BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 49 hits Enz. Inhib. hit(s) with Target = 'Serum paraoxonase/arylesterase 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50139137
PNG
(CHEMBL3759162)
Show SMILES [Cl-].CCCCn1cc[n+](Cc2cc(=O)oc3cc(C)cc(C)c23)c1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
2.39E+3n/an/an/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Competitive inhibition of human serum PON1 using paraoxon as substrate by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM92331
PNG
(Lornoxicam)
Show SMILES CN1C(C(=O)Nc2ccccn2)=C(O)c2sc(Cl)cc2S1(=O)=O
Show InChI InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
9.00E+3 -28.8 1.36E+5n/an/an/an/a10.525



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50001839
PNG
(CHEMBL428647 | PACLITAXEL | taxol)
Show SMILES CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.65E+4n/a 4.20E+4n/an/an/an/an/an/a



Ahi Evran University



Assay Description
Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50316126
PNG
(Bleph-10 | Bleph-30 | Blephamide | CHEMBL455 | Cet...)
Show SMILES CC(=O)NS(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
8.60E+4n/a 1.80E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM17638
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
9.70E+4 -22.9 1.95E+5n/an/an/an/a10.525



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50127140
PNG
((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Show SMILES COc1cc(cc(OC)c1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)c2cc3OCOc3cc12
Show InChI InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.31E+5n/a 2.26E+5n/an/an/an/an/an/a



Ahi Evran University



Assay Description
Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM241973
PNG
(Oxytetracycline hydrochloride)
Show SMILES CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)c4c(O)cccc4[C@@]3(C)O)C(=O)[C@]2(O)C(O)=C(C(N)=O)C1=O
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
2.00E+5n/an/an/an/an/an/an/an/a



Atatürk University



Assay Description
PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...


J Enzyme Inhib Med Chem 28: 758-64 (2013)

More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM36351
PNG
(CID148124 | Docetaxel)
Show SMILES CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@]1(C)[C@@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c3ccccc3)C(C)=C([C@@H](O)C1=O)C2(C)C
Show InChI InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
2.91E+5n/a 6.65E+5n/an/an/an/an/an/a



Ahi Evran University



Assay Description
Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM92332
PNG
(Tenoxicam)
Show SMILES CN1C(C(=O)Nc2ccccn2)=C(O)c2sccc2S1(=O)=O
Show InChI InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
3.06E+5 -20.1 3.40E+5n/an/an/an/a10.525



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM10860
PNG
(4-(aminomethyl)benzene-1-sulfonamide | CHEMBL419 |...)
Show SMILES NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
3.40E+5n/a 1.90E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM82185
PNG
(Sulfosalazine, 3)
Show SMILES OC(=O)c1ccc(cc1O)\N=N\c1ccc(cc1)S(=O)(=O)Nc1ccccn1
Show InChI InChI=1S/C18H14N4O5S/c23-16-11-13(6-9-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
5.70E+5n/a 2.60E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM25902
PNG
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
Show InChI InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

AffyNet 
Article
PubMed
7.02E+5n/a 3.60E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
7.43E+5n/a 8.00E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50174201
PNG
(ARTHROTEC | DICLOFENAC SODIUM | GP 45840 | SOLARAZ...)
Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)/p-1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
8.05E+5 -17.7 1.64E+6n/an/an/an/a10.525



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM10868
PNG
(1,3,4-Thiadiazole-2-sulfonamide, 6 | 1,3,4-thiadia...)
Show SMILES Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C2H4N4O2S2/c3-1-5-6-2(9-1)10(4,7)8/h(H2,3,5)(H2,4,7,8)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents

AffyNet 
Article
PubMed
2.00E+6n/a 1.24E+6n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM241974
PNG
(Netilmycin sulfate)
Show SMILES CCN[C@@H]1C[C@H](N)[C@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@H](O)[C@H]1O[C@H]1OC[C@](C)(O)[C@H](NC)[C@H]1O
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
3.73E+6n/an/an/an/an/an/an/an/a



Atatürk University



Assay Description
PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...


J Enzyme Inhib Med Chem 28: 758-64 (2013)

More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM189358
PNG
(Ifosfamide | N,3-bis(2-chloroethyl)-2-oxo-1,3,2-ox...)
Show SMILES ClCCNP1(=O)OCCCN1CCCl
Show InChI InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
KEGG
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
8.97E+6n/a 2.33E+7n/an/an/an/an/an/a



Ahi Evran University



Assay Description
Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM92333
PNG
(Lincomycine)
Show SMILES CCCC1CC(N(C)C1)C(=O)NC(C(C)O)C1OC(SC)C(O)C(O)C1O
Show InChI InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
1.11E+7 -11.2 1.30E+7n/an/an/an/a10.525



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50022271
PNG
(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Show SMILES CC(C(O)=O)c1cccc(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.30E+7 -10.8 6.23E+6n/an/an/an/a10.525



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50335522
PNG
((2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3...)
Show SMILES CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
1.83E+7n/an/an/an/an/an/an/an/a



Atatürk University



Assay Description
PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...


J Enzyme Inhib Med Chem 28: 758-64 (2013)

More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM241975
PNG
(Clindamycin phosphate)
Show SMILES CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@H](C)Cl)[C@H]1O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]1O
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
3.58E+7n/an/an/an/an/an/an/an/a



Atatürk University



Assay Description
PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...


J Enzyme Inhib Med Chem 28: 758-64 (2013)

More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM241976
PNG
(Streptomycin sulfate)
Show SMILES CN[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]2N=C(N)N)O[C@H](C)[C@@]1(O)C=O
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
5.63E+7n/an/an/an/an/an/an/an/a



Atatürk University



Assay Description
PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...


J Enzyme Inhib Med Chem 28: 758-64 (2013)

More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM86068
PNG
(PPC)
Show SMILES Cc1ccc(cc1)-c1cc2cc(O)c(O)cc2oc1=O
Show InChI InChI=1S/C16H12O4/c1-9-2-4-10(5-3-9)12-6-11-7-13(17)14(18)8-15(11)20-16(12)19/h2-8,17-18H,1H3
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50139137
PNG
(CHEMBL3759162)
Show SMILES [Cl-].CCCCn1cc[n+](Cc2cc(=O)oc3cc(C)cc(C)c23)c1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 6.37E+3n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144692
PNG
(CHEMBL3759251)
Show SMILES [Cl-].O=C(C[n+]1cn(Cn2nnc3ccccc23)c2ccccc12)c1ccc2OCC(=O)Nc2c1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 8.76E+3n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144693
PNG
(CHEMBL3758983)
Show SMILES [Cl-].Cn1cc[n+](Cc2nc3ccccc3[nH]2)c1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.91E+4n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50139133
PNG
(CHEMBL3759178)
Show SMILES Cc1ccc2c(CCl)cc(=O)oc2c1C
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.14E+4n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50139135
PNG
(CHEMBL3759775)
Show SMILES [Cl-].Cc1cc(C)c2c(C[n+]3ccn(C)c3)cc(=O)oc2c1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.37E+4n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144739
PNG
(CHEMBL3759516)
Show SMILES [Cl-].CCCCn1cc[n+](Cc2nc3ccccc3[nH]2)c1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.90E+4n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50139132
PNG
(CHEMBL1462074)
Show SMILES Cc1cc(C)c2c(CCl)cc(=O)oc2c1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.14E+4n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50139134
PNG
(CHEMBL3758686)
Show SMILES CC(C)(C)c1ccc2oc(=O)cc(CCl)c2c1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.00E+4n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM243044
PNG
((2-Bromo-4,5-dimethoxyphenyl)(2,3-dibromo-5,6-dime...)
Show SMILES COc1cc(Br)c(cc1OC)C(=O)c1c(Br)c(Br)cc(OC)c1OC
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.23E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM243045
PNG
((3-Bromo-4,5-dimethoxyphenyl)(2,3-dibromo-5,6-dime...)
Show SMILES COc1cc(Br)c(Br)c(C(=O)c2cc(Br)c(OC)c(OC)c2)c1OC
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.25E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM243043
PNG
((2,3-dibromo-5,6-dimethoxyphenyl)(3,4-dimethoxyphe...)
Show SMILES COc1ccc(cc1OC)C(=O)c1c(Br)c(Br)cc(OC)c1OC
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.74E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144690
PNG
(CHEMBL3759001)
Show SMILES [Cl-].Cc1ccc2c(C[n+]3cn(Cn4nnc5ccccc45)c4ccccc34)cc(=O)oc2c1C
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.38E+5n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50139136
PNG
(CHEMBL3759337)
Show SMILES [Cl-].Cc1n(C)cc[n+]1Cc1cc(=O)oc2cc(C)cc(C)c12
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.17E+5n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144740
PNG
(CHEMBL3758357)
Show SMILES C(n1cnc2ccccc12)n1nnc2ccccc12
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5.64E+5n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144738
PNG
(CHEMBL3758838)
Show SMILES [Cl-].Cc1n(C)cc[n+]1Cc1nc2ccccc2[nH]1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 6.26E+5n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144691
PNG
(CHEMBL3759697)
Show SMILES [Cl-].CC(C)(C)c1ccc2oc(=O)cc(C[n+]3cn(Cn4nnc5ccccc45)c4ccccc34)c2c1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 6.27E+5n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM243048
PNG
((3-Bromo-4,5-dihydroxyphenyl)(2,3-dibromo-5,6-dihy...)
Show SMILES Oc1cc(Br)c(Br)c(C(=O)c2cc(O)c(O)c(Br)c2)c1O
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 7.01E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM243046
PNG
((2,3-Dibromo-5,6-dihydroxyphenyl)(3,4-dihydroxyphe...)
Show SMILES Oc1ccc(cc1O)C(=O)c1c(O)c(O)cc(Br)c1Br
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 8.32E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM243047
PNG
((2-Bromo-4,5-dihydroxyphenyl)(2,3-dibromo-5,6-dihy...)
Show SMILES Oc1cc(Br)c(cc1O)C(=O)c1c(O)c(O)cc(Br)c1Br
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.11E+6n/an/an/an/an/an/a



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM243042
PNG
((2,3-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanon...)
Show SMILES COc1ccc(cc1OC)C(=O)c1cccc(OC)c1OC
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.21E+6n/an/an/an/an/an/a



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50127646
PNG
(CHEMBL42577 | Phosphoric acid 4-amino-phenyl ester...)
Show SMILES CCOP(=O)(OCC)Oc1ccc(N)cc1
Show InChI InChI=1S/C10H16NO4P/c1-3-13-16(12,14-4-2)15-10-7-5-9(11)6-8-10/h5-8H,3-4,11H2,1-2H3
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
n/an/a 1.28E+6n/an/an/an/an/an/a



The University of Birmingham

Curated by ChEMBL


Assay Description
Inhibitory activity against human serum paraoxonase (PON1)


Bioorg Med Chem Lett 13: 1623-6 (2003)

More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144742
PNG
(CHEMBL3758332)
Show SMILES [Cl-].C(n1c[n+](Cc2ccccc2)c2ccccc12)n1nnc2ccccc12
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.06E+6n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM14675
PNG
(CHEMBL26128 | Fragment 5 | Phenylphosphate | pheno...)
Show SMILES OP(O)(=O)Oc1ccccc1
Show InChI InChI=1S/C6H7O4P/c7-11(8,9)10-6-4-2-1-3-5-6/h1-5H,(H2,7,8,9)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 3.25E+6n/an/an/an/an/an/a



The University of Birmingham

Curated by ChEMBL


Assay Description
Inhibitory activity against human serum paraoxonase (PON1)


Bioorg Med Chem Lett 13: 1623-6 (2003)

More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50127647
PNG
(CHEMBL296745 | Phosphoric acid diethyl ester pheny...)
Show SMILES CCOP(=O)(OCC)Oc1ccccc1
Show InChI InChI=1S/C10H15O4P/c1-3-12-15(11,13-4-2)14-10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents

AffyNet 
PubMed
n/an/a 3.27E+6n/an/an/an/an/an/a



The University of Birmingham

Curated by ChEMBL


Assay Description
Inhibitory activity against human serum paraoxonase (PON1)


Bioorg Med Chem Lett 13: 1623-6 (2003)

More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144741
PNG
(CHEMBL3760112)
Show SMILES [Cl-].CCCC[n+]1cn(Cn2nnc3ccccc23)c2ccccc12
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.33E+6n/an/an/an/an/an/a



In£n£ University

Curated by ChEMBL


Assay Description
Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM24514
PNG
(4-nitrophenoxyphosphonic acid | 4-nitrophenyl phos...)
Show SMILES OP(O)(=O)Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 1.85E+7n/an/an/an/an/an/a



The University of Birmingham

Curated by ChEMBL


Assay Description
Inhibitory activity against human serum paraoxonase (PON1)


Bioorg Med Chem Lett 13: 1623-6 (2003)

More data for this
Ligand-Target Pair