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Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Serotonin 4 (5-HT4) receptor' AND taxid = 9823   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM50079939
PNG
((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...)
Show SMILES COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1
Show InChI InChI=1S/C22H27ClN2O3/c1-26-20-5-3-2-4-19(20)25-10-8-16(9-11-25)13-24-14-18-15-27-21-7-6-17(23)12-22(21)28-18/h2-7,12,16,18,24H,8-11,13-15H2,1H3
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PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Knoll Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested for binding affinity against 5-hydroxytryptamine 4 receptor


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM50084959
PNG
(11'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadia...)
Show SMILES CN1CCC2(COc3cc4CCN(C(=O)c5ccc(cc5)-c5ccc(cc5C)-c5noc(C)n5)c4cc23)CC1
Show InChI InChI=1S/C32H32N4O3/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32/h4-9,16-18H,10-15,19H2,1-3H3
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PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against piglet hippocampus 5-hydroxytryptamine 4 receptor


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM50448450
PNG
(CHEMBL3126112)
Show SMILES CN1CCC(COC(=O)c2cc(Cl)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C16H21ClN2O4/c1-19-4-2-10(3-5-19)9-23-16(20)11-8-12(17)13(18)15-14(11)21-6-7-22-15/h8,10H,2-7,9,18H2,1H3
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PubMed
n/an/an/a 0.0800n/an/an/an/an/a



Molecular NeuroImaging LLC

Curated by ChEMBL


Assay Description
Binding affinity to 5HT4 receptor in pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 4 (5-HT4) receptor


(Sus scrofa)
BDBM50327858
PNG
((1-Butylpiperidin-4-yl)methyl 8-amino-7-iodo-2,3-d...)
Show SMILES CCCCN1CCC(COC(=O)c2cc(I)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C19H27IN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/a 0.0800n/an/an/an/an/a



Molecular NeuroImaging LLC

Curated by ChEMBL


Assay Description
Binding affinity to 5HT4 receptor in pig striatal membranes


Citation and Details
More data for this
Ligand-Target Pair