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Compile Data Set for Download or QSAR

Found 123 hits Enz. Inhib. hit(s) with Target = 'Sn1-specific diacylglycerol lipase alpha' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048620
PNG
(CHEMBL3319620)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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700n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes assessed as reduction in hydrolysis of inhibition of [14C]-sn-1-oleoyl-2-arachidono...


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148158
PNG
(CHEMBL3764017)
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n/an/a 0.600n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148192
PNG
(CHEMBL3765578)
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n/an/a 0.900n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM24567
PNG
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147615
PNG
(CHEMBL3764876)
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n/an/a 2.40n/an/an/an/an/an/a


TBA



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More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148188
PNG
(CHEMBL3763826)
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TBA



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More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148184
PNG
(CHEMBL3763853)
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TBA



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More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148193
PNG
(CHEMBL3765716)
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TBA



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More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148154
PNG
(CHEMBL3763831)
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TBA



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More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147617
PNG
(CHEMBL3765421)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148187
PNG
(CHEMBL3764093)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148191
PNG
(CHEMBL3763430)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147618
PNG
(CHEMBL3765022)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM24567
PNG
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membrane using [14C]SAG substrate in detergent free solution by FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147612
PNG
(CHEMBL3765158)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148184
PNG
(CHEMBL3763853)
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Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147615
PNG
(CHEMBL3764876)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50274180
PNG
(CHEMBL521157 | N-Formyl-L-isoleucine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)CC
Show InChI InChI=1S/C29H53NO5/c1-5-8-10-12-13-14-15-16-17-19-24(34-29(33)27(30-22-31)23(4)7-3)21-26-25(28(32)35-26)20-18-11-9-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t23?,24-,25-,26-,27-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148157
PNG
(CHEMBL3765824)
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TBA



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More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148183
PNG
(CHEMBL3764377)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147613
PNG
(CHEMBL3764778)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048620
PNG
(CHEMBL3319620)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048620
PNG
(CHEMBL3319620)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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n/an/a 18n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148155
PNG
(CHEMBL3765573)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147616
PNG
(CHEMBL3765497)
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TBA



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Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148161
PNG
(CHEMBL3765546)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50274021
PNG
(CHEMBL457232 | N-Formyl-L-valine-(1S)-1-[[(2S,3S)-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)C
Show InChI InChI=1S/C28H51NO5/c1-5-7-9-11-12-13-14-15-16-18-23(33-28(32)26(22(3)4)29-21-30)20-25-24(27(31)34-25)19-17-10-8-6-2/h21-26H,5-20H2,1-4H3,(H,29,30)/t23-,24-,25-,26-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148158
PNG
(CHEMBL3764017)
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TBA



Citation and Details
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Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147614
PNG
(CHEMBL3764349)
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TBA



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More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50274019
PNG
(CHEMBL516323 | N-Formyl-L-alanine-(1S)-1-[[(2S,3S)...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](C)NC=O
Show InChI InChI=1S/C26H47NO5/c1-4-6-8-10-11-12-13-14-15-17-22(31-25(29)21(3)27-20-28)19-24-23(26(30)32-24)18-16-9-7-5-2/h20-24H,4-19H2,1-3H3,(H,27,28)/t21-,22-,23-,24-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148153
PNG
(CHEMBL3765562)
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n/an/a 45n/an/an/an/an/an/a


TBA



Citation and Details
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Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148189
PNG
(CHEMBL3764044)
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Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048621
PNG
(CHEMBL3319619)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)14-13-20-16-23(11-12-24(20)33-26)34(30,31)27(18-25(28)29)17-19-7-6-10-22(15-19)32-21-8-4-3-5-9-21/h3-12,15-16H,13-14,17-18H2,1-2H3,(H,28,29)
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n/an/a 56n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50240877
PNG
(CHEMBL158897 | Quinolyl derivatives | cyclohexanon...)
Show SMILES O=C(NCCCCCCNC(=O)ON=C1CCCCC1)ON=C1CCCCC1
Show InChI InChI=1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
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n/an/a 60n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha overexpressed in african green monkey COS7 cells


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM24567
PNG
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha overexpressed in african green monkey COS7 cells


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148156
PNG
(CHEMBL3763964)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148183
PNG
(CHEMBL3764377)
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n/an/a 60n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048618
PNG
(CHEMBL3319622)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccc(cn2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H25F3N2O6S/c1-25(2)12-11-18-13-21(8-9-22(18)37-25)38(34,35)31(16-24(32)33)15-17-3-6-20(7-4-17)36-23-10-5-19(14-30-23)26(27,28)29/h3-10,13-14H,11-12,15-16H2,1-2H3,(H,32,33)
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n/an/a 65n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048636
PNG
(CHEMBL3319625)
Show SMILES OC(=O)CN(Cc1ccc(Oc2ccccc2)cc1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClNO5S/c22-17-8-12-20(13-9-17)29(26,27)23(15-21(24)25)14-16-6-10-19(11-7-16)28-18-4-2-1-3-5-18/h1-13H,14-15H2,(H,24,25)
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n/an/a 66n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148190
PNG
(CHEMBL3765750)
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n/an/a 80n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148181
PNG
(CHEMBL3765634)
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n/an/a 80n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147618
PNG
(CHEMBL3765022)
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n/an/a 82n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147617
PNG
(CHEMBL3765421)
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n/an/a 88n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048617
PNG
(CHEMBL3319623)
Show SMILES OC(=O)CN(Cc1cccc(Oc2ccccc2)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClNO5S/c22-17-9-11-20(12-10-17)29(26,27)23(15-21(24)25)14-16-5-4-8-19(13-16)28-18-6-2-1-3-7-18/h1-13H,14-15H2,(H,24,25)
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n/an/a 91n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50274183
PNG
(5-oxo-L-Proline-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-o...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H]1CCC(=O)N1
Show InChI InChI=1S/C27H47NO5/c1-3-5-7-9-10-11-12-13-14-16-21(32-27(31)23-18-19-25(29)28-23)20-24-22(26(30)33-24)17-15-8-6-4-2/h21-24H,3-20H2,1-2H3,(H,28,29)/t21-,22-,23-,24-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147616
PNG
(CHEMBL3765497)
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n/an/a 100n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148152
PNG
(CHEMBL3764007)
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n/an/a 130n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50242639
PNG
(5-((4-Azido-3-iodobenzamido)methyl)-N,N-dimethyl-1...)
Show SMILES CN(C)C(=O)n1nnnc1CNC(=O)c1ccc(N=[N+]=[N-])c(I)c1
Show InChI InChI=1S/C12H12IN9O2/c1-21(2)12(24)22-10(17-19-20-22)6-15-11(23)7-3-4-9(16-18-14)8(13)5-7/h3-5H,6H2,1-2H3,(H,15,23)
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n/an/a 130n/an/an/an/an/an/a



Università di Roma La Sapienza

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in COS cells after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048619
PNG
(CHEMBL3319621)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C26H25F3N2O6S/c1-25(2)11-10-18-13-21(7-8-22(18)37-25)38(34,35)31(16-24(32)33)15-17-4-3-5-20(12-17)36-23-9-6-19(14-30-23)26(27,28)29/h3-9,12-14H,10-11,15-16H2,1-2H3,(H,32,33)
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n/an/a 143n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50396276
PNG
(CHEMBL473511)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)OC(COC)COP(C)(F)=O
Show InChI InChI=1S/C23H44FO5P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(25)29-22(20-27-2)21-28-30(3,24)26/h11-12,22H,4-10,13-21H2,1-3H3/b12-11-
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n/an/a 160n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha


Citation and Details
More data for this
Ligand-Target Pair
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