BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 121 hits Enz. Inhib. hit(s) with Target = 'Serine-protein kinase ATM' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine-protein kinase ATM


(Homo sapiens)
BDBM50208517
PNG
(2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | C...)
Show SMILES O=c1cc(oc(c1)-c1cccc2Sc3ccccc3Sc12)N1CCOCC1
Show InChI InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
2.20n/an/an/an/an/an/an/an/a



University of California-San Francisco

Curated by ChEMBL


Assay Description
Inhibition of ATM


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50059640
PNG
(CHEMBL2140173)
Show SMILES C[C@H]1CN(CC(=O)Nc2ccc3Sc4c(Cc3c2)cccc4-c2cc(=O)cc(o2)N2CCOCC2)C[C@@H](C)O1
Show InChI InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MMDB
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



University Hospital Hradec Kralove

Curated by ChEMBL


Assay Description
Inhibition of ATM kinase in human glioma cells


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50208517
PNG
(2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | C...)
Show SMILES O=c1cc(oc(c1)-c1cccc2Sc3ccccc3Sc12)N1CCOCC1
Show InChI InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of ATM kinase


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50208517
PNG
(2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | C...)
Show SMILES O=c1cc(oc(c1)-c1cccc2Sc3ccccc3Sc12)N1CCOCC1
Show InChI InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50208517
PNG
(2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | C...)
Show SMILES O=c1cc(oc(c1)-c1cccc2Sc3ccccc3Sc12)N1CCOCC1
Show InChI InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of ATM isolated from human HeLa cell extract using glutathione S-transferase-p53N66 as substrate by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50044977
PNG
(CHEMBL3334621)
Show SMILES CC(C)(C#N)c1ccc(cc1)N1C(=O)OCc2cnc3ccc(cc3c12)-c1cnc2ccccc2c1
Show InChI InChI=1S/C30H22N4O2/c1-30(2,18-31)23-8-10-24(11-9-23)34-28-22(17-36-29(34)35)16-33-27-12-7-19(14-25(27)28)21-13-20-5-3-4-6-26(20)32-15-21/h3-16H,17H2,1-2H3
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>36n/an/an/an/an/an/a



The University of Texas MD Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of ATM (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341758
PNG
(3-(1H-indol-2-yl)-5-(4-(methylsulfonyl)phenyl)pyra...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H16N4O2S/c1-26(24,25)14-8-6-12(7-9-14)17-11-21-19(20)18(23-17)16-10-13-4-2-3-5-15(13)22-16/h2-11,22H,1H3,(H2,20,21)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50043385
PNG
(CHEMBL3355072)
Show SMILES C[C@@H]1Cn2ncc(c2CN1c1ccnc2[nH]ccc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1/C21H21N5O2S/c1-14-12-26-20(13-25(14)19-8-10-23-21-17(19)7-9-22-21)18(11-24-26)15-3-5-16(6-4-15)29(2,27)28/h3-11,14H,12-13H2,1-2H3,(H,22,23)/t14-/s2
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of ATM (unknown origin) using p53-Q10-K17 peptide substrate by alphascreen assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of ATM


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50324675
PNG
(2,2-diphenyl-N-(2,2,2-trichloro-1-(3-(4-fluoro-3-n...)
Show SMILES [O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c2ccccc2)C(Cl)(Cl)Cl)ccc1F
Show InChI InChI=1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Korea Advanced Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of ataxia telangiectasia-mutated


