BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 82 hits Enz. Inhib. hit(s) with Target = 'Small conductance calcium-activated potassium channel' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50092131
PNG
(1,7-diazonia-15,21-diazapentacyclo[20.6.2.27,14.08...)
Show SMILES C1CCN[c+]2ccn(CCCCCn3cc[c+](NCC1)c1ccccc31)c1ccccc21
Show InChI InChI=1S/C28H34N4/c1-7-17-29-25-15-21-31(27-13-5-3-11-23(25)27)19-9-2-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h3-6,11-16,21-22,29-30H,1-2,7-10,17-20H2/q+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
1.40n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50061977
PNG
(17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...)
Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21
Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.80n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50048403
PNG
(1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...)
Show SMILES Cc1cc(=[NH2+])c2ccccc2n1CCCCCCCCCCn1c(C)cc(=[NH2+])c2ccccc12
Show InChI InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
140n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50199404
PNG
(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)
Show SMILES COc1ccc(C[C@H]2c3cc(OC)c(OC)cc3CC[N+]2(C)C)cc1OC
Show InChI InChI=1S/C22H30NO4/c1-23(2)10-9-16-13-21(26-5)22(27-6)14-17(16)18(23)11-15-7-8-19(24-3)20(12-15)25-4/h7-8,12-14,18H,9-11H2,1-6H3/q+1/t18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
1.50E+3n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50377980
PNG
(CHEMBL558625)
Show SMILES C[N+]1(C)CCc2cc3OCOc3cc2[C@H]1[C@@H]1OC(=O)c2c1ccc1OCOc21
Show InChI InChI=1S/C21H20NO6/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3/q+1/t18-,19+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
4.40E+3n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM92478
PNG
(Atracurium besylate | CHEMBL1360)
Show SMILES COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC
Show InChI InChI=1S/C53H72N2O12/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3/q+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
5.90E+3n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50366799
PNG
(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Show SMILES COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c23)cc7)N(C)CCc6cc5OC)c4
Show InChI InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

DrugBank
KEGG
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
9.20E+3n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(RAT)
BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Pudue Pharma Discovery Research

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50377979
PNG
(PENUCURONIUM)
Show SMILES CC(=O)O[C@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@H](OC(C)=O)[C@@]4(C)CC[C@@H]3[C@@]2(C)C[C@@H]1[N+]1(C)CCCCC1)[N+]1(C)CCCCC1
Show InChI InChI=1S/C36H62N2O4/c1-25(39)41-33-23-27-13-14-28-29-15-16-31(37(5)19-9-7-10-20-37)34(42-26(2)40)35(29,3)18-17-30(28)36(27,4)24-32(33)38(6)21-11-8-12-22-38/h27-34H,7-24H2,1-6H3/q+2/t27-,28-,29-,30-,31-,32-,33-,34-,35-,36-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
1.60E+4n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275183
PNG
(1-ethyl-1H-benzo[d]imidazol-2(3H)-one | CHEMBL4528...)
Show SMILES CCn1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

AffyNet 
PDB
Article
PubMed
>5.00E+4n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50263331
PNG
((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Show SMILES C1C[C@@H](Nc2nc3ccccc3[nH]2)c2ccccc2C1
Show InChI InChI=1S/C17H17N3/c1-2-8-13-12(6-1)7-5-11-14(13)18-17-19-15-9-3-4-10-16(15)20-17/h1-4,6,8-10,14H,5,7,11H2,(H2,18,19,20)/t14-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
>5.00E+4n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275157
PNG
(CHEMBL453730 | N-cyclohexyl-2-(3,5-dimethyl-1H-pyr...)
Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(NC2CCCCC2)n1
Show InChI InChI=1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
>5.00E+4n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275184
PNG
(6,7-dichloro-3-(hydroxyimino)indolin-2-one | CHEMB...)
Show SMILES Clc1ccc2C(N=O)C(=O)Nc2c1Cl
Show InChI InChI=1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,7H,(H,11,13)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
>5.00E+4n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(RAT)
BDBM50260153
PNG
(Apamin | CHEMBL525408 | Octadecapeptide venom)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)[C@@H](C)O
Show InChI InChI=1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)/t36-,37-,38-,39+,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,59-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.0240n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat SK Calcium channel


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50084848
PNG
(BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinolini...)
Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(Cc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21
Show InChI InChI=1S/C43H48N4/c1-2-4-6-12-28-45-41-26-30-47(43-16-10-8-14-39(41)43)33-37-23-19-35(20-24-37)31-34-17-21-36(22-18-34)32-46-29-25-40(44-27-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-26,29-30,44-45H,1-6,11-12,27-28,31-33H2/q+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
n/an/a 80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215069
PNG
(1,2,3-tris-[3-(4-(N-ethyl)-quinoliniumylamino)-pro...)
Show SMILES CCn1cc\c(=[NH+]\CCCOc2cccc(OCCCNc3cc[n+](CC)c4ccccc34)c2OCCC\[NH+]=c2/ccn(CC)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C48H54N6O3/c1-4-52-31-25-40(37-17-7-10-20-43(37)52)49-28-14-34-55-46-23-13-24-47(56-35-15-29-50-41-26-32-53(5-2)44-21-11-8-18-38(41)44)48(46)57-36-16-30-51-42-27-33-54(6-3)45-22-12-9-19-39(42)45/h7-13,17-27,31-33H,4-6,14-16,28-30,34-36H2,1-3H3/p+3/b49-40-,51-42+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 86n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50289333
PNG
(21,35-diazonia-2,13-diazaoctacyclo[33.6.2.214,21.1...)
Show SMILES C1c2cc3Cn4cc[c+](NCCCCCCCCCCN[c+]5ccn(Cc6ccc(c1c6)-c2cc3)c1ccccc51)c1ccccc41
Show InChI InChI=1S/C43H46N4/c1-2-4-6-12-24-45-41-22-26-47(43-16-10-8-14-39(41)43)31-33-18-20-37-35(28-33)29-34-27-32(17-19-36(34)37)30-46-25-21-40(44-23-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-22,25-28,44-45H,1-6,11-12,23-24,29-31H2/q+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215071
PNG
(CHEMBL375272 | N-[3-(4-quinolinylamino)-propyl]-N-...)
Show SMILES C(CCNc1ccnc2ccccc12)CCN(CCCNc1ccnc2ccccc12)c1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1
Show InChI InChI=1S/C56H59N9O2/c1(10-27-57-53-23-31-61-49-19-6-2-15-45(49)53)11-35-65(36-12-28-58-54-24-32-62-50-20-7-3-16-46(50)54)42-39-43(66-37-13-29-59-55-25-33-63-51-21-8-4-17-47(51)55)41-44(40-42)67-38-14-30-60-56-26-34-64-52-22-9-5-18-48(52)56/h2-9,15-26,31-34,39-41H,1,10-14,27-30,35-38H2,(H,57,61)(H,58,62)(H,59,63)(H,60,64)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 93n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50084852
PNG
(1,14-diazonia-22,33-diazaheptacyclo[32.6.2.214,21....)
Show SMILES C1CCCCCN[c+]2ccn(Cc3cccc(c3)-c3cccc(Cn4cc[c+](NCCCC1)c1ccccc41)c3)c1ccccc21
Show InChI InChI=1S/C42H46N4/c1-2-4-6-12-26-44-40-24-28-46(42-22-10-8-20-38(40)42)32-34-16-14-18-36(30-34)35-17-13-15-33(29-35)31-45-27-23-39(43-25-11-5-3-1)37-19-7-9-21-41(37)45/h7-10,13-24,27-30,43-44H,1-6,11-12,25-26,31-32H2/q+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 110n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215076
PNG
(CHEMBL229982 | N-[3-(4-quinolinylamino)-propyl]-N-...)
Show SMILES C(CCNc1ccnc2ccccc12)CCN(CCCNc1ccnc2ccccc12)Cc1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1
Show InChI InChI=1S/C57H61N9O2/c1(10-27-58-54-23-31-62-50-19-6-2-15-46(50)54)11-35-66(36-12-28-59-55-24-32-63-51-20-7-3-16-47(51)55)42-43-39-44(67-37-13-29-60-56-25-33-64-52-21-8-4-17-48(52)56)41-45(40-43)68-38-14-30-61-57-26-34-65-53-22-9-5-18-49(53)57/h2-9,15-26,31-34,39-41H,1,10-14,27-30,35-38,42H2,(H,58,62)(H,59,63)(H,60,64)(H,61,65)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 130n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215070
PNG
(1,2,3-tri[3-(4-quinolinylamino)-propoxy]-benzene |...)
Show SMILES C(CNc1ccnc2ccccc12)COc1cccc(OCCCNc2ccnc3ccccc23)c1OCCCNc1ccnc2ccccc12
Show InChI InChI=1S/C42H42N6O3/c1-4-14-34-31(11-1)37(19-25-46-34)43-22-8-28-49-40-17-7-18-41(50-29-9-23-44-38-20-26-47-35-15-5-2-12-32(35)38)42(40)51-30-10-24-45-39-21-27-48-36-16-6-3-13-33(36)39/h1-7,11-21,25-27H,8-10,22-24,28-30H2,(H,43,46)(H,44,47)(H,45,48)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 130n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50084849
PNG
(Bis-quinolinium cyclophane analogue | CHEMBL258254...)
Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(cc3)\C=C/c3ccc(Cn4cc[c+](NCCCC1)c1ccccc41)cc3)c1ccccc21
Show InChI InChI=1S/C44H48N4/c1-2-4-6-12-30-46-42-28-32-48(44-16-10-8-14-40(42)44)34-38-25-21-36(22-26-38)18-17-35-19-23-37(24-20-35)33-47-31-27-41(45-29-11-5-3-1)39-13-7-9-15-43(39)47/h7-10,13-28,31-32,45-46H,1-6,11-12,29-30,33-34H2/q+2/b18-17-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 150n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50084839
PNG
(Bis-quinolinium cyclophane analogue | CHEMBL6266 |...)
Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(cc3)-c3ccc(Cn4cc[c+](NCCCC1)c1ccccc41)cc3)c1ccccc21
Show InChI InChI=1S/C42H46N4/c1-2-4-6-12-28-44-40-26-30-46(42-16-10-8-14-38(40)42)32-34-19-23-36(24-20-34)35-21-17-33(18-22-35)31-45-29-25-39(43-27-11-5-3-1)37-13-7-9-15-41(37)45/h7-10,13-26,29-30,43-44H,1-6,11-12,27-28,31-32H2/q+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 170n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50084851
PNG
(Bis-quinolinium cyclophane analogue | CHEMBL266885...)
Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(CCc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21
Show InChI InChI=1S/C44H50N4/c1-2-4-6-12-30-46-42-28-32-48(44-16-10-8-14-40(42)44)34-38-25-21-36(22-26-38)18-17-35-19-23-37(24-20-35)33-47-31-27-41(45-29-11-5-3-1)39-13-7-9-15-43(39)47/h7-10,13-16,19-28,31-32,45-46H,1-6,11-12,17-18,29-30,33-34H2/q+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 180n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50054105
PNG
((Z)-1.1'-[stilbene-4,4'-diylbis(methylene)]bis(4-a...)
Show SMILES [NH2+]=c1ccn(Cc2ccc(\C=C/c3ccc(Cn4ccc(=[NH2+])c5ccccc45)cc3)cc2)c2ccccc12
Show InChI InChI=1S/C34H28N4/c35-31-19-21-37(33-7-3-1-5-29(31)33)23-27-15-11-25(12-16-27)9-10-26-13-17-28(18-14-26)24-38-22-20-32(36)30-6-2-4-8-34(30)38/h1-22,35-36H,23-24H2/p+2/b10-9-,35-31?,36-32?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 190n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215075
PNG
(CHEMBL229818 | N-[3-(4-quinolinylamino)-propyl]-3,...)
Show SMILES C(CNc1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1)CNc1ccnc2ccccc12
Show InChI InChI=1S/C42H43N7O2/c1-4-13-37-34(10-1)40(16-23-47-37)44-20-7-19-43-31-28-32(50-26-8-21-45-41-17-24-48-38-14-5-2-11-35(38)41)30-33(29-31)51-27-9-22-46-42-18-25-49-39-15-6-3-12-36(39)42/h1-6,10-18,23-25,28-30,43H,7-9,19-22,26-27H2,(H,44,47)(H,45,48)(H,46,49)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 220n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215072
PNG
(CHEMBL389273 | N-(4-quinolinyl)-3,4-di-[3-(4-quino...)
