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Compile Data Set for Download or QSAR

Found 24 hits Enz. Inhib. hit(s) with Target = 'Short transient receptor potential channel 6' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439218
PNG
(CHEMBL2418809)
Show SMILES CC1CCCN(C1C)C(=O)c1nc(Nc2cc3OCOc3cc2F)sc1Cl
Show InChI InChI=1S/C18H19ClFN3O3S/c1-9-4-3-5-23(10(9)2)17(24)15-16(19)27-18(22-15)21-12-7-14-13(6-11(12)20)25-8-26-14/h6-7,9-10H,3-5,8H2,1-2H3,(H,21,22)
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n/an/a 4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439220
PNG
(CHEMBL2418807)
Show SMILES CC1CCCN(C1C)C(=O)c1csc(Nc2ccc3OCOc3c2)n1
Show InChI InChI=1S/C18H21N3O3S/c1-11-4-3-7-21(12(11)2)17(22)14-9-25-18(20-14)19-13-5-6-15-16(8-13)24-10-23-15/h5-6,8-9,11-12H,3-4,7,10H2,1-2H3,(H,19,20)
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n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439217
PNG
(CHEMBL2418811)
Show SMILES C[C@H]1CCCN([C@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C
Show InChI InChI=1S/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439219
PNG
(CHEMBL2418808)
Show SMILES CC1CCCN(C1C)C(=O)c1nc(Nc2cc3OCOc3cc2F)sc1C
Show InChI InChI=1S/C19H22FN3O3S/c1-10-5-4-6-23(11(10)2)18(24)17-12(3)27-19(22-17)21-14-8-16-15(7-13(14)20)25-9-26-16/h7-8,10-11H,4-6,9H2,1-3H3,(H,21,22)
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n/an/a 25n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439213
PNG
(CHEMBL2418815)
Show SMILES CC1N(CCc2ccccc12)C(=O)c1nc(Nc2ccc3OCOc3c2)sc1C
Show InChI InChI=1S/C22H21N3O3S/c1-13-17-6-4-3-5-15(17)9-10-25(13)21(26)20-14(2)29-22(24-20)23-16-7-8-18-19(11-16)28-12-27-18/h3-8,11,13H,9-10,12H2,1-2H3,(H,23,24)
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n/an/a 32n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439216
PNG
(CHEMBL2418812)
Show SMILES C[C@@H]1CCCN([C@@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C
Show InChI InChI=1S/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/m1/s1
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n/an/a 50n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439214
PNG
(CHEMBL2418814)
Show SMILES CC1N(CCc2ccccc12)C(=O)c1csc(Nc2ccc3OCOc3c2)n1
Show InChI InChI=1S/C21H19N3O3S/c1-13-16-5-3-2-4-14(16)8-9-24(13)20(25)17-11-28-21(23-17)22-15-6-7-18-19(10-15)27-12-26-18/h2-7,10-11,13H,8-9,12H2,1H3,(H,22,23)
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n/an/a 63n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439221
PNG
(CHEMBL2418806)
Show SMILES CC1CCCN(C1C)C(=O)c1csc(Nc2ccc(C)cc2)n1
Show InChI InChI=1S/C18H23N3OS/c1-12-6-8-15(9-7-12)19-18-20-16(11-23-18)17(22)21-10-4-5-13(2)14(21)3/h6-9,11,13-14H,4-5,10H2,1-3H3,(H,19,20)
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n/an/a 80n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439215
PNG
(CHEMBL2418813)
Show SMILES O=C(N1CCc2ccccc2C1)c1csc(Nc2ccc3OCOc3c2)n1
Show InChI InChI=1S/C20H17N3O3S/c24-19(23-8-7-13-3-1-2-4-14(13)10-23)16-11-27-20(22-16)21-15-5-6-17-18(9-15)26-12-25-17/h1-6,9,11H,7-8,10,12H2,(H,21,22)
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n/an/a 160n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439227
PNG
(CHEMBL2418823)
Show SMILES CC1CCN(CC1)C(=O)c1csc(Nc2ccc3OCOc3c2)n1
Show InChI InChI=1S/C17H19N3O3S/c1-11-4-6-20(7-5-11)16(21)13-9-24-17(19-13)18-12-2-3-14-15(8-12)23-10-22-14/h2-3,8-9,11H,4-7,10H2,1H3,(H,18,19)
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n/an/a 160n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439232
PNG
(CHEMBL2418818)
Show SMILES CC1CCN(CC1)C(=O)c1csc(Nc2ccc(C)cc2)n1
Show InChI InChI=1S/C17H21N3OS/c1-12-3-5-14(6-4-12)18-17-19-15(11-22-17)16(21)20-9-7-13(2)8-10-20/h3-6,11,13H,7-10H2,1-2H3,(H,18,19)
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n/an/a 400n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM43434
PNG
(3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanili...)
Show SMILES COc1ccc(Nc2nc(cs2)C(=O)N2CCc3ccccc3C2)cc1
Show InChI InChI=1S/C20H19N3O2S/c1-25-17-8-6-16(7-9-17)21-20-22-18(13-26-20)19(24)23-11-10-14-4-2-3-5-15(14)12-23/h2-9,13H,10-12H2,1H3,(H,21,22)
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n/an/a 500n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439228
PNG
(CHEMBL2418822)
Show SMILES CC1CCN(CC1)C(=O)c1csc(Nc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C16H17ClFN3OS/c1-10-4-6-21(7-5-10)15(22)14-9-23-16(20-14)19-13-3-2-11(17)8-12(13)18/h2-3,8-10H,4-7H2,1H3,(H,19,20)
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n/an/a 630n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439226
PNG
(CHEMBL2418824)
Show SMILES CC1CCCCN1C(=O)c1csc(Nc2ccc(C)cc2)n1
Show InChI InChI=1S/C17H21N3OS/c1-12-6-8-14(9-7-12)18-17-19-15(11-22-17)16(21)20-10-4-3-5-13(20)2/h6-9,11,13H,3-5,10H2,1-2H3,(H,18,19)
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n/an/a 630n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439231
PNG
(CHEMBL2418819)
Show SMILES CC1CCN(CC1)C(=O)c1csc(Nc2ccc(Cl)cc2)n1
Show InChI InChI=1S/C16H18ClN3OS/c1-11-6-8-20(9-7-11)15(21)14-10-22-16(19-14)18-13-4-2-12(17)3-5-13/h2-5,10-11H,6-9H2,1H3,(H,18,19)
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n/an/a 800n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439230
PNG
(CHEMBL2418820)
Show SMILES COc1ccc(Nc2nc(cs2)C(=O)N2CCC(C)CC2)cc1
Show InChI InChI=1S/C17H21N3O2S/c1-12-7-9-20(10-8-12)16(21)15-11-23-17(19-15)18-13-3-5-14(22-2)6-4-13/h3-6,11-12H,7-10H2,1-2H3,(H,18,19)
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n/an/a 800n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439212
PNG
(CHEMBL2418816)
Show SMILES CC1N(CCc2ncccc12)C(=O)c1nc(Nc2ccc3OCOc3c2)sc1C
Show InChI InChI=1S/C21H20N4O3S/c1-12-15-4-3-8-22-16(15)7-9-25(12)20(26)19-13(2)29-21(24-19)23-14-5-6-17-18(10-14)28-11-27-17/h3-6,8,10,12H,7,9,11H2,1-2H3,(H,23,24)
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n/an/a 1.26E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439216
PNG
(CHEMBL2418812)
Show SMILES C[C@@H]1CCCN([C@@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C
Show InChI InChI=1S/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439223
PNG
(CHEMBL2418804)
Show SMILES COc1ccc(Nc2nc(cs2)C(=O)N2CCC(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H23N3O2S/c1-27-19-9-7-18(8-10-19)23-22-24-20(15-28-22)21(26)25-13-11-17(12-14-25)16-5-3-2-4-6-16/h2-10,15,17H,11-14H2,1H3,(H,23,24)
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n/an/a 1.60E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439229
PNG
(CHEMBL2418821)
Show SMILES CC1CCN(CC1)C(=O)c1csc(Nc2ccccc2Cl)n1
Show InChI InChI=1S/C16H18ClN3OS/c1-11-6-8-20(9-7-11)15(21)14-10-22-16(19-14)18-13-5-3-2-4-12(13)17/h2-5,10-11H,6-9H2,1H3,(H,18,19)
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n/an/a 3.16E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439222
PNG
(CHEMBL2418805)
Show SMILES Cc1ccc(Nc2nc(cs2)C(=O)N2CCC(CC2)C2CCCCC2)cc1
Show InChI InChI=1S/C22H29N3OS/c1-16-7-9-19(10-8-16)23-22-24-20(15-27-22)21(26)25-13-11-18(12-14-25)17-5-3-2-4-6-17/h7-10,15,17-18H,2-6,11-14H2,1H3,(H,23,24)
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n/an/a 4.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439211
PNG
(CHEMBL2418817)
Show SMILES Cc1sc(Nc2ccc(Cl)cc2F)nc1C(=O)N1CCc2ncccc2C1
Show InChI InChI=1S/C19H16ClFN4OS/c1-11-17(18(26)25-8-6-15-12(10-25)3-2-7-22-15)24-19(27-11)23-16-5-4-13(20)9-14(16)21/h2-5,7,9H,6,8,10H2,1H3,(H,23,24)
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n/an/a 6.30E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


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More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439225
PNG
(CHEMBL2418825)
Show SMILES Cc1ccc(Nc2nc(cs2)C(=O)N2CCCCC2c2ccccc2)cc1
Show InChI InChI=1S/C22H23N3OS/c1-16-10-12-18(13-11-16)23-22-24-19(15-27-22)21(26)25-14-6-5-9-20(25)17-7-3-2-4-8-17/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,23,24)
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n/an/a 1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens)
BDBM50439224
PNG
(CHEMBL2417565)
Show SMILES Cc1ccc(Nc2nc(cs2)C(=O)N2CCCC(C2)c2ccccc2)cc1
Show InChI InChI=1S/C22H23N3OS/c1-16-9-11-19(12-10-16)23-22-24-20(15-27-22)21(26)25-13-5-8-18(14-25)17-6-3-2-4-7-17/h2-4,6-7,9-12,15,18H,5,8,13-14H2,1H3,(H,23,24)
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UniProtKB/SwissProt

antibodypedia
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PC cid
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UniChem

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Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair