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Found 24 hits Enz. Inhib. hit(s) with Target = 'Sphingosine-1-phosphate lyase 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018286
PNG
(CHEMBL3290335)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2ccc(cc12)C#N
Show InChI InChI=1S/C27H23N7/c1-19-18-33(11-12-34(19)26-10-8-22(16-29)17-30-26)27-24-13-21(15-28)7-9-23(24)25(31-32-27)14-20-5-3-2-4-6-20/h2-10,13,17,19H,11-12,14,18H2,1H3/t19-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018286
PNG
(CHEMBL3290335)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2ccc(cc12)C#N
Show InChI InChI=1S/C27H23N7/c1-19-18-33(11-12-34(19)26-10-8-22(16-29)17-30-26)27-24-13-21(15-28)7-9-23(24)25(31-32-27)14-20-5-3-2-4-6-20/h2-10,13,17,19H,11-12,14,18H2,1H3/t19-/m1/s1
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n/an/a 94n/an/an/an/an/an/a



Institute for Advanced Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Inhibition of human S1PL using RBM13 as substrate measured after 1 hr by fluorogenic assay


Bioorg Med Chem 24: 4381-4389 (2016)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018284
PNG
(CHEMBL3290333)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C27H23F3N6/c1-18-17-35(11-12-36(18)25-10-7-20(15-31)16-32-25)26-23-14-21(27(28,29)30)8-9-22(23)24(33-34-26)13-19-5-3-2-4-6-19/h2-10,14,16,18H,11-13,17H2,1H3/t18-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018282
PNG
(CHEBI:79045 | CHEMBL3290331)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2ccc(Cl)cc12
Show InChI InChI=1S/C26H23ClN6/c1-18-17-32(11-12-33(18)25-10-7-20(15-28)16-29-25)26-23-14-21(27)8-9-22(23)24(30-31-26)13-19-5-3-2-4-6-19/h2-10,14,16,18H,11-13,17H2,1H3/t18-/m1/s1
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n/an/a 210n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018273
PNG
(CHEMBL3290322)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)[N+]([O-])=O)c1nnc(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H24N6O2/c1-18-17-29(13-14-30(18)24-12-11-20(16-26-24)31(32)33)25-22-10-6-5-9-21(22)23(27-28-25)15-19-7-3-2-4-8-19/h2-12,16,18H,13-15,17H2,1H3/t18-/m1/s1
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n/an/a 740n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018285
PNG
(CHEMBL3290334)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2cc(ccc12)C#N
Show InChI InChI=1S/C27H23N7/c1-19-18-33(11-12-34(19)26-10-8-22(16-29)17-30-26)27-23-9-7-21(15-28)13-24(23)25(31-32-27)14-20-5-3-2-4-6-20/h2-10,13,17,19H,11-12,14,18H2,1H3/t19-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018275
PNG
(CHEMBL3290324)
Show SMILES CC[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C27H26N6/c1-2-22-19-32(14-15-33(22)26-13-12-21(17-28)18-29-26)27-24-11-7-6-10-23(24)25(30-31-27)16-20-8-4-3-5-9-20/h3-13,18,22H,2,14-16,19H2,1H3/t22-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018281
PNG
(CHEMBL3290330)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C26H23ClN6/c1-18-17-32(11-12-33(18)25-10-7-20(15-28)16-29-25)26-22-9-8-21(27)14-23(22)24(30-31-26)13-19-5-3-2-4-6-19/h2-10,14,16,18H,11-13,17H2,1H3/t18-/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50268610
PNG
(6-[(R)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperaz...)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H24N6/c1-19-18-31(13-14-32(19)25-12-11-21(16-27)17-28-25)26-23-10-6-5-9-22(23)24(29-30-26)15-20-7-3-2-4-8-20/h2-12,17,19H,13-15,18H2,1H3/t19-/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018276
PNG
(CHEMBL3290325)
Show SMILES CC(C)[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C28H28N6/c1-20(2)26-19-33(14-15-34(26)27-13-12-22(17-29)18-30-27)28-24-11-7-6-10-23(24)25(31-32-28)16-21-8-4-3-5-9-21/h3-13,18,20,26H,14-16,19H2,1-2H3/t26-/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018271
PNG
(CHEMBL3290320)
Show SMILES CCOC(=O)c1ccc(nc1)N1CCN(C[C@H]1C)c1nnc(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C28H29N5O2/c1-3-35-28(34)22-13-14-26(29-18-22)33-16-15-32(19-20(33)2)27-24-12-8-7-11-23(24)25(30-31-27)17-21-9-5-4-6-10-21/h4-14,18,20H,3,15-17,19H2,1-2H3/t20-/m1/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018283
PNG
(CHEMBL3290332)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C27H23F3N6/c1-18-17-35(11-12-36(18)25-10-7-20(15-31)16-32-25)26-22-9-8-21(27(28,29)30)14-23(22)24(33-34-26)13-19-5-3-2-4-6-19/h2-10,14,16,18H,11-13,17H2,1H3/t18-/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50158336
