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Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Solute carrier family 2, facilitated glucose transporter member 1' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Solute carrier family 2, facilitated glucose transporter member 1


(Rattus norvegicus)
BDBM50250177
PNG
(((2R,3S,4S,5R,6R)-3,4,5,6-tetrahydroxytetrahydro-2...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)OC[C@H]3O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]3O)c2c1
Show InChI InChI=1S/C25H26ClNO9/c1-12-16(10-20(28)35-11-19-21(29)22(30)23(31)25(33)36-19)17-9-15(34-2)7-8-18(17)27(12)24(32)13-3-5-14(26)6-4-13/h3-9,19,21-23,25,29-31,33H,10-11H2,1-2H3/t19-,21-,22+,23-,25-/m1/s1
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n/an/a 710n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of GluT1-mediated [14C]D-glucose uptake in Wistar rat brain by perfusion technique


J Med Chem 52: 3348-53 (2009)

More data for this
Ligand-Target Pair
Solute carrier family 2, facilitated glucose transporter member 1


(Rattus norvegicus)
BDBM50326284
PNG
(1-(beta-D-Glucopyranosyl)-4-methyl-3-(5-(4-fluorop...)
Show SMILES Cc1cccc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(s1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H25FO6S/c1-13-3-2-4-18(30-24-23(29)22(28)21(27)19(12-26)31-24)17(13)11-16-9-10-20(32-16)14-5-7-15(25)8-6-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of GLUT1-mediated [3H]2-deoxy-glucose uptake in rat L6 cells after 15 mins by liquid scintillation counting


J Med Chem 53: 6355-60 (2010)

More data for this
Ligand-Target Pair
Solute carrier family 2, facilitated glucose transporter member 1


(Rattus norvegicus)
BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of GLUT1-mediated [3H]2-deoxy-glucose uptake in rat L6 cells after 15 mins by liquid scintillation counting


J Med Chem 53: 6355-60 (2010)

More data for this
Ligand-Target Pair
Solute carrier family 2, facilitated glucose transporter member 1


(Rattus norvegicus)
BDBM50250141
PNG
(((2R,3S,4S,5R,6R)-3,4,5,6-tetrahydroxytetrahydro-2...)
Show SMILES CC(C(=O)OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O)c1cccc(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C22H24O8/c1-12(21(27)29-11-16-18(24)19(25)20(26)22(28)30-16)14-8-5-9-15(10-14)17(23)13-6-3-2-4-7-13/h2-10,12,16,18-20,22,24-26,28H,11H2,1H3/t12?,16-,18-,19+,20-,22-/m1/s1
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n/an/a 3.29E+4n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of GluT1-mediated [14C]D-glucose uptake in Wistar rat brain by perfusion technique


J Med Chem 52: 3348-53 (2009)

More data for this
Ligand-Target Pair