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Compile Data Set for Download or QSAR

Found 123 hits Enz. Inhib. hit(s) with Target = 'Sn1-specific diacylglycerol lipase alpha' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048620
PNG
(CHEMBL3319620)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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700n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes assessed as reduction in hydrolysis of inhibition of [14C]-sn-1-oleoyl-2-arachidono...


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148158
PNG
(CHEMBL3764017)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)C1(CCC1)c1cccc(c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C29H29Cl2NO5S/c1-28(2)12-9-20-16-25(7-8-26(20)37-28)38(35,36)32(18-27(33)34)29(10-4-11-29)22-6-3-5-19(13-22)21-14-23(30)17-24(31)15-21/h3,5-8,13-17H,4,9-12,18H2,1-2H3,(H,33,34)
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n/an/a 0.600n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148192
PNG
(CHEMBL3765578)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)C1(CCCC1)c1cccc(c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C30H31Cl2NO5S/c1-29(2)13-10-21-17-26(8-9-27(21)38-29)39(36,37)33(19-28(34)35)30(11-3-4-12-30)23-7-5-6-20(14-23)22-15-24(31)18-25(32)16-22/h5-9,14-18H,3-4,10-13,19H2,1-2H3,(H,34,35)
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n/an/a 0.900n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM24567
PNG
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha expressed in African green monkey COS cells using sn-1-stearoyl-2-[14C]-arachidonoyl-glycerol as substrate ...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147615
PNG
(CHEMBL3764876)
Show SMILES OC(=O)CN(c1cccc(c1)-c1cccc(Cl)c1Cl)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C21H15Cl2F2NO5S/c22-18-6-2-5-17(20(18)23)13-3-1-4-14(11-13)26(12-19(27)28)32(29,30)16-9-7-15(8-10-16)31-21(24)25/h1-11,21H,12H2,(H,27,28)
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n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellula...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148188
PNG
(CHEMBL3763826)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1cccc(c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C26H25Cl2NO5S/c1-26(2)9-8-19-13-23(6-7-24(19)34-26)35(32,33)29(16-25(30)31)15-17-4-3-5-18(10-17)20-11-21(27)14-22(28)12-20/h3-7,10-14H,8-9,15-16H2,1-2H3,(H,30,31)
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148184
PNG
(CHEMBL3763853)
Show SMILES OC(=O)CN(Cc1cccc(c1)-c1cccc(Cl)c1Cl)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C22H17Cl2F2NO5S/c23-19-6-2-5-18(21(19)24)15-4-1-3-14(11-15)12-27(13-20(28)29)33(30,31)17-9-7-16(8-10-17)32-22(25)26/h1-11,22H,12-13H2,(H,28,29)
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148193
PNG
(CHEMBL3765716)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(cc1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C26H25Cl2NO5S/c1-26(2)10-9-19-13-23(7-8-24(19)34-26)35(32,33)29(16-25(30)31)15-17-3-5-18(6-4-17)20-11-21(27)14-22(28)12-20/h3-8,11-14H,9-10,15-16H2,1-2H3,(H,30,31)
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148154
PNG
(CHEMBL3763831)
Show SMILES OC(=O)CN(C1(CCC1)c1cccc(c1)-c1cc(Cl)cc(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H20Cl3NO4S/c25-19-5-7-22(8-6-19)33(31,32)28(15-23(29)30)24(9-2-10-24)18-4-1-3-16(11-18)17-12-20(26)14-21(27)13-17/h1,3-8,11-14H,2,9-10,15H2,(H,29,30)
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147617
PNG
(CHEMBL3765421)
Show SMILES OC(=O)CN(C1(CCC1)c1ccc(cc1)-c1ccc(Cl)cc1Cl)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C25H21Cl2F2NO5S/c26-18-6-11-21(22(27)14-18)16-2-4-17(5-3-16)25(12-1-13-25)30(15-23(31)32)36(33,34)20-9-7-19(8-10-20)35-24(28)29/h2-11,14,24H,1,12-13,15H2,(H,31,32)
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n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellula...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148187
PNG
(CHEMBL3764093)
