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Found 5 hits Enz. Inhib. hit(s) with Target = 'Serotonin 7 (5-HT7) receptor' AND taxid = 10141   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 7 (5-HT7) receptor


(Cavia porcellus)
BDBM50253208
PNG
(CHEMBL492871 | N-Benzyl-4-(2-diphenyl)-1-piperazin...)
Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)NCc1ccccc1
Show InChI InChI=1S/C29H35N3O/c33-29(30-24-25-12-4-1-5-13-25)18-8-3-11-19-31-20-22-32(23-21-31)28-17-10-9-16-27(28)26-14-6-2-7-15-26/h1-2,4-7,9-10,12-17H,3,8,11,18-24H2,(H,30,33)
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a 4.50E+6n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 7 (5-HT7) receptor


(Cavia porcellus)
BDBM50253130
PNG
(2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,...)
Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1CCc2ccccc2C1
Show InChI InChI=1S/C31H37N3O/c35-31(34-20-18-26-11-6-7-14-28(26)25-34)17-5-2-10-19-32-21-23-33(24-22-32)30-16-9-8-15-29(30)27-12-3-1-4-13-27/h1,3-4,6-9,11-16H,2,5,10,17-25H2
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a 490n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 7 (5-HT7) receptor


(Cavia porcellus)
BDBM50253244
PNG
(4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazineh...)
Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)NCc1ccncc1
Show InChI InChI=1S/C28H34N4O/c33-28(30-23-24-14-16-29-17-15-24)13-5-2-8-18-31-19-21-32(22-20-31)27-12-7-6-11-26(27)25-9-3-1-4-10-25/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-23H2,(H,30,33)
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a 310n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 7 (5-HT7) receptor


(Cavia porcellus)
BDBM50253281
PNG
(CHEMBL522691 | N-(4-Cyanophenylmethyl)-4-(2-diphen...)
Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)NCc1ccc(cc1)C#N
Show InChI InChI=1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35)
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
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Article
PubMed
n/an/an/an/a 600n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 7 (5-HT7) receptor


(Cavia porcellus)
BDBM21392
PNG
(3-(2-aminoethyl)-1H-indole-5-carboxamide | 5-CT | ...)
Show SMILES NCCc1c[nH]c2ccc(cc12)C(N)=O
Show InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/an/an/a 630n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction


Citation and Details
More data for this
Ligand-Target Pair