-6-14(22-3)12-17(15)21(18)11-5-4-9-19-2/h6-8,10,12,19H,4-5,9,11H2,1-3H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379523
PNG
(CHEMBL2012558)
Show SMILES COc1ccc2c(c1)n(CCCN)c1c(C)nccc21
Show InChI InChI=1S/C16H19N3O/c1-11-16-14(6-8-18-11)13-5-4-12(20-2)10-15(13)19(16)9-3-7-17/h4-6,8,10H,3,7,9,17H2,1-2H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379524
PNG
(CHEMBL2012561)
Show SMILES COc1ccc2c(c1)n(CCCCN)c1c(nccc21)C(C)C
Show InChI InChI=1S/C19H25N3O/c1-13(2)18-19-16(8-10-21-18)15-7-6-14(23-3)12-17(15)22(19)11-5-4-9-20/h6-8,10,12-13H,4-5,9,11,20H2,1-3H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379520
PNG
(CHEMBL2012573)
Show SMILES COc1ccc2c(c1)n(CCCCN(C)C)c1c(C)nccc21
Show InChI InChI=1S/C19H25N3O/c1-14-19-17(9-10-20-14)16-8-7-15(23-4)13-18(16)22(19)12-6-5-11-21(2)3/h7-10,13H,5-6,11-12H2,1-4H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379517
PNG
(CHEMBL2012570)
Show SMILES Cc1nccc2c3cc4OCOc4cc3n(CCCCN)c12
Show InChI InChI=1S/C17H19N3O2/c1-11-17-12(4-6-19-11)13-8-15-16(22-10-21-15)9-14(13)20(17)7-3-2-5-18/h4,6,8-9H,2-3,5,7,10,18H2,1H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379527
PNG
(CHEMBL2012564)
Show SMILES Cc1nccc2c3ccc(F)cc3n(CCCCN)c12
Show InChI InChI=1S/C16H18FN3/c1-11-16-14(6-8-19-11)13-5-4-12(17)10-15(13)20(16)9-3-2-7-18/h4-6,8,10H,2-3,7,9,18H2,1H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM100152
PNG
(7-methoxy-1-methyl-9H-$b-carboline;hydrochloride |...)
Show SMILES COc1ccc2c(c1)[nH]c1c(C)nccc21
Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379528
PNG
(CHEMBL2012565)
Show SMILES Cc1nccc2c3ccc(NS(C)(=O)=O)cc3n(CCCCN)c12
Show InChI InChI=1S/C17H22N4O2S/c1-12-17-15(7-9-19-12)14-6-5-13(20-24(2,22)23)11-16(14)21(17)10-4-3-8-18/h5-7,9,11,20H,3-4,8,10,18H2,1-2H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50778
PNG
((1S,2S,3R,8aS)-6-acetyl-3-carbamoyl-1-cyano-2-(3-t...)
Show SMILES CCOC(=O)[C@]1(C#N)[C@@H]2C=CC(=CN2[C@H]([C@@H]1c1ccsc1)C(N)=O)C(C)=O
Show InChI InChI=1S/C19H19N3O4S/c1-3-26-18(25)19(10-20)14-5-4-12(11(2)23)8-22(14)16(17(21)24)15(19)13-6-7-27-9-13/h4-9,14-16H,3H2,1-2H3,(H2,21,24)/t14-,15-,16+,19+/m0/s1
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379518
PNG
(CHEMBL2012571)
Show SMILES COc1ccc2c3ccnc(C)c3n(CCCCN)c2c1Cl
Show InChI InChI=1S/C17H20ClN3O/c1-11-16-13(7-9-20-11)12-5-6-14(22-2)15(18)17(12)21(16)10-4-3-8-19/h5-7,9H,3-4,8,10,19H2,1-2H3
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379515
PNG
(CHEMBL2012568)
Show SMILES COc1ccc2n(CCCCN)c3c(C)nccc3c2c1
Show InChI InChI=1S/C17H21N3O/c1-12-17-14(7-9-19-12)15-11-13(21-2)5-6-16(15)20(17)10-4-3-8-18/h5-7,9,11H,3-4,8,10,18H2,1-2H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379514
PNG
(CHEMBL2012567)
Show SMILES COc1cccc2n(CCCCN)c3c(C)nccc3c12
Show InChI InChI=1S/C17H21N3O/c1-12-17-13(8-10-19-12)16-14(6-5-7-15(16)21-2)20(17)11-4-3-9-18/h5-8,10H,3-4,9,11,18H2,1-2H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50379513
PNG
(CHEMBL2012566)
Show SMILES Cc1nccc2c3ccc(OC(C)(C)C)cc3n(CCCCN)c12
Show InChI InChI=1S/C20H27N3O/c1-14-19-17(9-11-22-14)16-8-7-15(24-20(2,3)4)13-18(16)23(19)12-6-5-10-21/h7-9,11,13H,5-6,10,12,21H2,1-4H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM138348
PNG
(US8877944, 99)
Show SMILES NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C3CCC(F)(F)CC3)C(=O)c12
Show InChI InChI=1S/C20H24F3N3O2/c21-13-9-12-11-26(19(28)17(12)16(10-13)18(24)27)15-3-7-25(8-4-15)14-1-5-20(22,23)6-2-14/h9-10,14-15H,1-8,11H2,(H2,24,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of human Haspin


J Med Chem 58: 6875-98 (2015)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50048357
PNG
(CHEMBL3309990)
Show SMILES Nc1nc2c3c(F)cccc3nc(Cc3ccc4OCOc4c3)n2n1
Show InChI InChI=1S/C17H12FN5O2/c18-10-2-1-3-11-15(10)16-21-17(19)22-23(16)14(20-11)7-9-4-5-12-13(6-9)25-8-24-12/h1-6H,7-8H2,(H2,19,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Nerviano Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of Haspin (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50048362
PNG
(CHEMBL3309995)
Show SMILES Nc1nc2c3ccc(N)cc3nc(Cc3ccc4OCOc4c3)n2n1
Show InChI InChI=1S/C17H14N6O2/c18-10-2-3-11-12(7-10)20-15(23-16(11)21-17(19)22-23)6-9-1-4-13-14(5-9)25-8-24-13/h1-5,7H,6,8,18H2,(H2,19,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Nerviano Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of Haspin (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50048364
PNG
(CHEMBL3309997)
Show SMILES OCCCNc1ccc2c3ncnn3c(nc2c1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C19H17N5O3/c25-7-1-6-20-13-3-4-14-15(9-13)23-18(24-19(14)21-10-22-24)12-2-5-16-17(8-12)27-11-26-16/h2-5,8-10,20,25H,1,6-7,11H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Nerviano Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of Haspin (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50048365
PNG
(CHEMBL3309998)
Show SMILES Nc1nc2c3ccc(NCCO)cc3nc(Cc3ccc4OCOc4c3)n2n1
Show InChI InChI=1S/C19H18N6O3/c20-19-23-18-13-3-2-12(21-5-6-26)9-14(13)22-17(25(18)24-19)8-11-1-4-15-16(7-11)28-10-27-15/h1-4,7,9,21,26H,5-6,8,10H2,(H2,20,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Nerviano Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of Haspin (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50048374
PNG
(CHEMBL3310151)
Show SMILES CN1CCN(CC1)c1cc(F)c2c3nc(N)nn3c(Cc3ccc4OCOc4c3)nc2c1
Show InChI InChI=1S/C22H22FN7O2/c1-28-4-6-29(7-5-28)14-10-15(23)20-16(11-14)25-19(30-21(20)26-22(24)27-30)9-13-2-3-17-18(8-13)32-12-31-17/h2-3,8,10-11H,4-7,9,12H2,1H3,(H2,24,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Nerviano Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of Haspin (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50021626
PNG
(CHEMBL3298400)
Show SMILES CC(C)(C)CNC(=O)CC1CNC(=O)c2cc(cn12)-c1ccsc1
Show InChI InChI=1S/C18H23N3O2S/c1-18(2,3)11-20-16(22)7-14-8-19-17(23)15-6-13(9-21(14)15)12-4-5-24-10-12/h4-6,9-10,14H,7-8,11H2,1-3H3,(H,19,23)(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Nerviano Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of haspin (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50343559
PNG
(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Show SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCO)c4-c3n2)C(N)=O)c1
Show InChI InChI=1S/C24H27F3N8O3/c1-33-6-8-34(9-7-33)15-3-5-18(38-24(25,26)27)17(12-15)30-23-29-13-14-2-4-16-20(22(28)37)32-35(10-11-36)21(16)19(14)31-23/h3,5,12-13,36H,2,4,6-11H2,1H3,(H2,28,37)(H,29,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Nerviano Medical Sciences srl

Curated by ChEMBL


Assay Description
Inhibition of Haspin assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50429867
PNG
(CHEMBL2333365)
Show SMILES Cc1c(F)c(ccc1C(=O)N1CCOc2ccc(cc2C1)-c1ccc(N)nc1)S(C)(=O)=O
Show InChI InChI=1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2,29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8,11-12H,9-10,13H2,1-2H3,(H2,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of Haspin (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens)
BDBM50021618
PNG
(CHEMBL3297762 | US9145418, 2)
Show SMILES CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cccc(Cl)c2)C2CCCCC2)CC1
Show InChI InChI=1S/C28H38ClN5O2/c1-32-10-12-33(13-11-32)19-25(20-6-3-2-4-7-20)31-27(35)16-24-17-30-28(36)26-15-22(18-34(24)26)21-8-5-9-23(29)14-21/h5,8-9,14-15,18,20,24-25H,2-4,6-7,10-13,16-17,19H2,1H3,(H,30,36)(H,31,35)/t24-,25+/m0/s1
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Nerviano Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of haspin (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair