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Compile Data Set for Download or QSAR

Found 65 hits Enz. Inhib. hit(s) with Target = 'Small conductance calcium-activated potassium channel protein 3' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50092131
PNG
(1,7-diazonia-15,21-diazapentacyclo[20.6.2.27,14.08...)
Show SMILES C1CCN[c+]2ccn(CCCCCn3cc[c+](NCC1)c1ccccc31)c1ccccc21
Show InChI InChI=1S/C28H34N4/c1-7-17-29-25-15-21-31(27-13-5-3-11-23(25)27)19-9-2-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h3-6,11-16,21-22,29-30H,1-2,7-10,17-20H2/q+2
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1.40n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50061977
PNG
(17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...)
Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21
Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2
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1.80n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50048403
PNG
(1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...)
Show SMILES Cc1cc(=[NH2+])c2ccccc2n1CCCCCCCCCCn1c(C)cc(=[NH2+])c2ccccc12
Show InChI InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2
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140n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50199404
PNG
(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)
Show SMILES COc1ccc(C[C@H]2c3cc(OC)c(OC)cc3CC[N+]2(C)C)cc1OC
Show InChI InChI=1S/C22H30NO4/c1-23(2)10-9-16-13-21(26-5)22(27-6)14-17(16)18(23)11-15-7-8-19(24-3)20(12-15)25-4/h7-8,12-14,18H,9-11H2,1-6H3/q+1/t18-/m0/s1
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1.50E+3n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50377980
PNG
(CHEMBL558625)
Show SMILES C[N+]1(C)CCc2cc3OCOc3cc2[C@H]1[C@@H]1OC(=O)c2c1ccc1OCOc21
Show InChI InChI=1S/C21H20NO6/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3/q+1/t18-,19+/m0/s1
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4.40E+3n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM92478
PNG
(Atracurium besylate | CHEMBL1360)
Show SMILES COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC
Show InChI InChI=1S/C53H72N2O12/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3/q+2
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5.90E+3n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50366799
PNG
(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Show SMILES COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c23)cc7)N(C)CCc6cc5OC)c4
Show InChI InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1
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9.20E+3n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50377979
PNG
(PENUCURONIUM)
Show SMILES CC(=O)O[C@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@H](OC(C)=O)[C@@]4(C)CC[C@@H]3[C@@]2(C)C[C@@H]1[N+]1(C)CCCCC1)[N+]1(C)CCCCC1
Show InChI InChI=1S/C36H62N2O4/c1-25(39)41-33-23-27-13-14-28-29-15-16-31(37(5)19-9-7-10-20-37)34(42-26(2)40)35(29,3)18-17-30(28)36(27,4)24-32(33)38(6)21-11-8-12-22-38/h27-34H,7-24H2,1-6H3/q+2/t27-,28-,29-,30-,31-,32-,33-,34-,35-,36-/m0/s1
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1.60E+4n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50263331
PNG
((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Show SMILES C1C[C@@H](Nc2nc3ccccc3[nH]2)c2ccccc2C1
Show InChI InChI=1S/C17H17N3/c1-2-8-13-12(6-1)7-5-11-14(13)18-17-19-15-9-3-4-10-16(15)20-17/h1-4,6,8-10,14H,5,7,11H2,(H2,18,19,20)/t14-/m1/s1
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>5.00E+4n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275157
PNG
(CHEMBL453730 | N-cyclohexyl-2-(3,5-dimethyl-1H-pyr...)
Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(NC2CCCCC2)n1
Show InChI InChI=1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19)
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>5.00E+4n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275184
PNG
(6,7-dichloro-3-(hydroxyimino)indolin-2-one | CHEMB...)
Show SMILES Clc1ccc2C(N=O)C(=O)Nc2c1Cl
Show InChI InChI=1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,7H,(H,11,13)
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>5.00E+4n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275183
PNG
(1-ethyl-1H-benzo[d]imidazol-2(3H)-one | CHEMBL4528...)
Show SMILES CCn1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12)
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>5.00E+4n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215069
PNG
(1,2,3-tris-[3-(4-(N-ethyl)-quinoliniumylamino)-pro...)