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50398033
PNG
(CHEMBL2181114)
Show SMILES CCOC(=O)C1(COC(=O)C1=C)C(=O)OCC
Show InChI InChI=1S/C11H14O6/c1-4-15-9(13)11(10(14)16-5-2)6-17-8(12)7(11)3/h3-6H2,1-2H3
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of ATM isolated from human HeLa cell extract using glutathione S-transferase-p53N66 as substrate by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341719
PNG
(3-amino-6-(2-cyanophenyl)-N-phenylpyrazine-2-carbo...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccccc1C#N
Show InChI InChI=1S/C18H13N5O/c19-10-12-6-4-5-9-14(12)15-11-21-17(20)16(23-15)18(24)22-13-7-2-1-3-8-13/h1-9,11H,(H2,20,21)(H,22,24)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 320n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341755
PNG
(3-(1H-benzo[d]imidazol-2-yl)-5-(4-(methylsulfonyl)...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C18H15N5O2S/c1-26(24,25)12-8-6-11(7-9-12)15-10-20-17(19)16(21-15)18-22-13-4-2-3-5-14(13)23-18/h2-10H,1H3,(H2,19,20)(H,22,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 380n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50398034
PNG
(CHEMBL2181113)
Show SMILES C=C1[C@H](COC1=O)C(=O)N1Cc2cc3ccccc3nc2C1
Show InChI InChI=1S/C17H14N2O3/c1-10-13(9-22-17(10)21)16(20)19-7-12-6-11-4-2-3-5-14(11)18-15(12)8-19/h2-6,13H,1,7-9H2/t13-/m0/s1
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 600n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of ATM isolated from human HeLa cell extract using glutathione S-transferase-p53N66 as substrate by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341757
PNG
(3-(benzo[d]thiazol-2-yl)-5-(4-(methylsulfonyl)phen...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)-c1nc2ccccc2s1
Show InChI InChI=1S/C18H14N4O2S2/c1-26(23,24)12-8-6-11(7-9-12)14-10-20-17(19)16(21-14)18-22-13-4-2-3-5-15(13)25-18/h2-10H,1H3,(H2,19,20)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 720n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341756
PNG
(3-(benzoxazol-2-yl)-5-(4-(methylsulfonyl)phenyl)py...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)-c1nc2ccccc2o1
Show InChI InChI=1S/C18H14N4O3S/c1-26(23,24)12-8-6-11(7-9-12)14-10-20-17(19)16(21-14)18-22-13-4-2-3-5-15(13)25-18/h2-10H,1H3,(H2,19,20)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 840n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341739
PNG
(3-amino-6-(4-(methylcarbamoyl)phenyl)-N-phenylpyra...)
Show SMILES CNC(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H17N5O2/c1-21-18(25)13-9-7-12(8-10-13)15-11-22-17(20)16(24-15)19(26)23-14-5-3-2-4-6-14/h2-11H,1H3,(H2,20,22)(H,21,25)(H,23,26)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341738
PNG
(3-amino-6-(4-carbamoylphenyl)-N-phenylpyrazine-2-c...)
Show SMILES NC(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H15N5O2/c19-16-15(18(25)22-13-4-2-1-3-5-13)23-14(10-21-16)11-6-8-12(9-7-11)17(20)24/h1-10H,(H2,19,21)(H2,20,24)(H,22,25)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341720
PNG
(3-amino-6-(2-(methylsulfinyl)phenyl)-N-phenylpyraz...)
Show SMILES CS(=O)c1ccccc1-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H16N4O2S/c1-25(24)15-10-6-5-9-13(15)14-11-20-17(19)16(22-14)18(23)21-12-7-3-2-4-8-12/h2-11H,1H3,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50208528
PNG
(2-dibenzofuran-4-yl-6-morpholin-4-yl-pyran-4-one |...)
Show SMILES O=c1cc(oc(c1)-c1cccc2c1oc1ccccc21)N1CCOCC1
Show InChI InChI=1S/C21H17NO4/c23-14-12-19(25-20(13-14)22-8-10-24-11-9-22)17-6-3-5-16-15-4-1-2-7-18(15)26-21(16)17/h1-7,12-13H,8-11H2
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 3.20E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of ATM kinase


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50208543
PNG
(6-(4-benzo[b]thiophen-3-ylphenyl)-2-morpholin-4-yl...)
Show SMILES O=c1cc(oc(c1)-c1csc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C17H15NO3S/c19-12-9-15(14-11-22-16-4-2-1-3-13(14)16)21-17(10-12)18-5-7-20-8-6-18/h1-4,9-11H,5-8H2
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.30E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of ATM kinase