Show SMILES C(CNc1ccnc2ccccc12)COc1ccc(CCNc2ccnc3ccccc23)cc1OCCCNc1ccnc2ccccc12
Show InChI InChI=1S/C41H40N6O2/c1-4-12-34-31(9-1)37(18-24-45-34)42-21-7-27-48-40-16-15-30(17-23-44-39-20-26-47-36-14-6-3-11-33(36)39)29-41(40)49-28-8-22-43-38-19-25-46-35-13-5-2-10-32(35)38/h1-6,9-16,18-20,24-26,29H,7-8,17,21-23,27-28H2,(H,42,45)(H,43,46)(H,44,47)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 270n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50054098
PNG
(1,1'-[biphenyl-3,3'-diylbis(methylene)]-bis(4-amin...)
Show SMILES [NH2+]=c1ccn(Cc2cccc(c2)-c2cccc(Cn3ccc(=[NH2+])c4ccccc34)c2)c2ccccc12
Show InChI InChI=1S/C32H26N4/c33-29-15-17-35(31-13-3-1-11-27(29)31)21-23-7-5-9-25(19-23)26-10-6-8-24(20-26)22-36-18-16-30(34)28-12-2-4-14-32(28)36/h1-20,33-34H,21-22H2/p+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 290n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50084846
PNG
(1-[7-(4-amino-1-quinoliniumylmethyl)-9H-2-fluoreny...)
Show SMILES [NH2+]=c1ccn(Cc2ccc-3c(Cc4cc(Cn5ccc(=[NH2+])c6ccccc56)ccc-34)c2)c2ccccc12
Show InChI InChI=1S/C33H26N4/c34-30-13-15-36(32-7-3-1-5-28(30)32)20-22-9-11-26-24(17-22)19-25-18-23(10-12-27(25)26)21-37-16-14-31(35)29-6-2-4-8-33(29)37/h1-18,34-35H,19-21H2/p+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 310n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215068
PNG
(CHEMBL229341 | N-[3-(4-quinolinylamino)-proyl]-3,5...)
Show SMILES C(CNCc1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1)CNc1ccnc2ccccc12
Show InChI InChI=1S/C43H45N7O2/c1-4-13-38-35(10-1)41(16-23-48-38)45-20-7-19-44-31-32-28-33(51-26-8-21-46-42-17-24-49-39-14-5-2-11-36(39)42)30-34(29-32)52-27-9-22-47-43-18-25-50-40-15-6-3-12-37(40)43/h1-6,10-18,23-25,28-30,44H,7-9,19-22,26-27,31H2,(H,45,48)(H,46,49)(H,47,50)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 360n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50054103
PNG
(1,1'-[biphenyl-4,4'-diylbis(methylene)]-bis(4-amin...)
Show SMILES [NH2+]=c1ccn(Cc2ccc(cc2)-c2ccc(Cn3ccc(=[NH2+])c4ccccc34)cc2)c2ccccc12
Show InChI InChI=1S/C32H26N4/c33-29-17-19-35(31-7-3-1-5-27(29)31)21-23-9-13-25(14-10-23)26-15-11-24(12-16-26)22-36-20-18-30(34)28-6-2-4-8-32(28)36/h1-20,33-34H,21-22H2/p+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 380n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50054095
PNG
(1-{4-[4-(4-amino-1-quinoliniumylmethyl)phenethyl]b...)
Show SMILES [NH2+]=c1ccn(Cc2ccc(CCc3ccc(Cn4ccc(=[NH2+])c5ccccc45)cc3)cc2)c2ccccc12
Show InChI InChI=1S/C34H30N4/c35-31-19-21-37(33-7-3-1-5-29(31)33)23-27-15-11-25(12-16-27)9-10-26-13-17-28(18-14-26)24-38-22-20-32(36)30-6-2-4-8-34(30)38/h1-8,11-22,35-36H,9-10,23-24H2/p+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 410n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50054096
PNG
(1-{4-[4-(4-amino-1-quinoliniumylmethyl)benzyl]benz...)
Show SMILES [NH2+]=c1ccn(Cc2ccc(Cc3ccc(Cn4ccc(=[NH2+])c5ccccc45)cc3)cc2)c2ccccc12
Show InChI InChI=1S/C33H28N4/c34-30-17-19-36(32-7-3-1-5-28(30)32)22-26-13-9-24(10-14-26)21-25-11-15-27(16-12-25)23-37-20-18-31(35)29-6-2-4-8-33(29)37/h1-20,34-35H,21-23H2/p+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 450n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215073
PNG
(CHEMBL229340 | N-[3-(4-quinolinyl)-aminopropyl]-N-...)