Show SMILES CCn1cc\c(=[NH+]\CCCOc2cccc(OCCCNc3cc[n+](CC)c4ccccc34)c2OCCC\[NH+]=c2/ccn(CC)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C48H54N6O3/c1-4-52-31-25-40(37-17-7-10-20-43(37)52)49-28-14-34-55-46-23-13-24-47(56-35-15-29-50-41-26-32-53(5-2)44-21-11-8-18-38(41)44)48(46)57-36-16-30-51-42-27-33-54(6-3)45-22-12-9-19-39(42)45/h7-13,17-27,31-33H,4-6,14-16,28-30,34-36H2,1-3H3/p+3/b49-40-,51-42+
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n/an/a 86n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215071
PNG
(CHEMBL375272 | N-[3-(4-quinolinylamino)-propyl]-N-...)
Show SMILES C(CCNc1ccnc2ccccc12)CCN(CCCNc1ccnc2ccccc12)c1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1
Show InChI InChI=1S/C56H59N9O2/c1(10-27-57-53-23-31-61-49-19-6-2-15-45(49)53)11-35-65(36-12-28-58-54-24-32-62-50-20-7-3-16-46(50)54)42-39-43(66-37-13-29-59-55-25-33-63-51-21-8-4-17-47(51)55)41-44(40-42)67-38-14-30-60-56-26-34-64-52-22-9-5-18-48(52)56/h2-9,15-26,31-34,39-41H,1,10-14,27-30,35-38H2,(H,57,61)(H,58,62)(H,59,63)(H,60,64)
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n/an/a 93n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215076
PNG
(CHEMBL229982 | N-[3-(4-quinolinylamino)-propyl]-N-...)
Show SMILES C(CCNc1ccnc2ccccc12)CCN(CCCNc1ccnc2ccccc12)Cc1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1
Show InChI InChI=1S/C57H61N9O2/c1(10-27-58-54-23-31-62-50-19-6-2-15-46(50)54)11-35-66(36-12-28-59-55-24-32-63-51-20-7-3-16-47(51)55)42-43-39-44(67-37-13-29-60-56-25-33-64-52-21-8-4-17-48(52)56)41-45(40-43)68-38-14-30-61-57-26-34-65-53-22-9-5-18-49(53)57/h2-9,15-26,31-34,39-41H,1,10-14,27-30,35-38,42H2,(H,58,62)(H,59,63)(H,60,64)(H,61,65)
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n/an/a 130n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215070
PNG
(1,2,3-tri[3-(4-quinolinylamino)-propoxy]-benzene |...)
Show SMILES C(CNc1ccnc2ccccc12)COc1cccc(OCCCNc2ccnc3ccccc23)c1OCCCNc1ccnc2ccccc12
Show InChI InChI=1S/C42H42N6O3/c1-4-14-34-31(11-1)37(19-25-46-34)43-22-8-28-49-40-17-7-18-41(50-29-9-23-44-38-20-26-47-35-15-5-2-12-32(35)38)42(40)51-30-10-24-45-39-21-27-48-36-16-6-3-13-33(36)39/h1-7,11-21,25-27H,8-10,22-24,28-30H2,(H,43,46)(H,44,47)(H,45,48)
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n/an/a 130n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215075
PNG
(CHEMBL229818 | N-[3-(4-quinolinylamino)-propyl]-3,...)
Show SMILES C(CNc1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1)CNc1ccnc2ccccc12
Show InChI InChI=1S/C42H43N7O2/c1-4-13-37-34(10-1)40(16-23-47-37)44-20-7-19-43-31-28-32(50-26-8-21-45-41-17-24-48-38-14-5-2-11-35(38)41)30-33(29-31)51-27-9-22-46-42-18-25-49-39-15-6-3-12-36(39)42/h1-6,10-18,23-25,28-30,43H,7-9,19-22,26-27H2,(H,44,47)(H,45,48)(H,46,49)
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n/an/a 220n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215072
PNG
(CHEMBL389273 | N-(4-quinolinyl)-3,4-di-[3-(4-quino...)