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50043387
PNG
(CHEMBL3355074)
Show SMILES C[C@@H]1Cn2ncc(C3CCN(CC3)S(C)(=O)=O)c2CN1c1cc(Cl)nc2[nH]ccc12
Show InChI InChI=1/C20H25ClN6O2S/c1-13-11-27-18(12-26(13)17-9-19(21)24-20-15(17)3-6-22-20)16(10-23-27)14-4-7-25(8-5-14)30(2,28)29/h3,6,9-10,13-14H,4-5,7-8,11-12H2,1-2H3,(H,22,24)/t13-/s2
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.30E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of ATM (unknown origin) using p53-Q10-K17 peptide substrate by alphascreen assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341753
PNG
((R)-3-amino-N-phenyl-6-(4-((tetrahydrofuran-3-yl)s...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccc(cc1)S(=O)(=O)[C@@H]1CCOC1
Show InChI InChI=1S/C21H20N4O4S/c22-20-19(21(26)24-15-4-2-1-3-5-15)25-18(12-23-20)14-6-8-16(9-7-14)30(27,28)17-10-11-29-13-17/h1-9,12,17H,10-11,13H2,(H2,22,23)(H,24,26)/t17-/m1/s1
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341748
PNG
(3-amino-N-phenyl-6-(4-(propylsulfonyl)phenyl)pyraz...)
Show SMILES CCCS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C20H20N4O3S/c1-2-12-28(26,27)16-10-8-14(9-11-16)17-13-22-19(21)18(24-17)20(25)23-15-6-4-3-5-7-15/h3-11,13H,2,12H2,1H3,(H2,21,22)(H,23,25)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5.40E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341734
PNG
(3-amino-6-(4-hydroxyphenyl)-N-phenylpyrazine-2-car...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccc(O)cc1
Show InChI InChI=1S/C17H14N4O2/c18-16-15(17(23)20-12-4-2-1-3-5-12)21-14(10-19-16)11-6-8-13(22)9-7-11/h1-10,22H,(H2,18,19)(H,20,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5.80E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341727
PNG
(3-amino-6-(3-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H16N4O3S/c1-26(24,25)14-9-5-6-12(10-14)15-11-20-17(19)16(22-15)18(23)21-13-7-3-2-4-8-13/h2-11H,1H3,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 6.60E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341749
PNG
(3-amino-6-(4-(sec-butylsulfonyl)phenyl)-N-phenylpy...)
Show SMILES CCC(C)S(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C21H22N4O3S/c1-3-14(2)29(27,28)17-11-9-15(10-12-17)18-13-23-20(22)19(25-18)21(26)24-16-7-5-4-6-8-16/h4-14H,3H2,1-2H3,(H2,22,23)(H,24,26)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 6.60E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341712
PNG
(3-amino-N,6-diphenylpyrazine-2-carboxamide | CHEMB...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C17H14N4O/c18-16-15(17(22)20-13-9-5-2-6-10-13)21-14(11-19-16)12-7-3-1-4-8-12/h1-11H,(H2,18,19)(H,20,22)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341714
PNG
(3-Amino-N-phenylpyrazine-2-carboxamide | CHEMBL176...)
Show SMILES Nc1nccnc1C(=O)Nc1ccccc1
Show InChI InChI=1S/C11H10N4O/c12-10-9(13-6-7-14-10)11(16)15-8-4-2-1-3-5-8/h1-7H,(H2,12,14)(H,15,16)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341715
PNG
(3-Amino-6-bromo-N-phenylpyrazine-2-carboxamide | C...)
Show SMILES Nc1ncc(Br)nc1C(=O)Nc1ccccc1
Show InChI InChI=1S/C11H9BrN4O/c12-8-6-14-10(13)9(16-8)11(17)15-7-4-2-1-3-5-7/h1-6H,(H2,13,14)(H,15,17)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341716
PNG
(3-Amino-6-cyclohexyl-N-phenylpyrazine-2-carboxamid...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)C1CCCCC1
Show InChI InChI=1S/C17H20N4O/c18-16-15(17(22)20-13-9-5-2-6-10-13)21-14(11-19-16)12-7-3-1-4-8-12/h2,5-6,9-12H,1,3-4,7-8H2,(H2,18,19)(H,20,22)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341717
PNG
(3-Amino-6-(cyclohex-1-en-1-yl)-N-phenylpyrazine-2-...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)C1=CCCCC1
Show InChI InChI=1S/C17H18N4O/c18-16-15(17(22)20-13-9-5-2-6-10-13)21-14(11-19-16)12-7-3-1-4-8-12/h2,5-7,9-11H,1,3-4,8H2,(H2,18,19)(H,20,22)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341713
PNG
(3-amino-N-phenyl-6-(pyridin-3-yl)pyrazine-2-carbox...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1cccnc1
Show InChI InChI=1S/C16H13N5O/c17-15-14(16(22)20-12-6-2-1-3-7-12)21-13(10-19-15)11-5-4-8-18-9-11/h1-10H,(H2,17,19)(H,20,22)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341718
PNG
(3-amino-N-phenyl-6-(pyridin-4-yl)pyrazine-2-carbox...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccncc1
Show InChI InChI=1S/C16H13N5O/c17-15-14(16(22)20-12-4-2-1-3-5-12)21-13(10-19-15)11-6-8-18-9-7-11/h1-10H,(H2,17,19)(H,20,22)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341721
PNG
