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Compile Data Set for Download or QSAR

Found 76 hits Enz. Inhib. hit(s) with Target = 'Serine-threonine protein phosphatase 2A regulatory subunit ' AND taxid = 9031   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110686
PNG
(14-Ethylidene-2-isopropyl-5-(6-methoxy-3,5-dimethy...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](C)[C@@H](CC(=O)C(=CC)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O)C(C)C
Show InChI InChI=1S/C41H58N4O10/c1-10-32-33(46)22-29(40(51)52)26(6)37(48)44-36(23(2)3)39(50)42-30(27(7)38(49)43-31(41(53)54)18-19-35(47)45(32)8)17-16-24(4)20-25(5)34(55-9)21-28-14-12-11-13-15-28/h10-17,20,23,25-27,29-31,34,36H,18-19,21-22H2,1-9H3,(H,42,50)(H,43,49)(H,44,48)(H,51,52)(H,53,54)/b17-16+,24-20+,32-10?/t25-,26-,27-,29+,30-,31+,34-,36-/m0/s1
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n/an/a 0.0300n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50061067
PNG
(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](C)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)C(=C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O
Show InChI InChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-19,24,26,28-31,34-38,40H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,61)(H,57,63)(H,58,66)(H,67,68)(H,69,70)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31+,34-,35-,36+,37-,38-,40+/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110681
PNG
(CHEMBL430266 | Calyculin-A)
Show SMILES COC[C@@H]([C@H](O)[C@H](O)C(=O)NCC[C@H](C)c1nc(\C=C\C[C@@H]2O[C@]3(C[C@@H](O)[C@@H]2C)O[C@H]([C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C(\C)=C\C=C\C(\C)=C/C#N)OC)[C@H](OP(O)(O)=O)C3(C)C)co1)N(C)C
Show InChI InChI=1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34-,35-,37-,38-,39+,40-,41-,42+,43-,44-,45+,46-,50+/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50061066
PNG
((5R,6S,9S,12S,13S,16R)-2-Eth-(Z)-ylidene-9-(3-guan...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](C)[C@@H](NC(=O)\C(=C\C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O
Show InChI InChI=1S/C41H60N8O10/c1-8-31-38(54)48-34(40(57)58)26(5)36(52)46-29(15-12-20-44-41(42)43)37(53)45-28(25(4)35(51)47-30(39(55)56)18-19-33(50)49(31)6)17-16-23(2)21-24(3)32(59-7)22-27-13-10-9-11-14-27/h8-11,13-14,16-17,21,24-26,28-30,32,34H,12,15,18-20,22H2,1-7H3,(H,45,53)(H,46,52)(H,47,51)(H,48,54)(H,55,56)(H,57,58)(H4,42,43,44)/b17-16+,23-21+,31-8-/t24-,25-,26-,28-,29-,30+,32-,34+/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Observed inhibition activity against protein phosphatase 2A (PP2A)


Citation and Details
More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110685
PNG
(25-Isobutyl-15-(6-methoxy-3,5-dimethyl-7-phenyl-he...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](C)[C@@H](CC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)C(=C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O
Show InChI InChI=1S/C47H68N6O12/c1-25(2)21-37-38(54)24-34(46(61)62)28(5)41(56)48-30(7)43(58)50-35(18-17-26(3)22-27(4)39(65-11)23-33-15-13-12-14-16-33)29(6)42(57)51-36(47(63)64)19-20-40(55)53(10)32(9)45(60)49-31(8)44(59)52-37/h12-18,22,25,27-31,34-37,39H,9,19-21,23-24H2,1-8,10-11H3,(H,48,56)(H,49,60)(H,50,58)(H,51,57)(H,52,59)(H,61,62)(H,63,64)/b18-17+,26-22+/t27-,28-,29-,30-,31+,34+,35-,36+,37-,39-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of microcystin analogues to catalytic subunits of Serine/threonine protein phosphatase 2A (PP2Ac)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110676
PNG
(CHEMBL280487 | okadaic acid)
Show SMILES C[C@@H](C[C@H](O)[C@H]1O[C@@H]2CC[C@@]3(CC[C@@H](O3)\C=C\[C@@H](C)[C@@H]3CC(C)=C[C@@]4(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]4O)O3)O[C@H]2[C@H](O)C1=C)[C@H]1O[C@@]2(CCCCO2)CC[C@H]1C
Show InChI InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1
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n/an/a 0.450n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Observed inhibition activity against protein phosphatase 2A (PP2A)


Citation and Details
More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50366883
PNG
(TAUTOMYCIN)
Show SMILES CO[C@H]([C@H](O)CC(=O)[C@@H](C)[C@@H](O)CC[C@@H](C)[C@@H]1O[C@]2(CC[C@@H](C)[C@H](CC[C@H](C)C(C)=O)O2)CC[C@@H]1C)[C@H](OC(=O)C[C@@H](O)C1=C(C)C(=O)OC1=O)C(C)C
Show InChI InChI=1S/C41H66O13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46H,11-20H2,1-10H3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38+,41+/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110676
PNG
(CHEMBL280487 | okadaic acid)
Show SMILES C[C@@H](C[C@H](O)[C@H]1O[C@@H]2CC[C@@]3(CC[C@@H](O3)\C=C\[C@@H](C)[C@@H]3CC(C)=C[C@@]4(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]4O)O3)O[C@H]2[C@H](O)C1=C)[C@H]1O[C@@]2(CCCCO2)CC[C@H]1C
Show InChI InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1
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The University of Newcastle

Curated by ChEMBL


Assay Description
Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110676
PNG
(CHEMBL280487 | okadaic acid)
Show SMILES C[C@@H](C[C@H](O)[C@H]1O[C@@H]2CC[C@@]3(CC[C@@H](O3)\C=C\[C@@H](C)[C@@H]3CC(C)=C[C@@]4(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]4O)O3)O[C@H]2[C@H](O)C1=C)[C@H]1O[C@@]2(CCCCO2)CC[C@H]1C
Show InChI InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Concentration required to inhibit the action of protein phosphatase 2A


Bioorg Med Chem Lett 12: 391-3 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110676
PNG
(CHEMBL280487 | okadaic acid)
Show SMILES C[C@@H](C[C@H](O)[C@H]1O[C@@H]2CC[C@@]3(CC[C@@H](O3)\C=C\[C@@H](C)[C@@H]3CC(C)=C[C@@]4(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]4O)O3)O[C@H]2[C@H](O)C1=C)[C@H]1O[C@@]2(CCCCO2)CC[C@H]1C
Show InChI InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition activity against protein phosphatase 2A (PP2A), activity taken from literature


Citation and Details
More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50061066
PNG
((5R,6S,9S,12S,13S,16R)-2-Eth-(Z)-ylidene-9-(3-guan...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](C)[C@@H](NC(=O)\C(=C\C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O
Show InChI InChI=1S/C41H60N8O10/c1-8-31-38(54)48-34(40(57)58)26(5)36(52)46-29(15-12-20-44-41(42)43)37(53)45-28(25(4)35(51)47-30(39(55)56)18-19-33(50)49(31)6)17-16-23(2)21-24(3)32(59-7)22-27-13-10-9-11-14-27/h8-11,13-14,16-17,21,24-26,28-30,32,34H,12,15,18-20,22H2,1-7H3,(H,45,53)(H,46,52)(H,47,51)(H,48,54)(H,55,56)(H,57,58)(H4,42,43,44)/b17-16+,23-21+,31-8-/t24-,25-,26-,28-,29-,30+,32-,34+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition activity against protein phosphatase 2A (PP2A), activity taken from literature


