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Compile Data Set for Download or QSAR

Found 8 hits Enz. Inhib. hit(s) with Target = 'Small conductance calcium-activated potassium channel protein 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Small conductance calcium-activated potassium channel protein 1


(Homo sapiens)
BDBM50092131
PNG
(1,7-diazonia-15,21-diazapentacyclo[20.6.2.27,14.08...)
Show SMILES C1CCN[c+]2ccn(CCCCCn3cc[c+](NCC1)c1ccccc31)c1ccccc21
Show InChI InChI=1S/C28H34N4/c1-7-17-29-25-15-21-31(27-13-5-3-11-23(25)27)19-9-2-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h3-6,11-16,21-22,29-30H,1-2,7-10,17-20H2/q+2
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n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of hSK1 calcium activated potassium channel (SKCa channel); Range is 1-2


J Med Chem 44: 1627-53 (2001)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1


(Homo sapiens)
BDBM50061977
PNG
(17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...)
Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21
Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2
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n/an/a 3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of hSK1 calcium activated potassium channel (SKCa channel)


J Med Chem 44: 1627-53 (2001)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1


(Homo sapiens)
BDBM50263327
PNG
(CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...)
Show SMILES Cc1ccnc(Nc2nc(cs2)-c2ccccn2)c1
Show InChI InChI=1S/C14H12N4S/c1-10-5-7-16-13(8-10)18-14-17-12(9-19-14)11-4-2-3-6-15-11/h2-9H,1H3,(H,16,17,18)
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n/an/a 4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1


(Homo sapiens)
BDBM50264020
PNG
(CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)
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n/an/a 43n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1


(Homo sapiens)
BDBM50275960
PNG
(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Show SMILES Clc1cc(NCc2cccs2)n2nccc2n1
Show InChI InChI=1S/C11H9ClN4S/c12-9-6-11(13-7-8-2-1-5-17-8)16-10(15-9)3-4-14-16/h1-6,13H,7H2
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n/an/a 300n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.1 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1


(Homo sapiens)
BDBM50275792
PNG
(CHEMBL452406 | N-benzyl-5-chloropyrazolo[1,5-a]pyr...)
Show SMILES Clc1cc(NCc2ccccc2)n2nccc2n1
Show InChI InChI=1S/C13H11ClN4/c14-11-8-13(18-12(17-11)6-7-16-18)15-9-10-4-2-1-3-5-10/h1-8,15H,9H2
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n/an/a 1.19E+3n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.1 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1


(Homo sapiens)
BDBM50377863
PNG
(AG-525 | CHEMBL257156)
Show SMILES COc1cc2CCN(C)[C@@H](CCC[C@@H]3N(C)CCc4cc(OC)c(OC)cc34)c2cc1OC
Show InChI InChI=1S/C27H38N2O4/c1-28-12-10-18-14-24(30-3)26(32-5)16-20(18)22(28)8-7-9-23-21-17-27(33-6)25(31-4)15-19(21)11-13-29(23)2/h14-17,22-23H,7-13H2,1-6H3/t22-,23-/m0/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Li£ge

Curated by ChEMBL


Assay Description
Inhibition of SK1 expressed in CHO FlipIn cells by whole cell patch-clamp assay


Bioorg Med Chem Lett 18: 3440-5 (2008)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1


(Homo sapiens)
BDBM50275090
PNG
((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Show SMILES Clc1cc2CCCC(Nc3nc4ccccc4[nH]3)c2cc1Cl
Show InChI InChI=1S/C17H15Cl2N3/c18-12-8-10-4-3-7-14(11(10)9-13(12)19)20-17-21-15-5-1-2-6-16(15)22-17/h1-2,5-6,8-9,14H,3-4,7H2,(H2,20,21,22)
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n/an/an/a 54n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of human SK1 channel by inside-out patch clamp technique


J Med Chem 51: 7625-34 (2009)

More data for this
Ligand-Target Pair