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Compile Data Set for Download or QSAR

Found 68 hits Enz. Inhib. hit(s) with Target = 'Serotonin 3a (5-HT3a) receptor' AND taxid = 10141   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50299660
PNG
(7-fluoro-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Show SMILES Fc1ccc2c(c1)nc(N1CCN(Cc3cnc[nH]3)CC1)c1cccn21
Show InChI InChI=1S/C19H19FN6/c20-14-3-4-17-16(10-14)23-19(18-2-1-5-26(17)18)25-8-6-24(7-9-25)12-15-11-21-13-22-15/h1-5,10-11,13H,6-9,12H2,(H,21,22)
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n/an/a 270n/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50258292
PNG
(2-(4-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pipera...)
Show SMILES OC(=O)CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C17H17FN4O2/c18-12-3-4-14-13(10-12)19-17(15-2-1-5-22(14)15)21-8-6-20(7-9-21)11-16(23)24/h1-5,10H,6-9,11H2,(H,23,24)
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n/an/a 1.88E+3n/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50258292
PNG
(2-(4-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pipera...)
Show SMILES OC(=O)CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C17H17FN4O2/c18-12-3-4-14-13(10-12)19-17(15-2-1-5-22(14)15)21-8-6-20(7-9-21)11-16(23)24/h1-5,10H,6-9,11H2,(H,23,24)
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n/an/a 1.91E+3n/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50299665
PNG
(7-hydroxy-4-(4-((3H-imidazol-4-yl)methyl)piperazin...)
Show SMILES Oc1ccc2c(c1)nc(N1CCN(Cc3cnc[nH]3)CC1)c1cccn21
Show InChI InChI=1S/C19H20N6O/c26-15-3-4-17-16(10-15)22-19(18-2-1-5-25(17)18)24-8-6-23(7-9-24)12-14-11-20-13-21-14/h1-5,10-11,13,26H,6-9,12H2,(H,20,21)
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n/an/a 2.63E+3n/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50258431
PNG
(CHEMBL523716 | [4-(7-Fluoropyrrolo[1,2-a]quinoxali...)
Show SMILES ONC(=N)CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C17H19FN6O/c18-12-3-4-14-13(10-12)20-17(15-2-1-5-24(14)15)23-8-6-22(7-9-23)11-16(19)21-25/h1-5,10,25H,6-9,11H2,(H2,19,21)
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n/an/a 5.75E+3n/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50258432
PNG
(7-Fluoro-4-[4-(4H-[1,2,4]triazol-3-ylmethyl)-piper...)
Show SMILES Fc1ccc2c(c1)nc(N1CCN(Cc3nnc[nH]3)CC1)c1cccn21
Show InChI InChI=1S/C18H18FN7/c19-13-3-4-15-14(10-13)22-18(16-2-1-5-26(15)16)25-8-6-24(7-9-25)11-17-20-12-21-23-17/h1-5,10,12H,6-9,11H2,(H,20,21,23)
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n/an/a 8.51E+3n/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50258294
PNG
(2-[4-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-piper...)
Show SMILES NC(=O)CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C17H18FN5O/c18-12-3-4-14-13(10-12)20-17(15-2-1-5-23(14)15)22-8-6-21(7-9-22)11-16(19)24/h1-5,10H,6-9,11H2,(H2,19,24)