Show SMILES OC(=O)CN(C1(CCC1)c1cccc(c1)-c1ccc(Cl)cc1Cl)S(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H19Cl4NO4S/c25-17-5-7-19(21(27)12-17)15-3-1-4-16(11-15)24(9-2-10-24)29(14-23(30)31)34(32,33)18-6-8-20(26)22(28)13-18/h1,3-8,11-13H,2,9-10,14H2,(H,30,31)
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n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148191
PNG
(CHEMBL3763430)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)C1(CCOC1)c1ccc(cc1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1/C29H29Cl2NO6S/c1-28(2)10-9-20-15-25(7-8-26(20)38-28)39(35,36)32(17-27(33)34)29(11-12-37-18-29)22-5-3-19(4-6-22)21-13-23(30)16-24(31)14-21/h3-8,13-16H,9-12,17-18H2,1-2H3,(H,33,34)
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n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147618
PNG
(CHEMBL3765022)
Show SMILES OC(=O)CN(C1(CCC1)c1ccc(cc1)-c1ccccc1OC(F)(F)F)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C26H22F5NO6S/c27-24(28)37-19-10-12-20(13-11-19)39(35,36)32(16-23(33)34)25(14-3-15-25)18-8-6-17(7-9-18)21-4-1-2-5-22(21)38-26(29,30)31/h1-2,4-13,24H,3,14-16H2,(H,33,34)
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n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM24567
PNG
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membrane using [14C]SAG substrate in detergent free solution by FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147612
PNG
(CHEMBL3765158)
Show SMILES OC(=O)CN(C1(CCC1)c1cccc(c1)-c1cc(Cl)cc(Cl)c1)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C25H21Cl2F2NO5S/c26-19-12-17(13-20(27)14-19)16-3-1-4-18(11-16)25(9-2-10-25)30(15-23(31)32)36(33,34)22-7-5-21(6-8-22)35-24(28)29/h1,3-8,11-14,24H,2,9-10,15H2,(H,31,32)
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148184
PNG
(CHEMBL3763853)
Show SMILES OC(=O)CN(Cc1cccc(c1)-c1cccc(Cl)c1Cl)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C22H17Cl2F2NO5S/c23-19-6-2-5-18(21(19)24)15-4-1-3-14(11-15)12-27(13-20(28)29)33(30,31)17-9-7-16(8-10-17)32-22(25)26/h1-11,22H,12-13H2,(H,28,29)
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n/an/a 14n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellula...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147615
PNG
(CHEMBL3764876)
Show SMILES OC(=O)CN(c1cccc(c1)-c1cccc(Cl)c1Cl)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C21H15Cl2F2NO5S/c22-18-6-2-5-17(20(18)23)13-3-1-4-14(11-13)26(12-19(27)28)32(29,30)16-9-7-15(8-10-16)31-21(24)25/h1-11,21H,12H2,(H,27,28)
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellula...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50274180
PNG
(CHEMBL521157 | N-Formyl-L-isoleucine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)CC
Show InChI InChI=1S/C29H53NO5/c1-5-8-10-12-13-14-15-16-17-19-24(34-29(33)27(30-22-31)23(4)7-3)21-26-25(28(32)35-26)20-18-11-9-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t23?,24-,25-,26-,27-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148157
PNG
(CHEMBL3765824)
Show SMILES OC(=O)CN(Cc1cccc(c1)-c1cc(Cl)cc(Cl)c1)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C22H17Cl2F2NO5S/c23-17-9-16(10-18(24)11-17)15-3-1-2-14(8-15)12-27(13-21(28)29)33(30,31)20-6-4-19(5-7-20)32-22(25)26/h1-11,22H,12-13H2,(H,28,29)
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148183
PNG
(CHEMBL3764377)
Show SMILES OC(=O)CN(Cc1cccc(c1)-c1ccccc1OC(F)(F)F)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C23H18F5NO6S/c24-22(25)34-17-8-10-18(11-9-17)36(32,33)29(14-21(30)31)13-15-4-3-5-16(12-15)19-6-1-2-7-20(19)35-23(26,27)28/h1-12,22H,13-14H2,(H,30,31)
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147613
PNG
(CHEMBL3764778)
Show SMILES OC(=O)CN(Cc1ccc(cc1)-c1ccccc1OC(F)(F)F)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C23H18F5NO6S/c24-22(25)34-17-9-11-18(12-10-17)36(32,33)29(14-21(30)31)13-15-5-7-16(8-6-15)19-3-1-2-4-20(19)35-23(26,27)28/h1-12,22H,13-14H2,(H,30,31)
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n/an/a 17n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048620
PNG
(CHEMBL3319620)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of DAGLalpha (unknown origin)


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048620
PNG
(CHEMBL3319620)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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n/an/a 18n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148155
PNG
(CHEMBL3765573)
Show SMILES C[C@H](N(CC(O)=O)S(=O)(=O)c1ccc(OC(F)F)cc1)c1ccc(cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1/C23H19Cl2F2NO5S/c1-14(15-2-4-16(5-3-15)20-11-6-17(24)12-21(20)25)28(13-22(29)30)34(31,32)19-9-7-18(8-10-19)33-23(26)27/h2-12,14,23H,13H2,1H3,(H,29,30)/t14-/s2
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147616
PNG
(CHEMBL3765497)
Show SMILES C[C@@H](N(CC(O)=O)S(=O)(=O)c1ccc(OC(F)F)cc1)c1ccc(cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1/C23H19Cl2F2NO5S/c1-14(15-2-4-16(5-3-15)20-11-6-17(24)12-21(20)25)28(13-22(29)30)34(31,32)19-9-7-18(8-10-19)33-23(26)27/h2-12,14,23H,13H2,1H3,(H,29,30)/t14-/s2
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellula...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148161
PNG
(CHEMBL3765546)
Show SMILES OC(=O)CN(Cc1ccc(cc1)-c1ccc(Cl)cc1Cl)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C22H17Cl2F2NO5S/c23-16-5-10-19(20(24)11-16)15-3-1-14(2-4-15)12-27(13-21(28)29)33(30,31)18-8-6-17(7-9-18)32-22(25)26/h1-11,22H,12-13H2,(H,28,29)
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50274021
PNG
(CHEMBL457232 | N-Formyl-L-valine-(1S)-1-[[(2S,3S)-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)C
Show InChI InChI=1S/C28H51NO5/c1-5-7-9-11-12-13-14-15-16-18-23(33-28(32)26(22(3)4)29-21-30)20-25-24(27(31)34-25)19-17-10-8-6-2/h21-26H,5-20H2,1-4H3,(H,29,30)/t23-,24-,25-,26-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148158
PNG
(CHEMBL3764017)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)C1(CCC1)c1cccc(c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C29H29Cl2NO5S/c1-28(2)12-9-20-16-25(7-8-26(20)37-28)38(35,36)32(18-27(33)34)29(10-4-11-29)22-6-3-5-19(13-22)21-14-23(30)17-24(31)15-21/h3,5-8,13-17H,4,9-12,18H2,1-2H3,(H,33,34)
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellula...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147614
PNG
(CHEMBL3764349)
Show SMILES OC(=O)CN(C1(CC1)c1ccc(cc1)-c1ccccc1OC(F)(F)F)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C25H20F5NO6S/c26-23(27)36-18-9-11-19(12-10-18)38(34,35)31(15-22(32)33)24(13-14-24)17-7-5-16(6-8-17)20-3-1-2-4-21(20)37-25(28,29)30/h1-12,23H,13-15H2,(H,32,33)
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50274019
PNG
(CHEMBL516323 | N-Formyl-L-alanine-(1S)-1-[[(2S,3S)...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](C)NC=O
Show InChI InChI=1S/C26H47NO5/c1-4-6-8-10-11-12-13-14-15-17-22(31-25(29)21(3)27-20-28)19-24-23(26(30)32-24)18-16-9-7-5-2/h20-24H,4-19H2,1-3H3,(H,27,28)/t21-,22-,23-,24-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148153
PNG
(CHEMBL3765562)
Show SMILES OC(=O)CN(C1(CCC1)c1cccc(c1)-c1cc(Cl)cc(Cl)c1)S(=O)(=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H20Cl2N2O4S/c26-21-12-19(13-22(27)14-21)18-3-1-4-20(11-18)25(9-2-10-25)29(16-24(30)31)34(32,33)23-7-5-17(15-28)6-8-23/h1,3-8,11-14H,2,9-10,16H2,(H,30,31)
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148189
PNG
(CHEMBL3764044)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H27NO5S/c1-26(2)14-13-22-16-23(11-12-24(22)32-26)33(30,31)27(18-25(28)29)17-19-7-6-10-21(15-19)20-8-4-3-5-9-20/h3-12,15-16H,13-14,17-18H2,1-2H3,(H,28,29)
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n/an/a 55n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048621
PNG
(CHEMBL3319619)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)14-13-20-16-23(11-12-24(20)33-26)34(30,31)27(18-25(28)29)17-19-7-6-10-22(15-19)32-21-8-4-3-5-9-21/h3-12,15-16H,13-14,17-18H2,1-2H3,(H,28,29)
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n/an/a 56n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50240877
PNG
(CHEMBL158897 | Quinolyl derivatives | cyclohexanon...)
Show SMILES O=C(NCCCCCCNC(=O)ON=C1CCCCC1)ON=C1CCCCC1
Show InChI InChI=1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
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n/an/a 60n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha overexpressed in african green monkey COS7 cells


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM24567
PNG
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha overexpressed in african green monkey COS7 cells


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148156
PNG
(CHEMBL3763964)
Show SMILES OC(=O)CN(C1(CCC1)c1cccc(c1)-c1cc(Cl)cc(Cl)c1)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C24H20Cl3NO4S/c25-19-6-2-7-22(14-19)33(31,32)28(15-23(29)30)24(8-3-9-24)18-5-1-4-16(10-18)17-11-20(26)13-21(27)12-17/h1-2,4-7,10-14H,3,8-9,15H2,(H,29,30)
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148183
PNG
(CHEMBL3764377)
Show SMILES OC(=O)CN(Cc1cccc(c1)-c1ccccc1OC(F)(F)F)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C23H18F5NO6S/c24-22(25)34-17-8-10-18(11-9-17)36(32,33)29(14-21(30)31)13-15-4-3-5-16(12-15)19-6-1-2-7-20(19)35-23(26,27)28/h1-12,22H,13-14H2,(H,30,31)
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellula...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048618
PNG
(CHEMBL3319622)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccc(cn2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H25F3N2O6S/c1-25(2)12-11-18-13-21(8-9-22(18)37-25)38(34,35)31(16-24(32)33)15-17-3-6-20(7-4-17)36-23-10-5-19(14-30-23)26(27,28)29/h3-10,13-14H,11-12,15-16H2,1-2H3,(H,32,33)
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Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048636
PNG
(CHEMBL3319625)
Show SMILES OC(=O)CN(Cc1ccc(Oc2ccccc2)cc1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClNO5S/c22-17-8-12-20(13-9-17)29(26,27)23(15-21(24)25)14-16-6-10-19(11-7-16)28-18-4-2-1-3-5-18/h1-13H,14-15H2,(H,24,25)
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Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148190
PNG
(CHEMBL3765750)
Show SMILES OC(=O)CN(C1(CCC1)c1cccc(c1)-c1cc(Cl)cc(Cl)c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H21Cl2NO4S/c25-20-13-18(14-21(26)15-20)17-6-4-7-19(12-17)24(10-5-11-24)27(16-23(28)29)32(30,31)22-8-2-1-3-9-22/h1-4,6-9,12-15H,5,10-11,16H2,(H,28,29)
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n/an/a 80n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148181
PNG
(CHEMBL3765634)
Show SMILES OC(=O)CN(Cc1ccc(cc1)-c1ccccc1)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C22H19F2NO5S/c23-22(24)30-19-10-12-20(13-11-19)31(28,29)25(15-21(26)27)14-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-13,22H,14-15H2,(H,26,27)
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n/an/a 80n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147618
PNG
(CHEMBL3765022)
Show SMILES OC(=O)CN(C1(CCC1)c1ccc(cc1)-c1ccccc1OC(F)(F)F)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C26H22F5NO6S/c27-24(28)37-19-10-12-20(13-11-19)39(35,36)32(16-23(33)34)25(14-3-15-25)18-8-6-17(7-9-18)21-4-1-2-5-22(21)38-26(29,30)31/h1-2,4-13,24H,3,14-16H2,(H,33,34)
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n/an/a 82n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellula...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147617
PNG
(CHEMBL3765421)
Show SMILES OC(=O)CN(C1(CCC1)c1ccc(cc1)-c1ccc(Cl)cc1Cl)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C25H21Cl2F2NO5S/c26-18-6-11-21(22(27)14-18)16-2-4-17(5-3-16)25(12-1-13-25)30(15-23(31)32)36(33,34)20-9-7-19(8-10-20)35-24(28)29/h2-11,14,24H,1,12-13,15H2,(H,31,32)
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n/an/a 88n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellula...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048617
PNG
(CHEMBL3319623)
Show SMILES OC(=O)CN(Cc1cccc(Oc2ccccc2)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClNO5S/c22-17-9-11-20(12-10-17)29(26,27)23(15-21(24)25)14-16-5-4-8-19(13-16)28-18-6-2-1-3-7-18/h1-13H,14-15H2,(H,24,25)
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n/an/a 91n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50274183
PNG
(5-oxo-L-Proline-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-o...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H]1CCC(=O)N1
Show InChI InChI=1S/C27H47NO5/c1-3-5-7-9-10-11-12-13-14-16-21(32-27(31)23-18-19-25(29)28-23)20-24-22(26(30)33-24)17-15-8-6-4-2/h21-24H,3-20H2,1-2H3,(H,28,29)/t21-,22-,23-,24-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50147616
PNG
(CHEMBL3765497)
Show SMILES C[C@@H](N(CC(O)=O)S(=O)(=O)c1ccc(OC(F)F)cc1)c1ccc(cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1/C23H19Cl2F2NO5S/c1-14(15-2-4-16(5-3-15)20-11-6-17(24)12-21(20)25)28(13-22(29)30)34(31,32)19-9-7-18(8-10-19)33-23(26)27/h2-12,14,23H,13H2,1H3,(H,29,30)/t14-/s2
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellula...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50148152
PNG
(CHEMBL3764007)
Show SMILES OC(=O)CN(C1(CC1)c1ccc(cc1)-c1ccc(Cl)cc1Cl)S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C24H19Cl2F2NO5S/c25-17-5-10-20(21(26)13-17)15-1-3-16(4-2-15)24(11-12-24)29(14-22(30)31)35(32,33)19-8-6-18(7-9-19)34-23(27)28/h1-10,13,23H,11-12,14H2,(H,30,31)
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n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50242639
PNG
(5-((4-Azido-3-iodobenzamido)methyl)-N,N-dimethyl-1...)
Show SMILES CN(C)C(=O)n1nnnc1CNC(=O)c1ccc(N=[N+]=[N-])c(I)c1
Show InChI InChI=1S/C12H12IN9O2/c1-21(2)12(24)22-10(17-19-20-22)6-15-11(23)7-3-4-9(16-18-14)8(13)5-7/h3-5H,6H2,1-2H3,(H,15,23)
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n/an/a 130n/an/an/an/an/an/a



Università di Roma La Sapienza

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in COS cells after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048619
PNG
(CHEMBL3319621)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C26H25F3N2O6S/c1-25(2)11-10-18-13-21(7-8-22(18)37-25)38(34,35)31(16-24(32)33)15-17-4-3-5-20(12-17)36-23-9-6-19(14-30-23)26(27,28)29/h3-9,12-14H,10-11,15-16H2,1-2H3,(H,32,33)
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n/an/a 143n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50396276
PNG
(CHEMBL473511)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)OC(COC)COP(C)(F)=O
Show InChI InChI=1S/C23H44FO5P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(25)29-22(20-27-2)21-28-30(3,24)26/h11-12,22H,4-10,13-21H2,1-3H3/b12-11-
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n/an/a 160n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha


Citation and Details
More data for this
Ligand-Target Pair
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