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Compile Data Set for Download or QSAR

Found 74 hits Enz. Inhib. hit(s) with Target = 'Signal transducer and activator of transcription 6' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50243934
PNG
(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2,3,6-triflu...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1c(F)cc(F)cc1F
Show InChI InChI=1S/C22H21F3N6O2/c23-13-9-18(24)16(19(25)10-13)11-27-21-17(20(26)32)12-28-22(30-21)29-14-1-3-15(4-2-14)31-5-7-33-8-6-31/h1-4,9-10,12H,5-8,11H2,(H2,26,32)(H2,27,28,29,30)
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n/an/a 0.700n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50304425
PNG
(2-(4-morpholinophenylamino)-4-(2,3,6-trifluorobenz...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1c(F)ccc(F)c1F
Show InChI InChI=1S/C22H21F3N6O2/c23-17-5-6-18(24)19(25)15(17)11-27-21-16(20(26)32)12-28-22(30-21)29-13-1-3-14(4-2-13)31-7-9-33-10-8-31/h1-6,12H,7-11H2,(H2,26,32)(H2,27,28,29,30)
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n/an/a 0.700n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244291
PNG
(4-[(2-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1ccccc1F
Show InChI InChI=1S/C22H23FN6O2/c23-19-4-2-1-3-15(19)13-25-21-18(20(24)30)14-26-22(28-21)27-16-5-7-17(8-6-16)29-9-11-31-12-10-29/h1-8,14H,9-13H2,(H2,24,30)(H2,25,26,27,28)
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n/an/a 1.40n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50243884
PNG
(4-[(2,5-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1cc(F)ccc1F
Show InChI InChI=1S/C22H22F2N6O2/c23-15-1-6-19(24)14(11-15)12-26-21-18(20(25)31)13-27-22(29-21)28-16-2-4-17(5-3-16)30-7-9-32-10-8-30/h1-6,11,13H,7-10,12H2,(H2,25,31)(H2,26,27,28,29)
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n/an/a 1.60n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244292
PNG
(4-[(3-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1cccc(F)c1
Show InChI InChI=1S/C22H23FN6O2/c23-16-3-1-2-15(12-16)13-25-21-19(20(24)30)14-26-22(28-21)27-17-4-6-18(7-5-17)29-8-10-31-11-9-29/h1-7,12,14H,8-11,13H2,(H2,24,30)(H2,25,26,27,28)
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n/an/a 1.80n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50243933
PNG
(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2,3,5-triflu...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1cc(F)cc(F)c1F
Show InChI InChI=1S/C22H21F3N6O2/c23-14-9-13(19(25)18(24)10-14)11-27-21-17(20(26)32)12-28-22(30-21)29-15-1-3-16(4-2-15)31-5-7-33-8-6-31/h1-4,9-10,12H,5-8,11H2,(H2,26,32)(H2,27,28,29,30)
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n/an/a 1.80n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50304429
PNG
(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)
Show SMILES NC(=O)CN1CCN(CC1)c1ccc(Nc2ncc3ccn(Cc4cc(F)cc(F)c4)c3n2)cc1
Show InChI InChI=1S/C25H25F2N7O/c26-19-11-17(12-20(27)13-19)15-34-6-5-18-14-29-25(31-24(18)34)30-21-1-3-22(4-2-21)33-9-7-32(8-10-33)16-23(28)35/h1-6,11-14H,7-10,15-16H2,(H2,28,35)(H,29,30,31)
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n/an/a 1.90n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50243882
PNG
(4-[(2,3-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1cccc(F)c1F
Show InChI InChI=1S/C22H22F2N6O2/c23-18-3-1-2-14(19(18)24)12-26-21-17(20(25)31)13-27-22(29-21)28-15-4-6-16(7-5-15)30-8-10-32-11-9-30/h1-7,13H,8-12H2,(H2,25,31)(H2,26,27,28,29)
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n/an/a 2.10n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50243885
PNG
(4-[(2,6-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1c(F)cccc1F
Show InChI InChI=1S/C22H22F2N6O2/c23-18-2-1-3-19(24)16(18)12-26-21-17(20(25)31)13-27-22(29-21)28-14-4-6-15(7-5-14)30-8-10-32-11-9-30/h1-7,13H,8-12H2,(H2,25,31)(H2,26,27,28,29)
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n/an/a 2.20n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50304433
PNG
(7-(3,5-Difluorobenzyl)-N-[4-(4-methylpiperazin-1-y...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ccn(Cc4cc(F)cc(F)c4)c3n2)cc1
Show InChI InChI=1S/C24H24F2N6/c1-30-8-10-31(11-9-30)22-4-2-21(3-5-22)28-24-27-15-18-6-7-32(23(18)29-24)16-17-12-19(25)14-20(26)13-17/h2-7,12-15H,8-11,16H2,1H3,(H,27,28,29)
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n/an/a 3.20n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50304428
PNG
(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)
Show SMILES CNC(=O)CN1CCN(CC1)c1ccc(Nc2ncc3ccn(Cc4cc(F)cc(F)c4)c3n2)cc1
Show InChI InChI=1S/C26H27F2N7O/c1-29-24(36)17-33-8-10-34(11-9-33)23-4-2-22(3-5-23)31-26-30-15-19-6-7-35(25(19)32-26)16-18-12-20(27)14-21(28)13-18/h2-7,12-15H,8-11,16-17H2,1H3,(H,29,36)(H,30,31,32)
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n/an/a 4.70n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50243932
PNG
(4-[(3,5-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1cc(F)cc(F)c1
Show InChI InChI=1S/C22H22F2N6O2/c23-15-9-14(10-16(24)11-15)12-26-21-19(20(25)31)13-27-22(29-21)28-17-1-3-18(4-2-17)30-5-7-32-8-6-30/h1-4,9-11,13H,5-8,12H2,(H2,25,31)(H2,26,27,28,29)
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n/an/a 5.5n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50304432
PNG
(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3ncn(Cc4cc(F)cc(F)c4)c3n2)cc1
Show InChI InChI=1S/C24H25F2N7O/c25-18-11-17(12-19(26)13-18)15-33-16-28-22-14-27-24(30-23(22)33)29-20-1-3-21(4-2-20)32-7-5-31(6-8-32)9-10-34/h1-4,11-14,16,34H,5-10,15H2,(H,27,29,30)
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n/an/a 5.60n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244256
PNG
(4-Benzylamino-2-{[4-(4-methylpiperazin-1-yl)phenyl...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NCc3ccccc3)n2)cc1
Show InChI InChI=1S/C23H27N7O/c1-29-11-13-30(14-12-29)19-9-7-18(8-10-19)27-23-26-16-20(21(24)31)22(28-23)25-15-17-5-3-2-4-6-17/h2-10,16H,11-15H2,1H3,(H2,24,31)(H2,25,26,27,28)
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n/an/a 6.20n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244258
PNG
(4-(benzylamino)-2-(4-morpholinophenylamino)pyrimid...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1ccccc1
Show InChI InChI=1S/C22H24N6O2/c23-20(29)19-15-25-22(27-21(19)24-14-16-4-2-1-3-5-16)26-17-6-8-18(9-7-17)28-10-12-30-13-11-28/h1-9,15H,10-14H2,(H2,23,29)(H2,24,25,26,27)
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n/an/a 6.5n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244258
PNG
(4-(benzylamino)-2-(4-morpholinophenylamino)pyrimid...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1ccccc1
Show InChI InChI=1S/C22H24N6O2/c23-20(29)19-15-25-22(27-21(19)24-14-16-4-2-1-3-5-16)26-17-6-8-18(9-7-17)28-10-12-30-13-11-28/h1-9,15H,10-14H2,(H2,23,29)(H2,24,25,26,27)
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n/an/a 6.5n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244257
PNG
(4-Benzylamino-2-[(4-piperazin-1-ylphenyl)amino]-py...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCNCC2)nc1NCc1ccccc1
Show InChI InChI=1S/C22H25N7O/c23-20(30)19-15-26-22(28-21(19)25-14-16-4-2-1-3-5-16)27-17-6-8-18(9-7-17)29-12-10-24-11-13-29/h1-9,15,24H,10-14H2,(H2,23,30)(H2,25,26,27,28)
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n/an/a 7n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244331
PNG
(4-[(2-Chlorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN6O2/c23-19-4-2-1-3-15(19)13-25-21-18(20(24)30)14-26-22(28-21)27-16-5-7-17(8-6-16)29-9-11-31-12-10-29/h1-8,14H,9-13H2,(H2,24,30)(H2,25,26,27,28)
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n/an/a 7.90n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244329
PNG
(4-[(2-Methoxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Show SMILES COc1ccccc1CNc1nc(Nc2ccc(cc2)N2CCOCC2)ncc1C(N)=O
Show InChI InChI=1S/C23H26N6O3/c1-31-20-5-3-2-4-16(20)14-25-22-19(21(24)30)15-26-23(28-22)27-17-6-8-18(9-7-17)29-10-12-32-13-11-29/h2-9,15H,10-14H2,1H3,(H2,24,30)(H2,25,26,27,28)
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n/an/a 8.20n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244294
PNG
(4-[(2-Methylbenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Show SMILES Cc1ccccc1CNc1nc(Nc2ccc(cc2)N2CCOCC2)ncc1C(N)=O
Show InChI InChI=1S/C23H26N6O2/c1-16-4-2-3-5-17(16)14-25-22-20(21(24)30)15-26-23(28-22)27-18-6-8-19(9-7-18)29-10-12-31-13-11-29/h2-9,15H,10-14H2,1H3,(H2,24,30)(H2,25,26,27,28)
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n/an/a 11n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50304434
PNG
(7-(3,5-Difluorobenzyl)-N-(4-piperazin-1-ylphenyl)-...)
Show SMILES Fc1cc(F)cc(Cn2ccc3cnc(Nc4ccc(cc4)N4CCNCC4)nc23)c1
Show InChI InChI=1S/C23H22F2N6/c24-18-11-16(12-19(25)13-18)15-31-8-5-17-14-27-23(29-22(17)31)28-20-1-3-21(4-2-20)30-9-6-26-7-10-30/h1-5,8,11-14,26H,6-7,9-10,15H2,(H,27,28,29)
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n/an/a 12n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244223
PNG
(4-Benzylamino-2-{[4-(4-hydroxypiperidin-1-yl)pheny...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCC(O)CC2)nc1NCc1ccccc1
Show InChI InChI=1S/C23H26N6O2/c24-21(31)20-15-26-23(28-22(20)25-14-16-4-2-1-3-5-16)27-17-6-8-18(9-7-17)29-12-10-19(30)11-13-29/h1-9,15,19,30H,10-14H2,(H2,24,31)(H2,25,26,27,28)
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n/an/a 16n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244259
PNG
(4-Benzylamino-2-{[4-(1-methylpiperidin-4-yl)phenyl...)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc(C(N)=O)c(NCc3ccccc3)n2)cc1
Show InChI InChI=1S/C24H28N6O/c1-30-13-11-19(12-14-30)18-7-9-20(10-8-18)28-24-27-16-21(22(25)31)23(29-24)26-15-17-5-3-2-4-6-17/h2-10,16,19H,11-15H2,1H3,(H2,25,31)(H2,26,27,28,29)
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n/an/a 17n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50243794
PNG
(4-[(3-Hydroxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1cccc(O)c1
Show InChI InChI=1S/C22H24N6O3/c23-20(30)19-14-25-22(27-21(19)24-13-15-2-1-3-18(29)12-15)26-16-4-6-17(7-5-16)28-8-10-31-11-9-28/h1-7,12,14,29H,8-11,13H2,(H2,23,30)(H2,24,25,26,27)
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n/an/a 19n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50197554
PNG
(2-(3-chloro-4-hydroxyphenethylamino)-4-(benzylamin...)
Show SMILES NC(=O)c1cnc(NCCc2ccc(O)c(Cl)c2)nc1NCc1ccccc1
Show InChI InChI=1S/C20H20ClN5O2/c21-16-10-13(6-7-17(16)27)8-9-23-20-25-12-15(18(22)28)19(26-20)24-11-14-4-2-1-3-5-14/h1-7,10,12,27H,8-9,11H2,(H2,22,28)(H2,23,24,25,26)
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n/an/a 21n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50197554
PNG
(2-(3-chloro-4-hydroxyphenethylamino)-4-(benzylamin...)
Show SMILES NC(=O)c1cnc(NCCc2ccc(O)c(Cl)c2)nc1NCc1ccccc1
Show InChI InChI=1S/C20H20ClN5O2/c21-16-10-13(6-7-17(16)27)8-9-23-20-25-12-15(18(22)28)19(26-20)24-11-14-4-2-1-3-5-14/h1-7,10,12,27H,8-9,11H2,(H2,22,28)(H2,23,24,25,26)
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n/an/a 21n/an/an/an/an/an/a



Astellas Pharm Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in human IL4-stimulated FW4 cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244330
PNG
(4-[(2-Hydroxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1ccccc1O
Show InChI InChI=1S/C22H24N6O3/c23-20(30)18-14-25-22(27-21(18)24-13-15-3-1-2-4-19(15)29)26-16-5-7-17(8-6-16)28-9-11-31-12-10-28/h1-8,14,29H,9-13H2,(H2,23,30)(H2,24,25,26,27)
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n/an/a 22n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244369
PNG
(4-{[2-(Methylsulfanyl)benzyl]amino}-2-[(4-morpholi...)
Show SMILES CSc1ccccc1CNc1nc(Nc2ccc(cc2)N2CCOCC2)ncc1C(N)=O
Show InChI InChI=1S/C23H26N6O2S/c1-32-20-5-3-2-4-16(20)14-25-22-19(21(24)30)15-26-23(28-22)27-17-6-8-18(9-7-17)29-10-12-31-13-11-29/h2-9,15H,10-14H2,1H3,(H2,24,30)(H2,25,26,27,28)
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n/an/a 23n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244332
PNG
(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2-trifluorom...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1ccccc1C(F)(F)F
Show InChI InChI=1S/C23H23F3N6O2/c24-23(25,26)19-4-2-1-3-15(19)13-28-21-18(20(27)33)14-29-22(31-21)30-16-5-7-17(8-6-16)32-9-11-34-12-10-32/h1-8,14H,9-13H2,(H2,27,33)(H2,28,29,30,31)
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n/an/a 25n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50243725
PNG
(4-[(3-Methoxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Show SMILES COc1cccc(CNc2nc(Nc3ccc(cc3)N3CCOCC3)ncc2C(N)=O)c1
Show InChI InChI=1S/C23H26N6O3/c1-31-19-4-2-3-16(13-19)14-25-22-20(21(24)30)15-26-23(28-22)27-17-5-7-18(8-6-17)29-9-11-32-12-10-29/h2-8,13,15H,9-12,14H2,1H3,(H2,24,30)(H2,25,26,27,28)
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n/an/a 25n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50304430
PNG
(CHEMBL595488 | [4-(4-{[7-(3,5-Difluorobenzyl)-7H-p...)
Show SMILES OC(=O)CN1CCN(CC1)c1ccc(Nc2ncc3ccn(Cc4cc(F)cc(F)c4)c3n2)cc1
Show InChI InChI=1S/C25H24F2N6O2/c26-19-11-17(12-20(27)13-19)15-33-6-5-18-14-28-25(30-24(18)33)29-21-1-3-22(4-2-21)32-9-7-31(8-10-32)16-23(34)35/h1-6,11-14H,7-10,15-16H2,(H,34,35)(H,28,29,30)
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n/an/a 26n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50370949
PNG
(CHEMBL226930)
Show SMILES CNC(=O)c1cnc(NCCc2ccc(O)c(Cl)c2)nc1NCc1ccccc1
Show InChI InChI=1S/C21H22ClN5O2/c1-23-20(29)16-13-26-21(24-10-9-14-7-8-18(28)17(22)11-14)27-19(16)25-12-15-5-3-2-4-6-15/h2-8,11,13,28H,9-10,12H2,1H3,(H,23,29)(H2,24,25,26,27)
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n/an/a 30n/an/an/an/an/an/a



Astellas Pharm Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in human IL4-stimulated FW4 cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50304431
PNG
(CHEMBL594821 | N-{4-[4-(2-Aminoethyl)piperazin-1-y...)
Show SMILES NCCN1CCN(CC1)c1ccc(Nc2ncc3ccn(Cc4cc(F)cc(F)c4)c3n2)cc1
Show InChI InChI=1S/C25H27F2N7/c26-20-13-18(14-21(27)15-20)17-34-7-5-19-16-29-25(31-24(19)34)30-22-1-3-23(4-2-22)33-11-9-32(8-6-28)10-12-33/h1-5,7,13-16H,6,8-12,17,28H2,(H,29,30,31)
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n/an/a 34n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50243723
PNG
(4-[(3-Chlorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1cccc(Cl)c1
Show InChI InChI=1S/C22H23ClN6O2/c23-16-3-1-2-15(12-16)13-25-21-19(20(24)30)14-26-22(28-21)27-17-4-6-18(7-5-17)29-8-10-31-11-9-29/h1-7,12,14H,8-11,13H2,(H2,24,30)(H2,25,26,27,28)
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n/an/a 36n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50304435
PNG
(7-(3-Fluorobenzyl)-N-(4-morpholin-4-ylphenyl)-7Hpy...)
Show SMILES Fc1cccc(Cn2ccc3cnc(Nc4ccc(cc4)N4CCOCC4)nc23)c1
Show InChI InChI=1S/C23H22FN5O/c24-19-3-1-2-17(14-19)16-29-9-8-18-15-25-23(27-22(18)29)26-20-4-6-21(7-5-20)28-10-12-30-13-11-28/h1-9,14-15H,10-13,16H2,(H,25,26,27)
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n/an/a 37n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244366
PNG
(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2-nitrobenzy...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C22H23N7O4/c23-20(30)18-14-25-22(26-16-5-7-17(8-6-16)28-9-11-33-12-10-28)27-21(18)24-13-15-3-1-2-4-19(15)29(31)32/h1-8,14H,9-13H2,(H2,23,30)(H2,24,25,26,27)
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n/an/a 38n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50370952
PNG
(CHEMBL228018)
Show SMILES Cc1cccc(Nc2nc(NCCc3ccc(O)c(Cl)c3)ncc2C(N)=O)c1
Show InChI InChI=1S/C20H20ClN5O2/c1-12-3-2-4-14(9-12)25-19-15(18(22)28)11-24-20(26-19)23-8-7-13-5-6-17(27)16(21)10-13/h2-6,9-11,27H,7-8H2,1H3,(H2,22,28)(H2,23,24,25,26)
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n/an/a 45n/an/an/an/an/an/a



Astellas Pharm Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in human IL4-stimulated FW4 cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244189
PNG
(4-(Benzylamino)-2-{[2-(3,5-dichloro-4-hydroxypheny...)
Show SMILES NC(=O)c1cnc(NCCc2cc(Cl)c(O)c(Cl)c2)nc1NCc1ccccc1
Show InChI InChI=1S/C20H19Cl2N5O2/c21-15-8-13(9-16(22)17(15)28)6-7-24-20-26-11-14(18(23)29)19(27-20)25-10-12-4-2-1-3-5-12/h1-5,8-9,11,28H,6-7,10H2,(H2,23,29)(H2,24,25,26,27)
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n/an/a 61n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50370950
PNG
(CHEMBL387668)
Show SMILES Cc1cccc(Nc2nc(NCCc3ccc(O)c(F)c3)ncc2C(N)=O)c1
Show InChI InChI=1S/C20H20FN5O2/c1-12-3-2-4-14(9-12)25-19-15(18(22)28)11-24-20(26-19)23-8-7-13-5-6-17(27)16(21)10-13/h2-6,9-11,27H,7-8H2,1H3,(H2,22,28)(H2,23,24,25,26)
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n/an/a 64n/an/an/an/an/an/a



Astellas Pharm Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in human IL4-stimulated FW4 cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244191
PNG
(4-Benzylamino-2-{[4-(3-hydroxypropyl)phenyl]amino}...)
Show SMILES NC(=O)c1cnc(Nc2ccc(CCCO)cc2)nc1NCc1ccccc1
Show InChI InChI=1S/C21H23N5O2/c22-19(28)18-14-24-21(25-17-10-8-15(9-11-17)7-4-12-27)26-20(18)23-13-16-5-2-1-3-6-16/h1-3,5-6,8-11,14,27H,4,7,12-13H2,(H2,22,28)(H2,23,24,25,26)
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n/an/a 81n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50370956
PNG
(CHEMBL389647)
Show SMILES Cc1cccc(Nc2nc(NCCc3ccc(O)c(Br)c3)ncc2C(N)=O)c1
Show InChI InChI=1S/C20H20BrN5O2/c1-12-3-2-4-14(9-12)25-19-15(18(22)28)11-24-20(26-19)23-8-7-13-5-6-17(27)16(21)10-13/h2-6,9-11,27H,7-8H2,1H3,(H2,22,28)(H2,23,24,25,26)
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n/an/a 83n/an/an/an/an/an/a



Astellas Pharm Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in human IL4-stimulated FW4 cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50243934
PNG
(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2,3,6-triflu...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1c(F)cc(F)cc1F
Show InChI InChI=1S/C22H21F3N6O2/c23-13-9-18(24)16(19(25)10-13)11-27-21-17(20(26)32)12-28-22(30-21)29-14-1-3-15(4-2-14)31-5-7-33-8-6-31/h1-4,9-10,12H,5-8,11H2,(H2,26,32)(H2,27,28,29,30)
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n/an/a 88n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50197567
PNG
(2-(4-hydroxyphenethylamino)-4-(benzylamino)pyrimid...)
Show SMILES NC(=O)c1cnc(NCCc2ccc(O)cc2)nc1NCc1ccccc1
Show InChI InChI=1S/C20H21N5O2/c21-18(27)17-13-24-20(22-11-10-14-6-8-16(26)9-7-14)25-19(17)23-12-15-4-2-1-3-5-15/h1-9,13,26H,10-12H2,(H2,21,27)(H2,22,23,24,25)
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n/an/a 88n/an/an/an/an/an/a



Astellas Pharm Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in human IL4-stimulated FW4 cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50197567
PNG
(2-(4-hydroxyphenethylamino)-4-(benzylamino)pyrimid...)
Show SMILES NC(=O)c1cnc(NCCc2ccc(O)cc2)nc1NCc1ccccc1
Show InChI InChI=1S/C20H21N5O2/c21-18(27)17-13-24-20(22-11-10-14-6-8-16(26)9-7-14)25-19(17)23-12-15-4-2-1-3-5-15/h1-9,13,26H,10-12H2,(H2,21,27)(H2,22,23,24,25)
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n/an/a 88n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244190
PNG
(4-Benzylamino-2-{[4-(2-hydroxyethyl)phenyl]amino}p...)
Show SMILES NC(=O)c1cnc(Nc2ccc(CCO)cc2)nc1NCc1ccccc1
Show InChI InChI=1S/C20H21N5O2/c21-18(27)17-13-23-20(24-16-8-6-14(7-9-16)10-11-26)25-19(17)22-12-15-4-2-1-3-5-15/h1-9,13,26H,10-12H2,(H2,21,27)(H2,22,23,24,25)
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n/an/a 95n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244222
PNG
(4-(Benzylamino)-2-{[4-(3-hydroxypyrrolidine-1-yl)p...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCC(O)C2)nc1NCc1ccccc1
Show InChI InChI=1S/C22H24N6O2/c23-20(30)19-13-25-22(27-21(19)24-12-15-4-2-1-3-5-15)26-16-6-8-17(9-7-16)28-11-10-18(29)14-28/h1-9,13,18,29H,10-12,14H2,(H2,23,30)(H2,24,25,26,27)
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n/an/a 98n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50370951
PNG
(CHEMBL427436)
Show SMILES NC(=O)c1cnc(NCCc2ccc(O)cc2)nc1NC1CCCCC1
Show InChI InChI=1S/C19H25N5O2/c20-17(26)16-12-22-19(21-11-10-13-6-8-15(25)9-7-13)24-18(16)23-14-4-2-1-3-5-14/h6-9,12,14,25H,1-5,10-11H2,(H2,20,26)(H2,21,22,23,24)
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n/an/a 100n/an/an/an/an/an/a



Astellas Pharm Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in human IL4-stimulated FW4 cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50304436
PNG
(7-(3,5-Difluorobenzyl)-N-(4-morpholin-4-ylphenyl)-...)
Show SMILES Fc1cc(F)cc(Cn2ccc3cnc(Nc4ccc(cc4)N4CCOCC4)nc23)c1
Show InChI InChI=1S/C23H21F2N5O/c24-18-11-16(12-19(25)13-18)15-30-6-5-17-14-26-23(28-22(17)30)27-20-1-3-21(4-2-20)29-7-9-31-10-8-29/h1-6,11-14H,7-10,15H2,(H,26,27,28)
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n/an/a 120n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50244225
PNG
(4-Benzylamino-2-[(4-piperidin-1-ylphenyl)amino]pyr...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCCCC2)nc1NCc1ccccc1
Show InChI InChI=1S/C23H26N6O/c24-21(30)20-16-26-23(28-22(20)25-15-17-7-3-1-4-8-17)27-18-9-11-19(12-10-18)29-13-5-2-6-14-29/h1,3-4,7-12,16H,2,5-6,13-15H2,(H2,24,30)(H2,25,26,27,28)
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n/an/a 120n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 6


(Homo sapiens)
BDBM50243724
PNG
(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(3-trifluorom...)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N6O2/c24-23(25,26)16-3-1-2-15(12-16)13-28-21-19(20(27)33)14-29-22(31-21)30-17-4-6-18(7-5-17)32-8-10-34-11-9-32/h1-7,12,14H,8-11,13H2,(H2,27,33)(H2,28,29,30,31)
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n/an/a 130n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells


Citation and Details
More data for this
Ligand-Target Pair
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