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Compile Data Set for Download or QSAR

Found 54 hits Enz. Inhib. hit(s) with Target = 'Sporulation kinase A' AND taxid = 224308   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215968
PNG
(CHEMBL57324)
Show SMILES Cc1cc(NC(=O)c2cc(I)cc(I)c2O)c(Cl)cc1C(C#N)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H14Cl2I2N2O2/c1-11-6-20(28-22(30)16-7-14(25)8-19(26)21(16)29)18(24)9-15(11)17(10-27)12-2-4-13(23)5-3-12/h2-9,17,29H,1H3,(H,28,30)
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n/an/a 3.80E+3n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of histidine protein kinase (KinA) phosphorylation in the presence of response regulator (Spo0F)


Bioorg Med Chem Lett 8: 1923-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00326-6
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215967
PNG
(CHEMBL56579)
Show SMILES Cc1cc(NC(=O)c2cc(Cl)cc(Cl)c2O)c(Cl)cc1C(C#N)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H14Cl4N2O2/c1-11-6-20(28-22(30)16-7-14(24)8-19(26)21(16)29)18(25)9-15(11)17(10-27)12-2-4-13(23)5-3-12/h2-9,17,29H,1H3,(H,28,30)
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n/an/a 4.80E+3n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of histidine protein kinase (KinA) phosphorylation in the presence of response regulator (Spo0F)


Bioorg Med Chem Lett 8: 1923-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00326-6
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218645
PNG
(CHEMBL288462)
Show SMILES CC(C)(C)c1cccc(-c2nc3cc(ccc3[nH]2)C(N)=N)c1O
Show InChI InChI=1S/C18H20N4O/c1-18(2,3)12-6-4-5-11(15(12)23)17-21-13-8-7-10(16(19)20)9-14(13)22-17/h4-9,23H,1-3H3,(H3,19,20)(H,21,22)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218644
PNG
(CHEMBL416972)
Show SMILES NC(=N)c1ccc2cc([nH]c2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C21H17N3O/c22-21(23)16-7-6-15-12-19(24-20(15)13-16)14-8-10-18(11-9-14)25-17-4-2-1-3-5-17/h1-13,24H,(H3,22,23)
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n/an/a 7.70E+3n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215985
PNG
(CHEMBL57037)
Show SMILES Oc1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)-c1n[nH]c(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H7Cl2N5O5/c15-9-2-1-6(3-10(9)16)13-17-14(19-18-13)8-4-7(20(23)24)5-11(12(8)22)21(25)26/h1-5,22H,(H,17,18,19)
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n/an/a 8.00E+3n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218640
PNG
(CHEMBL38683)
Show SMILES CC(C)(C)c1cc(-c2nc3cc(ccc3[nH]2)C2=NCCN2)c(O)c(c1)C(C)(C)C
Show InChI InChI=1S/C24H30N4O/c1-23(2,3)15-12-16(20(29)17(13-15)24(4,5)6)22-27-18-8-7-14(11-19(18)28-22)21-25-9-10-26-21/h7-8,11-13,29H,9-10H2,1-6H3,(H,25,26)(H,27,28)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218648
PNG
(CHEMBL290098)
Show SMILES CC(C)(N)CNC(=O)c1ccc2[nH]c(nc2c1)-c1cc(cc(c1O)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C26H36N4O2/c1-24(2,3)16-12-17(21(31)18(13-16)25(4,5)6)22-29-19-10-9-15(11-20(19)30-22)23(32)28-14-26(7,8)27/h9-13,31H,14,27H2,1-8H3,(H,28,32)(H,29,30)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218643
PNG
(CHEMBL39634)
Show SMILES CC(C)(C)c1cc(-c2nc3cc(ccc3[nH]2)C(N)=N)c(O)c(c1)C(C)(C)C
Show InChI InChI=1S/C22H28N4O/c1-21(2,3)13-10-14(18(27)15(11-13)22(4,5)6)20-25-16-8-7-12(19(23)24)9-17(16)26-20/h7-11,27H,1-6H3,(H3,23,24)(H,25,26)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218655
PNG
(CHEMBL38914)
Show SMILES CC(C)(C)c1cc(-c2nc3cc(ccc3o2)C(N)=N)c(O)c(c1)C(C)(C)C
Show InChI InChI=1S/C22H27N3O2/c1-21(2,3)13-10-14(18(26)15(11-13)22(4,5)6)20-25-16-9-12(19(23)24)7-8-17(16)27-20/h7-11,26H,1-6H3,(H3,23,24)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218647
PNG
(CHEMBL38867)
Show SMILES CC(C)(C)c1cc(-c2nc3ccc(cc3o2)C(N)=N)c(O)c(c1)C(C)(C)C
Show InChI InChI=1S/C22H27N3O2/c1-21(2,3)13-10-14(18(26)15(11-13)22(4,5)6)20-25-16-8-7-12(19(23)24)9-17(16)27-20/h7-11,26H,1-6H3,(H3,23,24)
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n/an/a 1.54E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215976
PNG
(CHEMBL58536)
Show SMILES Oc1c(Cl)cc(Cl)cc1-c1n[nH]c(n1)-c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C15H7Cl3F3N3O/c16-7-4-8(12(25)11(18)5-7)14-22-13(23-24-14)6-1-2-10(17)9(3-6)15(19,20)21/h1-5,25H,(H,22,23,24)
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n/an/a 1.60E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218659
PNG
(CHEMBL43691)
Show SMILES NC(=N)c1ccc2[nH]c(nc2c1)-c1ccc(cc1)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H21N5/c27-25(28)19-13-16-23-24(17-19)30-26(29-23)18-11-14-22(15-12-18)31(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-17H,(H3,27,28)(H,29,30)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50065970
PNG
(CHEMBL57656 | N-(3,4-Dichloro-phenyl)-2-hydroxy-3,...)
Show SMILES Oc1c(I)cc(I)cc1C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H7Cl2I2NO2/c14-9-2-1-7(5-10(9)15)18-13(20)8-3-6(16)4-11(17)12(8)19/h1-5,19H,(H,18,20)
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n/an/a 2.20E+4n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of histidine protein kinase (KinA) phosphorylation in the presence of response regulator (Spo0F)


Bioorg Med Chem Lett 8: 1923-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00326-6
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215978
PNG
(CHEMBL58439)
Show SMILES Oc1c(Br)cc(Br)cc1-c1n[nH]c(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H7Br2Cl2N3O/c15-7-4-8(12(22)9(16)5-7)14-19-13(20-21-14)6-1-2-10(17)11(18)3-6/h1-5,22H,(H,19,20,21)
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n/an/a 2.40E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218653
PNG
(CHEMBL39178)
Show SMILES CC(C)(C)c1cc(cc(c1)C(C)(C)C)-c1nc2cc(ccc2[nH]1)C(N)=N
Show InChI InChI=1S/C22H28N4/c1-21(2,3)15-9-14(10-16(12-15)22(4,5)6)20-25-17-8-7-13(19(23)24)11-18(17)26-20/h7-12H,1-6H3,(H3,23,24)(H,25,26)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50100895
PNG
(2-(4-(4-carbamimidoylphenoxy)phenyl)-1H-indole-6-c...)
Show SMILES NC(=N)c1ccc(Oc2ccc(cc2)-c2cc3ccc(cc3[nH]2)C(N)=N)cc1
Show InChI InChI=1S/C22H19N5O/c23-21(24)14-5-9-18(10-6-14)28-17-7-3-13(4-8-17)19-11-15-1-2-16(22(25)26)12-20(15)27-19/h1-12,27H,(H3,23,24)(H3,25,26)
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n/an/a 3.10E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component system (TCS) from Bacillus subtilis


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215974
PNG
(3,3'',4'',5-tetrachlorosalicylanilide | 3,3',4',5-...)
Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H7Cl4NO2/c14-6-3-8(12(19)11(17)4-6)13(20)18-7-1-2-9(15)10(16)5-7/h1-5,19H,(H,18,20)
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n/an/a 3.70E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218651
PNG
(CHEMBL39490)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C20H16N4O/c21-19(22)14-8-11-17-18(12-14)24-20(23-17)13-6-9-16(10-7-13)25-15-4-2-1-3-5-15/h1-12H,(H3,21,22)(H,23,24)
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n/an/a 4.20E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F two component system (TCS) from Bacillus subtilis


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218656
PNG
(CHEMBL39040)
Show SMILES Cn1c(nc2cc(ccc12)C(N)=N)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C21H18N4O/c1-25-19-12-9-15(20(22)23)13-18(19)24-21(25)14-7-10-17(11-8-14)26-16-5-3-2-4-6-16/h2-13H,1H3,(H3,22,23)
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n/an/a 4.40E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215977
PNG
(CHEMBL58560)
Show SMILES Oc1c(cc(cc1C(F)(F)F)C(F)(F)F)-c1n[nH]c(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H7Cl2F6N3O/c17-10-2-1-6(3-11(10)18)13-25-14(27-26-13)8-4-7(15(19,20)21)5-9(12(8)28)16(22,23)24/h1-5,28H,(H,25,26,27)
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n/an/a 4.40E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215974
PNG
(3,3'',4'',5-tetrachlorosalicylanilide | 3,3',4',5-...)
Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H7Cl4NO2/c14-6-3-8(12(19)11(17)4-6)13(20)18-7-1-2-9(15)10(16)5-7/h1-5,19H,(H,18,20)
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n/an/a 4.50E+4n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of histidine protein kinase (KinA) phosphorylation in the presence of response regulator (Spo0F)


Bioorg Med Chem Lett 8: 1923-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00326-6
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218646
PNG
(CHEMBL290549)
Show SMILES NC(=N)c1ccc2nc(oc2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C20H15N3O2/c21-19(22)14-8-11-17-18(12-14)25-20(23-17)13-6-9-16(10-7-13)24-15-4-2-1-3-5-15/h1-12H,(H3,21,22)
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n/an/a 4.90E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218654
PNG
(CHEMBL40096)
Show SMILES CC(C)(C)c1ccc(O)c(c1)-c1nc2cc(ccc2[nH]1)C(N)=N
Show InChI InChI=1S/C18H20N4O/c1-18(2,3)11-5-7-15(23)12(9-11)17-21-13-6-4-10(16(19)20)8-14(13)22-17/h4-9,23H,1-3H3,(H3,19,20)(H,21,22)
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n/an/a 6.40E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50216089
PNG
(CHEMBL441791)
Show SMILES Oc1c(Cl)cc(Cl)cc1-c1n[nH]c(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H7Cl4N3O/c15-7-4-8(12(22)11(18)5-7)14-19-13(20-21-14)6-1-2-9(16)10(17)3-6/h1-5,22H,(H,19,20,21)
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n/an/a 6.70E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218649
PNG
(CHEMBL417892)
Show SMILES COc1c(cc(cc1C(C)(C)C)C(C)(C)C)-c1nc2cc(ccc2[nH]1)C(N)=N
Show InChI InChI=1S/C23H30N4O/c1-22(2,3)14-11-15(19(28-7)16(12-14)23(4,5)6)21-26-17-9-8-13(20(24)25)10-18(17)27-21/h8-12H,1-7H3,(H3,24,25)(H,26,27)
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n/an/a 7.60E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215981
PNG
(CHEMBL60977)
Show SMILES Oc1c(Cl)cc(Cl)cc1-c1n[nH]c(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H8Cl3N3O/c15-8-3-1-7(2-4-8)13-18-14(20-19-13)10-5-9(16)6-11(17)12(10)21/h1-6,21H,(H,18,19,20)
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n/an/a 8.00E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218642
PNG
(CHEMBL39543)
Show SMILES CC(C)(C)c1cc(-c2nc3cc(ccc3[nH]2)C(O)=O)c(O)c(c1)C(C)(C)C
Show InChI InChI=1S/C22H26N2O3/c1-21(2,3)13-10-14(18(25)15(11-13)22(4,5)6)19-23-16-8-7-12(20(26)27)9-17(16)24-19/h7-11,25H,1-6H3,(H,23,24)(H,26,27)
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n/an/a 8.60E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50216090
PNG
(CHEMBL60976)
Show SMILES Oc1c(Cl)cc(Cl)cc1-c1n[nH]c(n1)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H8Cl3N3O/c15-8-3-1-2-7(4-8)13-18-14(20-19-13)10-5-9(16)6-11(17)12(10)21/h1-6,21H,(H,18,19,20)
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n/an/a 8.70E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218650
PNG
(CHEMBL2114423)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H16N4/c21-19(22)16-10-11-17-18(12-16)24-20(23-17)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-12H,(H3,21,22)(H,23,24)
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n/an/a 8.80E+4n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215983
PNG
(CHEMBL301880)
Show SMILES NS(=O)(=O)c1ccc(O)c(c1)-c1n[nH]c(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H10Cl2N4O3S/c15-10-3-1-7(5-11(10)16)13-18-14(20-19-13)9-6-8(24(17,22)23)2-4-12(9)21/h1-6,21H,(H2,17,22,23)(H,18,19,20)
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n/an/a 9.10E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215970
PNG
(CHEMBL56781)
Show SMILES Oc1c(Cl)cc(cc1Cl)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H7Cl4NO2/c14-8-2-1-7(5-9(8)15)18-13(20)6-3-10(16)12(19)11(17)4-6/h1-5,19H,(H,18,20)
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n/an/a 9.80E+4n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of histidine protein kinase (KinA) phosphorylation in the presence of response regulator (Spo0F)


Bioorg Med Chem Lett 8: 1923-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00326-6
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215987
PNG
(CHEMBL300324)
Show SMILES Oc1c(Br)cc(Br)cc1-c1n[nH]c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C20H13Br2N3O2/c21-13-10-16(18(26)17(22)11-13)20-23-19(24-25-20)12-6-8-15(9-7-12)27-14-4-2-1-3-5-14/h1-11,26H,(H,23,24,25)
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n/an/a 1.00E+5n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218658
PNG
(CHEMBL290462)
Show SMILES NC(=N)c1ccc2oc(nc2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C20H15N3O2/c21-19(22)14-8-11-18-17(12-14)23-20(25-18)13-6-9-16(10-7-13)24-15-4-2-1-3-5-15/h1-12H,(H3,21,22)
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n/an/a 1.38E+5n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218652
PNG
(CHEMBL39218)
Show SMILES CC(C)(C)c1cccc(c1)-c1nc2cc(ccc2[nH]1)C(N)=N
Show InChI InChI=1S/C18H20N4/c1-18(2,3)13-6-4-5-12(9-13)17-21-14-8-7-11(16(19)20)10-15(14)22-17/h4-10H,1-3H3,(H3,19,20)(H,21,22)
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n/an/a 1.63E+5n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218657
PNG
(CHEMBL289173)
Show SMILES CC(C)c1ccc(cc1)-c1nc2cc(ccc2[nH]1)C(N)=N
Show InChI InChI=1S/C17H18N4/c1-10(2)11-3-5-12(6-4-11)17-20-14-8-7-13(16(18)19)9-15(14)21-17/h3-10H,1-2H3,(H3,18,19)(H,20,21)
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n/an/a 2.20E+5n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215972
PNG
(CHEMBL57827)
Show SMILES Oc1c(Cl)cc(Cl)cc1NC(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H8Cl4N2O2/c14-6-3-10(17)12(20)11(4-6)19-13(21)18-7-1-2-8(15)9(16)5-7/h1-5,20H,(H2,18,19,21)
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n/an/a 3.65E+5n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of histidine protein kinase (KinA) phosphorylation in the presence of response regulator (Spo0F)


Bioorg Med Chem Lett 8: 1923-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00326-6
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50218641
PNG
(CHEMBL39438)
Show SMILES COC(=O)c1ccc2[nH]c(nc2c1)-c1cc(cc(c1O)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C23H28N2O3/c1-22(2,3)14-11-15(19(26)16(12-14)23(4,5)6)20-24-17-9-8-13(21(27)28-7)10-18(17)25-20/h8-12,26H,1-7H3,(H,24,25)
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n/an/a 3.80E+5n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215988
PNG
(CHEMBL58319)
Show SMILES Oc1c(Cl)cc(Cl)cc1-c1n[nH]c(n1)-c1ccccc1
Show InChI InChI=1S/C14H9Cl2N3O/c15-9-6-10(12(20)11(16)7-9)14-17-13(18-19-14)8-4-2-1-3-5-8/h1-7,20H,(H,17,18,19)
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n/an/a 3.80E+5n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215971
PNG
(CHEMBL299692)
Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccccc1
Show InChI InChI=1S/C13H9Cl2NO2/c14-8-6-10(12(17)11(15)7-8)13(18)16-9-4-2-1-3-5-9/h1-7,17H,(H,16,18)
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n/an/a 3.85E+5n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of histidine protein kinase (KinA) phosphorylation in the presence of response regulator (Spo0F)


Bioorg Med Chem Lett 8: 1923-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00326-6
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50100897
PNG
(2-(2-Hydroxy-phenyl)-1H-benzoimidazole-5-carboxami...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1ccccc1O
Show InChI InChI=1S/C14H12N4O/c15-13(16)8-5-6-10-11(7-8)18-14(17-10)9-3-1-2-4-12(9)19/h1-7,19H,(H3,15,16)(H,17,18)
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n/an/a 4.70E+5n/an/an/an/an/an/a



Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of KinA/Sp0F system two component (TCS) from Bacillus subtilis.


Bioorg Med Chem Lett 11: 1545-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00024-5
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215964
PNG
(CHEMBL293285)
Show SMILES Clc1cc(Cl)cc(c1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H7Cl4NO/c14-8-3-7(4-9(15)5-8)13(19)18-10-1-2-11(16)12(17)6-10/h1-6H,(H,18,19)
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n/an/a>5.00E+5n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of histidine protein kinase (KinA) phosphorylation in the presence of response regulator (Spo0F)


Bioorg Med Chem Lett 8: 1923-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00326-6
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50216088
PNG
(CHEMBL58201)
Show SMILES CC(C)c1ccc(cc1)-c1n[nH]c(n1)-c1cc(Cl)cc(Cl)c1O
Show InChI InChI=1S/C17H15Cl2N3O/c1-9(2)10-3-5-11(6-4-10)16-20-17(22-21-16)13-7-12(18)8-14(19)15(13)23/h3-9,23H,1-2H3,(H,20,21,22)
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n/an/a>5.00E+5n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50216087
PNG
(CHEMBL301277)
Show SMILES Oc1c(Cl)cccc1-c1n[nH]c(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H8Cl3N3O/c15-9-5-4-7(6-11(9)17)13-18-14(20-19-13)8-2-1-3-10(16)12(8)21/h1-6,21H,(H,18,19,20)
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n/an/a>5.00E+5n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215986
PNG
(CHEMBL292823)
Show SMILES Oc1ccc(Cl)cc1-c1n[nH]c(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H8Cl3N3O/c15-8-2-4-12(21)9(6-8)14-18-13(19-20-14)7-1-3-10(16)11(17)5-7/h1-6,21H,(H,18,19,20)
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n/an/a>5.00E+5n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215984
PNG
(CHEMBL291781)
Show SMILES COc1ccc(cc1)-c1n[nH]c(n1)-c1cc(Cl)cc(Cl)c1O
Show InChI InChI=1S/C15H11Cl2N3O2/c1-22-10-4-2-8(3-5-10)14-18-15(20-19-14)11-6-9(16)7-12(17)13(11)21/h2-7,21H,1H3,(H,18,19,20)
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n/an/a>5.00E+5n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215982
PNG
(CHEMBL58045)
Show SMILES Oc1c(Cl)cc(Cl)cc1-c1n[nH]c(n1)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C14H8Cl2N4O3/c15-8-5-10(12(21)11(16)6-8)14-17-13(18-19-14)7-1-3-9(4-2-7)20(22)23/h1-6,21H,(H,17,18,19)
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n/an/a>5.00E+5n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215965
PNG
(CHEMBL57828)
Show SMILES Oc1c(Cl)cc(Cl)cc1NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H7Cl4NO2/c14-7-4-10(17)12(19)11(5-7)18-13(20)6-1-2-8(15)9(16)3-6/h1-5,19H,(H,18,20)
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n/an/a>5.00E+5n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of histidine protein kinase (KinA) phosphorylation in the presence of response regulator (Spo0F)


Bioorg Med Chem Lett 8: 1923-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00326-6
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215980
PNG
(CHEMBL61254)
Show SMILES Cc1ccc(cc1C)-c1n[nH]c(n1)-c1cc(Cl)cc(Cl)c1O
Show InChI InChI=1S/C16H13Cl2N3O/c1-8-3-4-10(5-9(8)2)15-19-16(21-20-15)12-6-11(17)7-13(18)14(12)22/h3-7,22H,1-2H3,(H,19,20,21)
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n/an/a>5.00E+5n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of KinA/Sp0F assay


Bioorg Med Chem Lett 8: 1929-34 (1998)


Article DOI: 10.1016/s0960-894x(98)00325-4
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215966
PNG
(CHEMBL301903)
Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H9Cl4NO2/c15-8-4-9(13(20)12(18)5-8)14(21)19-6-7-1-2-10(16)11(17)3-7/h1-5,20H,6H2,(H,19,21)
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n/an/a>5.00E+5n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of histidine protein kinase (KinA) phosphorylation in the presence of response regulator (Spo0F)


Bioorg Med Chem Lett 8: 1923-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00326-6
More data for this
Ligand-Target Pair
Sporulation kinase A


(Bacillus subtilis (strain 168))
BDBM50215975
PNG
(CHEMBL57526)
Show SMILES CN(C(=O)c1cc(I)cc(I)c1O)c1cc(C)c(cc1Cl)C(C#N)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H16Cl2I2N2O2/c1-12-7-21(29(2)23(31)17-8-15(26)9-20(27)22(17)30)19(25)10-16(12)18(11-28)13-3-5-14(24)6-4-13/h3-10,18,30H,1-2H3
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n/an/a>5.00E+5n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

Curated by ChEMBL


Assay Description
Inhibition of histidine protein kinase (KinA) phosphorylation in the presence of response regulator (Spo0F)


Bioorg Med Chem Lett 8: 1923-8 (1998)


Article DOI: 10.1016/s0960-894x(98)00326-6
More data for this
Ligand-Target Pair
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