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Compile Data Set for Download or QSAR

Found 9 hits Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 1' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 1


(Rattus norvegicus)
BDBM50426887
PNG
(CHEMBL2323695)
Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)N2CCNCC2)cc1C
Show InChI InChI=1S/C32H49N5O8/c1-18(2)25-22(29(36-35-25)45-30-28(42)27(41)26(40)23(17-38)44-30)16-21-10-9-20(15-19(21)3)7-6-8-24(39)34-32(4,5)31(43)37-13-11-33-12-14-37/h9-10,15,18,23,26-28,30,33,38,40-42H,6-8,11-14,16-17H2,1-5H3,(H,34,39)(H,35,36)/t23-,26-,27+,28-,30+/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Kissei Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT1


Bioorg Med Chem 21: 748-65 (2013)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Rattus norvegicus)
BDBM50394534
PNG
(CHEMBL2159102)
Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(C)cc1C
Show InChI InChI=1S/C21H30N2O6/c1-10(2)16-14(8-13-6-5-11(3)7-12(13)4)20(23-22-16)29-21-19(27)18(26)17(25)15(9-24)28-21/h5-7,10,15,17-19,21,24-27H,8-9H2,1-4H3,(H,22,23)/t15-,17-,18+,19-,21+/m1/s1
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n/an/a 67n/an/an/an/an/an/a



Kissei Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake


Bioorg Med Chem 20: 6598-612 (2012)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Rattus norvegicus)
BDBM50426888
PNG
(CHEMBL2323694)
Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)N2CCNCC2)cc1
Show InChI InChI=1S/C31H47N5O8/c1-18(2)24-21(28(35-34-24)44-29-27(41)26(40)25(39)22(17-37)43-29)16-20-10-8-19(9-11-20)6-5-7-23(38)33-31(3,4)30(42)36-14-12-32-13-15-36/h8-11,18,22,25-27,29,32,37,39-41H,5-7,12-17H2,1-4H3,(H,33,38)(H,34,35)/t22-,25+,26+,27-,29+/m1/s1
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n/an/a 104n/an/an/an/an/an/a



Kissei Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT1


Bioorg Med Chem 21: 748-65 (2013)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Rattus norvegicus)
BDBM50394533
PNG
(CHEMBL2159101)
Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(O)cc1C
Show InChI InChI=1S/C20H28N2O7/c1-9(2)15-13(7-11-4-5-12(24)6-10(11)3)19(22-21-15)29-20-18(27)17(26)16(25)14(8-23)28-20/h4-6,9,14,16-18,20,23-27H,7-8H2,1-3H3,(H,21,22)/t14-,16-,17+,18-,20+/m1/s1
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n/an/a 183n/an/an/an/an/an/a



Kissei Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake


Bioorg Med Chem 20: 6598-612 (2012)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Rattus norvegicus)
BDBM50394533
PNG
(CHEMBL2159101)
Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(O)cc1C
Show InChI InChI=1S/C20H28N2O7/c1-9(2)15-13(7-11-4-5-12(24)6-10(11)3)19(22-21-15)29-20-18(27)17(26)16(25)14(8-23)28-20/h4-6,9,14,16-18,20,23-27H,7-8H2,1-3H3,(H,21,22)/t14-,16-,17+,18-,20+/m1/s1
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n/an/a 183n/an/an/an/an/an/a



Kissei Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT1


Bioorg Med Chem 21: 748-65 (2013)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Rattus norvegicus)
BDBM50394532
PNG
(CHEMBL2159094)
Show SMILES OC[C@H]1O[C@@H](Oc2[nH]nc(c2Cc2ccccc2OCc2ccccc2)C(F)(F)F)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C24H25F3N2O7/c25-24(26,27)21-15(10-14-8-4-5-9-16(14)34-12-13-6-2-1-3-7-13)22(29-28-21)36-23-20(33)19(32)18(31)17(11-30)35-23/h1-9,17-20,23,30-33H,10-12H2,(H,28,29)/t17-,18-,19+,20-,23+/m1/s1
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n/an/a 227n/an/an/an/an/an/a



Kissei Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake


Bioorg Med Chem 20: 6598-612 (2012)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Rattus norvegicus)
BDBM50394531
PNG
(CHEMBL2159091)
Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccccc1OCc1ccccc1
Show InChI InChI=1S/C26H32N2O7/c1-15(2)21-18(12-17-10-6-7-11-19(17)33-14-16-8-4-3-5-9-16)25(28-27-21)35-26-24(32)23(31)22(30)20(13-29)34-26/h3-11,15,20,22-24,26,29-32H,12-14H2,1-2H3,(H,27,28)/t20-,22-,23+,24-,26+/m1/s1
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n/an/a 308n/an/an/an/an/an/a



Kissei Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake


Bioorg Med Chem 20: 6598-612 (2012)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Rattus norvegicus)
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/a 350n/an/an/an/an/an/a



Kissei Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake


Bioorg Med Chem 20: 6598-612 (2012)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Rattus norvegicus)
BDBM50340014
PNG
(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Show SMILES Cn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H16ClF3N4OS2/c1-27-17(25-26-19(27)31-10-12-2-5-14(21)6-3-12)9-28-15-8-13(20(22,23)24)4-7-16(15)30-11-18(28)29/h2-8H,9-11H2,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillatio...


Bioorg Med Chem Lett 21: 2472-5 (2011)

More data for this
Ligand-Target Pair