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Found 326 hits Enz. Inhib. hit(s) with Target = 'Serotonin 4 (5-HT4) receptor' AND taxid = 10141   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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0.110n/an/an/an/an/an/an/an/a



FAES, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 4 receptor in guinea pig striatum using [3H]GR-113808 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50181840
PNG
((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-Meth...)
Show SMILES O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H20N2O2/c20-17(14-10-18-15-5-2-1-4-13(14)15)21-11-12-7-9-19-8-3-6-16(12)19/h1-2,4-5,10,12,16,18H,3,6-9,11H2/t12-,16-/m0/s1
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0.183n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50181844
PNG
((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-amin...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OC[C@@H]1CCN2CCC[C@@H]12
Show InChI InChI=1S/C16H21ClN2O3/c1-21-15-8-13(18)12(17)7-11(15)16(20)22-9-10-4-6-19-5-2-3-14(10)19/h7-8,10,14H,2-6,9,18H2,1H3/t10-,14-/m0/s1
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0.183n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50327858
PNG
((1-Butylpiperidin-4-yl)methyl 8-amino-7-iodo-2,3-d...)
Show SMILES CCCCN1CCC(COC(=O)c2cc(I)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C19H27IN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
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0.200n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50327865
PNG
((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(2-fluoroe...)
Show SMILES CCCCN1CCC(COC(=O)c2ccc(N)c(OCCF)c2)CC1
Show InChI InChI=1S/C19H29FN2O3/c1-2-3-9-22-10-6-15(7-11-22)14-25-19(23)16-4-5-17(21)18(13-16)24-12-8-20/h4-5,13,15H,2-3,6-12,14,21H2,1H3
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0.215n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50327864
PNG
((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(fluoromet...)
Show SMILES CCCCN1CCC(COC(=O)c2ccc(N)c(OCF)c2)CC1
Show InChI InChI=1S/C18H27FN2O3/c1-2-3-8-21-9-6-14(7-10-21)12-23-18(22)15-4-5-16(20)17(11-15)24-13-19/h4-5,11,14H,2-3,6-10,12-13,20H2,1H3
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0.334n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50327863
PNG
((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Show SMILES CCCCN1CCC(COC(=O)c2cc(F)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C19H27FN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
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0.334n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50181845
PNG
((1S,7aS)-1-{[(4-amino-5-chloro-2-methoxybenzoyl)am...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CC[N@@+]2(C)CCC[C@@H]12
Show InChI InChI=1S/C17H24ClN3O2/c1-21-6-3-4-15(21)11(5-7-21)10-20-17(22)12-8-13(18)14(19)9-16(12)23-2/h8-9,11,15H,3-7,10H2,1-2H3,(H2-,19,20,22)/p+1/t11-,15-,21+/m0/s1
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0.350n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50181837
PNG
((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Show SMILES Cn1nc(C(=O)OC[C@@H]2CCN3CCC[C@@H]23)c2ccccc12
Show InChI InChI=1S/C17H21N3O2/c1-19-15-6-3-2-5-13(15)16(18-19)17(21)22-11-12-8-10-20-9-4-7-14(12)20/h2-3,5-6,12,14H,4,7-11H2,1H3/t12-,14-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50327859
PNG
((1-Butylpiperidin-4-yl)methyl 8-amino-7-cyano-2,3-...)
Show SMILES CCCCN1CCC(COC(=O)c2cc(C#N)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C20H27N3O4/c1-2-3-6-23-7-4-14(5-8-23)13-27-20(24)16-11-15(12-21)17(22)19-18(16)25-9-10-26-19/h11,14H,2-10,13,22H2,1H3
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0.450n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50327860
PNG
((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Show SMILES CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3OCCOc23)CC1
Show InChI InChI=1S/C20H29ClN2O4/c1-3-4-7-23-8-5-14(6-9-23)13-27-20(24)15-12-16(21)17(22-2)19-18(15)25-10-11-26-19/h12,14,22H,3-11,13H2,1-2H3
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0.577n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50181842
PNG
((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 5-Fluo...)
Show SMILES Fc1ccc2[nH]cc(C(=O)OC[C@@H]3CCN4CCC[C@@H]34)c2c1
Show InChI InChI=1S/C17H19FN2O2/c18-12-3-4-15-13(8-12)14(9-19-15)17(21)22-10-11-5-7-20-6-1-2-16(11)20/h3-4,8-9,11,16,19H,1-2,5-7,10H2/t11-,16-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50327861
PNG
((1-Butylpiperidin-4-yl)methyl 4-Amino-3-methoxyben...)
Show SMILES CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1
Show InChI InChI=1S/C18H28N2O3/c1-3-4-9-20-10-7-14(8-11-20)13-23-18(21)15-5-6-16(19)17(12-15)22-2/h5-6,12,14H,3-4,7-11,13,19H2,1-2H3
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0.738n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50442803
PNG
(CHEMBL2440453)
Show SMILES CC(O)CCN1CCC(CNC(=O)c2c3OCCCn3c3ccccc23)CC1
Show InChI InChI=1S/C22H31N3O3/c1-16(26)7-11-24-12-8-17(9-13-24)15-23-21(27)20-18-5-2-3-6-19(18)25-10-4-14-28-22(20)25/h2-3,5-6,16-17,26H,4,7-15H2,1H3,(H,23,27)
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0.794n/an/an/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Displacement of [125I]SB207710 from 5-HT4 receptor in guinea pig brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50181841
PNG
((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1H-ind...)
Show SMILES O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1[nH]nc2ccccc12
Show InChI InChI=1S/C16H19N3O2/c20-16(15-12-4-1-2-5-13(12)17-18-15)21-10-11-7-9-19-8-3-6-14(11)19/h1-2,4-5,11,14H,3,6-10H2,(H,17,18)/t11-,14-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50327862
PNG
((1-Propylpiperidin-4-yl)methyl 4-Amino-3-methoxybe...)
Show SMILES CCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1
Show InChI InChI=1S/C17H26N2O3/c1-3-8-19-9-6-13(7-10-19)12-22-17(20)14-4-5-15(18)16(11-14)21-2/h4-5,11,13H,3,6-10,12,18H2,1-2H3
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0.901n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50079375
PNG
(CHEMBL3417008)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCC1CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C21H31ClN2O3/c1-26-20-12-19(23)18(22)11-17(20)21(25)27-14-16-7-9-24(10-8-16)13-15-5-3-2-4-6-15/h11-12,15-16H,2-10,13-14,23H2,1H3
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0.950n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50181839
PNG
(CHEMBL202434 | N-exo-((4S,7alphaS)-tetrahydro-1H-p...)
Show SMILES Clc1cc(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2nccn2c1
Show InChI InChI=1S/C16H19ClN4O/c17-12-8-13(15-18-4-7-21(15)10-12)16(22)19-9-11-3-6-20-5-1-2-14(11)20/h4,7-8,10-11,14H,1-3,5-6,9H2,(H,19,22)/t11-,14-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM85026
PNG
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)
Show SMILES CCCCN1CCC(CNC(=O)c2c3OCCCn3c3ccccc23)CC1
Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26)
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1.60n/an/an/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Displacement of [125I]SB207710 from 5-HT4 receptor in guinea pig brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50293279
PNG
(1-Methyl-5-[(1-propylpiperidin-4-yl)methyloxy]-pyr...)
Show SMILES CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1
Show InChI InChI=1S/C19H25N3OS/c1-3-8-21-10-6-15(7-11-21)12-23-18-16-5-4-9-22(16)17-14(2)13-24-19(17)20-18/h4-5,9,13,15H,3,6-8,10-12H2,1-2H3
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1.74n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum membrane