Show SMILES NCCCCCCCCN(CCCNc1ccnc2ccccc12)C(=O)\C=C\C(=O)NCCCNc1ccnc2ccccc12
Show InChI InChI=1S/C36H47N7O2/c37-21-9-3-1-2-4-10-27-43(28-12-24-39-34-20-26-41-32-16-8-6-14-30(32)34)36(45)18-17-35(44)42-23-11-22-38-33-19-25-40-31-15-7-5-13-29(31)33/h5-8,13-20,25-26H,1-4,9-12,21-24,27-28,37H2,(H,38,40)(H,39,41)(H,42,44)/b18-17+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 490n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50048412
PNG
(4N-[10-(1-benzyl-4-quinoliniumylamino)decyl]-1-ben...)
Show SMILES C(CCCCC\[NH+]=c1/ccn(Cc2ccccc2)c2ccccc12)CCCC\[NH+]=c1/ccn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C42H46N4/c1(3-5-17-29-43-39-27-31-45(33-35-19-9-7-10-20-35)41-25-15-13-23-37(39)41)2-4-6-18-30-44-40-28-32-46(34-36-21-11-8-12-22-36)42-26-16-14-24-38(40)42/h7-16,19-28,31-32H,1-6,17-18,29-30,33-34H2/p+2/b43-39+,44-40+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus)
BDBM50356161
PNG
(CHEMBL1909931)
Show SMILES CC(C)c1cccc2cc[n+](C)c(Cc3cccc(Cc4[n+](C)ccc5cccc(C(C)C)c45)c3)c12
Show InChI InChI=1S/C34H38N2/c1-23(2)29-14-8-12-27-16-18-35(5)31(33(27)29)21-25-10-7-11-26(20-25)22-32-34-28(17-19-36(32)6)13-9-15-30(34)24(3)4/h7-20,23-24H,21-22H2,1-6H3/q+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



University of Li£ge

Curated by ChEMBL


Assay Description
Inhibition of cloned rat SK2 channel expressed in human HEK293 cells by patch clamp assay in the presence of 1 uM intracellular Ca2+


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50377980
PNG
(CHEMBL558625)
Show SMILES C[N+]1(C)CCc2cc3OCOc3cc2[C@H]1[C@@H]1OC(=O)c2c1ccc1OCOc21
Show InChI InChI=1S/C21H20NO6/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3/q+1/t18-,19+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(RAT)
BDBM50323040
PNG
(1-(3-Thiophen-2-yl-phenyl)-ethanone, O-(phenylamin...)
Show SMILES CC(=NOC(=O)Nc1ccccc1)c1cccc(c1)-c1cccs1
Show InChI InChI=1S/C19H16N2O2S/c1-14(21-23-19(22)20-17-9-3-2-4-10-17)15-7-5-8-16(13-15)18-11-6-12-24-18/h2-13H,1H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I]apamin from SK+Ca channel in rat cerebral cortex


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215074
PNG
(CHEMBL425668 | N-(3-guanidinopropyl)-N-[4-(4'-amin...)
Show SMILES NCc1ccc(cc1)-c1ccc(CN(CCCN=C(N)N)C(=O)C=CC(=O)NCCCN=C(N)N)cc1
Show InChI InChI=1S/C26H37N9O2/c27-17-19-3-7-21(8-4-19)22-9-5-20(6-10-22)18-35(16-2-15-34-26(30)31)24(37)12-11-23(36)32-13-1-14-33-25(28)29/h3-12H,1-2,13-18,27H2,(H,32,36)(H4,28,29,33)(H4,30,31,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215079
PNG
(4,4'bis(guanidinomethyl)-cis-stilbene | CHEMBL2291...)
Show SMILES NC(N)=NCc1ccc(\C=C/c2ccc(CN=C(N)N)cc2)cc1
Show InChI InChI=1S/C18H22N6/c19-17(20)23-11-15-7-3-13(4-8-15)1-2-14-5-9-16(10-6-14)12-24-18(21)22/h1-10H,11-12H2,(H4,19,20,23)(H4,21,22,24)/b2-1-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215078
PNG
(CHEMBL373955 | N-(3-guanidinopropyl)-N(8-aminoocty...)