Show SMILES C(CNc1ccnc2ccccc12)COc1ccc(CCNc2ccnc3ccccc23)cc1OCCCNc1ccnc2ccccc12
Show InChI InChI=1S/C41H40N6O2/c1-4-12-34-31(9-1)37(18-24-45-34)42-21-7-27-48-40-16-15-30(17-23-44-39-20-26-47-36-14-6-3-11-33(36)39)29-41(40)49-28-8-22-43-38-19-25-46-35-13-5-2-10-32(35)38/h1-6,9-16,18-20,24-26,29H,7-8,17,21-23,27-28H2,(H,42,45)(H,43,46)(H,44,47)
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n/an/a 270n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215068
PNG
(CHEMBL229341 | N-[3-(4-quinolinylamino)-proyl]-3,5...)
Show SMILES C(CNCc1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1)CNc1ccnc2ccccc12
Show InChI InChI=1S/C43H45N7O2/c1-4-13-38-35(10-1)41(16-23-48-38)45-20-7-19-44-31-32-28-33(51-26-8-21-46-42-17-24-49-39-14-5-2-11-36(39)42)30-34(29-32)52-27-9-22-47-43-18-25-50-40-15-6-3-12-37(40)43/h1-6,10-18,23-25,28-30,44H,7-9,19-22,26-27,31H2,(H,45,48)(H,46,49)(H,47,50)
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n/an/a 360n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215073
PNG
(CHEMBL229340 | N-[3-(4-quinolinyl)-aminopropyl]-N-...)
Show SMILES NCCCCCCCCN(CCCNc1ccnc2ccccc12)C(=O)\C=C\C(=O)NCCCNc1ccnc2ccccc12
Show InChI InChI=1S/C36H47N7O2/c37-21-9-3-1-2-4-10-27-43(28-12-24-39-34-20-26-41-32-16-8-6-14-30(32)34)36(45)18-17-35(44)42-23-11-22-38-33-19-25-40-31-15-7-5-13-29(31)33/h5-8,13-20,25-26H,1-4,9-12,21-24,27-28,37H2,(H,38,40)(H,39,41)(H,42,44)/b18-17+
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n/an/a 490n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50377980
PNG
(CHEMBL558625)
Show SMILES C[N+]1(C)CCc2cc3OCOc3cc2[C@H]1[C@@H]1OC(=O)c2c1ccc1OCOc21
Show InChI InChI=1S/C21H20NO6/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3/q+1/t18-,19+/m0/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215074
PNG
(CHEMBL425668 | N-(3-guanidinopropyl)-N-[4-(4'-amin...)
Show SMILES NCc1ccc(cc1)-c1ccc(CN(CCCN=C(N)N)C(=O)C=CC(=O)NCCCN=C(N)N)cc1
Show InChI InChI=1S/C26H37N9O2/c27-17-19-3-7-21(8-4-19)22-9-5-20(6-10-22)18-35(16-2-15-34-26(30)31)24(37)12-11-23(36)32-13-1-14-33-25(28)29/h3-12H,1-2,13-18,27H2,(H,32,36)(H4,28,29,33)(H4,30,31,34)
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n/an/a 1.70E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215079
PNG
(4,4'bis(guanidinomethyl)-cis-stilbene | CHEMBL2291...)
Show SMILES NC(N)=NCc1ccc(\C=C/c2ccc(CN=C(N)N)cc2)cc1
Show InChI InChI=1S/C18H22N6/c19-17(20)23-11-15-7-3-13(4-8-15)1-2-14-5-9-16(10-6-14)12-24-18(21)22/h1-10H,11-12H2,(H4,19,20,23)(H4,21,22,24)/b2-1-
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n/an/a 2.50E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215078
PNG
(CHEMBL373955 | N-(3-guanidinopropyl)-N(8-aminoocty...)
Show SMILES NCCCCCCCCN(CCCN=C(N)N)C(=O)C=CC(=O)NCCCN=C(N)N
Show InChI InChI=1S/C20H41N9O2/c21-11-5-3-1-2-4-6-15-29(16-8-14-28-20(24)25)18(31)10-9-17(30)26-12-7-13-27-19(22)23/h9-10H,1-8,11-16,21H2,(H,26,30)(H4,22,23,27)(H4,24,25,28)
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n/an/a 2.70E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50215077
PNG
(CHEMBL390821 | N-(3-guanidinopropyl)-N-(8-aminooct...)
Show SMILES NCCCCCCCCN(CCCN=C(N)N)C(=O)C=CC(=O)NCCCN=C(N)N
Show InChI InChI=1S/C20H41N9O2/c21-11-5-3-1-2-4-6-15-29(16-8-14-28-20(24)25)18(31)10-9-17(30)26-12-7-13-27-19(22)23/h9-10H,1-8,11-16,21H2,(H,26,30)(H4,22,23,27)(H4,24,25,28)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275153
PNG
(2-(2-Phenylpyrrolidin-1-yl)-1H-benzoimidazole | CH...)
Show SMILES C1CC(N(C1)c1nc2ccccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C17H17N3/c1-2-7-13(8-3-1)16-11-6-12-20(16)17-18-14-9-4-5-10-15(14)19-17/h1-5,7-10,16H,6,11-12H2,(H,18,19)
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n/an/an/a 1.60E+3n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275152
PNG
(2-(2-Phenylpiperidin-1-yl)-1H-benzoimidazole | CHE...)
Show SMILES C1CCN(C(C1)c1ccccc1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C18H19N3/c1-2-8-14(9-3-1)17-12-6-7-13-21(17)18-19-15-10-4-5-11-16(15)20-18/h1-5,8-11,17H,6-7,12-13H2,(H,19,20)
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n/an/an/a 750n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275131
PNG
(2-(1H-Benzoimidazol-2-yl)-1,2,3,4-tetrahydroisoqui...)
Show SMILES C1Cc2ccccc2CN1c1nc2ccccc2[nH]1
Show InChI InChI=1S/C16H15N3/c1-2-6-13-11-19(10-9-12(13)5-1)16-17-14-7-3-4-8-15(14)18-16/h1-8H,9-11H2,(H,17,18)
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n/an/an/a 1.40E+4n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275130
PNG
((1H-Benzoimidazol-2-yl)indan-1-ylamine | CHEMBL458...)
Show SMILES C1Cc2ccccc2C1Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C16H15N3/c1-2-6-12-11(5-1)9-10-13(12)17-16-18-14-7-3-4-8-15(14)19-16/h1-8,13H,9-10H2,(H2,17,18,19)
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n/an/an/a 790n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275129
PNG
((1H-Benzoimidazol-2-yl)-1,2,3,4-tetrahydronaphthal...)
Show SMILES C1CC(Nc2nc3ccccc3[nH]2)c2ccccc2C1
Show InChI InChI=1S/C17H17N3/c1-2-8-13-12(6-1)7-5-11-14(13)18-17-19-15-9-3-4-10-16(15)20-17/h1-4,6,8-10,14H,5,7,11H2,(H2,18,19,20)
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n/an/an/a 130n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275128
PNG
((1H-Benzoimidazol-2-yl)-(6,7,8,9-tetrahydro-5H-ben...)
Show SMILES C1CCc2ccccc2C(C1)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C18H19N3/c1-3-9-14-13(7-1)8-2-4-10-15(14)19-18-20-16-11-5-6-12-17(16)21-18/h1,3,5-7,9,11-12,15H,2,4,8,10H2,(H2,19,20,21)
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n/an/an/a 590n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275127
PNG
((1H-Benzoimidazol-2-yl)indan-2-ylamine | CHEMBL453...)
Show SMILES C1C(Cc2ccccc12)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C16H15N3/c1-2-6-12-10-13(9-11(12)5-1)17-16-18-14-7-3-4-8-15(14)19-16/h1-8,13H,9-10H2,(H2,17,18,19)
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n/an/an/a 1.70E+3n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275126
PNG
((1H-Benzoimidazol-2-yl)-(1,2,3,4-tetrahydronaphtha...)
Show SMILES C1Cc2ccccc2CC1Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C17H17N3/c1-2-6-13-11-14(10-9-12(13)5-1)18-17-19-15-7-3-4-8-16(15)20-17/h1-8,14H,9-11H2,(H2,18,19,20)
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n/an/an/a 2.00E+3n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275125
PNG
((1H-Benzoimidazol-2-yl)-(2-methyl-1,2,3,4-tetrahyd...)
