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Compile Data Set for Download or QSAR

Found 30 hits Enz. Inhib. hit(s) with Target = 'Sterol regulatory element-binding protein 2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM20182
PNG
((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Show SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1
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n/an/a 300n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351538
PNG
(CHEMBL1824673)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C18H19N3O2S2/c1-3-4-16-11-14(9-10-19-16)18-20-17(12-24-18)13-5-7-15(8-6-13)21-25(2,22)23/h5-12,21H,3-4H2,1-2H3
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n/an/a 700n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351539
PNG
(CHEMBL1824674)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NS(=O)(=O)c2cccs2)cc1
Show InChI InChI=1S/C21H19N3O2S3/c1-2-4-18-13-16(10-11-22-18)21-23-19(14-28-21)15-6-8-17(9-7-15)24-29(25,26)20-5-3-12-27-20/h3,5-14,24H,2,4H2,1H3
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n/an/a 900n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351538
PNG
(CHEMBL1824673)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C18H19N3O2S2/c1-3-4-16-11-14(9-10-19-16)18-20-17(12-24-18)13-5-7-15(8-6-13)21-25(2,22)23/h5-12,21H,3-4H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells by densitometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351541
PNG
(CHEMBL1824676)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NC(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C22H25N3O2S/c1-5-6-18-13-16(11-12-23-18)20-25-19(14-28-20)15-7-9-17(10-8-15)24-21(26)27-22(2,3)4/h7-14H,5-6H2,1-4H3,(H,24,26)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351540
PNG
(CHEMBL1824675)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C24H23N3O2S2/c1-3-4-21-15-19(13-14-25-21)24-26-23(16-30-24)18-7-9-20(10-8-18)27-31(28,29)22-11-5-17(2)6-12-22/h5-16,27H,3-4H2,1-2H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351534
PNG
(CHEMBL1824669)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NC(C)C)cc1
Show InChI InChI=1S/C20H23N3S/c1-4-5-18-12-16(10-11-21-18)20-23-19(13-24-20)15-6-8-17(9-7-15)22-14(2)3/h6-14,22H,4-5H2,1-3H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351535
PNG
(CHEMBL1824670)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NCc2ccccc2)cc1
Show InChI InChI=1S/C24H23N3S/c1-2-6-22-15-20(13-14-25-22)24-27-23(17-28-24)19-9-11-21(12-10-19)26-16-18-7-4-3-5-8-18/h3-5,7-15,17,26H,2,6,16H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351529
PNG
(CHEMBL1824664)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccccc1OC
Show InChI InChI=1S/C18H18N2OS/c1-3-6-14-11-13(9-10-19-14)18-20-16(12-22-18)15-7-4-5-8-17(15)21-2/h4-5,7-12H,3,6H2,1-2H3
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n/an/a 3.20E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351536
PNG
(CHEMBL1824671)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NCC2CC2)cc1
Show InChI InChI=1S/C21H23N3S/c1-2-3-19-12-17(10-11-22-19)21-24-20(14-25-21)16-6-8-18(9-7-16)23-13-15-4-5-15/h6-12,14-15,23H,2-5,13H2,1H3
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n/an/a 4.90E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM78179
PNG
(2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole;hydrobr...)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(C)cc1
Show InChI InChI=1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3
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n/an/a 5.60E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351521
PNG
(CHEMBL1824658)
Show SMILES CCc1cc(ccn1)-c1nc(cs1)-c1ccc(C)cc1
Show InChI InChI=1S/C17H16N2S/c1-3-15-10-14(8-9-18-15)17-19-16(11-20-17)13-6-4-12(2)5-7-13/h4-11H,3H2,1-2H3
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n/an/a 6.80E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351537
PNG
(CHEMBL1824672)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C19H19N3OS/c1-3-4-17-11-15(9-10-20-17)19-22-18(12-24-19)14-5-7-16(8-6-14)21-13(2)23/h5-12H,3-4H2,1-2H3,(H,21,23)
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n/an/a 7.10E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351542
PNG
(CHEMBL1824661)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(OC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C24H20N2O2S/c1-2-6-20-15-19(13-14-25-20)23-26-22(16-29-23)17-9-11-21(12-10-17)28-24(27)18-7-4-3-5-8-18/h3-5,7-16H,2,6H2,1H3
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n/an/a 7.70E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351533
PNG
(CHEMBL1824668)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(N)cc1