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50399614
PNG
(CHEMBL2181170)
Show SMILES CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1
Show InChI InChI=1S/C21H24FN3O/c1-2-11-25-12-8-15(9-13-25)14-26-21-17-6-4-10-23-19(17)16-5-3-7-18(22)20(16)24-21/h3-7,10,15H,2,8-9,11-14H2,1H3
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2.20n/an/an/an/an/an/an/an/a



Universit£ de Caen Basse-Normandie

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50399614
PNG
(CHEMBL2181170)
Show SMILES CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1
Show InChI InChI=1S/C21H24FN3O/c1-2-11-25-12-8-15(9-13-25)14-26-21-17-6-4-10-23-19(17)16-5-3-7-18(22)20(16)24-21/h3-7,10,15H,2,8-9,11-14H2,1H3
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2.20n/an/an/an/an/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50079377
PNG
(CHEMBL3417007)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C21H32ClN3O2/c1-27-20-12-19(23)18(22)11-17(20)21(26)24-13-15-7-9-25(10-8-15)14-16-5-3-2-4-6-16/h11-12,15-16H,2-10,13-14,23H2,1H3,(H,24,26)
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2.30n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50079367
PNG
(CHEMBL3416998)
Show SMILES Cl.COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCNCC2)CC1
Show InChI InChI=1S/C21H32ClN3O2/c1-27-21-13-19(23)18(22)12-17(21)20(26)3-2-15-6-10-25(11-7-15)14-16-4-8-24-9-5-16/h12-13,15-16,24H,2-11,14,23H2,1H3
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2.5n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50399621
PNG
(CHEMBL2181166)
Show SMILES Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc21
Show InChI InChI=1S/C27H27FIN3O/c28-24-7-1-5-22-25-23(6-2-14-30-25)27(31-26(22)24)33-18-20-12-16-32(17-13-20)15-3-4-19-8-10-21(29)11-9-19/h1-2,5-11,14,20H,3-4,12-13,15-18H2
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2.5n/an/an/an/an/an/an/an/a



Universit£ de Caen Basse-Normandie

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50122716
PNG
(5-(Piperidin-4-ylmethoxy)-9-propyl-1,2,3,4-tetrahy...)
Show SMILES CCCN1CCC(COc2nc3ccccc3c3NCCCc23)CC1
Show InChI InChI=1S/C21H29N3O/c1-2-12-24-13-9-16(10-14-24)15-25-21-18-7-5-11-22-20(18)17-6-3-4-8-19(17)23-21/h3-4,6,8,16,22H,2,5,7,9-15H2,1H3
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2.90n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Ability to displace [3H]GR-113808 from 5-hydroxytryptamine 4 receptor


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50079365
PNG
(CHEMBL3416996)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCC2)CC1
Show InChI InChI=1S/C21H31ClN2O2/c1-26-21-13-19(23)18(22)12-17(21)20(25)7-6-15-8-10-24(11-9-15)14-16-4-2-3-5-16/h12-13,15-16H,2-11,14,23H2,1H3
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3n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50079366
PNG
(CHEMBL3416997)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCCCC2)CC1
Show InChI InChI=1S/C23H35ClN2O2/c1-28-23-15-21(25)20(24)14-19(23)22(27)9-8-17-10-12-26(13-11-17)16-18-6-4-2-3-5-7-18/h14-15,17-18H,2-13,16,25H2,1H3
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3.90n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50443687
PNG
(CHEMBL3093187)
Show SMILES Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc21
Show InChI InChI=1S/C22H23F4N3O/c23-18-6-1-4-16-19-17(5-2-10-27-19)21(28-20(16)18)30-14-15-7-12-29(13-8-15)11-3-9-22(24,25)26/h1-2,4-6,10,15H,3,7-9,11-14H2
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4.20n/an/an/an/an/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50399622
PNG
(CHEMBL2181168)
Show SMILES CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1
Show InChI InChI=1S/C21H24IN3O/c1-2-11-25-12-8-15(9-13-25)14-26-21-17-6-4-10-23-19(17)16-5-3-7-18(22)20(16)24-21/h3-7,10,15H,2,8-9,11-14H2,1H3
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4.60n/an/an/an/an/an/an/an/a



Universit£ de Caen Basse-Normandie

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50079369
PNG
(CHEMBL3417000)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCCC2C)CC1
Show InChI InChI=1/C23H35ClN2O2/c1-16-5-3-4-6-18(16)15-26-11-9-17(10-12-26)7-8-22(27)19-13-20(24)21(25)14-23(19)28-2/h13-14,16-18H,3-12,15,25H2,1-2H3
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4.90n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50005833
PNG
((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12
Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m0/s1
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5.20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50413548
PNG
(CHEMBL512679)
Show SMILES CCCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1
Show InChI InChI=1S/C20H27N3OS/c1-3-4-9-22-11-7-16(8-12-22)13-24-19-17-6-5-10-23(17)18-15(2)14-25-20(18)21-19/h5-6,10,14,16H,3-4,7-9,11-13H2,1-2H3
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5.37n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum membrane


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50413547
PNG
(CHEMBL448702)
Show SMILES CC(C)N1CCC(COc2nc3scc(C)c3n3cccc23)CC1
Show InChI InChI=1S/C19H25N3OS/c1-13(2)21-9-6-15(7-10-21)11-23-18-16-5-4-8-22(16)17-14(3)12-24-19(17)20-18/h4-5,8,12-13,15H,6-7,9-11H2,1-3H3
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6.46n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum membrane


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50079362
PNG
(CHEMBL3417009)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C22H33ClN2O2/c1-27-22-14-20(24)19(23)13-18(22)21(26)8-7-16-9-11-25(12-10-16)15-17-5-3-2-4-6-17/h13-14,16-17H,2-12,15,24H2,1H3
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6.60n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50079288
PNG
(3-Cyclopropyl-2-oxo-2,3-dihydro-benzoimidazole-1-c...)
Show SMILES CC(C)N1CCN(CCNC(=O)n2c3ccccc3n(C3CC3)c2=O)CC1
Show InChI InChI=1S/C20H29N5O2/c1-15(2)23-13-11-22(12-14-23)10-9-21-19(26)25-18-6-4-3-5-17(18)24(20(25)27)16-7-8-16/h3-6,15-16H,7-14H2,1-2H3,(H,21,26)
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6.70n/an/an/an/an/an/an/an/a



FAES, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 4 receptor in guinea pig striatum using [3H]GR-113808 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50181843
PNG
(CHEMBL201414 | cis-N-[(hexahydro-1H-pyrrolizin-l-y...)
Show SMILES CC(C)n1c2ccccc2n(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c1=O
Show InChI InChI=1S/C19H26N4O2/c1-13(2)22-16-6-3-4-7-17(16)23(19(22)25)18(24)20-12-14-9-11-21-10-5-8-15(14)21/h3-4,6-7,13-15H,5,8-12H2,1-2H3,(H,20,24)/t14-,15-/m0/s1
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7n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50079368
PNG
(CHEMBL3416999)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCC2CCCCC2)CC1
Show InChI InChI=1S/C23H35ClN2O2/c1-28-23-16-21(25)20(24)15-19(23)22(27)8-7-18-10-13-26(14-11-18)12-9-17-5-3-2-4-6-17/h15-18H,2-14,25H2,1H3
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8.20n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50079297
PNG
(3-Cyclopropyl-2-oxo-2,3-dihydro-benzoimidazole-1-c...)
Show SMILES CCCN1CCN(CCNC(=O)n2c3ccccc3n(C3CC3)c2=O)CC1
Show InChI InChI=1S/C20H29N5O2/c1-2-10-22-12-14-23(15-13-22)11-9-21-19(26)25-18-6-4-3-5-17(18)24(20(25)27)16-7-8-16/h3-6,16H,2,7-15H2,1H3,(H,21,26)
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8.20n/an/an/an/an/an/an/an/a



FAES, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 4 receptor in guinea pig striatum using [3H]GR-113808 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50413546
PNG
(CHEMBL513254)
Show SMILES Cc1csc2nc(OCC3CCN(CC=C)CC3)c3cccn3c12
Show InChI InChI=1S/C19H23N3OS/c1-3-8-21-10-6-15(7-11-21)12-23-18-16-5-4-9-22(16)17-14(2)13-24-19(17)20-18/h3-5,9,13,15H,1,6-8,10-12H2,2H3
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8.51n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum membrane


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50413545
PNG
(CHEMBL469575)
Show SMILES C=CCN1CCC(COc2nc3ccsc3n3cccc23)CC1
Show InChI InChI=1S/C18H21N3OS/c1-2-8-20-10-5-14(6-11-20)13-22-17-16-4-3-9-21(16)18-15(19-17)7-12-23-18/h2-4,7,9,12,14H,1,5-6,8,10-11,13H2
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8.71n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum membrane


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50079364
PNG
(CHEMBL3416995)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCC2)CC1
Show InChI InChI=1S/C20H29ClN2O2/c1-25-20-12-18(22)17(21)11-16(20)19(24)6-5-14-7-9-23(10-8-14)13-15-3-2-4-15/h11-12,14-15H,2-10,13,22H2,1H3
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8.80n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50443688
PNG
(CHEMBL3093186)
Show SMILES Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc21
Show InChI InChI=1S/C21H21F4N3O/c22-17-5-1-3-15-18-16(4-2-9-26-18)20(27-19(15)17)29-13-14-6-10-28(11-7-14)12-8-21(23,24)25/h1-5,9,14H,6-8,10-13H2
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9n/an/an/an/an/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM84950
PNG
(CAS_183782 | NSC_183782 | RS 67333)
Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1
Show InChI InChI=1S/C19H29ClN2O2/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2/h12-14H,3-11,21H2,1-2H3
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9.30n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50413544
PNG
(CHEMBL511794)
Show SMILES CCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1
Show InChI InChI=1S/C18H23N3OS/c1-3-20-9-6-14(7-10-20)11-22-17-15-5-4-8-21(15)16-13(2)12-23-18(16)19-17/h4-5,8,12,14H,3,6-7,9-11H2,1-2H3
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9.55n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum membrane


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50079285
PNG
(3-Cyclopropyl-2-oxo-2,3-dihydro-benzoimidazole-1-c...)
Show SMILES CN1CCN(CCNC(=O)n2c3ccccc3n(C3CC3)c2=O)CC1
Show InChI InChI=1S/C18H25N5O2/c1-20-10-12-21(13-11-20)9-8-19-17(24)23-16-5-3-2-4-15(16)22(18(23)25)14-6-7-14/h2-5,14H,6-13H2,1H3,(H,19,24)
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10n/an/an/an/an/an/an/an/a



FAES, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 4 receptor in guinea pig striatum using [3H]GR-113808 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50122722
PNG
(9-Butyl-5-(piperidin-4-ylmethoxy)-1,2,3,4-tetrahyd...)
Show SMILES CCCCN1CCC(COc2nc3ccccc3c3NCCCc23)CC1
Show InChI InChI=1S/C22H31N3O/c1-2-3-13-25-14-10-17(11-15-25)16-26-22-19-8-6-12-23-21(19)18-7-4-5-9-20(18)24-22/h4-5,7,9,17,23H,2-3,6,8,10-16H2,1H3
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10n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Ability to displace [3H]GR-113808 from 5-hydroxytryptamine 4 receptor


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50122721
PNG
(6-(1-Ethyl-piperidin-4-ylmethoxy)-8,9,10,11-tetrah...)
Show SMILES CCN1CCC(COc2nc3ccccc3c3NCCCCc23)CC1
Show InChI InChI=1S/C21H29N3O/c1-2-24-13-10-16(11-14-24)15-25-21-18-8-5-6-12-22-20(18)17-7-3-4-9-19(17)23-21/h3-4,7,9,16,22H,2,5-6,8,10-15H2,1H3
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11n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Ability to displace [3H]GR-113808 from 5-hydroxytryptamine 4 receptor


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50413543
PNG
(CHEMBL472481)
Show SMILES Cc1csc2nc(OCC3CCN(CCC=C)CC3)c3cccn3c12
Show InChI InChI=1S/C20H25N3OS/c1-3-4-9-22-11-7-16(8-12-22)13-24-19-17-6-5-10-23(17)18-15(2)14-25-20(18)21-19/h3,5-6,10,14,16H,1,4,7-9,11-13H2,2H3
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11.2n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum membrane


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Cavia porcellus)
BDBM50413542
PNG
(CHEMBL469582)
Show SMILES CCCN1CCC(COc2nc3sccc3n3cccc23)CC1
Show InChI InChI=1S/C18H23N3OS/c1-2-8-20-10-5-14(6-11-20)13-22-17-15-4-3-9-21(15)16-7-12-23-18(16)19-17/h3-4,7,9,12,14H,2,5-6,8,10-11,13H2,1H3
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11.8n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum membrane


Citation and Details
More data for this
Ligand-Target Pair
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