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Compile Data Set for Download or QSAR

Found 214 hits Enz. Inhib. hit(s) with Target = 'Similar to alpha-tubulin isoform 1' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50078205
PNG
(CHEMBL3414643)
Show SMILES COc1ccc2\C(=C/c3cc(OC)c(OC)c(OC)c3)[C@@H](O)CCc2c1
Show InChI InChI=1/C21H24O5/c1-23-15-6-7-16-14(12-15)5-8-18(22)17(16)9-13-10-19(24-2)21(26-4)20(11-13)25-3/h6-7,9-12,18,22H,5,8H2,1-4H3/b17-9+/t18-/s2
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n/an/a 410n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 60 mins by microplate reader based turbidimetry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 440n/an/an/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50012278
PNG
((2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLAS...)
Show SMILES CC[C@]1(O)C[C@@H]2CN(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
Show InChI InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



Special Design and Construction Bureau SDCB"Technolog"

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization by turbidity assay


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50009561
PNG
((E)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol | 2...)
Show SMILES COc1ccc(\C=C\c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5+
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n/an/a 680n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 680n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50051065
PNG
(CHEMBL3318073)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)n1nc(Nc2ccc(C)cc2)nc1N
Show InChI InChI=1S/C19H21N5O4/c1-11-5-7-13(8-6-11)21-19-22-18(20)24(23-19)17(25)12-9-14(26-2)16(28-4)15(10-12)27-3/h5-10H,1-4H3,(H3,20,21,22,23)
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n/an/a 750n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by turbidimetry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50035218
PNG
(CHEMBL61 | PODOFILOX | Podophyllinic acid lactone ...)
Show SMILES COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12
Show InChI InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
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n/an/a 810n/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization measured for 1 hr at 1 min intervals by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50035218
PNG
(CHEMBL61 | PODOFILOX | Podophyllinic acid lactone ...)
Show SMILES COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12
Show InChI InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
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n/an/a 830n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50046752
PNG
(CHEMBL3309648)
Show SMILES COc1ccc(F)c(c1)C1C2=C(COC2=O)Nc2c1c1cccnc1c1ncccc21
Show InChI InChI=1/C24H16FN3O3/c1-30-12-6-7-16(25)15(10-12)18-19-13-4-2-8-26-22(13)23-14(5-3-9-27-23)21(19)28-17-11-31-24(29)20(17)18/h2-10,18,28H,11H2,1H3
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n/an/a 830n/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization measured for 1 hr at 1 min intervals by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50058381
PNG
(CHEMBL3334927)
Show SMILES COC(=O)[C@@H]1[C@H](c2cc(OC)c(OC)c(OC)c2)c2cc3OCOc3cc2C=C1c1nc2ccc(Br)cc2[nH]1
Show InChI InChI=1/C29H25BrN2O7/c1-34-23-9-15(10-24(35-2)27(23)36-3)25-17-12-22-21(38-13-39-22)8-14(17)7-18(26(25)29(33)37-4)28-31-19-6-5-16(30)11-20(19)32-28/h5-12,25-26H,13H2,1-4H3,(H,31,32)/t25-,26+/s2
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n/an/a 860n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50058412
PNG
(CHEMBL3334928)
Show SMILES COC(=O)[C@@H]1[C@H](c2cc(OC)c(OC)c(OC)c2)c2cc3OCOc3cc2C=C1c1nc2ccc(OC)cc2[nH]1
Show InChI InChI=1/C30H28N2O8/c1-34-17-6-7-20-21(12-17)32-29(31-20)19-8-15-9-22-23(40-14-39-22)13-18(15)26(27(19)30(33)38-5)16-10-24(35-2)28(37-4)25(11-16)36-3/h6-13,26-27H,14H2,1-5H3,(H,31,32)/t26-,27+/s2
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n/an/a 910n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50046812
PNG
(CHEMBL3309649)
Show SMILES Fc1ccc(cc1F)C1C2=C(COC2=O)Nc2c1c1cccnc1c1ncccc21
Show InChI InChI=1/C23H13F2N3O2/c24-14-6-5-11(9-15(14)25)17-18-12-3-1-7-26-21(12)22-13(4-2-8-27-22)20(18)28-16-10-30-23(29)19(16)17/h1-9,17,28H,10H2
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n/an/a 920n/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization measured for 1 hr at 1 min intervals by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50045474
PNG
(CHEMBL3310106)
Show SMILES Oc1ccc(\C=C\C(=O)N2CCN(CC2)C(c2ccccc2)c2ccccc2)cc1O
Show InChI InChI=1S/C26H26N2O3/c29-23-13-11-20(19-24(23)30)12-14-25(31)27-15-17-28(18-16-27)26(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-14,19,26,29-30H,15-18H2/b14-12+
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n/an/a 920n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 1.00E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assembly


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073397
PNG
(CHEMBL3408700)
Show SMILES FC(F)(F)c1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C19H13BrF3N3O/c20-15-8-4-13(5-9-15)16-11-17(26-25-16)24-18(27)10-3-12-1-6-14(7-2-12)19(21,22)23/h1-11H,(H2,24,25,26,27)/b10-3+
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n/an/a 1.02E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073397
PNG
(CHEMBL3408700)
Show SMILES FC(F)(F)c1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C19H13BrF3N3O/c20-15-8-4-13(5-9-15)16-11-17(26-25-16)24-18(27)10-3-12-1-6-14(7-2-12)19(21,22)23/h1-11H,(H2,24,25,26,27)/b10-3+
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n/an/a 1.02E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50069096
PNG
(CHEMBL3403517)
Show SMILES COc1ccc2N(CCCc2c1)c1nc(C)nc2oc(C)cc12
Show InChI InChI=1S/C18H19N3O2/c1-11-9-15-17(19-12(2)20-18(15)23-11)21-8-4-5-13-10-14(22-3)6-7-16(13)21/h6-7,9-10H,4-5,8H2,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assembly


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50084938
PNG
(CHEMBL3427378)
Show SMILES COC(=O)c1oc2cc(OC)ccc2c1Nc1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C20H21NO7/c1-23-12-6-7-13-14(10-12)28-19(20(22)27-5)17(13)21-11-8-15(24-2)18(26-4)16(9-11)25-3/h6-10,21H,1-5H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assembly after 20 mins incubation by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 1.10E+3n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assembly after 20 mins incubation by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50051067
PNG
(CHEMBL3318075)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)n1nc(Nc2ccc(C)c(C)c2)nc1N
Show InChI InChI=1S/C20H23N5O4/c1-11-6-7-14(8-12(11)2)22-20-23-19(21)25(24-20)18(26)13-9-15(27-3)17(29-5)16(10-13)28-4/h6-10H,1-5H3,(H3,21,22,23,24)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by turbidimetry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 1.20E+3n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by turbidimetry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073396
PNG
(CHEMBL3408699)
Show SMILES [O-][N+](=O)c1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C18H13BrN4O3/c19-14-6-4-13(5-7-14)16-11-17(22-21-16)20-18(24)10-3-12-1-8-15(9-2-12)23(25)26/h1-11H,(H2,20,21,22,24)/b10-3+
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n/an/a 1.24E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073396
PNG
(CHEMBL3408699)
Show SMILES [O-][N+](=O)c1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C18H13BrN4O3/c19-14-6-4-13(5-7-14)16-11-17(22-21-16)20-18(24)10-3-12-1-8-15(9-2-12)23(25)26/h1-11H,(H2,20,21,22,24)/b10-3+
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n/an/a 1.24E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50058371
PNG
(CHEMBL3334924)
Show SMILES COC(=O)[C@@H]1[C@H](c2cc(OC)c(OC)c(OC)c2)c2cc3OCOc3cc2C=C1c1nc2ccccc2[nH]1
Show InChI InChI=1/C29H26N2O7/c1-33-23-11-16(12-24(34-2)27(23)35-3)25-17-13-22-21(37-14-38-22)10-15(17)9-18(26(25)29(32)36-4)28-30-19-7-5-6-8-20(19)31-28/h5-13,25-26H,14H2,1-4H3,(H,30,31)/t25-,26+/s2
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n/an/a 1.29E+3n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50014846
PNG
((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Show SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
Show InChI InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
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n/an/a 1.34E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073387
PNG
(CHEMBL3408692)
Show SMILES FC(F)(F)c1ccc(\C=C/C(=O)Nc2cc([nH]n2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H14F3N3O/c20-19(21,22)15-9-6-13(7-10-15)8-11-18(26)23-17-12-16(24-25-17)14-4-2-1-3-5-14/h1-12H,(H2,23,24,25,26)/b11-8-
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n/an/a 1.34E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50014846
PNG
((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Show SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
Show InChI InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
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n/an/a 1.34E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073387
PNG
(CHEMBL3408692)
Show SMILES FC(F)(F)c1ccc(\C=C/C(=O)Nc2cc([nH]n2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H14F3N3O/c20-19(21,22)15-9-6-13(7-10-15)8-11-18(26)23-17-12-16(24-25-17)14-4-2-1-3-5-14/h1-12H,(H2,23,24,25,26)/b11-8-
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n/an/a 1.34E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073402
PNG
(CHEMBL3408705)
Show SMILES COc1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C19H16BrN3O2/c1-25-16-9-2-13(3-10-16)4-11-19(24)21-18-12-17(22-23-18)14-5-7-15(20)8-6-14/h2-12H,1H3,(H2,21,22,23,24)/b11-4+
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n/an/a 1.35E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073402
PNG
(CHEMBL3408705)
Show SMILES COc1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C19H16BrN3O2/c1-25-16-9-2-13(3-10-16)4-11-19(24)21-18-12-17(22-23-18)14-5-7-15(20)8-6-14/h2-12H,1H3,(H2,21,22,23,24)/b11-4+
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n/an/a 1.35E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50051068
PNG
(CHEMBL3318076)
Show SMILES CCc1ccc(Nc2nc(N)n(n2)C(=O)c2cc(OC)c(OC)c(OC)c2)cc1
Show InChI InChI=1S/C20H23N5O4/c1-5-12-6-8-14(9-7-12)22-20-23-19(21)25(24-20)18(26)13-10-15(27-2)17(29-4)16(11-13)28-3/h6-11H,5H2,1-4H3,(H3,21,22,23,24)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization by turbidimetry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50045476
PNG
(CHEMBL3310108)
Show SMILES Oc1ccc(\C=C\C(=O)N2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)cc1O
Show InChI InChI=1S/C26H24F2N2O3/c27-21-7-3-19(4-8-21)26(20-5-9-22(28)10-6-20)30-15-13-29(14-16-30)25(33)12-2-18-1-11-23(31)24(32)17-18/h1-12,17,26,31-32H,13-16H2/b12-2+
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n/an/a 1.44E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50084939
PNG
(CHEMBL3427379)
Show SMILES CCOC(=O)c1oc2cc(OC)ccc2c1Nc1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C21H23NO7/c1-6-28-21(23)20-18(14-8-7-13(24-2)11-15(14)29-20)22-12-9-16(25-3)19(27-5)17(10-12)26-4/h7-11,22H,6H2,1-5H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin assembly after 20 mins incubation by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073446
PNG
(CHEMBL3408708)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)\C=C\c2ccc(cc2)C(F)(F)F)n[nH]1
Show InChI InChI=1S/C20H16F3N3O/c1-13-2-7-15(8-3-13)17-12-18(26-25-17)24-19(27)11-6-14-4-9-16(10-5-14)20(21,22)23/h2-12H,1H3,(H2,24,25,26,27)/b11-6+
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n/an/a 1.53E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073446
PNG
(CHEMBL3408708)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)\C=C\c2ccc(cc2)C(F)(F)F)n[nH]1
Show InChI InChI=1S/C20H16F3N3O/c1-13-2-7-15(8-3-13)17-12-18(26-25-17)24-19(27)11-6-14-4-9-16(10-5-14)20(21,22)23/h2-12H,1H3,(H2,24,25,26,27)/b11-6+
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n/an/a 1.53E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073386
PNG
(CHEMBL3408691)
Show SMILES [O-][N+](=O)c1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccccc2)cc1
Show InChI InChI=1S/C18H14N4O3/c23-18(11-8-13-6-9-15(10-7-13)22(24)25)19-17-12-16(20-21-17)14-4-2-1-3-5-14/h1-12H,(H2,19,20,21,23)/b11-8+
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n/an/a 1.56E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073386
PNG
(CHEMBL3408691)
Show SMILES [O-][N+](=O)c1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccccc2)cc1
Show InChI InChI=1S/C18H14N4O3/c23-18(11-8-13-6-9-15(10-7-13)22(24)25)19-17-12-16(20-21-17)14-4-2-1-3-5-14/h1-12H,(H2,19,20,21,23)/b11-8+
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n/an/a 1.56E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50045475
PNG
(CHEMBL3310107)
Show SMILES Oc1ccc(\C=C\C(=O)N2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)cc1O
Show InChI InChI=1/C26H25ClN2O3/c27-22-10-8-21(9-11-22)26(20-4-2-1-3-5-20)29-16-14-28(15-17-29)25(32)13-7-19-6-12-23(30)24(31)18-19/h1-13,18,26,30-31H,14-17H2/b13-7+
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n/an/a 1.56E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073404
PNG
(CHEMBL3408707)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)\C=C\c2ccc(cc2)[N+]([O-])=O)n[nH]1
Show InChI InChI=1S/C19H16N4O3/c1-13-2-7-15(8-3-13)17-12-18(22-21-17)20-19(24)11-6-14-4-9-16(10-5-14)23(25)26/h2-12H,1H3,(H2,20,21,22,24)/b11-6+
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n/an/a 1.62E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073404
PNG
(CHEMBL3408707)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)\C=C\c2ccc(cc2)[N+]([O-])=O)n[nH]1
Show InChI InChI=1S/C19H16N4O3/c1-13-2-7-15(8-3-13)17-12-18(22-21-17)20-19(24)11-6-14-4-9-16(10-5-14)23(25)26/h2-12H,1H3,(H2,20,21,22,24)/b11-6+
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n/an/a 1.62E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073394
PNG
(CHEMBL3408697)
Show SMILES COc1ccc(\C=C/C(=O)Nc2cc([nH]n2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H17N3O2/c1-24-16-10-7-14(8-11-16)9-12-19(23)20-18-13-17(21-22-18)15-5-3-2-4-6-15/h2-13H,1H3,(H2,20,21,22,23)/b12-9-
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n/an/a 1.64E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073394
PNG
(CHEMBL3408697)
Show SMILES COc1ccc(\C=C/C(=O)Nc2cc([nH]n2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H17N3O2/c1-24-16-10-7-14(8-11-16)9-12-19(23)20-18-13-17(21-22-18)15-5-3-2-4-6-15/h2-13H,1H3,(H2,20,21,22,23)/b12-9-
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n/an/a 1.64E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50045463
PNG
(CHEMBL3309815)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C20H22N2O4/c1-26-19-5-3-2-4-16(19)21-10-12-22(13-11-21)20(25)9-7-15-6-8-17(23)18(24)14-15/h2-9,14,23-24H,10-13H2,1H3/b9-7+
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n/an/a 1.72E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50045307
PNG
(CHEMBL3311089)
Show SMILES COc1ccc(cc1OC)C(=O)Nc1nnc(\C=C\c2cc(OC)c(OC)c(OC)c2Br)s1
Show InChI InChI=1S/C22H22BrN3O6S/c1-28-14-8-6-13(11-15(14)29-2)21(27)24-22-26-25-17(33-22)9-7-12-10-16(30-3)19(31-4)20(32-5)18(12)23/h6-11H,1-5H3,(H,24,26,27)/b9-7+
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n/an/a 1.73E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073506
PNG
(CHEMBL3408713)
Show SMILES COc1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(C)cc2)cc1
Show InChI InChI=1S/C20H19N3O2/c1-14-3-8-16(9-4-14)18-13-19(23-22-18)21-20(24)12-7-15-5-10-17(25-2)11-6-15/h3-13H,1-2H3,(H2,21,22,23,24)/b12-7+
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n/an/a 1.76E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073506
PNG
(CHEMBL3408713)
Show SMILES COc1ccc(\C=C\C(=O)Nc2cc([nH]n2)-c2ccc(C)cc2)cc1
Show InChI InChI=1S/C20H19N3O2/c1-14-3-8-16(9-4-14)18-13-19(23-22-18)21-20(24)12-7-15-5-10-17(25-2)11-6-15/h3-13H,1-2H3,(H2,21,22,23,24)/b12-7+
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n/an/a 1.76E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 1.77E+3n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 60 mins by microplate reader based turbidimetry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073399
PNG
(CHEMBL3408702)
Show SMILES Fc1ccc(\C=C/C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C18H13BrFN3O/c19-14-6-4-13(5-7-14)16-11-17(23-22-16)21-18(24)10-3-12-1-8-15(20)9-2-12/h1-11H,(H2,21,22,23,24)/b10-3-
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n/an/a 1.78E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50073399
PNG
(CHEMBL3408702)
Show SMILES Fc1ccc(\C=C/C(=O)Nc2cc([nH]n2)-c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C18H13BrFN3O/c19-14-6-4-13(5-7-14)16-11-17(23-22-16)21-18(24)10-3-12-1-8-15(20)9-2-12/h1-11H,(H2,21,22,23,24)/b10-3-
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n/an/a 1.78E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometry


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Ligand-Target Pair
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