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Compile Data Set for Download or QSAR

Found 9 hits Enz. Inhib. hit(s) with Target = 'Serotonin 4 (5-HT4) receptor' AND taxid = 9823   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM50421360
PNG
(CHEMBL358119 | SB-207058)
Show SMILES CCCCN1CCC(COC(=O)c2c3OCCCn3c3ccccc23)CC1
Show InChI InChI=1S/C22H30N2O3/c1-2-3-11-23-13-9-17(10-14-23)16-27-22(25)20-18-7-4-5-8-19(18)24-12-6-15-26-21(20)24/h4-5,7-8,17H,2-3,6,9-16H2,1H3
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Article
0.0631n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane


Citation and Details

Article DOI: 10.1016/S0960-894X(01)80176-1
BindingDB Entry DOI: 10.7270/Q25T3MSB
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM50421359
PNG
(CHEMBL145075)
Show SMILES CCCCN1CCC(COC(=O)c2c3OCCn3c3ccccc23)CC1
Show InChI InChI=1S/C21H28N2O3/c1-2-3-10-22-11-8-16(9-12-22)15-26-21(24)19-17-6-4-5-7-18(17)23-13-14-25-20(19)23/h4-7,16H,2-3,8-15H2,1H3
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Article
0.0794n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane


Citation and Details

Article DOI: 10.1016/S0960-894X(01)80176-1
BindingDB Entry DOI: 10.7270/Q25T3MSB
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM82505
PNG
(CAS_121881 | NSC_121881 | SB204070)
Show SMILES CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
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Article
0.126n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane


Citation and Details

Article DOI: 10.1016/S0960-894X(01)80176-1
BindingDB Entry DOI: 10.7270/Q25T3MSB
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM50421362
PNG
(CHEMBL143862)
Show SMILES CCCCN1CCC(COC(=O)c2c3OCCCCn3c3ccccc23)CC1
Show InChI InChI=1S/C23H32N2O3/c1-2-3-12-24-14-10-18(11-15-24)17-28-23(26)21-19-8-4-5-9-20(19)25-13-6-7-16-27-22(21)25/h4-5,8-9,18H,2-3,6-7,10-17H2,1H3
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Article
0.200n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane


Citation and Details

Article DOI: 10.1016/S0960-894X(01)80176-1
BindingDB Entry DOI: 10.7270/Q25T3MSB
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM50421361
PNG
(CHEMBL143426)
Show SMILES CCCCN1CCC(COC(=O)c2c[nH]c3ccccc23)CC1
Show InChI InChI=1S/C19H26N2O2/c1-2-3-10-21-11-8-15(9-12-21)14-23-19(22)17-13-20-18-7-5-4-6-16(17)18/h4-7,13,15,20H,2-3,8-12,14H2,1H3
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Article
2.5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane


Citation and Details

Article DOI: 10.1016/S0960-894X(01)80176-1
BindingDB Entry DOI: 10.7270/Q25T3MSB
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM50084959
PNG
(11'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadia...)
Show SMILES CN1CCC2(COc3cc4CCN(C(=O)c5ccc(cc5)-c5ccc(cc5C)-c5noc(C)n5)c4cc23)CC1
Show InChI InChI=1S/C32H32N4O3/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32/h4-9,16-18H,10-15,19H2,1-3H3
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PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against piglet hippocampus 5-hydroxytryptamine 4 receptor


J Med Chem 41: 1218-35 (1998)


Article DOI: 10.1021/jm970457s
BindingDB Entry DOI: 10.7270/Q2XS5WMN
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM50079939
PNG
((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...)
Show SMILES COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1
Show InChI InChI=1S/C22H27ClN2O3/c1-26-20-5-3-2-4-19(20)25-10-8-16(9-11-25)13-24-14-18-15-27-21-7-6-17(23)12-22(21)28-18/h2-7,12,16,18,24H,8-11,13-15H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Knoll Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested for binding affinity against 5-hydroxytryptamine 4 receptor


J Med Chem 42: 3342-55 (1999)


Article DOI: 10.1021/jm9910122
BindingDB Entry DOI: 10.7270/Q2WH2P6K
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM50327858
PNG
((1-Butylpiperidin-4-yl)methyl 8-amino-7-iodo-2,3-d...)
Show SMILES CCCCN1CCC(COC(=O)c2cc(I)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C19H27IN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
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n/an/an/a 0.0800n/an/an/an/an/a



Molecular NeuroImaging LLC

Curated by ChEMBL


Assay Description
Binding affinity to 5HT4 receptor in pig striatal membranes


Bioorg Med Chem Lett 23: 6243-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.097
BindingDB Entry DOI: 10.7270/Q2RJ4KZ2
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM50448450
PNG
(CHEMBL3126112)
Show SMILES CN1CCC(COC(=O)c2cc(Cl)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C16H21ClN2O4/c1-19-4-2-10(3-5-19)9-23-16(20)11-8-12(17)13(18)15-14(11)21-6-7-22-15/h8,10H,2-7,9,18H2,1H3
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n/an/an/a 0.0800n/an/an/an/an/a



Molecular NeuroImaging LLC

Curated by ChEMBL


Assay Description
Binding affinity to 5HT4 receptor in pig striatal membranes


Bioorg Med Chem Lett 23: 6243-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.097
BindingDB Entry DOI: 10.7270/Q2RJ4KZ2
More data for this
Ligand-Target Pair