Citation and Details
More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110682
PNG
(25-Isobutyl-15-(6-methoxy-3,5-dimethyl-7-phenyl-he...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](C)[C@@H](CC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)CN(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O
Show InChI InChI=1S/C46H68N6O12/c1-25(2)20-36-37(53)23-33(45(60)61)28(5)41(56)48-31(8)44(59)49-34(17-16-26(3)21-27(4)38(64-10)22-32-14-12-11-13-15-32)29(6)42(57)50-35(46(62)63)18-19-40(55)52(9)24-39(54)47-30(7)43(58)51-36/h11-17,21,25,27-31,33-36,38H,18-20,22-24H2,1-10H3,(H,47,54)(H,48,56)(H,49,59)(H,50,57)(H,51,58)(H,60,61)(H,62,63)/b17-16+,26-21+/t27-,28-,29-,30+,31-,33+,34-,35+,36-,38-/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of microcystin analogues to catalytic subunits of Serine/threonine protein phosphatase 2A (PP2Ac)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110700
PNG
(7-Cyclohexyl-25-isobutyl-15-(6-methoxy-3,5-dimethy...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](C)[C@@H](CC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)CN(C2CCCCC2)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O
Show InChI InChI=1S/C51H76N6O12/c1-29(2)24-41-42(58)27-38(50(65)66)32(5)46(61)53-35(8)49(64)54-39(21-20-30(3)25-31(4)43(69-9)26-36-16-12-10-13-17-36)33(6)47(62)55-40(51(67)68)22-23-45(60)57(37-18-14-11-15-19-37)28-44(59)52-34(7)48(63)56-41/h10,12-13,16-17,20-21,25,29,31-35,37-41,43H,11,14-15,18-19,22-24,26-28H2,1-9H3,(H,52,59)(H,53,61)(H,54,64)(H,55,62)(H,56,63)(H,65,66)(H,67,68)/b21-20+,30-25+/t31-,32-,33-,34+,35-,38+,39-,40+,41-,43-/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of microcystin analogues to catalytic subunits of Serine/threonine protein phosphatase 2A (PP2Ac)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110681
PNG
(CHEMBL430266 | Calyculin-A)
Show SMILES COC[C@@H]([C@H](O)[C@H](O)C(=O)NCC[C@H](C)c1nc(\C=C\C[C@@H]2O[C@]3(C[C@@H](O)[C@@H]2C)O[C@H]([C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C(\C)=C\C=C\C(\C)=C/C#N)OC)[C@H](OP(O)(O)=O)C3(C)C)co1)N(C)C
Show InChI InChI=1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34-,35-,37-,38-,39+,40-,41-,42+,43-,44-,45+,46-,50+/m0/s1
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n/an/a 2n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Concentration required to inhibit the action of protein phosphatase 2A


Bioorg Med Chem Lett 12: 391-3 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50061067
PNG
(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](C)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)C(=C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O
Show InChI InChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-19,24,26,28-31,34-38,40H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,61)(H,57,63)(H,58,66)(H,67,68)(H,69,70)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31+,34-,35-,36+,37-,38-,40+/m0/s1
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n/an/a 3n/an/an/an/an/an/a



University of California at Irvine

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound required against protein phosphatase 2A using pNPP assay


Bioorg Med Chem Lett 13: 2903-6 (2003)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110693
PNG
(25-Cyclohexylmethyl-15-(6-methoxy-3,5-dimethyl-7-p...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](C)[C@@H](CC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](C)NC(=O)C(=C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O
Show InChI InChI=1S/C50H72N6O12/c1-28(24-29(2)42(68-9)26-36-18-14-11-15-19-36)20-21-38-31(4)45(60)54-39(50(66)67)22-23-43(58)56(8)34(7)48(63)52-33(6)47(62)55-40(25-35-16-12-10-13-17-35)41(57)27-37(49(64)65)30(3)44(59)51-32(5)46(61)53-38/h11,14-15,18-21,24,29-33,35,37-40,42H,7,10,12-13,16-17,22-23,25-27H2,1-6,8-9H3,(H,51,59)(H,52,63)(H,53,61)(H,54,60)(H,55,62)(H,64,65)(H,66,67)/b21-20+,28-24+/t29-,30-,31-,32-,33+,37+,38-,39+,40-,42-/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of microcystin analogues to catalytic subunits of Serine/threonine protein phosphatase 2A (PP2Ac)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110690
PNG
(CHEMBL17377 | FOSTRIECIN | Phosphoric acid mono-{3...)
Show SMILES C[C@@](O)(\C=C\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\C=C/C=C\C=C\CO)OP(O)(O)=O
Show InChI InChI=1S/C19H27O9P/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26)/b3-2-,6-4+,8-5-,12-11+/t15-,16+,17+,19+/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110690
PNG
(CHEMBL17377 | FOSTRIECIN | Phosphoric acid mono-{3...)
Show SMILES C[C@@](O)(\C=C\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\C=C/C=C\C=C\CO)OP(O)(O)=O
Show InChI InChI=1S/C19H27O9P/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26)/b3-2-,6-4+,8-5-,12-11+/t15-,16+,17+,19+/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against partially purified (chicken skeletal muscle) Protein phosphatase 2A


Bioorg Med Chem Lett 10: 1687-90 (2000)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110681
PNG
(CHEMBL430266 | Calyculin-A)
Show SMILES COC[C@@H]([C@H](O)[C@H](O)C(=O)NCC[C@H](C)c1nc(\C=C\C[C@@H]2O[C@]3(C[C@@H](O)[C@@H]2C)O[C@H]([C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C(\C)=C\C=C\C(\C)=C/C#N)OC)[C@H](OP(O)(O)=O)C3(C)C)co1)N(C)C
Show InChI InChI=1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34-,35-,37-,38-,39+,40-,41-,42+,43-,44-,45+,46-,50+/m0/s1
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n/an/a 7.30n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A)


Citation and Details
More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110694
PNG
(11,22-Dicarboxy-25-isobutyl-15-(6-methoxy-3,5-dime...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](C)[C@@H](CC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C[NH3+])NC(=O)C(=C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O
Show InChI InChI=1S/C47H69N7O12/c1-25(2)20-36-38(55)23-33(46(62)63)28(5)41(57)49-30(7)43(59)50-34(17-16-26(3)21-27(4)39(66-10)22-32-14-12-11-13-15-32)29(6)42(58)51-35(47(64)65)18-19-40(56)54(9)31(8)44(60)53-37(24-48)45(61)52-36/h11-17,21,25,27-30,33-37,39H,8,18-20,22-24,48H2,1-7,9-10H3,(H,49,57)(H,50,59)(H,51,58)(H,52,61)(H,53,60)(H,62,63)(H,64,65)/p+1/b17-16+,26-21+/t27-,28-,29-,30-,33+,34-,35+,36-,37+,39-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of microcystin analogues to catalytic subunits of Serine/threonine protein phosphatase 2A (PP2Ac)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50061069
PNG
(CHEMBL384277 | Calyculin C)
Show SMILES COC[C@@H]([C@H](O)[C@H](O)C(=O)N[C@H](C)C[C@H](C)c1nc(\C=C\CC2O[C@]3(CC(O)C2C)OC([C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C(\C)=C\C=C\C(\C)=C/C#N)OC)[C@H](OP(O)(O)=O)C3(C)C)co1)N(C)C
Show InChI InChI=1S/C51H83N4O15P/c1-29(21-22-52)17-15-18-30(2)31(3)23-32(4)43(58)36(8)39(56)25-42(66-14)46-47(70-71(62,63)64)50(9,10)51(69-46)26-40(57)35(7)41(68-51)20-16-19-37-27-67-49(54-37)33(5)24-34(6)53-48(61)45(60)44(59)38(28-65-13)55(11)12/h15-19,21,23,27,32-36,38-47,56-60H,20,24-26,28H2,1-14H3,(H,53,61)(H2,62,63,64)/b17-15+,19-16+,29-21-,30-18+,31-23+/t32-,33+,34-,35?,36+,38+,39+,40?,41?,42+,43-,44+,45+,46?,47+,51-/m1/s1
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n/an/a 9.70n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A)


Citation and Details
More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50366883
PNG
(TAUTOMYCIN)
Show SMILES CO[C@H]([C@H](O)CC(=O)[C@@H](C)[C@@H](O)CC[C@@H](C)[C@@H]1O[C@]2(CC[C@@H](C)[C@H](CC[C@H](C)C(C)=O)O2)CC[C@@H]1C)[C@H](OC(=O)C[C@@H](O)C1=C(C)C(=O)OC1=O)C(C)C
Show InChI InChI=1S/C41H66O13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46H,11-20H2,1-10H3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38+,41+/m0/s1
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n/an/a 10n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A)


Citation and Details
More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110677
PNG
(2,3-Dimethyl-7-oxa-bicyclo[2.2.1]heptane-2,3-dicar...)
Show SMILES C[C@@]1(C2CC[C@@H](O2)[C@@]1(C)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6?,9+,10-/m1/s1
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n/an/a 50n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110675
PNG
(2-Methyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3...)
Show SMILES C[C@@]12[C@H]3CCC(O3)[C@@H]1C(=O)OC2=O
Show InChI InChI=1S/C9H10O4/c1-9-5-3-2-4(12-5)6(9)7(10)13-8(9)11/h4-6H,2-3H2,1H3/t4?,5-,6-,9-/m1/s1
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n/an/a 120n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50090505
PNG
((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Show SMILES C[C@]12[C@@H]3CC[C@@H](O3)[C@@]1(C)C(=O)OC2=O
Show InChI InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-
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n/an/a 200n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50090505
PNG
((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Show SMILES C[C@]12[C@@H]3CC[C@@H](O3)[C@@]1(C)C(=O)OC2=O
Show InChI InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-
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n/an/a 260n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against partially purified (chicken skeletal muscle) Protein phosphatase 2A


Bioorg Med Chem Lett 10: 1687-90 (2000)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50090505
PNG
((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Show SMILES C[C@]12[C@@H]3CC[C@@H](O3)[C@@]1(C)C(=O)OC2=O
Show InChI InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-
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n/an/a 260n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of Serine/threonine protein phosphatase 2A by anhydride modified Cantharidin analogues


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50090505
PNG
((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Show SMILES C[C@]12[C@@H]3CC[C@@H](O3)[C@@]1(C)C(=O)OC2=O
Show InChI InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-
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n/an/a 360n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory concentration against protein phosphatase 2A was determined


Bioorg Med Chem Lett 11: 2941-6 (2001)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50366474
PNG
(NORCANTHARIDIN)
Show SMILES O=C1OC(=O)[C@@H]2[C@H]3CC[C@@H](O3)[C@H]12
Show InChI InChI=1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2/t3-,4-,5-,6+/m1/s1
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n/an/a 370n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against partially purified (chicken skeletal muscle) Protein phosphatase 2A


Bioorg Med Chem Lett 10: 1687-90 (2000)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110696
PNG
(4,10-Dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione ...)
Show SMILES O=C1OC(=O)[C@H]2C3CC[C@@H](O3)C12
Show InChI InChI=1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2/t3-,4?,5?,6+/m1/s1
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n/an/a 370n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of Serine/threonine protein phosphatase 2A by anhydride modified Cantharidin analogues


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50090502
PNG
((1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxyl...)
Show SMILES COC(=O)C1[C@H]2CC[C@H](O2)C1C(O)=O
Show InChI InChI=1S/C9H12O5/c1-13-9(12)7-5-3-2-4(14-5)6(7)8(10)11/h4-7H,2-3H2,1H3,(H,10,11)/t4-,5+,6?,7?/m0/s1
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n/an/a 410n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory concentration against protein phosphatase 2A was determined


Bioorg Med Chem Lett 11: 2941-6 (2001)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50090502
PNG
((1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxyl...)
Show SMILES COC(=O)C1[C@H]2CC[C@H](O2)C1C(O)=O
Show InChI InChI=1S/C9H12O5/c1-13-9(12)7-5-3-2-4(14-5)6(7)8(10)11/h4-7H,2-3H2,1H3,(H,10,11)/t4-,5+,6?,7?/m0/s1
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n/an/a 410n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against partially purified (chicken skeletal muscle) Protein phosphatase 2A


Bioorg Med Chem Lett 10: 1687-90 (2000)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110695
PNG
(7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid ...)
Show SMILES COC(=O)C1[C@H]2CCC(O2)C1C(O)=O
Show InChI InChI=1S/C9H12O5/c1-13-9(12)7-5-3-2-4(14-5)6(7)8(10)11/h4-7H,2-3H2,1H3,(H,10,11)/t4?,5-,6?,7?/m1/s1
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n/an/a 410n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of Serine/threonine protein phosphatase 2A by anhydride modified Cantharidin analogues


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50090509
PNG
((1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxyl...)
Show SMILES CCOC(=O)C1[C@H]2CC[C@H](O2)C1C(O)=O
Show InChI InChI=1S/C10H14O5/c1-2-14-10(13)8-6-4-3-5(15-6)7(8)9(11)12/h5-8H,2-4H2,1H3,(H,11,12)/t5-,6+,7?,8?/m0/s1
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n/an/a 450n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against partially purified (chicken skeletal muscle) Protein phosphatase 2A


Bioorg Med Chem Lett 10: 1687-90 (2000)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50090509
PNG
((1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxyl...)
Show SMILES CCOC(=O)C1[C@H]2CC[C@H](O2)C1C(O)=O
Show InChI InChI=1S/C10H14O5/c1-2-14-10(13)8-6-4-3-5(15-6)7(8)9(11)12/h5-8H,2-4H2,1H3,(H,11,12)/t5-,6+,7?,8?/m0/s1
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The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory concentration against protein phosphatase 2A was determined


Bioorg Med Chem Lett 11: 2941-6 (2001)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110692
PNG
(7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid ...)
Show SMILES CCOC(=O)C1[C@H]2CCC(O2)C1C(O)=O
Show InChI InChI=1S/C10H14O5/c1-2-14-10(13)8-6-4-3-5(15-6)7(8)9(11)12/h5-8H,2-4H2,1H3,(H,11,12)/t5?,6-,7?,8?/m1/s1
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n/an/a 450n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of Serine/threonine protein phosphatase 2A by anhydride modified Cantharidin analogues


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110698
PNG
(7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid ...)
Show SMILES CCCOC(=O)C1[C@H]2CCC(O2)C1C(O)=O
Show InChI InChI=1S/C11H16O5/c1-2-5-15-11(14)9-7-4-3-6(16-7)8(9)10(12)13/h6-9H,2-5H2,1H3,(H,12,13)/t6?,7-,8?,9?/m1/s1
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n/an/a 470n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of Serine/threonine protein phosphatase 2A by anhydride modified Cantharidin analogues


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50090501
PNG
((1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxyl...)
Show SMILES CCCOC(=O)C1[C@H]2CC[C@H](O2)C1C(O)=O
Show InChI InChI=1S/C11H16O5/c1-2-5-15-11(14)9-7-4-3-6(16-7)8(9)10(12)13/h6-9H,2-5H2,1H3,(H,12,13)/t6-,7+,8?,9?/m0/s1
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n/an/a 470n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory concentration against protein phosphatase 2A was determined


Bioorg Med Chem Lett 11: 2941-6 (2001)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50090501
PNG
((1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxyl...)
Show SMILES CCCOC(=O)C1[C@H]2CC[C@H](O2)C1C(O)=O
Show InChI InChI=1S/C11H16O5/c1-2-5-15-11(14)9-7-4-3-6(16-7)8(9)10(12)13/h6-9H,2-5H2,1H3,(H,12,13)/t6-,7+,8?,9?/m0/s1
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n/an/a 470n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against partially purified (chicken skeletal muscle) Protein phosphatase 2A


Bioorg Med Chem Lett 10: 1687-90 (2000)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50106047
PNG
((R)-2-((1S,2R,6S,7R)-3,5-Dioxo-10-oxa-4-aza-tricyc...)
Show SMILES OC(=O)[C@@H](Cc1cnc[nH]1)N1C(=O)[C@H]2[C@@H]3CC[C@@H](O3)[C@H]2C1=O
Show InChI InChI=1S/C14H15N3O5/c18-12-10-8-1-2-9(22-8)11(10)13(19)17(12)7(14(20)21)3-6-4-15-5-16-6/h4-5,7-11H,1-3H2,(H,15,16)(H,20,21)/t7-,8-,9+,10-,11+/m1/s1
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n/an/a 810n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory concentration against protein phosphatase 2A (PP2A) was determined


Bioorg Med Chem Lett 11: 2941-6 (2001)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50106041
PNG
((S)-2-((1S,2R,6S,7R)-3,5-Dioxo-10-oxa-4-aza-tricyc...)
Show SMILES OC(=O)[C@H](Cc1cnc[nH]1)N1C(=O)[C@H]2[C@@H]3CC[C@@H](O3)[C@H]2C1=O
Show InChI InChI=1S/C14H15N3O5/c18-12-10-8-1-2-9(22-8)11(10)13(19)17(12)7(14(20)21)3-6-4-15-5-16-6/h4-5,7-11H,1-3H2,(H,15,16)(H,20,21)/t7-,8-,9+,10-,11+/m0/s1
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n/an/a 1.35E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory concentration against protein phosphatase 2A (PP2A) was determined


Bioorg Med Chem Lett 11: 2941-6 (2001)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50090505
PNG
((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Show SMILES C[C@]12[C@@H]3CC[C@@H](O3)[C@@]1(C)C(=O)OC2=O
Show InChI InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-
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n/an/a 1.70E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Concentration required to inhibit the action of protein phosphatase 2A


Bioorg Med Chem Lett 12: 391-3 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50366474
PNG
(NORCANTHARIDIN)
Show SMILES O=C1OC(=O)[C@@H]2[C@H]3CC[C@@H](O3)[C@H]12
Show InChI InChI=1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2/t3-,4-,5-,6+/m1/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Concentration required to inhibit the action of protein phosphatase 2A


Bioorg Med Chem Lett 12: 391-3 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50366474
PNG
(NORCANTHARIDIN)
Show SMILES O=C1OC(=O)[C@@H]2[C@H]3CC[C@@H](O3)[C@H]12
Show InChI InChI=1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2/t3-,4-,5-,6+/m1/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory concentration against protein phosphatase 2A (PP2A) was determined


Bioorg Med Chem Lett 11: 2941-6 (2001)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50451451
PNG
(CI-920 | FOSTRIECIN SODIUM | Fostriecin Sodium)
Show SMILES CC(O)(\C=C\C1CC=CC(=O)O1)C(CC(O)\C=C\C=C\C=C\CO)OP(O)([O-])=O
Show InChI InChI=1S/C19H27O9P.Na/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20;/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26);/q;+1/p-1/b3-2+,6-4+,8-5+,12-11+;
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n/an/a 3.40E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Concentration required to inhibit the action of protein phosphatase 2A


Bioorg Med Chem Lett 12: 391-3 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50110687
PNG
(Acetic acid 1-(5-{4-[6-(5-bromo-2,6,6-trimethyl-te...)
Show SMILES CC(=O)OC(C)(C)[C@H]1CC[C@@](C)(O1)[C@@H](O)CC[C@](C)(O)[C@H]1CC[C@H]2O[C@H](CC[C@]2(C)O1)[C@]1(C)CC[C@@H](Br)C(C)(C)O1
Show InChI InChI=1S/C32H55BrO8/c1-20(34)38-28(4,5)23-14-18-30(7,39-23)22(35)13-16-29(6,36)24-10-11-25-31(8,40-24)19-15-26(37-25)32(9)17-12-21(33)27(2,3)41-32/h21-26,35-36H,10-19H2,1-9H3/t21-,22+,23-,24-,25-,26-,29+,30-,31+,32+/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)