PNG
(2-(4-octylphenethyl)-2-aminopropane-1,3-diol | 2-A...)
Show SMILES CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1
Show InChI InChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3
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n/an/a 1.70E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018280
PNG
(CHEMBL3290329)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(CCc2ccccc2)c2ccccc12
Show InChI InChI=1S/C27H26N6/c1-20-19-32(15-16-33(20)26-14-12-22(17-28)18-29-26)27-24-10-6-5-9-23(24)25(30-31-27)13-11-21-7-3-2-4-8-21/h2-10,12,14,18,20H,11,13,15-16,19H2,1H3/t20-/m1/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018279
PNG
(CHEMBL3290328)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H22N6/c1-18-17-30(13-14-31(18)23-12-11-19(15-26)16-27-23)25-22-10-6-5-9-21(22)24(28-29-25)20-7-3-2-4-8-20/h2-12,16,18H,13-14,17H2,1H3/t18-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018278
PNG
(CHEMBL3290327)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cl)c2ccccc12
Show InChI InChI=1S/C19H17ClN6/c1-13-12-25(8-9-26(13)17-7-6-14(10-21)11-22-17)19-16-5-3-2-4-15(16)18(20)23-24-19/h2-7,11,13H,8-9,12H2,1H3/t13-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018277
PNG
(CHEMBL3290326)
Show SMILES OC[C@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H24N6O/c27-15-20-10-11-25(28-16-20)32-13-12-31(17-21(32)18-33)26-23-9-5-4-8-22(23)24(29-30-26)14-19-6-2-1-3-7-19/h1-11,16,21,33H,12-14,17-18H2/t21-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50269082
PNG
(6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]nicot...)
Show SMILES N#Cc1ccc(nc1)N1CCN(CC1)c1nnc(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H22N6/c26-17-20-10-11-24(27-18-20)30-12-14-31(15-13-30)25-22-9-5-4-8-21(22)23(28-29-25)16-19-6-2-1-3-7-19/h1-11,18H,12-16H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50268609
PNG
(6-[(S)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperaz...)
Show SMILES C[C@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H24N6/c1-19-18-31(13-14-32(19)25-12-11-21(16-27)17-28-25)26-23-10-6-5-9-22(23)24(29-30-26)15-20-7-3-2-4-8-20/h2-12,17,19H,13-15,18H2,1H3/t19-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018272
PNG
(CHEMBL3290321)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C(F)(F)F)c1nnc(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H24F3N5/c1-18-17-33(13-14-34(18)24-12-11-20(16-30-24)26(27,28)29)25-22-10-6-5-9-21(22)23(31-32-25)15-19-7-3-2-4-8-19/h2-12,16,18H,13-15,17H2,1H3/t18-/m1/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018274
PNG
(CHEMBL3290323)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C(O)=O)c1nnc(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H25N5O2/c1-18-17-30(13-14-31(18)24-12-11-20(16-27-24)26(32)33)25-22-10-6-5-9-21(22)23(28-29-25)15-19-7-3-2-4-8-19/h2-12,16,18H,13-15,17H2,1H3,(H,32,33)/t18-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50158336
PNG
(2-(4-octylphenethyl)-2-aminopropane-1,3-diol | 2-A...)
Show SMILES CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1
Show InChI InChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3
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n/an/a 5.20E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of S1PL (unknown origin)


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018270
PNG
(CHEMBL1852164)
Show SMILES C\C(=N/O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO
Show InChI InChI=1S/C9H15N3O5/c1-4(12-17)9-10-2-5(11-9)7(15)8(16)6(14)3-13/h2,6-8,13-17H,3H2,1H3,(H,10,11)/b12-4+/t6-,7-,8-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of S1PL (unknown origin)


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018269
PNG
(CHEMBL488336)
Show SMILES CC(=O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO
Show InChI InChI=1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
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PC cid
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UniChem

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AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of S1PL (unknown origin)


J Med Chem 57: 5074-84 (2014)

More data for this
Ligand-Target Pair