Show InChI InChI=1S/C17H17N3S/c1-2-3-15-10-13(8-9-19-15)17-20-16(11-21-17)12-4-6-14(18)7-5-12/h4-11H,2-3,18H2,1H3
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n/an/a 8.60E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351531
PNG
(CHEMBL1824666)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1cccc(O)c1
Show InChI InChI=1S/C17H16N2OS/c1-2-4-14-9-13(7-8-18-14)17-19-16(11-21-17)12-5-3-6-15(20)10-12/h3,5-11,20H,2,4H2,1H3
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n/an/a 9.50E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351530
PNG
(CHEMBL1824665)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(O)cc1
Show InChI InChI=1S/C17H16N2OS/c1-2-3-14-10-13(8-9-18-14)17-19-16(11-21-17)12-4-6-15(20)7-5-12/h4-11,20H,2-3H2,1H3
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n/an/a 9.60E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351526
PNG
(CHEMBL1616869)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(Br)cc1
Show InChI InChI=1S/C17H15BrN2S/c1-2-3-15-10-13(8-9-19-15)17-20-16(11-21-17)12-4-6-14(18)7-5-12/h4-11H,2-3H2,1H3
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n/an/a 9.80E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM78179
PNG
(2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole;hydrobr...)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(C)cc1
Show InChI InChI=1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells by densitometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351528
PNG
(CHEMBL1824663)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1cccc(OC)c1
Show InChI InChI=1S/C18H18N2OS/c1-3-5-15-10-14(8-9-19-15)18-20-17(12-22-18)13-6-4-7-16(11-13)21-2/h4,6-12H,3,5H2,1-2H3
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n/an/a 1.02E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM93773
PNG
(4-(4-chlorophenyl)-2-(2-propyl-4-pyridinyl)thiazol...)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15ClN2S/c1-2-3-15-10-13(8-9-19-15)17-20-16(11-21-17)12-4-6-14(18)7-5-12/h4-11H,2-3H2,1H3
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n/an/a 1.07E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351524
PNG
(CHEMBL1824660)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2S/c1-2-3-15-10-13(8-9-19-15)17-20-16(11-21-17)12-4-6-14(18)7-5-12/h4-11H,2-3H2,1H3
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n/an/a 1.24E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351527
PNG
(CHEMBL1824662)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H18N2OS/c1-3-4-15-11-14(9-10-19-15)18-20-17(12-22-18)13-5-7-16(21-2)8-6-13/h5-12H,3-4H2,1-2H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351532
PNG
(CHEMBL1824667)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccccc1O
Show InChI InChI=1S/C17H16N2OS/c1-2-5-13-10-12(8-9-18-13)17-19-15(11-21-17)14-6-3-4-7-16(14)20/h3-4,6-11,20H,2,5H2,1H3
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n/an/a 1.44E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351518
PNG
(CHEMBL1824655)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1cccs1
Show InChI InChI=1S/C15H14N2S2/c1-2-4-12-9-11(6-7-16-12)15-17-13(10-19-15)14-5-3-8-18-14/h3,5-10H,2,4H2,1H3
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n/an/a 1.47E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50159362
PNG
(CHEMBL3785912)
Show SMILES CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCNC(=O)c1cccnc1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Catabasis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 in human HepG2 cells assessed as reduction of PCSK9 secretion after 16 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351519
PNG
(CHEMBL1824656)
Show SMILES Cc1ccc(cc1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C16H13NS/c1-12-7-9-13(10-8-12)15-11-18-16(17-15)14-5-3-2-4-6-14/h2-11H,1H3
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n/an/a 1.86E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351523
PNG
(CHEMBL1824659)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C17H16N2S/c1-2-6-15-11-14(9-10-18-15)17-19-16(12-20-17)13-7-4-3-5-8-13/h3-5,7-12H,2,6H2,1H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351522
PNG
(CHEMBL1300882 | cid_715106)
Show SMILES Cc1ccc(cc1)-c1csc(n1)-c1ccncc1
Show InChI InChI=1S/C15H12N2S/c1-11-2-4-12(5-3-11)14-10-18-15(17-14)13-6-8-16-9-7-13/h2-10H,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351520
PNG
(CHEMBL1824657)
Show SMILES CCCc1cc(ccn1)-c1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1S/C21H21N/c1-3-4-21-15-20(13-14-22-21)19-11-9-18(10-12-19)17-7-5-16(2)6-8-17/h5-15H,3-4H2,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair