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Found 79 hits Enz. Inhib. hit(s) with Target = 'Sodium channel protein type I I alpha subunit' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50172364
PNG
(2-{[(1R,3S,5R,7S,9R,11S,12S,14R,16R,18S,20R,21Z,24...)
Show SMILES C[C@@H]1C[C@@H]2O[C@@H]3C[C@@H]4OC(=O)C=C(C)[C@H]4O[C@@]3(C)C[C@H]2O[C@H]2CC[C@@]3(C)O[C@@]4(C)C[C@H]5O[C@H]6C[C@H]7O[C@@]8(C)[C@@H](O)C[C@@H](CC(=C)C=O)O[C@@H]8C[C@@H]7O[C@@H]6\C=C/C[C@]5(C)O[C@@H]4C[C@@H]3O[C@H]12
Show InChI InChI=1S/C50H70O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,24,26,28-42,44-45,52H,1,11-15,17-23H2,2-8H3/b10-9-/t26-,28-,29-,30+,31+,32+,33+,34-,35+,36-,37+,38-,39+,40-,41-,42-,44-,45-,46+,47-,48+,49+,50+/m1/s1
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n/an/a 15.0n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against synaptosomes using [3H]PbTx-3


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50172364
PNG
(2-{[(1R,3S,5R,7S,9R,11S,12S,14R,16R,18S,20R,21Z,24...)
Show SMILES C[C@@H]1C[C@@H]2O[C@@H]3C[C@@H]4OC(=O)C=C(C)[C@H]4O[C@@]3(C)C[C@H]2O[C@H]2CC[C@@]3(C)O[C@@]4(C)C[C@H]5O[C@H]6C[C@H]7O[C@@]8(C)[C@@H](O)C[C@@H](CC(=C)C=O)O[C@@H]8C[C@@H]7O[C@@H]6\C=C/C[C@]5(C)O[C@@H]4C[C@@H]3O[C@H]12
Show InChI InChI=1S/C50H70O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,24,26,28-42,44-45,52H,1,11-15,17-23H2,2-8H3/b10-9-/t26-,28-,29-,30+,31+,32+,33+,34-,35+,36-,37+,38-,39+,40-,41-,42-,44-,45-,46+,47-,48+,49+,50+/m1/s1
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n/an/a 15.0n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against synaptosome using [3H]PbTx-3


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143966
PNG
(2-Chloro-N-[2-{4-[3-(4-fluoro-phenoxy)-2-hydroxy-p...)
Show SMILES OC(COc1ccc(F)cc1)CN1CCN(CC1)C(CNS(=O)(=O)c1ccccc1Cl)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C28H30ClF4N3O4S/c29-25-3-1-2-4-27(25)41(38,39)34-17-26(20-5-7-21(8-6-20)28(31,32)33)36-15-13-35(14-16-36)18-23(37)19-40-24-11-9-22(30)10-12-24/h1-12,23,26,34,37H,13-19H2
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n/an/a 76n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in vitro in rat cerebral cortex membrane at ...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143963
PNG
(CHEMBL64869 | N-[2-{4-[3-(4-Bromo-phenoxy)-2-hydro...)
Show SMILES Cc1cccc(c1)S(=O)(=O)NCC(N1CCN(CC(O)COc2ccc(Br)cc2)CC1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H33BrF3N3O4S/c1-21-3-2-4-27(17-21)41(38,39)34-18-28(22-5-7-23(8-6-22)29(31,32)33)36-15-13-35(14-16-36)19-25(37)20-40-26-11-9-24(30)10-12-26/h2-12,17,25,28,34,37H,13-16,18-20H2,1H3
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n/an/a 95n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in vitro in rat cerebral cortex membrane at ...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143950
PNG
(CHEMBL305591 | N-Benzyl-2-{4-[3-(2,6-dimethyl-phen...)
Show SMILES Cc1cccc(C)c1OCC(O)CN1CCN(CC1)C(C(=O)NCc1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C30H36FN3O3/c1-22-7-6-8-23(2)29(22)37-21-27(35)20-33-15-17-34(18-16-33)28(25-11-13-26(31)14-12-25)30(36)32-19-24-9-4-3-5-10-24/h3-14,27-28,35H,15-21H2,1-2H3,(H,32,36)
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n/an/a 149n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143952
PNG
(CHEMBL59712 | N-{1-[2-Hydroxy-3-(4-methoxy-phenoxy...)
Show SMILES COc1ccc(OCC(O)CN2CCC(CC2)N(C(=O)c2ccc(OC)cc2)c2ccccc2)cc1
Show InChI InChI=1S/C29H34N2O5/c1-34-26-10-8-22(9-11-26)29(33)31(23-6-4-3-5-7-23)24-16-18-30(19-17-24)20-25(32)21-36-28-14-12-27(35-2)13-15-28/h3-15,24-25,32H,16-21H2,1-2H3
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n/an/a 183n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143954
PNG
(CHEMBL433100 | N-(4-Fluoro-phenyl)-N-{1-[2-hydroxy...)
Show SMILES COc1ccc(OCC(O)CN2CCC(CC2)N(C(=O)c2ccc(OC)cc2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C29H33FN2O5/c1-35-26-9-3-21(4-10-26)29(34)32(23-7-5-22(30)6-8-23)24-15-17-31(18-16-24)19-25(33)20-37-28-13-11-27(36-2)12-14-28/h3-14,24-25,33H,15-20H2,1-2H3
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n/an/a 191n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143958
PNG
(CHEMBL63060 | N-(4-Fluoro-phenyl)-N-{1-[2-hydroxy-...)
Show SMILES COc1ccc(OCC(O)CN2CCC(CC2)N(C(=O)c2ccccc2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C28H31FN2O4/c1-34-26-11-13-27(14-12-26)35-20-25(32)19-30-17-15-24(16-18-30)31(23-9-7-22(29)8-10-23)28(33)21-5-3-2-4-6-21/h2-14,24-25,32H,15-20H2,1H3
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n/an/a 194n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143962
PNG
(CHEMBL62878 | N-(2-{4-[3-(4-Chloro-phenoxy)-2-hydr...)
Show SMILES OC(COc1ccc(Cl)cc1)CN1CCN(CC1)C(CNC(=O)c1ccc(cc1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C29H31ClF3N3O3/c30-24-10-12-26(13-11-24)39-20-25(37)19-35-14-16-36(17-15-35)27(21-4-2-1-3-5-21)18-34-28(38)22-6-8-23(9-7-22)29(31,32)33/h1-13,25,27,37H,14-20H2,(H,34,38)
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n/an/a 208n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143975
PNG
(2-(4-Fluoro-phenyl)-2-{4-[2-hydroxy-3-(4-methoxy-p...)
Show SMILES COc1ccc(CNC(=O)C(N2CCN(CC(O)COc3ccc(OC)cc3)CC2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C30H36FN3O5/c1-37-26-9-3-22(4-10-26)19-32-30(36)29(23-5-7-24(31)8-6-23)34-17-15-33(16-18-34)20-25(35)21-39-28-13-11-27(38-2)12-14-28/h3-14,25,29,35H,15-21H2,1-2H3,(H,32,36)
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n/an/a 214n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143964
PNG
(4-Chloro-N-(4-fluoro-phenyl)-N-{1-[2-hydroxy-3-(4-...)
Show SMILES COc1ccc(OCC(O)CN2CCC(CC2)N(C(=O)c2ccc(Cl)cc2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C28H30ClFN2O4/c1-35-26-10-12-27(13-11-26)36-19-25(33)18-31-16-14-24(15-17-31)32(23-8-6-22(30)7-9-23)28(34)20-2-4-21(29)5-3-20/h2-13,24-25,33H,14-19H2,1H3
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n/an/a 214n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143945
PNG
(4-Chloro-N-{1-[2-hydroxy-3-(4-methoxy-phenoxy)-pro...)
Show SMILES COc1ccc(OCC(O)CN2CCC(CC2)N(C(=O)c2ccc(Cl)cc2)c2ccccc2)cc1
Show InChI InChI=1S/C28H31ClN2O4/c1-34-26-11-13-27(14-12-26)35-20-25(32)19-30-17-15-24(16-18-30)31(23-5-3-2-4-6-23)28(33)21-7-9-22(29)10-8-21/h2-14,24-25,32H,15-20H2,1H3
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n/an/a 228n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143970
PNG
(CHEMBL61336 | N-(2-{4-[2-Hydroxy-3-(4-methoxy-phen...)
Show SMILES COc1ccc(OCC(O)CN2CCN(CC2)C(CNC(=O)c2ccc(cc2)C(F)(F)F)c2ccccc2)cc1
Show InChI InChI=1S/C30H34F3N3O4/c1-39-26-11-13-27(14-12-26)40-21-25(37)20-35-15-17-36(18-16-35)28(22-5-3-2-4-6-22)19-34-29(38)23-7-9-24(10-8-23)30(31,32)33/h2-14,25,28,37H,15-21H2,1H3,(H,34,38)
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n/an/a 253n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143957
PNG
(CHEMBL60847 | N-Benzyl-2-(4-fluoro-phenyl)-2-{4-[2...)
Show SMILES COc1ccc(OCC(O)CN2CCN(CC2)C(C(=O)NCc2ccccc2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C29H34FN3O4/c1-36-26-11-13-27(14-12-26)37-21-25(34)20-32-15-17-33(18-16-32)28(23-7-9-24(30)10-8-23)29(35)31-19-22-5-3-2-4-6-22/h2-14,25,28,34H,15-21H2,1H3,(H,31,35)
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n/an/a 254n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143961
PNG
(CHEMBL62240 | N-{1-[2-Hydroxy-3-(4-methoxy-phenoxy...)
Show SMILES COc1ccc(OCC(O)CN2CCC(CC2)N(C(=O)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C28H32N2O4/c1-33-26-12-14-27(15-13-26)34-21-25(31)20-29-18-16-24(17-19-29)30(23-10-6-3-7-11-23)28(32)22-8-4-2-5-9-22/h2-15,24-25,31H,16-21H2,1H3
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n/an/a 261n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143949
PNG
(CHEMBL60843 | N-Benzyl-2-{4-[3-(2,6-dimethyl-pheno...)
Show SMILES Cc1cccc(C)c1OCC(O)CN1CCN(CC1)C(C(=O)NCc1ccccc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C31H36F3N3O3/c1-22-7-6-8-23(2)29(22)40-21-27(38)20-36-15-17-37(18-16-36)28(25-11-13-26(14-12-25)31(32,33)34)30(39)35-19-24-9-4-3-5-10-24/h3-14,27-28,38H,15-21H2,1-2H3,(H,35,39)
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n/an/a 296n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143967
PNG
(CHEMBL60568 | N-Benzyl-2-{4-[3-(2,6-dimethyl-pheno...)
Show SMILES Cc1ccc(cc1)C(N1CCN(CC(O)COc2c(C)cccc2C)CC1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C31H39N3O3/c1-23-12-14-27(15-13-23)29(31(36)32-20-26-10-5-4-6-11-26)34-18-16-33(17-19-34)21-28(35)22-37-30-24(2)8-7-9-25(30)3/h4-15,28-29,35H,16-22H2,1-3H3,(H,32,36)
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ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143976
PNG
(2-{4-[3-(2,6-Dimethyl-phenoxy)-2-hydroxy-propyl]-p...)
Show SMILES COc1ccc(CNC(=O)C(N2CCN(CC(O)COc3c(C)cccc3C)CC2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C31H38FN3O4/c1-22-5-4-6-23(2)30(22)39-21-27(36)20-34-15-17-35(18-16-34)29(25-9-11-26(32)12-10-25)31(37)33-19-24-7-13-28(38-3)14-8-24/h4-14,27,29,36H,15-21H2,1-3H3,(H,33,37)
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n/an/a 343n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143956
PNG
(2-{4-[3-(2,6-Dimethyl-phenoxy)-2-hydroxy-propyl]-p...)
Show SMILES COc1ccc(CNC(=O)C(N2CCN(CC(O)COc3c(C)cccc3C)CC2)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C32H41N3O4/c1-23-8-12-27(13-9-23)30(32(37)33-20-26-10-14-29(38-4)15-11-26)35-18-16-34(17-19-35)21-28(36)22-39-31-24(2)6-5-7-25(31)3/h5-15,28,30,36H,16-22H2,1-4H3,(H,33,37)
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ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143974
PNG
(2-{4-[3-(2,6-Dimethyl-phenoxy)-2-hydroxy-propyl]-p...)
Show SMILES COc1ccc(CNC(=O)C(N2CCN(CC(O)COc3c(C)cccc3C)CC2)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C32H38F3N3O4/c1-22-5-4-6-23(2)30(22)42-21-27(39)20-37-15-17-38(18-16-37)29(25-9-11-26(12-10-25)32(33,34)35)31(40)36-19-24-7-13-28(41-3)14-8-24/h4-14,27,29,39H,15-21H2,1-3H3,(H,36,40)
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n/an/a 355n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143955
PNG
(2-{4-[2-Hydroxy-3-(4-methoxy-phenoxy)-propyl]-pipe...)
Show SMILES COc1ccc(CNC(=O)C(N2CCN(CC(O)COc3ccc(OC)cc3)CC2)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C31H36F3N3O5/c1-40-26-9-3-22(4-10-26)19-35-30(39)29(23-5-7-24(8-6-23)31(32,33)34)37-17-15-36(16-18-37)20-25(38)21-42-28-13-11-27(41-2)12-14-28/h3-14,25,29,38H,15-21H2,1-2H3,(H,35,39)
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n/an/a 359n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143965
PNG
(CHEMBL60666 | N-(2-{4-[3-(4-Chloro-phenoxy)-2-hydr...)
Show SMILES COc1ccccc1C(=O)NCC(N1CCN(CC(O)COc2ccc(Cl)cc2)CC1)c1ccccc1
Show InChI InChI=1S/C29H34ClN3O4/c1-36-28-10-6-5-9-26(28)29(35)31-19-27(22-7-3-2-4-8-22)33-17-15-32(16-18-33)20-24(34)21-37-25-13-11-23(30)12-14-25/h2-14,24,27,34H,15-21H2,1H3,(H,31,35)
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n/an/a 363n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143947
PNG
(4-Fluoro-N-{2-[4-(2-hydroxy-3-phenoxy-propyl)-pipe...)
Show SMILES OC(COc1ccccc1)CN1CCN(CC1)C(CNC(=O)c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C28H32FN3O3/c29-24-13-11-23(12-14-24)28(34)30-19-27(22-7-3-1-4-8-22)32-17-15-31(16-18-32)20-25(33)21-35-26-9-5-2-6-10-26/h1-14,25,27,33H,15-21H2,(H,30,34)
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n/an/a 363n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50017659
PNG
(2-(Dimethylamino)ethyl p-(butylamino)benzoate | 2-...)
Show SMILES CCCCNc1ccc(cc1)C(=O)OCCN(C)C
Show InChI InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
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n/an/a 400n/an/an/an/an/an/a


TBA

Assay Description
Antagonism of batrachotoxin-mediated sodium ion uptake into cultured neuroblastoma cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143951
PNG
(1-Allyloxy-3-{4-[(4-chloro-phenyl)-phenyl-methyl]-...)
Show SMILES OC(COCC=C)CN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H29ClN2O2/c1-2-16-28-18-22(27)17-25-12-14-26(15-13-25)23(19-6-4-3-5-7-19)20-8-10-21(24)11-9-20/h2-11,22-23,27H,1,12-18H2
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n/an/a 401n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143971
PNG
(CHEMBL59644 | N-Benzyl-2-{4-[2-hydroxy-3-(4-methox...)
Show SMILES COc1ccc(OCC(O)CN2CCN(CC2)C(C(=O)NCc2ccccc2)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C30H34F3N3O4/c1-39-26-11-13-27(14-12-26)40-21-25(37)20-35-15-17-36(18-16-35)28(23-7-9-24(10-8-23)30(31,32)33)29(38)34-19-22-5-3-2-4-6-22/h2-14,25,28,37H,15-21H2,1H3,(H,34,38)
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n/an/a 429n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50290406
PNG
(Benzoic acid 3-dimethylaminomethyl-5-hydroxy-5-(1-...)
Show SMILES CO[C@]12CCC3(C)C(CCC[C@]3(O1)[C@H](O)C[C@@H](CCOC(=O)c1ccccc1)CN(C)C)C2
Show InChI InChI=1S/C27H41NO5/c1-25-14-15-26(31-4)18-22(25)11-8-13-27(25,33-26)23(29)17-20(19-28(2)3)12-16-32-24(30)21-9-6-5-7-10-21/h5-7,9-10,20,22-23,29H,8,11-19H2,1-4H3/t20-,22?,23-,25?,26-,27+/m1/s1
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n/an/a 500n/an/an/an/an/an/a


TBA

Assay Description
Antagonism of batrachotoxin-mediated sodium ion uptake into cultured neuroblastoma cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143969
PNG
(CHEMBL64583 | N-(2-{4-[3-(4-Bromo-phenoxy)-2-hydro...)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)NCC(N1CCN(CC(O)COc2ccc(Br)cc2)CC1)c1ccccc1
Show InChI InChI=1S/C29H36BrN3O6S/c1-37-26-12-13-28(38-2)29(18-26)40(35,36)31-19-27(22-6-4-3-5-7-22)33-16-14-32(15-17-33)20-24(34)21-39-25-10-8-23(30)9-11-25/h3-13,18,24,27,31,34H,14-17,19-21H2,1-2H3
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n/an/a 522n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143968
PNG
(4-Fluoro-N-(2-{4-[2-hydroxy-3-(4-methoxy-phenoxy)-...)
Show SMILES COc1ccc(OCC(O)CN2CCN(CC2)C(CNC(=O)c2ccc(F)cc2)c2ccccc2)cc1
Show InChI InChI=1S/C29H34FN3O4/c1-36-26-11-13-27(14-12-26)37-21-25(34)20-32-15-17-33(18-16-32)28(22-5-3-2-4-6-22)19-31-29(35)23-7-9-24(30)10-8-23/h2-14,25,28,34H,15-21H2,1H3,(H,31,35)
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n/an/a 531n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143959
PNG
(CHEMBL61283 | N-(2-{4-[3-(4-Chloro-phenoxy)-2-hydr...)
Show SMILES COc1ccc(cc1)C(=O)NCC(N1CCN(CC(O)COc2ccc(Cl)cc2)CC1)c1ccccc1
Show InChI InChI=1S/C29H34ClN3O4/c1-36-26-11-7-23(8-12-26)29(35)31-19-28(22-5-3-2-4-6-22)33-17-15-32(16-18-33)20-25(34)21-37-27-13-9-24(30)10-14-27/h2-14,25,28,34H,15-21H2,1H3,(H,31,35)
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n/an/a 538n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143972
PNG
(2-{4-[3-(2,6-Dimethyl-phenoxy)-2-hydroxy-propyl]-p...)
Show SMILES COc1ccc(CNC(=O)C(N2CCN(CC(O)COc3c(C)cccc3C)CC2)c2ccc(OC)cc2)cc1
Show InChI InChI=1S/C32H41N3O5/c1-23-6-5-7-24(2)31(23)40-22-27(36)21-34-16-18-35(19-17-34)30(26-10-14-29(39-4)15-11-26)32(37)33-20-25-8-12-28(38-3)13-9-25/h5-15,27,30,36H,16-22H2,1-4H3,(H,33,37)
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n/an/a 571n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143973
PNG
(CHEMBL291629 | N-Benzyl-2-{4-[2-hydroxy-3-(4-metho...)
Show SMILES COc1ccc(OCC(O)CN2CCN(CC2)C(C(=O)NCc2ccccc2)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C30H37N3O4/c1-23-8-10-25(11-9-23)29(30(35)31-20-24-6-4-3-5-7-24)33-18-16-32(17-19-33)21-26(34)22-37-28-14-12-27(36-2)13-15-28/h3-15,26,29,34H,16-22H2,1-2H3,(H,31,35)
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n/an/a 579n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143960
PNG
(CHEMBL64688 | N-(2-{4-[2-Hydroxy-3-(4-methoxy-phen...)
Show SMILES COc1ccc(OCC(O)CN2CCN(CC2)C(CNC(=O)c2ccccc2OC)c2ccccc2)cc1
Show InChI InChI=1S/C30H37N3O5/c1-36-25-12-14-26(15-13-25)38-22-24(34)21-32-16-18-33(19-17-32)28(23-8-4-3-5-9-23)20-31-30(35)27-10-6-7-11-29(27)37-2/h3-15,24,28,34H,16-22H2,1-2H3,(H,31,35)
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n/an/a 721n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143946
PNG
(CHEMBL64177 | N-(2-{4-[2-Hydroxy-3-(4-methoxy-phen...)
Show SMILES COc1ccc(OCC(O)CN2CCN(CC2)C(CNC(=O)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C29H35N3O4/c1-35-26-12-14-27(15-13-26)36-22-25(33)21-31-16-18-32(19-17-31)28(23-8-4-2-5-9-23)20-30-29(34)24-10-6-3-7-11-24/h2-15,25,28,33H,16-22H2,1H3,(H,30,34)
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n/an/a 745n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143953
PNG
(CHEMBL64831 | N-(2-{4-[2-Hydroxy-3-(4-methoxy-phen...)
Show SMILES COc1ccc(OCC(O)CN2CCN(CC2)C(CNC(=O)c2ccc(OC)cc2)c2ccccc2)cc1
Show InChI InChI=1S/C30H37N3O5/c1-36-26-10-8-24(9-11-26)30(35)31-20-29(23-6-4-3-5-7-23)33-18-16-32(17-19-33)21-25(34)22-38-28-14-12-27(37-2)13-15-28/h3-15,25,29,34H,16-22H2,1-2H3,(H,31,35)
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n/an/a 871n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Rattus norvegicus)
BDBM50143948
PNG
(1-Phenoxy-3-{4-[phenyl-(4-trifluoromethyl-phenyl)-...)
Show SMILES OC(COc1ccccc1)CN1CCN(CC1)C(c1ccccc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H29F3N2O2/c28-27(29,30)23-13-11-22(12-14-23)26(21-7-3-1-4-8-21)32-17-15-31(16-18-32)19-24(33)20-34-25-9-5-2-6-10-25/h1-14,24,26,33H,15-20H2
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n/an/a 893n/an/an/an/an/an/a



ArQule Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membrane


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50096974
PNG
(CHEMBL41306 | N'-(2-Chloro-5-methylsulfanyl-phenyl...)
Show SMILES CSc1cccc(c1)N(C)C(N)=Nc1cc(SC)ccc1Cl
Show InChI InChI=1S/C16H18ClN3S2/c1-20(11-5-4-6-12(9-11)21-2)16(18)19-15-10-13(22-3)7-8-14(15)17/h4-10H,1-3H3,(H2,18,19)
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n/an/a 1.75E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Neuronal sodium channel blocking activity by [14C]guanidinium flux assay


Bioorg Med Chem Lett 11: 501-4 (2001)

More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50021422
PNG
(2,6,6-Trimethyl-bicyclo[3.1.1]heptane-3-carboxylic...)
Show SMILES CC1C2CC(CC1C(=O)OC1(C)CCN(C)CC1)C2(C)C
Show InChI InChI=1S/C18H31NO2/c1-12-14(10-13-11-15(12)17(13,2)3)16(20)21-18(4)6-8-19(5)9-7-18/h12-15H,6-11H2,1-5H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channel


J Med Chem 29: 1512-6 (1986)

More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50021422
PNG
(2,6,6-Trimethyl-bicyclo[3.1.1]heptane-3-carboxylic...)
Show SMILES CC1C2CC(CC1C(=O)OC1(C)CCN(C)CC1)C2(C)C
Show InChI InChI=1S/C18H31NO2/c1-12-14(10-13-11-15(12)17(13,2)3)16(20)21-18(4)6-8-19(5)9-7-18/h12-15H,6-11H2,1-5H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channel


J Med Chem 29: 1512-6 (1986)

More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50021441
PNG
(2-Phenethyl-benzoic acid 1,4-dimethyl-piperidin-4-...)
Show SMILES CN1CCC(C)(CC1)OC(=O)c1ccccc1CCc1ccccc1
Show InChI InChI=1S/C22H27NO2/c1-22(14-16-23(2)17-15-22)25-21(24)20-11-7-6-10-19(20)13-12-18-8-4-3-5-9-18/h3-11H,12-17H2,1-2H3
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n/an/a 3.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channel


J Med Chem 29: 1512-6 (1986)

More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50021446
PNG
(2-Benzyl-benzoic acid 1-methyl-piperidin-4-yl este...)
Show SMILES CN1CCC(CC1)OC(=O)c1ccccc1Cc1ccccc1
Show InChI InChI=1S/C20H23NO2/c1-21-13-11-18(12-14-21)23-20(22)19-10-6-5-9-17(19)15-16-7-3-2-4-8-16/h2-10,18H,11-15H2,1H3
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n/an/a 3.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channel


J Med Chem 29: 1512-6 (1986)

More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50021444
PNG
(2-Phenoxy-benzoic acid 1-methyl-piperidin-4-yl est...)
Show SMILES CN1CCC(CC1)OC(=O)c1ccccc1Oc1ccccc1
Show InChI InChI=1S/C19H21NO3/c1-20-13-11-16(12-14-20)23-19(21)17-9-5-6-10-18(17)22-15-7-3-2-4-8-15/h2-10,16H,11-14H2,1H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channel


J Med Chem 29: 1512-6 (1986)

More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50021438
PNG
(Biphenyl-2-carboxylic acid 1,4-dimethyl-piperidin-...)
Show SMILES CN1CCC(C)(CC1)OC(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C20H23NO2/c1-20(12-14-21(2)15-13-20)23-19(22)18-11-7-6-10-17(18)16-8-4-3-5-9-16/h3-11H,12-15H2,1-2H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channel


J Med Chem 29: 1512-6 (1986)

More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50021432
PNG
(2-Phenethyl-benzoic acid 2-diethylamino-ethyl este...)
Show SMILES CCN(CC)CCOC(=O)c1ccccc1CCc1ccccc1
Show InChI InChI=1S/C21H27NO2/c1-3-22(4-2)16-17-24-21(23)20-13-9-8-12-19(20)15-14-18-10-6-5-7-11-18/h5-13H,3-4,14-17H2,1-2H3
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n/an/a 3.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channel


J Med Chem 29: 1512-6 (1986)

More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50290405
PNG
(1-(1-Benzyloxy-8-methyl-2-oxa-tricyclo[5.3.1.0*3,8...)
Show SMILES CN(C)CCC[C@@H](O)[C@@]12CCCC3C[C@](CCC13C)(OCc1ccccc1)O2
Show InChI InChI=1S/C24H37NO3/c1-22-14-15-23(27-18-19-9-5-4-6-10-19)17-20(22)11-7-13-24(22,28-23)21(26)12-8-16-25(2)3/h4-6,9-10,20-21,26H,7-8,11-18H2,1-3H3/t20?,21-,22?,23-,24+/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonism of batrachotoxin-mediated sodium ion uptake into cultured neuroblastoma cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50021421
PNG
(Biphenyl-2-carboxylic acid 3-diethylamino-propyl e...)
Show SMILES CCN(CC)CCCOC(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C20H25NO2/c1-3-21(4-2)15-10-16-23-20(22)19-14-9-8-13-18(19)17-11-6-5-7-12-17/h5-9,11-14H,3-4,10,15-16H2,1-2H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channel


J Med Chem 29: 1512-6 (1986)

More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50290404
PNG
(Benzoic acid 5-hydroxy-3-methoxymethyl-5-(1-methox...)
Show SMILES COC[C@H](CCOC(=O)c1ccccc1)C[C@@H](O)[C@@]12CCCC3C[C@](CCC13C)(OC)O2
Show InChI InChI=1S/C26H38O6/c1-24-13-14-25(30-3)17-21(24)10-7-12-26(24,32-25)22(27)16-19(18-29-2)11-15-31-23(28)20-8-5-4-6-9-20/h4-6,8-9,19,21-22,27H,7,10-18H2,1-3H3/t19-,21?,22-,24?,25-,26+/m1/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonism of batrachotoxin-mediated sodium ion uptake into cultured neuroblastoma cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50021439
PNG
(2-Phenethyl-benzoic acid 1-methyl-piperidin-4-yl e...)
Show SMILES CN1CCC(CC1)OC(=O)c1ccccc1CCc1ccccc1
Show InChI InChI=1S/C21H25NO2/c1-22-15-13-19(14-16-22)24-21(23)20-10-6-5-9-18(20)12-11-17-7-3-2-4-8-17/h2-10,19H,11-16H2,1H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channel


J Med Chem 29: 1512-6 (1986)

More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50021436
PNG
(2-Phenethyl-benzoic acid 3-diethylamino-propyl est...)
Show SMILES CCN(CC)CCCOC(=O)c1ccccc1CCc1ccccc1
Show InChI InChI=1S/C22H29NO2/c1-3-23(4-2)17-10-18-25-22(24)21-14-9-8-13-20(21)16-15-19-11-6-5-7-12-19/h5-9,11-14H,3-4,10,15-18H2,1-2H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channel


J Med Chem 29: 1512-6 (1986)

More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50021427
PNG
(Biphenyl-2-carboxylic acid 2-diethylamino-1-methyl...)
Show SMILES CCN(CC)CC(C)OC(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C20H25NO2/c1-4-21(5-2)15-16(3)23-20(22)19-14-10-9-13-18(19)17-11-7-6-8-12-17/h6-14,16H,4-5,15H2,1-3H3
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n/an/a 6.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channel


J Med Chem 29: 1512-6 (1986)

More data for this
Ligand-Target Pair
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