Show SMILES NCCCCCCCCN(CCCN=C(N)N)C(=O)C=CC(=O)NCCCN=C(N)N
Show InChI InChI=1S/C20H41N9O2/c21-11-5-3-1-2-4-6-15-29(16-8-14-28-20(24)25)18(31)10-9-17(30)26-12-7-13-27-19(22)23/h9-10H,1-8,11-16,21H2,(H,26,30)(H4,22,23,27)(H4,24,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.70E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215077
PNG
(CHEMBL390821 | N-(3-guanidinopropyl)-N-(8-aminooct...)
Show SMILES NCCCCCCCCN(CCCN=C(N)N)C(=O)C=CC(=O)NCCCN=C(N)N
Show InChI InChI=1S/C20H41N9O2/c21-11-5-3-1-2-4-6-15-29(16-8-14-28-20(24)25)18(31)10-9-17(30)26-12-7-13-27-19(22)23/h9-10H,1-8,11-16,21H2,(H,26,30)(H4,22,23,27)(H4,24,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275153
PNG
(2-(2-Phenylpyrrolidin-1-yl)-1H-benzoimidazole | CH...)
Show SMILES C1CC(N(C1)c1nc2ccccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C17H17N3/c1-2-7-13(8-3-1)16-11-6-12-20(16)17-18-14-9-4-5-10-15(14)19-17/h1-5,7-10,16H,6,11-12H2,(H,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/a 1.60E+3n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275152
PNG
(2-(2-Phenylpiperidin-1-yl)-1H-benzoimidazole | CHE...)
Show SMILES C1CCN(C(C1)c1ccccc1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C18H19N3/c1-2-8-14(9-3-1)17-12-6-7-13-21(17)18-19-15-10-4-5-11-16(15)20-18/h1-5,8-11,17H,6-7,12-13H2,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/a 750n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275131
PNG
(2-(1H-Benzoimidazol-2-yl)-1,2,3,4-tetrahydroisoqui...)
Show SMILES C1Cc2ccccc2CN1c1nc2ccccc2[nH]1
Show InChI InChI=1S/C16H15N3/c1-2-6-13-11-19(10-9-12(13)5-1)16-17-14-7-3-4-8-15(14)18-16/h1-8H,9-11H2,(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/an/a 1.40E+4n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275130
PNG
((1H-Benzoimidazol-2-yl)indan-1-ylamine | CHEMBL458...)
Show SMILES C1Cc2ccccc2C1Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C16H15N3/c1-2-6-12-11(5-1)9-10-13(12)17-16-18-14-7-3-4-8-15(14)19-16/h1-8,13H,9-10H2,(H2,17,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/a 790n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275129
PNG
((1H-Benzoimidazol-2-yl)-1,2,3,4-tetrahydronaphthal...)
Show SMILES C1CC(Nc2nc3ccccc3[nH]2)c2ccccc2C1
Show InChI InChI=1S/C17H17N3/c1-2-8-13-12(6-1)7-5-11-14(13)18-17-19-15-9-3-4-10-16(15)20-17/h1-4,6,8-10,14H,5,7,11H2,(H2,18,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/a 130n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275128
PNG
((1H-Benzoimidazol-2-yl)-(6,7,8,9-tetrahydro-5H-ben...)
Show SMILES C1CCc2ccccc2C(C1)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C18H19N3/c1-3-9-14-13(7-1)8-2-4-10-15(14)19-18-20-16-11-5-6-12-17(16)21-18/h1,3,5-7,9,11-12,15H,2,4,8,10H2,(H2,19,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/a 590n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275127
PNG
((1H-Benzoimidazol-2-yl)indan-2-ylamine | CHEMBL453...)
Show SMILES C1C(Cc2ccccc12)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C16H15N3/c1-2-6-12-10-13(9-11(12)5-1)17-16-18-14-7-3-4-8-15(14)19-16/h1-8,13H,9-10H2,(H2,17,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/a 1.70E+3n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275126
PNG
((1H-Benzoimidazol-2-yl)-(1,2,3,4-tetrahydronaphtha...)
Show SMILES C1Cc2ccccc2CC1Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C17H17N3/c1-2-6-13-11-14(10-9-12(13)5-1)18-17-19-15-7-3-4-8-16(15)20-17/h1-8,14H,9-11H2,(H2,18,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/a 2.00E+3n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 82 total )  |  Next  |  Last  >>
Jump to: