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Compile Data Set for Download or QSAR

Found 390 hits Enz. Inhib. hit(s) with Target = 'Sodium/calcium exchanger 1(NCX1)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140907
PNG
(US8912224, 345)
Show SMILES Cc1ccccc1[C@@H]1CCc2cc(Oc3ncc(s3)C(=O)NCCOP(O)(O)=O)ccc2O1
Show InChI InChI=1S/C22H23N2O7PS/c1-14-4-2-3-5-17(14)19-8-6-15-12-16(7-9-18(15)31-19)30-22-24-13-20(33-22)21(25)23-10-11-29-32(26,27)28/h2-5,7,9,12-13,19H,6,8,10-11H2,1H3,(H,23,25)(H2,26,27,28)/t19-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140915
PNG
(US8912224, 353)
Show SMILES O=C(NCc1ccno1)c1csc(Oc2ccc3O[C@@H](CCc3c2)c2ccccc2)n1
Show InChI InChI=1S/C23H19N3O4S/c27-22(24-13-18-10-11-25-30-18)19-14-31-23(26-19)28-17-7-9-21-16(12-17)6-8-20(29-21)15-4-2-1-3-5-15/h1-5,7,9-12,14,20H,6,8,13H2,(H,24,27)/t20-/m0/s1
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n/an/a 92n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140607
PNG
(US8912224, 36)
Show SMILES O=C(NCc1ccncc1)c1cnc(Oc2ccc3O[C@@H](CCc3c2)c2ccccc2)s1
Show InChI InChI=1S/C25H21N3O3S/c29-24(27-15-17-10-12-26-13-11-17)23-16-28-25(32-23)30-20-7-9-22-19(14-20)6-8-21(31-22)18-4-2-1-3-5-18/h1-5,7,9-14,16,21H,6,8,15H2,(H,27,29)/t21-/m0/s1
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140778
PNG
(US8912224, 210)
Show SMILES C(NCc1cnc(Oc2ccc3O[C@@H](CCc3c2)c2ccccc2)s1)c1ccno1
Show InChI InChI=1S/C23H21N3O3S/c1-2-4-16(5-3-1)21-8-6-17-12-18(7-9-22(17)28-21)27-23-25-15-20(30-23)14-24-13-19-10-11-26-29-19/h1-5,7,9-12,15,21,24H,6,8,13-14H2/t21-/m0/s1
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140772
PNG
(US8912224, 204)
Show SMILES OCCNC(=O)c1cnc(Oc2ccc3O[C@@H](CCc3c2)c2ccccc2)s1
Show InChI InChI=1S/C21H20N2O4S/c24-11-10-22-20(25)19-13-23-21(28-19)26-16-7-9-18-15(12-16)6-8-17(27-18)14-4-2-1-3-5-14/h1-5,7,9,12-13,17,24H,6,8,10-11H2,(H,22,25)/t17-/m0/s1
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140739
PNG
(US8912224, 171)
Show SMILES O=C(NCc1ccno1)c1cnc(Oc2ccc3O[C@@H](CCc3c2)c2ccccc2)s1
Show InChI InChI=1S/C23H19N3O4S/c27-22(24-13-18-10-11-26-30-18)21-14-25-23(31-21)28-17-7-9-20-16(12-17)6-8-19(29-20)15-4-2-1-3-5-15/h1-5,7,9-12,14,19H,6,8,13H2,(H,24,27)/t19-/m0/s1
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140727
PNG
(US8912224, 159)
Show SMILES C(NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1)c1ccno1
Show InChI InChI=1/C23H21N3O3S/c1-2-4-16(5-3-1)21-8-6-17-12-18(7-9-22(17)28-21)27-23-25-15-20(30-23)14-24-13-19-10-11-26-29-19/h1-5,7,9-12,15,21,24H,6,8,13-14H2
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140810
PNG
(US8912224, 245)
Show SMILES COC(=O)CNCc1cnc(Oc2ccc3O[C@@H](CCc3c2)c2ccccc2)s1
Show InChI InChI=1S/C22H22N2O4S/c1-26-21(25)14-23-12-18-13-24-22(29-18)27-17-8-10-20-16(11-17)7-9-19(28-20)15-5-3-2-4-6-15/h2-6,8,10-11,13,19,23H,7,9,12,14H2,1H3/t19-/m0/s1
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140616
PNG
(US8912224, 45)
Show SMILES Fc1cccc(c1)C1CCc2cc(Oc3ncc(CNC(=O)Cc4cccnc4)s3)ccc2O1
Show InChI InChI=1/C26H22FN3O3S/c27-20-5-1-4-18(12-20)23-8-6-19-13-21(7-9-24(19)33-23)32-26-30-16-22(34-26)15-29-25(31)11-17-3-2-10-28-14-17/h1-5,7,9-10,12-14,16,23H,6,8,11,15H2,(H,29,31)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140618
PNG
(US8912224, 47)
Show SMILES O=S(=O)(NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1)c1cccnc1
Show InChI InChI=1/C24H21N3O4S2/c28-33(29,21-7-4-12-25-16-21)27-15-20-14-26-24(32-20)30-19-9-11-23-18(13-19)8-10-22(31-23)17-5-2-1-3-6-17/h1-7,9,11-14,16,22,27H,8,10,15H2
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140619
PNG
(US8912224, 48)
Show SMILES O=C(NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1)c1ccno1
Show InChI InChI=1/C23H19N3O4S/c27-22(21-10-11-26-30-21)24-13-18-14-25-23(31-18)28-17-7-9-20-16(12-17)6-8-19(29-20)15-4-2-1-3-5-15/h1-5,7,9-12,14,19H,6,8,13H2,(H,24,27)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140620
PNG
(US8912224, 49)
Show SMILES Fc1cccc(c1)C1CCc2cc(Oc3ncc(s3)C(=O)NCc3ccno3)ccc2O1
Show InChI InChI=1/C23H18FN3O4S/c24-16-3-1-2-14(10-16)19-6-4-15-11-17(5-7-20(15)30-19)29-23-26-13-21(32-23)22(28)25-12-18-8-9-27-31-18/h1-3,5,7-11,13,19H,4,6,12H2,(H,25,28)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140629
PNG
(US8912224, 59)
Show SMILES Cc1nc(Oc2ccc3OC(CCc3c2)c2ccccc2)sc1C(=O)NCc1ccncc1
Show InChI InChI=1/C26H23N3O3S/c1-17-24(25(30)28-16-18-11-13-27-14-12-18)33-26(29-17)31-21-8-10-23-20(15-21)7-9-22(32-23)19-5-3-2-4-6-19/h2-6,8,10-15,22H,7,9,16H2,1H3,(H,28,30)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140630
PNG
(US8912224, 60 | US8912224, 61)
Show SMILES O=C(NCc1ccncc1)c1cnc(Oc2ccc3OC(CCc3c2)c2ccsc2)s1
Show InChI InChI=1/C23H19N3O3S2/c27-22(25-12-15-5-8-24-9-6-15)21-13-26-23(31-21)28-18-2-4-19-16(11-18)1-3-20(29-19)17-7-10-30-14-17/h2,4-11,13-14,20H,1,3,12H2,(H,25,27)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140830
PNG
(US8912224, 266)
Show SMILES OCCNCc1cnc(Oc2ccc3O[C@@H](CCc3c2)c2ccccc2)s1
Show InChI InChI=1S/C21H22N2O3S/c24-11-10-22-13-18-14-23-21(27-18)25-17-7-9-20-16(12-17)6-8-19(26-20)15-4-2-1-3-5-15/h1-5,7,9,12,14,19,22,24H,6,8,10-11,13H2/t19-/m0/s1
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140586
PNG
(US8912224, 15)
Show SMILES O=C(NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1)c1cccnc1
Show InChI InChI=1/C25H21N3O3S/c29-24(19-7-4-12-26-14-19)27-15-21-16-28-25(32-21)30-20-9-11-23-18(13-20)8-10-22(31-23)17-5-2-1-3-6-17/h1-7,9,11-14,16,22H,8,10,15H2,(H,27,29)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140587
PNG
(US8912224, 16)
Show SMILES O=C(Cc1cccnc1)NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C26H23N3O3S/c30-25(13-18-5-4-12-27-15-18)28-16-22-17-29-26(33-22)31-21-9-11-24-20(14-21)8-10-23(32-24)19-6-2-1-3-7-19/h1-7,9,11-12,14-15,17,23H,8,10,13,16H2,(H,28,30)
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US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140590
PNG
(US8912224, 19)
Show SMILES O=C(Cc1ccccn1)NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C26H23N3O3S/c30-25(15-20-8-4-5-13-27-20)28-16-22-17-29-26(33-22)31-21-10-12-24-19(14-21)9-11-23(32-24)18-6-2-1-3-7-18/h1-8,10,12-14,17,23H,9,11,15-16H2,(H,28,30)
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US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140592
PNG
(US8912224, 21)
Show SMILES Cc1nccc(CNC(=O)c2cnc(Oc3ccc4OC(CCc4c3)c3ccccc3)s2)n1
Show InChI InChI=1/C25H22N4O3S/c1-16-26-12-11-19(29-16)14-27-24(30)23-15-28-25(33-23)31-20-8-10-22-18(13-20)7-9-21(32-22)17-5-3-2-4-6-17/h2-6,8,10-13,15,21H,7,9,14H2,1H3,(H,27,30)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140595
PNG
(US8912224, 24)
Show SMILES O=C(NCc1ccno1)c1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C23H19N3O4S/c27-22(24-13-18-10-11-26-30-18)21-14-25-23(31-21)28-17-7-9-20-16(12-17)6-8-19(29-20)15-4-2-1-3-5-15/h1-5,7,9-12,14,19H,6,8,13H2,(H,24,27)
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US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140600
PNG
(US8912224, 29)
Show SMILES CN(C)c1cc(CNC(=O)c2cnc(Oc3ccc4OC(CCc4c3)c3ccccc3)s2)ccn1
Show InChI InChI=1/C27H26N4O3S/c1-31(2)25-14-18(12-13-28-25)16-29-26(32)24-17-30-27(35-24)33-21-9-11-23-20(15-21)8-10-22(34-23)19-6-4-3-5-7-19/h3-7,9,11-15,17,22H,8,10,16H2,1-2H3,(H,29,32)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140874
PNG
(US8912224, 311)
Show SMILES OCCNCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C21H22N2O3S/c24-11-10-22-13-18-14-23-21(27-18)25-17-7-9-20-16(12-17)6-8-19(26-20)15-4-2-1-3-5-15/h1-5,7,9,12,14,19,22,24H,6,8,10-11,13H2
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140875
PNG
(US8912224, 312)
Show SMILES OCCN(CCO)C(=O)c1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C23H24N2O5S/c26-12-10-25(11-13-27)22(28)21-15-24-23(31-21)29-18-7-9-20-17(14-18)6-8-19(30-20)16-4-2-1-3-5-16/h1-5,7,9,14-15,19,26-27H,6,8,10-13H2
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140877
PNG
(US8912224, 314)
Show SMILES O=C(N1CCOCC1)c1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C23H22N2O4S/c26-22(25-10-12-27-13-11-25)21-15-24-23(30-21)28-18-7-9-20-17(14-18)6-8-19(29-20)16-4-2-1-3-5-16/h1-5,7,9,14-15,19H,6,8,10-13H2
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140879
PNG
(US8912224, 317)
Show SMILES CCCCNC(=O)c1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C23H24N2O3S/c1-2-3-13-24-22(26)21-15-25-23(29-21)27-18-10-12-20-17(14-18)9-11-19(28-20)16-7-5-4-6-8-16/h4-8,10,12,14-15,19H,2-3,9,11,13H2,1H3,(H,24,26)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140880
PNG
(US8912224, 318)
Show SMILES CC(C)CNC(=O)c1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C23H24N2O3S/c1-15(2)13-24-22(26)21-14-25-23(29-21)27-18-9-11-20-17(12-18)8-10-19(28-20)16-6-4-3-5-7-16/h3-7,9,11-12,14-15,19H,8,10,13H2,1-2H3,(H,24,26)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140888
PNG
(US8912224, 326)
Show SMILES Cc1ccccc1[C@@H]1CCc2cc(Oc3ncc(s3)C(=O)NCCO)ccc2O1
Show InChI InChI=1S/C22H22N2O4S/c1-14-4-2-3-5-17(14)19-8-6-15-12-16(7-9-18(15)28-19)27-22-24-13-20(29-22)21(26)23-10-11-25/h2-5,7,9,12-13,19,25H,6,8,10-11H2,1H3,(H,23,26)/t19-/m0/s1
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM47064
PNG
(US8912224, 57)
Show SMILES NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C19H18N2O2S/c20-11-16-12-21-19(24-16)22-15-7-9-18-14(10-15)6-8-17(23-18)13-4-2-1-3-5-13/h1-5,7,9-10,12,17H,6,8,11,20H2
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the PBX Calcium Assay Kit from BD (Becton, Dickinson and Company) with...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140913
PNG
(US8912224, 351)
Show SMILES CCCNC(=O)c1csc(Oc2ccc3O[C@@H](CCc3c2)c2ccccc2)n1
Show InChI InChI=1S/C22H22N2O3S/c1-2-12-23-21(25)18-14-28-22(24-18)26-17-9-11-20-16(13-17)8-10-19(27-20)15-6-4-3-5-7-15/h3-7,9,11,13-14,19H,2,8,10,12H2,1H3,(H,23,25)/t19-/m0/s1
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140912
PNG
(US8912224, 350)
Show SMILES OCCNC(=O)c1csc(Oc2ccc3O[C@@H](CCc3c2)c2ccccc2)n1
Show InChI InChI=1S/C21H20N2O4S/c24-11-10-22-20(25)17-13-28-21(23-17)26-16-7-9-19-15(12-16)6-8-18(27-19)14-4-2-1-3-5-14/h1-5,7,9,12-13,18,24H,6,8,10-11H2,(H,22,25)/t18-/m0/s1
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140916
PNG
(US8912224, 354)
Show SMILES CC(O)CNC(=O)c1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C22H22N2O4S/c1-14(25)12-23-21(26)20-13-24-22(29-20)27-17-8-10-19-16(11-17)7-9-18(28-19)15-5-3-2-4-6-15/h2-6,8,10-11,13-14,18,25H,7,9,12H2,1H3,(H,23,26)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140908
PNG
(US8912224, 346)
Show SMILES O=C(CN1CCCC1)NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C25H27N3O3S/c29-24(17-28-12-4-5-13-28)26-15-21-16-27-25(32-21)30-20-9-11-23-19(14-20)8-10-22(31-23)18-6-2-1-3-7-18/h1-3,6-7,9,11,14,16,22H,4-5,8,10,12-13,15,17H2,(H,26,29)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140928
PNG
(US8912224, 366)
Show SMILES COc1c(F)cccc1C1CCc2cc(Oc3ncc(s3)C(=O)NCc3ccno3)ccc2O1
Show InChI InChI=1/C24H20FN3O5S/c1-30-22-17(3-2-4-18(22)25)20-7-5-14-11-15(6-8-19(14)32-20)31-24-27-13-21(34-24)23(29)26-12-16-9-10-28-33-16/h2-4,6,8-11,13,20H,5,7,12H2,1H3,(H,26,29)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140629
PNG
(US8912224, 59)
Show SMILES Cc1nc(Oc2ccc3OC(CCc3c2)c2ccccc2)sc1C(=O)NCc1ccncc1
Show InChI InChI=1/C26H23N3O3S/c1-17-24(25(30)28-16-18-11-13-27-14-12-18)33-26(29-17)31-21-8-10-23-20(15-21)7-9-22(32-23)19-5-3-2-4-6-19/h2-6,8,10-15,22H,7,9,16H2,1H3,(H,28,30)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the PBX Calcium Assay Kit from BD (Becton, Dickinson and Company) with...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140604
PNG
(US8912224, 33)
Show SMILES Cc1cc(C)nc(CNC(=O)c2cnc(Oc3ccc4OC(CCc4c3)c3ccccc3)s2)n1
Show InChI InChI=1/C26H24N4O3S/c1-16-12-17(2)30-24(29-16)15-27-25(31)23-14-28-26(34-23)32-20-9-11-22-19(13-20)8-10-21(33-22)18-6-4-3-5-7-18/h3-7,9,11-14,21H,8,10,15H2,1-2H3,(H,27,31)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140605
PNG
(US8912224, 34)
Show SMILES Cc1noc(C)c1CCNC(=O)c1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C26H25N3O4S/c1-16-21(17(2)33-29-16)12-13-27-25(30)24-15-28-26(34-24)31-20-9-11-23-19(14-20)8-10-22(32-23)18-6-4-3-5-7-18/h3-7,9,11,14-15,22H,8,10,12-13H2,1-2H3,(H,27,30)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140608
PNG
(US8912224, 37)
Show SMILES O=C(NCc1ccncc1)c1cnc(Oc2ccc3O[C@H](CCc3c2)c2ccccc2)s1
Show InChI InChI=1S/C25H21N3O3S/c29-24(27-15-17-10-12-26-13-11-17)23-16-28-25(32-23)30-20-7-9-22-19(14-20)6-8-21(31-22)18-4-2-1-3-5-18/h1-5,7,9-14,16,21H,6,8,15H2,(H,27,29)/t21-/m1/s1
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140613
PNG
(US8912224, 42)
Show SMILES Oc1cc(CNC(=O)c2cnc(Oc3ccc4OC(CCc4c3)c3ccccc3)s2)ccn1
Show InChI InChI=1/C25H21N3O4S/c29-23-12-16(10-11-26-23)14-27-24(30)22-15-28-25(33-22)31-19-7-9-21-18(13-19)6-8-20(32-21)17-4-2-1-3-5-17/h1-5,7,9-13,15,20H,6,8,14H2,(H,26,29)(H,27,30)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140615
PNG
(US8912224, 44)
Show SMILES Fc1cccc(c1)C1CCc2cc(Oc3ncc(CNC(=O)c4cccnc4)s3)ccc2O1
Show InChI InChI=1/C25H20FN3O3S/c26-19-5-1-3-16(11-19)22-8-6-17-12-20(7-9-23(17)32-22)31-25-29-15-21(33-25)14-28-24(30)18-4-2-10-27-13-18/h1-5,7,9-13,15,22H,6,8,14H2,(H,28,30)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140617
PNG
(US8912224, 46)
Show SMILES Fc1cccc(c1)C1CCc2cc(Oc3ncc(CNC(=O)Cc4ccncc4)s3)ccc2O1
Show InChI InChI=1/C26H22FN3O3S/c27-20-3-1-2-18(13-20)23-6-4-19-14-21(5-7-24(19)33-23)32-26-30-16-22(34-26)15-29-25(31)12-17-8-10-28-11-9-17/h1-3,5,7-11,13-14,16,23H,4,6,12,15H2,(H,29,31)
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US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140621
PNG
(US8912224, 50)
Show SMILES Cn1cnc(c1)S(=O)(=O)NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C23H22N4O4S2/c1-27-14-22(25-15-27)33(28,29)26-13-19-12-24-23(32-19)30-18-8-10-21-17(11-18)7-9-20(31-21)16-5-3-2-4-6-16/h2-6,8,10-12,14-15,20,26H,7,9,13H2,1H3
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US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140622
PNG
(US8912224, 51)
Show SMILES Cc1c(CNC(=O)c2cnc(Oc3ccc4OC(CCc4c3)c3cccc(F)c3)s2)cnn1C
Show InChI InChI=1/C25H23FN4O3S/c1-15-18(13-29-30(15)2)12-27-24(31)23-14-28-25(34-23)32-20-7-9-22-17(11-20)6-8-21(33-22)16-4-3-5-19(26)10-16/h3-5,7,9-11,13-14,21H,6,8,12H2,1-2H3,(H,27,31)
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US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140625
PNG
(US8912224, 54)
Show SMILES C[C@H](NC(=O)c1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1)c1nccs1
Show InChI InChI=1S/C24H21N3O3S2/c1-15(23-25-11-12-31-23)27-22(28)21-14-26-24(32-21)29-18-8-10-20-17(13-18)7-9-19(30-20)16-5-3-2-4-6-16/h2-6,8,10-15,19H,7,9H2,1H3,(H,27,28)/t15-,19?/m0/s1
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140627
PNG
(US8912224, 56)
Show SMILES Cc1nccc(CNC(=O)c2cnc(Oc3ccc4OC(CCc4c3)c3cccc(F)c3)s2)n1
Show InChI InChI=1/C25H21FN4O3S/c1-15-27-10-9-19(30-15)13-28-24(31)23-14-29-25(34-23)32-20-6-8-22-17(12-20)5-7-21(33-22)16-3-2-4-18(26)11-16/h2-4,6,8-12,14,21H,5,7,13H2,1H3,(H,28,31)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140630
PNG
(US8912224, 60 | US8912224, 61)
Show SMILES O=C(NCc1ccncc1)c1cnc(Oc2ccc3OC(CCc3c2)c2ccsc2)s1
Show InChI InChI=1/C23H19N3O3S2/c27-22(25-12-15-5-8-24-9-6-15)21-13-26-23(31-21)28-18-2-4-19-16(11-18)1-3-20(29-19)17-7-10-30-14-17/h2,4-11,13-14,20H,1,3,12H2,(H,25,27)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140635
PNG
(US8912224, 65)
Show SMILES Cc1noc(C)c1C(=O)NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C25H23N3O4S/c1-15-23(16(2)32-28-15)24(29)26-13-20-14-27-25(33-20)30-19-9-11-22-18(12-19)8-10-21(31-22)17-6-4-3-5-7-17/h3-7,9,11-12,14,21H,8,10,13H2,1-2H3,(H,26,29)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140648
PNG
(US8912224, 79)
Show SMILES O=C(NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1)c1ccncc1
Show InChI InChI=1/C25H21N3O3S/c29-24(18-10-12-26-13-11-18)27-15-21-16-28-25(32-21)30-20-7-9-23-19(14-20)6-8-22(31-23)17-4-2-1-3-5-17/h1-5,7,9-14,16,22H,6,8,15H2,(H,27,29)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140649
PNG
(US8912224, 80)
Show SMILES Clc1cnccc1C(=O)NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C25H20ClN3O3S/c26-21-15-27-11-10-20(21)24(30)28-13-19-14-29-25(33-19)31-18-7-9-23-17(12-18)6-8-22(32-23)16-4-2-1-3-5-16/h1-5,7,9-12,14-15,22H,6,8,13H2,(H,28,30)
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Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140658
PNG
(US8912224, 89)
Show SMILES O=C(NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1)c1ccncn1
Show InChI InChI=1/C24H20N4O3S/c29-23(20-10-11-25-15-28-20)26-13-19-14-27-24(32-19)30-18-7-9-22-17(12-18)6-8-21(31-22)16-4-2-1-3-5-16/h1-5,7,9-12,14-15,21H,6,8,13H2,(H,26,29)
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US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140672
PNG
(US8912224, 103)
Show SMILES C(NC1CC1)c1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1
Show InChI InChI=1/C22H22N2O2S/c1-2-4-15(5-3-1)20-10-6-16-12-18(9-11-21(16)26-20)25-22-24-14-19(27-22)13-23-17-7-8-17/h1-5,9,11-12,14,17,20,23H,6-8,10,13H2
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US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)

More data for this
Ligand-Target Pair
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