Show SMILES CC1CCc2ccccc2C1Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C18H19N3/c1-12-10-11-13-6-2-3-7-14(13)17(12)21-18-19-15-8-4-5-9-16(15)20-18/h2-9,12,17H,10-11H2,1H3,(H2,19,20,21)
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n/an/an/a 170n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275154
PNG
((1H-Benzoimidazol-2-yl)-(3,4-dichlorobenzyl)amine ...)
Show SMILES Clc1ccc(CNc2nc3ccccc3[nH]2)cc1Cl
Show InChI InChI=1S/C14H11Cl2N3/c15-10-6-5-9(7-11(10)16)8-17-14-18-12-3-1-2-4-13(12)19-14/h1-7H,8H2,(H2,17,18,19)
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n/an/an/a 200n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275052
PNG
((1H-Benzoimidazol-2-yl)-(6-chloro-1,2,3,4-tetrahyd...)
Show SMILES Clc1ccc2C(CCCc2c1)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C17H16ClN3/c18-12-8-9-13-11(10-12)4-3-7-14(13)19-17-20-15-5-1-2-6-16(15)21-17/h1-2,5-6,8-10,14H,3-4,7H2,(H2,19,20,21)
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n/an/an/a 120n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275051
PNG
((1H-Benzoimidazol-2-yl)-(5-chloro-1,2,3,4-tetrahyd...)
Show SMILES Clc1cccc2C(CCCc12)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C17H16ClN3/c18-13-7-3-6-12-11(13)5-4-10-14(12)19-17-20-15-8-1-2-9-16(15)21-17/h1-3,6-9,14H,4-5,10H2,(H2,19,20,21)
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n/an/an/a 44n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275050
PNG
((1H-Benzoimidazol-2-yl)-(7-fluoro-1,2,3,4-tetrahyd...)
Show SMILES Fc1ccc2CCCC(Nc3nc4ccccc4[nH]3)c2c1
Show InChI InChI=1S/C17H16FN3/c18-12-9-8-11-4-3-7-14(13(11)10-12)19-17-20-15-5-1-2-6-16(15)21-17/h1-2,5-6,8-10,14H,3-4,7H2,(H2,19,20,21)
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n/an/an/a 34n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275049
PNG
((1H-Benzoimidazol-2-yl)-(7-bromo-1,2,3,4-tetrahydr...)
Show SMILES Brc1ccc2CCCC(Nc3nc4ccccc4[nH]3)c2c1
Show InChI InChI=1S/C17H16BrN3/c18-12-9-8-11-4-3-7-14(13(11)10-12)19-17-20-15-5-1-2-6-16(15)21-17/h1-2,5-6,8-10,14H,3-4,7H2,(H2,19,20,21)
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n/an/an/a 11n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275090
PNG
((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Show SMILES Clc1cc2CCCC(Nc3nc4ccccc4[nH]3)c2cc1Cl
Show InChI InChI=1S/C17H15Cl2N3/c18-12-8-10-4-3-7-14(11(10)9-13(12)19)20-17-21-15-5-1-2-6-16(15)22-17/h1-2,5-6,8-9,14H,3-4,7H2,(H2,20,21,22)
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n/an/an/a 9.10n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275089
PNG
((1H-Benzoimidazol-2-yl)-(7-methyl-1,2,3,4-tetrahyd...)
Show SMILES Cc1ccc2CCCC(Nc3nc4ccccc4[nH]3)c2c1
Show InChI InChI=1S/C18H19N3/c1-12-9-10-13-5-4-8-15(14(13)11-12)19-18-20-16-6-2-3-7-17(16)21-18/h2-3,6-7,9-11,15H,4-5,8H2,1H3,(H2,19,20,21)
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n/an/an/a 20n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275088
PNG
((1H-Benzoimidazol-2-yl)-(5,7-dimethyl-1,2,3,4-tetr...)
Show SMILES Cc1cc(C)c2CCCC(Nc3nc4ccccc4[nH]3)c2c1
Show InChI InChI=1S/C19H21N3/c1-12-10-13(2)14-6-5-9-16(15(14)11-12)20-19-21-17-7-3-4-8-18(17)22-19/h3-4,7-8,10-11,16H,5-6,9H2,1-2H3,(H2,20,21,22)
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n/an/an/a 33n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275087
PNG
((1H-Benzoimidazol-2-yl)-(7-methoxy-1,2,3,4-tetrahy...)
Show SMILES COc1ccc2CCCC(Nc3nc4ccccc4[nH]3)c2c1
Show InChI InChI=1S/C18H19N3O/c1-22-13-10-9-12-5-4-8-15(14(12)11-13)19-18-20-16-6-2-3-7-17(16)21-18/h2-3,6-7,9-11,15H,4-5,8H2,1H3,(H2,19,20,21)
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n/an/an/a 61n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275054
PNG
((1H-Benzoimidazol-2-yl)chroman-4-ylamine | CHEMBL5...)
Show SMILES C1CC(Nc2nc3ccccc3[nH]2)c2ccccc2O1
Show InChI InChI=1S/C16H15N3O/c1-4-8-15-11(5-1)12(9-10-20-15)17-16-18-13-6-2-3-7-14(13)19-16/h1-8,12H,9-10H2,(H2,17,18,19)
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n/an/an/a>1.00E+4n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275207
PNG
((1H-Benzoimidazol-2-yl)thiochroman-4-yl-amine | CH...)
Show SMILES C1CC(Nc2nc3ccccc3[nH]2)c2ccccc2S1
Show InChI InChI=1S/C16H15N3S/c1-4-8-15-11(5-1)12(9-10-20-15)17-16-18-13-6-2-3-7-14(13)19-16/h1-8,12H,9-10H2,(H2,17,18,19)
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n/an/an/a 130n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275208
PNG
((1H-Benzoimidazol-2-yl)-(5,6,7,8-tetrahydroisoquin...)
Show SMILES C1CC(Nc2nc3ccccc3[nH]2)c2cnccc2C1
Show InChI InChI=1S/C16H16N4/c1-2-6-15-14(5-1)19-16(20-15)18-13-7-3-4-11-8-9-17-10-12(11)13/h1-2,5-6,8-10,13H,3-4,7H2,(H2,18,19,20)
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n/an/an/a 6.50E+3n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275209
PNG
((1H-Benzoimidazol-2-yl)-(4,5,6,7-tetrahydrobenzo[b...)
Show SMILES C1CC(Nc2nc3ccccc3[nH]2)c2ccsc2C1
Show InChI InChI=1S/C15H15N3S/c1-2-5-13-12(4-1)17-15(18-13)16-11-6-3-7-14-10(11)8-9-19-14/h1-2,4-5,8-9,11H,3,6-7H2,(H2,16,17,18)
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n/an/an/a 540n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275232
PNG
((1H-Benzoimidazol-2-yl)-(1,2,3,4-tetrahydrophenant...)
Show SMILES C1CC(Nc2nc3ccccc3[nH]2)c2c(C1)ccc1ccccc21
Show InChI InChI=1S/C21H19N3/c1-2-8-16-14(6-1)12-13-15-7-5-11-19(20(15)16)24-21-22-17-9-3-4-10-18(17)23-21/h1-4,6,8-10,12-13,19H,5,7,11H2,(H2,22,23,24)
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n/an/an/a 31n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275233
PNG
((1H-Benzoimidazol-2-yl)(7-phenyl-1,2,3,4-tetrahydr...)
Show SMILES C1CC(Nc2nc3ccccc3[nH]2)c2cc(ccc2C1)-c1ccccc1
Show InChI InChI=1S/C23H21N3/c1-2-7-16(8-3-1)18-14-13-17-9-6-12-20(19(17)15-18)24-23-25-21-10-4-5-11-22(21)26-23/h1-5,7-8,10-11,13-15,20H,6,9,12H2,(H2,24,25,26)
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n/an/an/a 600n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50275234
PNG
((S)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-benzo...)
Show SMILES C1C[C@H](Nc2nc3ccccc3[nH]2)c2ccccc2C1
Show InChI InChI=1S/C17H17N3/c1-2-8-13-12(6-1)7-5-11-14(13)18-17-19-15-9-3-4-10-16(15)20-17/h1-4,6,8-10,14H,5,7,11H2,(H2,18,19,20)/t14-/m0/s1
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n/an/an/a 450n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
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