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Found 14 hits Enz. Inhib. hit(s) with Target = 'Serotonin 1d (5-HT1d) receptor' AND taxid = 10141   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM50060417
PNG
(5-Methyl-3,5-dihydro-2H-pyrrolo[2,3-f]indole-1-car...)
Show SMILES Cn1ccc2cc3N(CCc3cc12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22)
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1.00E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by PDSP Ki Database




Br J Pharmacol 117: 427-434 (1996)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM82505
PNG
(CAS_121881 | NSC_121881 | SB204070)
Show SMILES CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by PDSP Ki Database




Br J Pharmacol 112: 789-94 (1994)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM82272
PNG
(SB 200646 | SB200646a)
Show SMILES Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc12
Show InChI InChI=1S/C15H14N4O/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13/h2-10H,1H3,(H2,17,18,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by PDSP Ki Database




Behav Brain Res 73: 149-52 (1996)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/a 3n/an/an/an/an/an/a



Pfizer, Inc

Curated by ChEMBL


Assay Description
Binding affinity of the compound against 5-hydroxytryptamine 1D receptor


J Med Chem 35: 4503-5 (1992)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM50081704
PNG
(5-Methoxy-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1...)
Show SMILES COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1
Show InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Pfizer, Inc

Curated by ChEMBL


Assay Description
Binding affinity of the compound against 5-hydroxytryptamine 1D receptor


J Med Chem 35: 4503-5 (1992)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM30707
PNG
(2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamin...)
Show SMILES COc1ccc2[nH]cc(CCN(C)C)c2c1
Show InChI InChI=1S/C13H18N2O/c1-15(2)7-6-10-9-14-13-5-4-11(16-3)8-12(10)13/h4-5,8-9,14H,6-7H2,1-3H3
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n/an/a 49n/an/an/an/an/an/a



Pfizer, Inc

Curated by ChEMBL


Assay Description
Binding affinity of the compound against 5-hydroxytryptamine 1D receptor


J Med Chem 35: 4503-5 (1992)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM50286672
PNG
((S)-2-(2-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-a...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)NCC(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)cc12
Show InChI InChI=1S/C23H27N5O5/c24-8-7-15-11-26-19-6-5-17(10-18(15)19)33-13-22(31)27-12-21(30)28-20(23(25)32)9-14-1-3-16(29)4-2-14/h1-6,10-11,20,26,29H,7-9,12-13,24H2,(H2,25,32)(H,27,31)(H,28,30)/t20-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards guinea pig 5-hydroxytryptamine 1D receptor was determined


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM50081702
PNG
(5-Methoxy-3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1...)
Show SMILES COc1ccc2[nH]cc(C[C@@H]3CCCN3C)c2c1
Show InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m0/s1
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n/an/a 420n/an/an/an/an/an/a



Pfizer, Inc

Curated by ChEMBL


Assay Description
Binding affinity of the compound against 5-hydroxytryptamine 1D receptor


J Med Chem 35: 4503-5 (1992)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM50081704
PNG
(5-Methoxy-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1...)
Show SMILES COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1
Show InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1
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n/an/an/an/a 43n/an/an/an/a



Pfizer, Inc

Curated by ChEMBL


Assay Description
Effect of the compound on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.


J Med Chem 35: 4503-5 (1992)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/an/an/a 16n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of guinea pig substantia nigra


J Med Chem 33: 2087-93 (1990)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM50285522
PNG
(1-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Show SMILES CN1CCC[C@@H]1Cc1c[nH]c2ccc(cc12)-n1cnc2cc(ccc12)C#N
Show InChI InChI=1S/C22H21N5/c1-26-8-2-3-17(26)10-16-13-24-20-6-5-18(11-19(16)20)27-14-25-21-9-15(12-23)4-7-22(21)27/h4-7,9,11,13-14,17,24H,2-3,8,10H2,1H3/t17-/m1/s1
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n/an/an/an/a 0.0420n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra


Bioorg Med Chem Lett 5: 2391-2396 (1995)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/an/an/a 5.20n/an/an/an/a



Pfizer, Inc

Curated by ChEMBL


Assay Description
Effect of the compound on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.


J Med Chem 35: 4503-5 (1992)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/an/an/a 8.5n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra


Bioorg Med Chem Lett 5: 2391-2396 (1995)

More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(GUINEA PIG)
BDBM50285523
PNG
(CHEMBL80189 | [2-(5-Imidazo[4,5-b]pyridin-3-yl-1H-...)
Show SMILES CN(C)CCc1c[nH]c2ccc(cc12)-n1cnc2cccnc12
Show InChI InChI=1S/C18H19N5/c1-22(2)9-7-13-11-20-16-6-5-14(10-15(13)16)23-12-21-17-4-3-8-19-18(17)23/h3-6,8,10-12,20H,7,9H2,1-2H3
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n/an/an/an/a 14n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra


Bioorg Med Chem Lett 5: 2391-2396 (1995)

More data for this
Ligand-Target Pair