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n/an/a 1.12E+4n/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410872
PNG
(CHEMBL207952)
Show SMILES CCOc1nc2ccccc2nc1C(=O)Nc1ccc(O)c(CN2CCCCC2)c1
Show InChI InChI=1S/C23H26N4O3/c1-2-30-23-21(25-18-8-4-5-9-19(18)26-23)22(29)24-17-10-11-20(28)16(14-17)15-27-12-6-3-7-13-27/h4-5,8-11,14,28H,2-3,6-7,12-13,15H2,1H3,(H,24,29)
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n/an/an/a 7.94E+5n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410873
PNG
(CHEMBL383292)
Show SMILES COc1nc2ccccc2nc1C(=O)Nc1cc(CN2CCCC2)c(O)c(c1)N1CCCC1
Show InChI InChI=1S/C25H29N5O3/c1-33-25-22(27-19-8-2-3-9-20(19)28-25)24(32)26-18-14-17(16-29-10-4-5-11-29)23(31)21(15-18)30-12-6-7-13-30/h2-3,8-9,14-15,31H,4-7,10-13,16H2,1H3,(H,26,32)
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n/an/an/a>1.00E+6n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410874
PNG
(CHEMBL207964)
Show SMILES COc1nc2ccccc2nc1C(=O)Nc1cc(CN2CCNCC2)c(O)c(c1)N1CCNCC1
Show InChI InChI=1S/C25H31N7O3/c1-35-25-22(29-19-4-2-3-5-20(19)30-25)24(34)28-18-14-17(16-31-10-6-26-7-11-31)23(33)21(15-18)32-12-8-27-9-13-32/h2-5,14-15,26-27,33H,6-13,16H2,1H3,(H,28,34)
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n/an/an/a 1.00E+5n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410875
PNG
(CHEMBL376943)
Show SMILES CCOc1nc2ccccc2nc1C(=O)Nc1ccc(O)c(CN2CCCC2)c1
Show InChI InChI=1S/C22H24N4O3/c1-2-29-22-20(24-17-7-3-4-8-18(17)25-22)21(28)23-16-9-10-19(27)15(13-16)14-26-11-5-6-12-26/h3-4,7-10,13,27H,2,5-6,11-12,14H2,1H3,(H,23,28)
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n/an/an/a 3.16E+5n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410876
PNG
(CHEMBL207459)
Show SMILES CCOc1nc2ccccc2nc1C(=O)Nc1cc(CN2CCN(CC)CC2)c(O)c(c1)N1CCN(CC)CC1
Show InChI InChI=1S/C30H41N7O3/c1-4-34-11-13-36(14-12-34)21-22-19-23(20-26(28(22)38)37-17-15-35(5-2)16-18-37)31-29(39)27-30(40-6-3)33-25-10-8-7-9-24(25)32-27/h7-10,19-20,38H,4-6,11-18,21H2,1-3H3,(H,31,39)
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n/an/an/a>1.00E+6n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410877
PNG
(CHEMBL209142)
Show SMILES CCOc1nc2ccccc2nc1C(=O)Nc1cc(CN2CCOCC2)c(O)c(c1)N1CCOCC1
Show InChI InChI=1S/C26H31N5O5/c1-2-36-26-23(28-20-5-3-4-6-21(20)29-26)25(33)27-19-15-18(17-30-7-11-34-12-8-30)24(32)22(16-19)31-9-13-35-14-10-31/h3-6,15-16,32H,2,7-14,17H2,1H3,(H,27,33)
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n/an/an/a>1.00E+6n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410878
PNG
(CHEMBL207233)
Show SMILES COc1nc2ccccc2nc1C(=O)Nc1cc(CN2CCOCC2)c(O)c(c1)N1CCOCC1
Show InChI InChI=1S/C25H29N5O5/c1-33-25-22(27-19-4-2-3-5-20(19)28-25)24(32)26-18-14-17(16-29-6-10-34-11-7-29)23(31)21(15-18)30-8-12-35-13-9-30/h2-5,14-15,31H,6-13,16H2,1H3,(H,26,32)
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n/an/an/a>1.00E+6n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410879