(3-amino-6-(2-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Show SMILES CS(=O)(=O)c1ccccc1-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H16N4O3S/c1-26(24,25)15-10-6-5-9-13(15)14-11-20-17(19)16(22-14)18(23)21-12-7-3-2-4-8-12/h2-11H,1H3,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341722
PNG
(3-amino-6-(2-hydroxyphenyl)-N-phenylpyrazine-2-car...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C17H14N4O2/c18-16-15(17(23)20-11-6-2-1-3-7-11)21-13(10-19-16)12-8-4-5-9-14(12)22/h1-10,22H,(H2,18,19)(H,20,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341723
PNG
(3-amino-6-(2-methoxyphenyl)-N-phenylpyrazine-2-car...)
Show SMILES COc1ccccc1-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H16N4O2/c1-24-15-10-6-5-9-13(15)14-11-20-17(19)16(22-14)18(23)21-12-7-3-2-4-8-12/h2-11H,1H3,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341724
PNG
(3-amino-6-(2-chlorophenyl)-N-phenylpyrazine-2-carb...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccccc1Cl
Show InChI InChI=1S/C17H13ClN4O/c18-13-9-5-4-8-12(13)14-10-20-16(19)15(22-14)17(23)21-11-6-2-1-3-7-11/h1-10H,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341725
PNG
(3-amino-N-phenyl-6-(o-tolyl)pyrazine-2-carboxamide...)
Show SMILES Cc1ccccc1-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H16N4O/c1-12-7-5-6-10-14(12)15-11-20-17(19)16(22-15)18(23)21-13-8-3-2-4-9-13/h2-11H,1H3,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341726
PNG
(3-amino-6-(3-cyanophenyl)-N-phenylpyrazine-2-carbo...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C18H13N5O/c19-10-12-5-4-6-13(9-12)15-11-21-17(20)16(23-15)18(24)22-14-7-2-1-3-8-14/h1-9,11H,(H2,20,21)(H,22,24)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341728
PNG
(3-amino-6-(3-hydroxyphenyl)-N-phenylpyrazine-2-car...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1cccc(O)c1
Show InChI InChI=1S/C17H14N4O2/c18-16-15(17(23)20-12-6-2-1-3-7-12)21-14(10-19-16)11-5-4-8-13(22)9-11/h1-10,22H,(H2,18,19)(H,20,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341729
PNG
(3-amino-6-(3-methoxyphenyl)-N-phenylpyrazine-2-car...)
Show SMILES COc1cccc(c1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H16N4O2/c1-24-14-9-5-6-12(10-14)15-11-20-17(19)16(22-15)18(23)21-13-7-3-2-4-8-13/h2-11H,1H3,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341730
PNG
(3-amino-6-(3-chlorophenyl)-N-phenylpyrazine-2-carb...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H13ClN4O/c18-12-6-4-5-11(9-12)14-10-20-16(19)15(22-14)17(23)21-13-7-2-1-3-8-13/h1-10H,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341731
PNG
(3-amino-N-phenyl-6-(m-tolyl)pyrazine-2-carboxamide...)
Show SMILES Cc1cccc(c1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H16N4O/c1-12-6-5-7-13(10-12)15-11-20-17(19)16(22-15)18(23)21-14-8-3-2-4-9-14/h2-11H,1H3,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341732
PNG
(3-amino-6-(4-cyanophenyl)-N-phenylpyrazine-2-carbo...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C18H13N5O/c19-10-12-6-8-13(9-7-12)15-11-21-17(20)16(23-15)18(24)22-14-4-2-1-3-5-14/h1-9,11H,(H2,20,21)(H,22,24)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341733
PNG
(3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H16N4O3S/c1-26(24,25)14-9-7-12(8-10-14)15-11-20-17(19)16(22-15)18(23)21-13-5-3-2-4-6-13/h2-11H,1H3,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341735
PNG
(3-amino-6-(4-methoxyphenyl)-N-phenylpyrazine-2-car...)
Show SMILES COc1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H16N4O2/c1-24-14-9-7-12(8-10-14)15-11-20-17(19)16(22-15)18(23)21-13-5-3-2-4-6-13/h2-11H,1H3,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341736
PNG
(3-amino-6-(4-chlorophenyl)-N-phenylpyrazine-2-carb...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H13ClN4O/c18-12-8-6-11(7-9-12)14-10-20-16(19)15(22-14)17(23)21-13-4-2-1-3-5-13/h1-10H,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341737
PNG
(3-amino-N-phenyl-6-(p-tolyl)pyrazine-2-carboxamide...)
Show SMILES Cc1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H16N4O/c1-12-7-9-13(10-8-12)15-11-20-17(19)16(22-15)18(23)21-14-5-3-2-4-6-14/h2-11H,1H3,(H2,19,20)(H,21,23)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Serine-protein kinase ATM


(Homo sapiens)
BDBM50341740
PNG
(3-amino-6-(4-(azetidine-1-carbonyl)phenyl)-N-pheny...)
Show SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccc(cc1)C(=O)N1CCC1
Show InChI InChI=1S/C21H19N5O2/c22-19-18(20(27)24-16-5-2-1-3-6-16)25-17(13-23-19)14-7-9-15(10-8-14)21(28)26-11-4-12-26/h1-3,5-10,13H,4,11-12H2,(H2,22,23)(H,24,27)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>8.00E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 121 total )  |  Next  |  Last  >>
Jump to: