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Compile Data Set for Download or QSAR

Found 320 hits Enz. Inhib. hit(s) with Target = 'Similar to alpha-tubulin isoform 1' AND taxid = 9913   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50156464
PNG
(CHEMBL3793652)
Show SMILES COc1ccc(cc1O)-c1nnc2n(C)c(=O)c3ccccc3n12
Show InChI InChI=1S/C17H14N4O3/c1-20-16(23)11-5-3-4-6-12(11)21-15(18-19-17(20)21)10-7-8-14(24-2)13(22)9-10/h3-9,22H,1-2H3
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n/an/a 150n/an/an/an/an/an/a



Universit£ de Lille

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization after 1 hr by fluorescence spectrometry


Eur J Med Chem 115: 393-405 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.056
BindingDB Entry DOI: 10.7270/Q2RN39RQ
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50145077
PNG
(CHEMBL3764535)
Show SMILES O=C(c1[nH]c2[nH]c(CCCC#C)nc(=O)c2c1-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H19N3O2/c1-2-3-6-15-18-25-23-20(24(29)26-18)19(16-11-7-4-8-12-16)21(27-23)22(28)17-13-9-5-10-14-17/h1,4-5,7-14H,3,6,15H2,(H2,25,26,27,29)
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n/an/a 250n/an/an/an/an/an/a



Texas State University

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin assembly after 15 mins by turbidimetric analysis


J Med Chem 59: 480-5 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01426
BindingDB Entry DOI: 10.7270/Q2PV6N7Q
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50212990
PNG
(CHEMBL59709)
Show SMILES CCC1CN2CC(C[C@@](C(=O)OC)(c3[nH]c4ccccc4c3CC2)c2cc3c(cc2OC)N(C)C2C33CCN4CC=CC(CC)(C34)C(OC(C)=O)[C@]2(O)C(=O)OC)[C@H]1C(C)(C)C
Show InChI InChI=1S/C50H66N4O8/c1-11-30-27-53-22-18-33-32-16-13-14-17-36(32)51-40(33)49(44(56)60-9,26-31(28-53)39(30)46(4,5)6)35-24-34-37(25-38(35)59-8)52(7)42-48(34)20-23-54-21-15-19-47(12-2,41(48)54)43(62-29(3)55)50(42,58)45(57)61-10/h13-17,19,24-25,30-31,39,41-43,51,58H,11-12,18,20-23,26-28H2,1-10H3/t30?,31?,39-,41?,42?,43?,47?,48?,49-,50-/m0/s1
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n/an/a 400n/an/an/an/an/an/a


TBA

Assay Description
In vitro inhibitory activity against bovine brain tubulin assembly at a concentration of 3-3.5 mg/ml


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50212990
PNG
(CHEMBL59709)
Show SMILES CCC1CN2CC(C[C@@](C(=O)OC)(c3[nH]c4ccccc4c3CC2)c2cc3c(cc2OC)N(C)C2C33CCN4CC=CC(CC)(C34)C(OC(C)=O)[C@]2(O)C(=O)OC)[C@H]1C(C)(C)C
Show InChI InChI=1S/C50H66N4O8/c1-11-30-27-53-22-18-33-32-16-13-14-17-36(32)51-40(33)49(44(56)60-9,26-31(28-53)39(30)46(4,5)6)35-24-34-37(25-38(35)59-8)52(7)42-48(34)20-23-54-21-15-19-47(12-2,41(48)54)43(62-29(3)55)50(42,58)45(57)61-10/h13-17,19,24-25,30-31,39,41-43,51,58H,11-12,18,20-23,26-28H2,1-10H3/t30?,31?,39-,41?,42?,43?,47?,48?,49-,50-/m0/s1
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n/an/a 400n/an/an/an/an/an/a


TBA

Assay Description
In vitro inhibitory activity against bovine brain tubulin assembly at a concentration of 3-3.5 mg/ml


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50078205
PNG
(CHEMBL3414643)
Show SMILES COc1ccc2\C(=C/c3cc(OC)c(OC)c(OC)c3)[C@@H](O)CCc2c1
Show InChI InChI=1S/C21H24O5/c1-23-15-6-7-16-14(12-15)5-8-18(22)17(16)9-13-10-19(24-2)21(26-4)20(11-13)25-3/h6-7,9-12,18,22H,5,8H2,1-4H3/b17-9+/t18-/m0/s1
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n/an/a 410n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 60 mins by microplate reader based turbidimetry


J Med Chem 58: 2538-46 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00118
BindingDB Entry DOI: 10.7270/Q24M966N
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 440n/an/an/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetry


Eur J Med Chem 84: 476-90 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.050
BindingDB Entry DOI: 10.7270/Q2VH5QGD
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50212992
PNG
(CHEMBL60543)
Show SMILES CCC1CN2CC(C[C@@](C(=O)OC)(c3[nH]c4ccccc4c3CC2)c2cc3c(cc2OC)N(C)C2C33CCN4CC=CC(CC)(C34)C(OC(C)=O)[C@]2(O)C(=O)OC)[C@H]1c1ccccc1
Show InChI InChI=1S/C52H62N4O8/c1-8-32-29-55-24-20-36-35-18-13-14-19-39(35)53-43(36)51(47(58)62-6,28-34(30-55)42(32)33-16-11-10-12-17-33)38-26-37-40(27-41(38)61-5)54(4)45-50(37)22-25-56-23-15-21-49(9-2,44(50)56)46(64-31(3)57)52(45,60)48(59)63-7/h10-19,21,26-27,32,34,42,44-46,53,60H,8-9,20,22-25,28-30H2,1-7H3/t32?,34?,42-,44?,45?,46?,49?,50?,51+,52+/m1/s1
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TBA

Assay Description
In vitro inhibitory activity against bovine brain tubulin assembly at a concentration of 3-3.5 mg/ml


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50012278
PNG
((2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLAS...)
Show SMILES CC[C@]1(O)C[C@@H]2CN(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
Show InChI InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



Special Design and Construction Bureau SDCB"Technolog"

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization by turbidity assay


Eur J Med Chem 94: 237-51 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.051
BindingDB Entry DOI: 10.7270/Q2FN17XK
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50212992
PNG
(CHEMBL60543)
Show SMILES CCC1CN2CC(C[C@@](C(=O)OC)(c3[nH]c4ccccc4c3CC2)c2cc3c(cc2OC)N(C)C2C33CCN4CC=CC(CC)(C34)C(OC(C)=O)[C@]2(O)C(=O)OC)[C@H]1c1ccccc1
Show InChI InChI=1S/C52H62N4O8/c1-8-32-29-55-24-20-36-35-18-13-14-19-39(35)53-43(36)51(47(58)62-6,28-34(30-55)42(32)33-16-11-10-12-17-33)38-26-37-40(27-41(38)61-5)54(4)45-50(37)22-25-56-23-15-21-49(9-2,44(50)56)46(64-31(3)57)52(45,60)48(59)63-7/h10-19,21,26-27,32,34,42,44-46,53,60H,8-9,20,22-25,28-30H2,1-7H3/t32?,34?,42-,44?,45?,46?,49?,50?,51+,52+/m1/s1
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TBA

Assay Description
In vitro inhibitory activity against bovine brain tubulin assembly at a concentration of 3-3.5 mg/ml


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50147584
PNG
(CHEMBL2022434)
Show SMILES COc1ccc2C(=CCCc2c1N)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C20H23NO4/c1-22-16-9-8-14-13(6-5-7-15(14)19(16)21)12-10-17(23-2)20(25-4)18(11-12)24-3/h6,8-11H,5,7,21H2,1-4H3
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n/an/a 620n/an/an/an/an/an/a



Baylor University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization preincubated for 15 mins by spectrophotometric analysis


Bioorg Med Chem 24: 938-56 (2016)


Article DOI: 10.1016/j.bmc.2016.01.007
BindingDB Entry DOI: 10.7270/Q24Q7WVQ
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 650n/an/an/an/an/an/a



Texas State University

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin assembly after 15 mins by turbidimetric analysis


J Med Chem 59: 480-5 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01426
BindingDB Entry DOI: 10.7270/Q2PV6N7Q
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 680n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method


Bioorg Med Chem 22: 4285-92 (2014)


Article DOI: 10.1016/j.bmc.2014.05.029
BindingDB Entry DOI: 10.7270/Q21Z462G
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50009561
PNG
((E)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol | 2...)
Show SMILES COc1ccc(\C=C\c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5+
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n/an/a 680n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Eur J Med Chem 93: 291-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.018
BindingDB Entry DOI: 10.7270/Q208670J
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50051065
PNG
(CHEMBL3318073)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)n1nc(Nc2ccc(C)cc2)nc1N
Show InChI InChI=1S/C19H21N5O4/c1-11-5-7-13(8-6-11)21-19-22-18(20)24(23-19)17(25)12-9-14(26-2)16(28-4)15(10-12)27-3/h5-10H,1-4H3,(H3,20,21,22,23)
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n/an/a 750n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by turbidimetry


J Med Chem 57: 6795-808 (2014)


Article DOI: 10.1021/jm5008193
BindingDB Entry DOI: 10.7270/Q26111Z5
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50035218
PNG
(CHEMBL61 | PODOFILOX | Podophyllinic acid lactone ...)
Show SMILES COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12
Show InChI InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
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n/an/a 810n/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization measured for 1 hr at 1 min intervals by fluorescence assay


Bioorg Med Chem Lett 24: 3356-60 (2014)


Article DOI: 10.1016/j.bmcl.2014.05.096
BindingDB Entry DOI: 10.7270/Q2X068PJ
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50035218
PNG
(CHEMBL61 | PODOFILOX | Podophyllinic acid lactone ...)
Show SMILES COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12
Show InChI InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
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n/an/a 830n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by fluorescence analysis


Bioorg Med Chem 22: 5466-75 (2014)


Article DOI: 10.1016/j.bmc.2014.07.031
BindingDB Entry DOI: 10.7270/Q25D8TH0
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50046752
PNG
(CHEMBL3309648)
Show SMILES COc1ccc(F)c(c1)C1C2=C(COC2=O)Nc2c1c1cccnc1c1ncccc21
Show InChI InChI=1S/C24H16FN3O3/c1-30-12-6-7-16(25)15(10-12)18-19-13-4-2-8-26-22(13)23-14(5-3-9-27-23)21(19)28-17-11-31-24(29)20(17)18/h2-10,18,28H,11H2,1H3
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n/an/a 830n/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization measured for 1 hr at 1 min intervals by fluorescence assay


Bioorg Med Chem Lett 24: 3356-60 (2014)


Article DOI: 10.1016/j.bmcl.2014.05.096
BindingDB Entry DOI: 10.7270/Q2X068PJ
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50058381
PNG
(CHEMBL3334927)
Show SMILES COC(=O)[C@@H]1[C@H](c2cc(OC)c(OC)c(OC)c2)c2cc3OCOc3cc2C=C1c1nc2ccc(Br)cc2[nH]1
Show InChI InChI=1S/C29H25BrN2O7/c1-34-23-9-15(10-24(35-2)27(23)36-3)25-17-12-22-21(38-13-39-22)8-14(17)7-18(26(25)29(33)37-4)28-31-19-6-5-16(30)11-20(19)32-28/h5-12,25-26H,13H2,1-4H3,(H,31,32)/t25-,26+/m1/s1
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n/an/a 860n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by fluorescence analysis


Bioorg Med Chem 22: 5466-75 (2014)


Article DOI: 10.1016/j.bmc.2014.07.031
BindingDB Entry DOI: 10.7270/Q25D8TH0
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50058412
PNG
(CHEMBL3334928)
Show SMILES COC(=O)[C@@H]1[C@H](c2cc(OC)c(OC)c(OC)c2)c2cc3OCOc3cc2C=C1c1nc2ccc(OC)cc2[nH]1
Show InChI InChI=1S/C30H28N2O8/c1-34-17-6-7-20-21(12-17)32-29(31-20)19-8-15-9-22-23(40-14-39-22)13-18(15)26(27(19)30(33)38-5)16-10-24(35-2)28(37-4)25(11-16)36-3/h6-13,26-27H,14H2,1-5H3,(H,31,32)/t26-,27+/m1/s1
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n/an/a 910n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by fluorescence analysis


Bioorg Med Chem 22: 5466-75 (2014)


Article DOI: 10.1016/j.bmc.2014.07.031
BindingDB Entry DOI: 10.7270/Q25D8TH0
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50046812
PNG
(CHEMBL3309649)
Show SMILES Fc1ccc(cc1F)C1C2=C(COC2=O)Nc2c1c1cccnc1c1ncccc21
Show InChI InChI=1S/C23H13F2N3O2/c24-14-6-5-11(9-15(14)25)17-18-12-3-1-7-26-21(12)22-13(4-2-8-27-22)20(18)28-16-10-30-23(29)19(16)17/h1-9,17,28H,10H2
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n/an/a 920n/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization measured for 1 hr at 1 min intervals by fluorescence assay


Bioorg Med Chem Lett 24: 3356-60 (2014)


Article DOI: 10.1016/j.bmcl.2014.05.096
BindingDB Entry DOI: 10.7270/Q2X068PJ
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50045474
PNG
(CHEMBL3310106)
Show SMILES Oc1ccc(\C=C\C(=O)N2CCN(CC2)C(c2ccccc2)c2ccccc2)cc1O
Show InChI InChI=1S/C26H26N2O3/c29-23-13-11-20(19-24(23)30)12-14-25(31)27-15-17-28(18-16-27)26(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-14,19,26,29-30H,15-18H2/b14-12+
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n/an/a 920n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method


Bioorg Med Chem 22: 4285-92 (2014)


Article DOI: 10.1016/j.bmc.2014.05.029
BindingDB Entry DOI: 10.7270/Q21Z462G
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 1.00E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assembly


Bioorg Med Chem 23: 2408-23 (2015)


Article DOI: 10.1016/j.bmc.2015.03.061
BindingDB Entry DOI: 10.7270/Q2765H1D
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50156812
PNG
(PHENSTATIN)
Show SMILES COc1ccc(cc1O)C(=O)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C17H18O6/c1-20-13-6-5-10(7-12(13)18)16(19)11-8-14(21-2)17(23-4)15(9-11)22-3/h5-9,18H,1-4H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization preincubated for 30 mins followed by GTP addition measured after 20 mins by spectrophotometric method


Bioorg Med Chem 24: 2307-17 (2016)


Article DOI: 10.1016/j.bmc.2016.04.001
BindingDB Entry DOI: 10.7270/Q2KW5HX2
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50147362
PNG
(CHEMBL330407 | ST-3100)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1N
Show InChI InChI=1S/C18H21NO4/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11H,19H2,1-4H3/b6-5-
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n/an/a 1.00E+3n/an/an/an/an/an/a



Pharmaceutical Research Laboratories, Ajinomoto Co. Inc., Kawasaki, Japan.

Curated by ChEMBL


Assay Description
Tubulin polymerization inhibitory activity using bovine brain tubulin


Bioorg Med Chem Lett 8: 3153-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00579-4
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50215149
PNG
(CHEMBL108634)
Show SMILES COc1ccc(cc1N)-c1sc(N)nc1-c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C19H21N3O4S/c1-23-13-6-5-10(7-12(13)20)18-16(22-19(21)27-18)11-8-14(24-2)17(26-4)15(9-11)25-3/h5-9H,20H2,1-4H3,(H2,21,22)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Pharmaceutical Research Laboratories, Ajinomoto Co. Inc., Kawasaki, Japan.

Curated by ChEMBL


Assay Description
Tubulin polymerization inhibitory activity using bovine brain tubulin


Bioorg Med Chem Lett 8: 3153-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00579-4
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073397
PNG
(CHEMBL3408700)
Show SMILES FC(F)(F)c1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C19H13BrF3N3O/c20-15-8-4-13(5-9-15)16-11-17(26-25-16)24-18(27)10-3-12-1-6-14(7-2-12)19(21,22)23/h1-11H,(H2,24,25,26,27)/b10-3+
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n/an/a 1.02E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Eur J Med Chem 93: 291-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.018
BindingDB Entry DOI: 10.7270/Q208670J
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073397
PNG
(CHEMBL3408700)
Show SMILES FC(F)(F)c1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C19H13BrF3N3O/c20-15-8-4-13(5-9-15)16-11-17(26-25-16)24-18(27)10-3-12-1-6-14(7-2-12)19(21,22)23/h1-11H,(H2,24,25,26,27)/b10-3+
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n/an/a 1.02E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Eur J Med Chem 93: 291-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.018
BindingDB Entry DOI: 10.7270/Q208670J
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50069096
PNG
(CHEMBL3403517)
Show SMILES COc1ccc2N(CCCc2c1)c1nc(C)nc2oc(C)cc12
Show InChI InChI=1S/C18H19N3O2/c1-11-9-15-17(19-12(2)20-18(15)23-11)21-8-4-5-13-10-14(22-3)6-7-16(13)21/h6-7,9-10H,4-5,8H2,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assembly


Bioorg Med Chem 23: 2408-23 (2015)


Article DOI: 10.1016/j.bmc.2015.03.061
BindingDB Entry DOI: 10.7270/Q2765H1D
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50084938
PNG
(CHEMBL3427378)
Show SMILES COC(=O)c1oc2cc(OC)ccc2c1Nc1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C20H21NO7/c1-23-12-6-7-13-14(10-12)28-19(20(22)27-5)17(13)21-11-8-15(24-2)18(26-4)16(9-11)25-3/h6-10,21H,1-5H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assembly after 20 mins incubation by spectrophotometric analysis


J Med Chem 58: 3209-22 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00155
BindingDB Entry DOI: 10.7270/Q2QV3P6V
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 1.10E+3n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assembly after 20 mins incubation by spectrophotometric analysis


J Med Chem 58: 3209-22 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00155
BindingDB Entry DOI: 10.7270/Q2QV3P6V
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50135180
PNG
(CHEMBL3746143)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)c1sc2c(C)cccc2c1NC(=O)CI
Show InChI InChI=1S/C21H20INO5S/c1-11-6-5-7-13-17(23-16(24)10-22)21(29-20(11)13)18(25)12-8-14(26-2)19(28-4)15(9-12)27-3/h5-9H,10H2,1-4H3,(H,23,24)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by spectrophotometry


Eur J Med Chem 108: 39-52 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.022
BindingDB Entry DOI: 10.7270/Q2PN97GZ
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50147364
PNG
(CHEMBL217041)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)c(N)c1
Show InChI InChI=1S/C18H21NO4/c1-20-14-8-7-13(15(19)11-14)6-5-12-9-16(21-2)18(23-4)17(10-12)22-3/h5-11H,19H2,1-4H3/b6-5-
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n/an/a 1.10E+3n/an/an/an/an/an/a



Baylor University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization preincubated for 15 mins by spectrophotometric analysis


Bioorg Med Chem 24: 938-56 (2016)


Article DOI: 10.1016/j.bmc.2016.01.007
BindingDB Entry DOI: 10.7270/Q24Q7WVQ
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetry


Eur J Med Chem 84: 476-90 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.050
BindingDB Entry DOI: 10.7270/Q2VH5QGD
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50051067
PNG
(CHEMBL3318075)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)n1nc(Nc2ccc(C)c(C)c2)nc1N
Show InChI InChI=1S/C20H23N5O4/c1-11-6-7-14(8-12(11)2)22-20-23-19(21)25(24-20)18(26)13-9-15(27-3)17(29-5)16(10-13)28-4/h6-10H,1-5H3,(H3,21,22,23,24)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by turbidimetry


J Med Chem 57: 6795-808 (2014)


Article DOI: 10.1021/jm5008193
BindingDB Entry DOI: 10.7270/Q26111Z5
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 1.20E+3n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by turbidimetry


J Med Chem 57: 6795-808 (2014)


Article DOI: 10.1021/jm5008193
BindingDB Entry DOI: 10.7270/Q26111Z5
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 1.20E+3n/an/an/an/an/an/a



Baylor University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization preincubated for 15 mins by spectrophotometric analysis


Bioorg Med Chem 24: 938-56 (2016)


Article DOI: 10.1016/j.bmc.2016.01.007
BindingDB Entry DOI: 10.7270/Q24Q7WVQ
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50147362
PNG
(CHEMBL330407 | ST-3100)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1N
Show InChI InChI=1S/C18H21NO4/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11H,19H2,1-4H3/b6-5-
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n/an/a 1.20E+3n/an/an/an/an/an/a



Baylor University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization preincubated for 15 mins by spectrophotometric analysis


Bioorg Med Chem 24: 938-56 (2016)


Article DOI: 10.1016/j.bmc.2016.01.007
BindingDB Entry DOI: 10.7270/Q24Q7WVQ
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 1.20E+3n/an/an/an/an/an/a



Guru Nanak Dev University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization preincubated for 15 mins followed by GTP addition measured after 20 mins by spectrophotometric meth...


Eur J Med Chem 116: 102-115 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.050
BindingDB Entry DOI: 10.7270/Q29S1SWW
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073396
PNG
(CHEMBL3408699)
Show SMILES [O-][N+](=O)c1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C18H13BrN4O3/c19-14-6-4-13(5-7-14)16-11-17(22-21-16)20-18(24)10-3-12-1-8-15(9-2-12)23(25)26/h1-11H,(H2,20,21,22,24)/b10-3+
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n/an/a 1.24E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Eur J Med Chem 93: 291-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.018
BindingDB Entry DOI: 10.7270/Q208670J
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073396
PNG
(CHEMBL3408699)
Show SMILES [O-][N+](=O)c1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C18H13BrN4O3/c19-14-6-4-13(5-7-14)16-11-17(22-21-16)20-18(24)10-3-12-1-8-15(9-2-12)23(25)26/h1-11H,(H2,20,21,22,24)/b10-3+
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n/an/a 1.24E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Eur J Med Chem 93: 291-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.018
BindingDB Entry DOI: 10.7270/Q208670J
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50058371
PNG
(CHEMBL3334924)
Show SMILES COC(=O)[C@@H]1[C@H](c2cc(OC)c(OC)c(OC)c2)c2cc3OCOc3cc2C=C1c1nc2ccccc2[nH]1
Show InChI InChI=1S/C29H26N2O7/c1-33-23-11-16(12-24(34-2)27(23)35-3)25-17-13-22-21(37-14-38-22)10-15(17)9-18(26(25)29(32)36-4)28-30-19-7-5-6-8-20(19)31-28/h5-13,25-26H,14H2,1-4H3,(H,30,31)/t25-,26+/m1/s1
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n/an/a 1.29E+3n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by fluorescence analysis


Bioorg Med Chem 22: 5466-75 (2014)


Article DOI: 10.1016/j.bmc.2014.07.031
BindingDB Entry DOI: 10.7270/Q25D8TH0
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50147588
PNG
(CHEMBL3087395)
Show SMILES COc1ccc2c(CCCC=C2c2cc(OC)c(OC)c(OC)c2)c1N
Show InChI InChI=1S/C21H25NO4/c1-23-17-10-9-15-14(7-5-6-8-16(15)20(17)22)13-11-18(24-2)21(26-4)19(12-13)25-3/h7,9-12H,5-6,8,22H2,1-4H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Baylor University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization preincubated for 15 mins by spectrophotometric analysis


Bioorg Med Chem 24: 938-56 (2016)


Article DOI: 10.1016/j.bmc.2016.01.007
BindingDB Entry DOI: 10.7270/Q24Q7WVQ
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50212991
PNG
(CHEMBL305587)
Show SMILES CCC1CN2CC(C[C@@](C(=O)OC)(c3[nH]c4ccccc4c3CC2)c2cc3c(cc2OC)N(C)C2C33CCN4CC=CC(CC)(C34)C(OC(C)=O)[C@]2(O)C(=O)OC)[C@H]1CC
Show InChI InChI=1S/C48H62N4O8/c1-9-29-26-51-21-17-33-32-15-12-13-16-36(32)49-39(33)47(43(54)58-7,25-30(27-51)31(29)10-2)35-23-34-37(24-38(35)57-6)50(5)41-46(34)19-22-52-20-14-18-45(11-3,40(46)52)42(60-28(4)53)48(41,56)44(55)59-8/h12-16,18,23-24,29-31,40-42,49,56H,9-11,17,19-22,25-27H2,1-8H3/t29?,30?,31-,40?,41?,42?,45?,46?,47-,48-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a


TBA

Assay Description
In vitro inhibitory activity against bovine brain tubulin assembly at a concentration of 3-3.5 mg/ml


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50014846
PNG
((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Show SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
Show InChI InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
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n/an/a 1.34E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method


Bioorg Med Chem 22: 4285-92 (2014)


Article DOI: 10.1016/j.bmc.2014.05.029
BindingDB Entry DOI: 10.7270/Q21Z462G
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073387
PNG
(CHEMBL3408692)
Show SMILES FC(F)(F)c1ccc(\C=C/C(=O)Nc2cc([nH]n2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H14F3N3O/c20-19(21,22)15-9-6-13(7-10-15)8-11-18(26)23-17-12-16(24-25-17)14-4-2-1-3-5-14/h1-12H,(H2,23,24,25,26)/b11-8-
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n/an/a 1.34E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Eur J Med Chem 93: 291-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.018
BindingDB Entry DOI: 10.7270/Q208670J
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50014846
PNG
((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Show SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
Show InChI InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
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n/an/a 1.34E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Eur J Med Chem 93: 291-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.018
BindingDB Entry DOI: 10.7270/Q208670J
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073387
PNG
(CHEMBL3408692)
Show SMILES FC(F)(F)c1ccc(\C=C/C(=O)Nc2cc([nH]n2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H14F3N3O/c20-19(21,22)15-9-6-13(7-10-15)8-11-18(26)23-17-12-16(24-25-17)14-4-2-1-3-5-14/h1-12H,(H2,23,24,25,26)/b11-8-
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n/an/a 1.34E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Eur J Med Chem 93: 291-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.018
BindingDB Entry DOI: 10.7270/Q208670J
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073402
PNG
(CHEMBL3408705)
Show SMILES COc1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C19H16BrN3O2/c1-25-16-9-2-13(3-10-16)4-11-19(24)21-18-12-17(22-23-18)14-5-7-15(20)8-6-14/h2-12H,1H3,(H2,21,22,23,24)/b11-4+
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n/an/a 1.35E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Eur J Med Chem 93: 291-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.018
BindingDB Entry DOI: 10.7270/Q208670J
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073402
PNG
(CHEMBL3408705)
Show SMILES COc1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C19H16BrN3O2/c1-25-16-9-2-13(3-10-16)4-11-19(24)21-18-12-17(22-23-18)14-5-7-15(20)8-6-14/h2-12H,1H3,(H2,21,22,23,24)/b11-4+
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n/an/a 1.35E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Eur J Med Chem 93: 291-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.018
BindingDB Entry DOI: 10.7270/Q208670J
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50051068
PNG
(CHEMBL3318076)
Show SMILES CCc1ccc(Nc2nc(N)n(n2)C(=O)c2cc(OC)c(OC)c(OC)c2)cc1
Show InChI InChI=1S/C20H23N5O4/c1-5-12-6-8-14(9-7-12)22-20-23-19(21)25(24-20)18(26)13-10-15(27-2)17(29-4)16(11-13)28-3/h6-11H,5H2,1-4H3,(H3,21,22,23,24)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by turbidimetry


J Med Chem 57: 6795-808 (2014)


Article DOI: 10.1021/jm5008193
BindingDB Entry DOI: 10.7270/Q26111Z5
More data for this
Ligand-Target Pair
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