PNG
(CHEMBL207266)
Show SMILES COc1nc2ccccc2nc1C(=O)Nc1ccc(O)c(CN2CCN(C)CC2)c1
Show InChI InChI=1S/C22H25N5O3/c1-26-9-11-27(12-10-26)14-15-13-16(7-8-19(15)28)23-21(29)20-22(30-2)25-18-6-4-3-5-17(18)24-20/h3-8,13,28H,9-12,14H2,1-2H3,(H,23,29)
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n/an/an/a 2.00E+3n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410880
PNG
(CHEMBL377027)
Show SMILES CCOc1nc2ccccc2nc1C(=O)Nc1ccc(O)c(CN2CCOCC2)c1
Show InChI InChI=1S/C22H24N4O4/c1-2-30-22-20(24-17-5-3-4-6-18(17)25-22)21(28)23-16-7-8-19(27)15(13-16)14-26-9-11-29-12-10-26/h3-8,13,27H,2,9-12,14H2,1H3,(H,23,28)
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n/an/an/a>1.00E+6n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410881
PNG
(CHEMBL207876)
Show SMILES CCOc1nc2ccccc2nc1C(=O)Nc1cc(CN2CCN(C)CC2)c(O)c(c1)N1CCN(C)CC1
Show InChI InChI=1S/C28H37N7O3/c1-4-38-28-25(30-22-7-5-6-8-23(22)31-28)27(37)29-21-17-20(19-34-13-9-32(2)10-14-34)26(36)24(18-21)35-15-11-33(3)12-16-35/h5-8,17-18,36H,4,9-16,19H2,1-3H3,(H,29,37)
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n/an/an/a>1.00E+6n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410882
PNG
(CHEMBL206843)
Show SMILES CCOc1nc2ccccc2nc1C(=O)Nc1cc(CN2CCCC2)c(O)c(c1)N1CCCC1
Show InChI InChI=1S/C26H31N5O3/c1-2-34-26-23(28-20-9-3-4-10-21(20)29-26)25(33)27-19-15-18(17-30-11-5-6-12-30)24(32)22(16-19)31-13-7-8-14-31/h3-4,9-10,15-16,32H,2,5-8,11-14,17H2,1H3,(H,27,33)
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Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410883
PNG
(CHEMBL379648)
Show SMILES CCN1CCN(Cc2cc(NC(=O)c3nc4ccccc4nc3OC)ccc2O)CC1
Show InChI InChI=1S/C23H27N5O3/c1-3-27-10-12-28(13-11-27)15-16-14-17(8-9-20(16)29)24-22(30)21-23(31-2)26-19-7-5-4-6-18(19)25-21/h4-9,14,29H,3,10-13,15H2,1-2H3,(H,24,30)
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n/an/an/a 1.26E+4n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410884
PNG
(CHEMBL208521)
Show SMILES CCOc1nc2ccccc2nc1C(=O)Nc1ccc(O)c(CN2CCN(C)CC2)c1
Show InChI InChI=1S/C23H27N5O3/c1-3-31-23-21(25-18-6-4-5-7-19(18)26-23)22(30)24-17-8-9-20(29)16(14-17)15-28-12-10-27(2)11-13-28/h4-9,14,29H,3,10-13,15H2,1-2H3,(H,24,30)
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n/an/an/a 2.51E+4n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410885
PNG
(CHEMBL206842)
Show SMILES COc1nc2ccccc2nc1C(=O)Nc1ccc(O)c(CN2CCCCC2)c1
Show InChI InChI=1S/C22H24N4O3/c1-29-22-20(24-17-7-3-4-8-18(17)25-22)21(28)23-16-9-10-19(27)15(13-16)14-26-11-5-2-6-12-26/h3-4,7-10,13,27H,2,5-6,11-12,14H2,1H3,(H,23,28)
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n/an/an/a 3.16E+5n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410886
PNG
(CHEMBL207265)
Show SMILES COc1nc2ccccc2nc1C(=O)Nc1ccc(O)c(CN2CCNCC2)c1
Show InChI InChI=1S/C21H23N5O3/c1-29-21-19(24-16-4-2-3-5-17(16)25-21)20(28)23-15-6-7-18(27)14(12-15)13-26-10-8-22-9-11-26/h2-7,12,22,27H,8-11,13H2,1H3,(H,23,28)
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n/an/an/a 3.16E+4n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410887
PNG
(CHEMBL206256)
Show SMILES COc1nc2ccccc2nc1C(=O)Nc1ccc(O)c(CN2CCOCC2)c1
Show InChI InChI=1S/C21H22N4O4/c1-28-21-19(23-16-4-2-3-5-17(16)24-21)20(27)22-15-6-7-18(26)14(12-15)13-25-8-10-29-11-9-25/h2-7,12,26H,8-11,13H2,1H3,(H,22,27)
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n/an/an/a 1.00E+6n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410888
PNG
(CHEMBL206416)
Show SMILES COc1nc2ccccc2nc1C(=O)Nc1ccc(O)c(CN2CCCC2)c1
Show InChI InChI=1S/C21H22N4O3/c1-28-21-19(23-16-6-2-3-7-17(16)24-21)20(27)22-15-8-9-18(26)14(12-15)13-25-10-4-5-11-25/h2-3,6-9,12,26H,4-5,10-11,13H2,1H3,(H,22,27)
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n/an/an/a 1.26E+5n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410889
PNG
(CHEMBL208938)
Show SMILES CCOc1nc2ccccc2nc1C(=O)Nc1ccc(O)c(CN2CCN(CC)CC2)c1
Show InChI InChI=1S/C24H29N5O3/c1-3-28-11-13-29(14-12-28)16-17-15-18(9-10-21(17)30)25-23(31)22-24(32-4-2)27-20-8-6-5-7-19(20)26-22/h5-10,15,30H,3-4,11-14,16H2,1-2H3,(H,25,31)
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n/an/an/a 1.26E+5n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410891
PNG
(CHEMBL207135)
Show SMILES CCN1CCN(Cc2cc(NC(=O)c3nc4ccccc4nc3OC)cc(N3CCN(CC)CC3)c2O)CC1
Show InChI InChI=1S/C29H39N7O3/c1-4-33-10-12-35(13-11-33)20-21-18-22(19-25(27(21)37)36-16-14-34(5-2)15-17-36)30-28(38)26-29(39-3)32-24-9-7-6-8-23(24)31-26/h6-9,18-19,37H,4-5,10-17,20H2,1-3H3,(H,30,38)
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n/an/an/a 7.94E+4n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410890
PNG
(CHEMBL206730)
Show SMILES CCOc1nc2ccccc2nc1C(=O)Nc1cc(CN2CCNCC2)c(O)c(c1)N1CCNCC1
Show InChI InChI=1S/C26H33N7O3/c1-2-36-26-23(30-20-5-3-4-6-21(20)31-26)25(35)29-19-15-18(17-32-11-7-27-8-12-32)24(34)22(16-19)33-13-9-28-10-14-33/h3-6,15-16,27-28,34H,2,7-14,17H2,1H3,(H,29,35)
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n/an/an/a>1.00E+6n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410892
PNG
(CHEMBL205540)
Show SMILES CCOc1nc2ccccc2nc1C(=O)Nc1ccc(O)c(CN2CCNCC2)c1
Show InChI InChI=1S/C22H25N5O3/c1-2-30-22-20(25-17-5-3-4-6-18(17)26-22)21(29)24-16-7-8-19(28)15(13-16)14-27-11-9-23-10-12-27/h3-8,13,23,28H,2,9-12,14H2,1H3,(H,24,29)
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n/an/an/a 3.98E+5n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50410893
PNG
(CHEMBL206999)
Show SMILES COc1nc2ccccc2nc1C(=O)Nc1cc(CN2CCN(C)CC2)c(O)c(c1)N1CCN(C)CC1
Show InChI InChI=1S/C27H35N7O3/c1-31-8-12-33(13-9-31)18-19-16-20(17-23(25(19)35)34-14-10-32(2)11-15-34)28-26(36)24-27(37-3)30-22-7-5-4-6-21(22)29-24/h4-7,16-17,35H,8-15,18H2,1-3H3,(H,28,36)
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n/an/an/a 1.58E+4n/an/an/an/an/a



Periyar College of Pharmaceutical Sciences for Girls

Curated by ChEMBL


Assay Description
Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50081970
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2ncccc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)12-4-2-6-16-14(12)17-15/h2-7H,8-11H2,1H3
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n/an/an/an/a 340n/an/an/an/a



European Research Centre for Drug Discovery and Development

Curated by ChEMBL


Assay Description
Intrinsic activity at 5HT3 receptor in voltage-stimulated guinea pig left atrium assessed as positive inotropic potency relative to serotonin


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50060688
PNG
(7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C16H17FN4/c1-19-7-9-20(10-8-19)16-15-3-2-6-21(15)14-5-4-12(17)11-13(14)18-16/h2-6,11H,7-10H2,1H3
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n/an/an/an/a 160n/an/an/an/a



European Research Centre for Drug Discovery and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5HT3 receptor in voltage-stimulated guinea pig left atrium assessed as positive inotropic potency


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417134
PNG
(CHEMBL1269779)
Show SMILES O=C(Nc1ccccc1)c1cnc2ccccc2n1
Show InChI InChI=1S/C15H11N3O/c19-15(17-11-6-2-1-3-7-11)14-10-16-12-8-4-5-9-13(12)18-14/h1-10H,(H,17,19)
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n/an/an/a 158n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417135
PNG
(CHEMBL1269047)
Show SMILES Cc1ccc(NC(=O)c2cnc3ccccc3n2)cc1
Show InChI InChI=1S/C16H13N3O/c1-11-6-8-12(9-7-11)18-16(20)15-10-17-13-4-2-3-5-14(13)19-15/h2-10H,1H3,(H,18,20)
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n/an/an/a 6.31E+3n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417136
PNG
(CHEMBL1269874)
Show SMILES COc1ccc(NC(=O)c2cnc3ccccc3n2)cc1
Show InChI InChI=1S/C16H13N3O2/c1-21-12-8-6-11(7-9-12)18-16(20)15-10-17-13-4-2-3-5-14(13)19-15/h2-10H,1H3,(H,18,20)
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n/an/an/a 1.00E+4n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417137
PNG
(CHEMBL1269048)
Show SMILES O=C(NCc1ccccc1)c1cnc2ccccc2n1
Show InChI InChI=1S/C16H13N3O/c20-16(18-10-12-6-2-1-3-7-12)15-11-17-13-8-4-5-9-14(13)19-15/h1-9,11H,10H2,(H,18,20)
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n/an/an/a 2.00E+3n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417138
PNG
(CHEMBL1269049)
Show SMILES O=C(NNc1ccccc1)c1cnc2ccccc2n1
Show InChI InChI=1S/C15H12N4O/c20-15(19-18-11-6-2-1-3-7-11)14-10-16-12-8-4-5-9-13(12)17-14/h1-10,18H,(H,19,20)
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n/an/an/a 1.58E+3n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417139
PNG
(CHEMBL1269875)
Show SMILES CC(=O)c1cccc(NC(=O)c2cnc3ccccc3n2)c1
Show InChI InChI=1S/C17H13N3O2/c1-11(21)12-5-4-6-13(9-12)19-17(22)16-10-18-14-7-2-3-8-15(14)20-16/h2-10H,1H3,(H,19,22)
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n/an/an/a 794n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417140
PNG
(CHEMBL1269876)
Show SMILES [O-][N+](=O)c1cccc(NC(=O)c2cnc3ccccc3n2)c1
Show InChI InChI=1S/C15H10N4O3/c20-15(17-10-4-3-5-11(8-10)19(21)22)14-9-16-12-6-1-2-7-13(12)18-14/h1-9H,(H,17,20)
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n/an/an/a 1.00E+4n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417141
PNG
(CHEMBL1269981)
Show SMILES Cc1c(Cl)cccc1NC(=O)c1cnc2ccccc2n1
Show InChI InChI=1S/C16H12ClN3O/c1-10-11(17)5-4-8-12(10)20-16(21)15-9-18-13-6-2-3-7-14(13)19-15/h2-9H,1H3,(H,20,21)
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n/an/an/a 25.1n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417142
PNG
(CHEMBL1269982)
Show SMILES O=C(Nc1nc2ccccc2s1)c1cnc2ccccc2n1
Show InChI InChI=1S/C16H10N4OS/c21-15(13-9-17-10-5-1-2-6-11(10)18-13)20-16-19-12-7-3-4-8-14(12)22-16/h1-9H,(H,19,20,21)
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n/an/an/a 3.16E+4n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417143
PNG
(CHEMBL1269983)
Show SMILES O=C(Nc1ccc(NC(=O)c2cnc3ccccc3n2)cc1)c1ccccc1
Show InChI InChI=1S/C22H16N4O2/c27-21(15-6-2-1-3-7-15)24-16-10-12-17(13-11-16)25-22(28)20-14-23-18-8-4-5-9-19(18)26-20/h1-14H,(H,24,27)(H,25,28)
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n/an/an/a 1.26E+4n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417144
PNG
(CHEMBL1269086)
Show SMILES CCCNC(=O)c1cnc2ccccc2n1
Show InChI InChI=1S/C12H13N3O/c1-2-7-13-12(16)11-8-14-9-5-3-4-6-10(9)15-11/h3-6,8H,2,7H2,1H3,(H,13,16)
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n/an/an/a 200n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417145
PNG
(CHEMBL1269087)
Show SMILES CCCCNC(=O)c1cnc2ccccc2n1
Show InChI InChI=1S/C13H15N3O/c1-2-3-8-14-13(17)12-9-15-10-6-4-5-7-11(10)16-12/h4-7,9H,2-3,8H2,1H3,(H,14,17)
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n/an/an/a 50.1n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417146
PNG
(CHEMBL1269088)
Show SMILES O=C(N1CCCC1)c1cnc2ccccc2n1
Show InChI InChI=1S/C13H13N3O/c17-13(16-7-3-4-8-16)12-9-14-10-5-1-2-6-11(10)15-12/h1-2,5-6,9H,3-4,7-8H2
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n/an/an/a 398n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417147
PNG
(CHEMBL1269119)
Show SMILES O=C(NC1CCCC1)c1cnc2ccccc2n1
Show InChI InChI=1S/C14H15N3O/c18-14(16-10-5-1-2-6-10)13-9-15-11-7-3-4-8-12(11)17-13/h3-4,7-10H,1-2,5-6H2,(H,16,18)
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n/an/an/a 316n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM85330
PNG
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
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n/an/an/a 126n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


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More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417148
PNG
(CHEMBL1269085)
Show SMILES Clc1cccc(NC(=O)c2cnc3ccccc3n2)c1
Show InChI InChI=1S/C15H10ClN3O/c16-10-4-3-5-11(8-10)18-15(20)14-9-17-12-6-1-2-7-13(12)19-14/h1-9H,(H,18,20)
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n/an/an/a 1.58E+3n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417149
PNG
(CHEMBL1270092)
Show SMILES O=C(Nc1ccccc1NC(=O)c1cnc2ccccc2n1)c1ccccc1
Show InChI InChI=1S/C22H16N4O2/c27-21(15-8-2-1-3-9-15)25-18-12-6-7-13-19(18)26-22(28)20-14-23-16-10-4-5-11-17(16)24-20/h1-14H,(H,25,27)(H,26,28)
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n/an/an/a 1.00E+5n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50417150
PNG
(CHEMBL1269120)
Show SMILES O=C(NC1CCCCC1)c1cnc2ccccc2n1
Show InChI InChI=1S/C15H17N3O/c19-15(17-11-6-2-1-3-7-11)14-10-16-12-8-4-5-9-13(12)18-14/h4-5,8-11H,1-3,6-7H2,(H,17,19)
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n/an/an/a 1.00E+3n/an/an/an/an/a



Birla Institute of Technology and Science

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of 2-methyl-5-HT-induced contrac...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a) receptor


(Cavia porcellus)
BDBM50060685
PNG
(9-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cccc(F)c2n2cccc12
Show InChI InChI=1S/C16H17FN4/c1-19-8-10-20(11-9-19)16-14-6-3-7-21(14)15-12(17)4-2-5-13(15)18-16/h2-7H,8-11H2,1H3
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n/an/an/a 64.6n/an/an/an/an/a



European Research Centre for Drug Discovery and Development

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...


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More data for this
Ligand-Target Pair
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