J Med Chem 45: 1151-75 (2002)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50135676
PNG
((S)-2-[(R)-2-(2-{[(R)-4-((4E,6E)-(2S,3S,8S,9S)-3-A...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@H](NC(C)=O)[C@H](C)C(=O)N[C@H](CCC(=O)N(C)C(=C)C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O)C(O)=O
Show InChI InChI=1S/C40H59N5O10/c1-23(2)20-33(40(53)54)44-37(49)27(6)41-38(50)28(7)45(9)35(47)19-18-32(39(51)52)43-36(48)26(5)31(42-29(8)46)17-16-24(3)21-25(4)34(55-10)22-30-14-12-11-13-15-30/h11-17,21,23,25-27,31-34H,7,18-20,22H2,1-6,8-10H3,(H,41,50)(H,42,46)(H,43,48)(H,44,49)(H,51,52)(H,53,54)/b17-16+,24-21+/t25-,26-,27+,31-,32+,33-,34-/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of California at Irvine

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound required against protein phosphatase 2A using pNPP assay


Bioorg Med Chem Lett 13: 2903-6 (2003)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50135679
PNG
((S)-2-[(R)-2-(2-{[(R)-4-((4E,6E)-(2S,3S,8S,9S)-3-A...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@H](NC(C)=O)[C@H](C)C(=O)N[C@H](CCC(=O)N(C)CC(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O)C(O)=O
Show InChI InChI=1S/C39H59N5O10/c1-23(2)19-32(39(52)53)43-37(49)27(6)40-34(46)22-44(8)35(47)18-17-31(38(50)51)42-36(48)26(5)30(41-28(7)45)16-15-24(3)20-25(4)33(54-9)21-29-13-11-10-12-14-29/h10-16,20,23,25-27,30-33H,17-19,21-22H2,1-9H3,(H,40,46)(H,41,45)(H,42,48)(H,43,49)(H,50,51)(H,52,53)/b16-15+,24-20+/t25-,26-,27+,30-,31+,32-,33-/m0/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



University of California at Irvine

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound required against protein phosphatase 2A using pNPP assay


Bioorg Med Chem Lett 13: 2903-6 (2003)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50135677
PNG
((R)-2-((4E,6E)-(2S,3S,8S,9S)-3-Acetylamino-9-metho...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@H](NC(C)=O)[C@H](C)C(=O)N[C@H](CCC(=O)N(C)C)C(O)=O
Show InChI InChI=1S/C29H43N3O6/c1-19(17-20(2)26(38-7)18-23-11-9-8-10-12-23)13-14-24(30-22(4)33)21(3)28(35)31-25(29(36)37)15-16-27(34)32(5)6/h8-14,17,20-21,24-26H,15-16,18H2,1-7H3,(H,30,33)(H,31,35)(H,36,37)/b14-13+,19-17+/t20-,21-,24-,25+,26-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of California at Irvine

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound required against protein phosphatase 2A using pNPP assay


Bioorg Med Chem Lett 13: 2903-6 (2003)

More data for this
Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit


(Gallus gallus)
BDBM50135681
PNG
((R)-2-((4E,6E)-(2S,3S,8S,9S)-3-Amino-9-methoxy-2,6...)
Show SMILES CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@H](N)[C@H](C)C(=O)N[C@H](CCC(=O)N(C)C(=C)C(=O)N[C@H](C)C(O)=O)C(O)=O
Show InChI InChI=1S/C32H46N4O8/c1-19(17-20(2)27(44-7)18-24-11-9-8-10-12-24)13-14-25(33)21(3)29(38)35-26(32(42)43)15-16-28(37)36(6)23(5)30(39)34-22(4)31(40)41/h8-14,17,20-22,25-27H,5,15-16,18,33H2,1-4,6-7H3,(H,34,39)(H,35,38)(H,40,41)(H,42,43)/b14-13+,19-17+/t20-,21-,22+,25-,26+,27-/m0/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of California at Irvine

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound required against protein phosphatase 2A using pNPP assay


Bioorg Med Chem Lett 13: 2903-6 (2003)

More data for this
Ligand-Target Pair
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