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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Sodium/myo-inositol cotransporter 2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/myo-inositol cotransporter 2


(Homo sapiens)
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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Article
PubMed
n/an/a 380n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of SGLT6 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/myo-inositol cotransporter 2


(Homo sapiens)
BDBM50340013
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H18Cl3F3N4O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(26,27)28)11-32-17-10-15(24)9-16(25)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12H2
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PubMed
n/an/a 9.20E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of SGLT6 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/myo-inositol cotransporter 2


(Homo sapiens)
BDBM50340012
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H21Cl3N4O2/c1-2-9-28-19(8-5-14-3-6-15(23)7-4-14)26-27-20(28)12-29-18-11-16(24)10-17(25)22(18)31-13-21(29)30/h3-4,6-7,10-11H,2,5,8-9,12-13H2,1H3
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PubMed
n/an/a 1.44E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of SGLT6 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation co...


Citation and Details
More data for this
Ligand-Target Pair