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Compile Data Set for Download or QSAR

Found 29 hits Enz. Inhib. hit(s) with Target = 'Sterol regulatory element-binding protein 2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM20182
PNG
((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Show SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1
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n/an/a 300n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351538
PNG
(CHEMBL1824673)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C18H19N3O2S2/c1-3-4-16-11-14(9-10-19-16)18-20-17(12-24-18)13-5-7-15(8-6-13)21-25(2,22)23/h5-12,21H,3-4H2,1-2H3
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n/an/a 700n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351539
PNG
(CHEMBL1824674)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NS(=O)(=O)c2cccs2)cc1
Show InChI InChI=1S/C21H19N3O2S3/c1-2-4-18-13-16(10-11-22-18)21-23-19(14-28-21)15-6-8-17(9-7-15)24-29(25,26)20-5-3-12-27-20/h3,5-14,24H,2,4H2,1H3
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n/an/a 900n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351538
PNG
(CHEMBL1824673)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C18H19N3O2S2/c1-3-4-16-11-14(9-10-19-16)18-20-17(12-24-18)13-5-7-15(8-6-13)21-25(2,22)23/h5-12,21H,3-4H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells by densitometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351541
PNG
(CHEMBL1824676)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NC(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C22H25N3O2S/c1-5-6-18-13-16(11-12-23-18)20-25-19(14-28-20)15-7-9-17(10-8-15)24-21(26)27-22(2,3)4/h7-14H,5-6H2,1-4H3,(H,24,26)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351540
PNG
(CHEMBL1824675)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C24H23N3O2S2/c1-3-4-21-15-19(13-14-25-21)24-26-23(16-30-24)18-7-9-20(10-8-18)27-31(28,29)22-11-5-17(2)6-12-22/h5-16,27H,3-4H2,1-2H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351534
PNG
(CHEMBL1824669)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NC(C)C)cc1
Show InChI InChI=1S/C20H23N3S/c1-4-5-18-12-16(10-11-21-18)20-23-19(13-24-20)15-6-8-17(9-7-15)22-14(2)3/h6-14,22H,4-5H2,1-3H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351535
PNG
(CHEMBL1824670)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NCc2ccccc2)cc1
Show InChI InChI=1S/C24H23N3S/c1-2-6-22-15-20(13-14-25-22)24-27-23(17-28-24)19-9-11-21(12-10-19)26-16-18-7-4-3-5-8-18/h3-5,7-15,17,26H,2,6,16H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351529
PNG
(CHEMBL1824664)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccccc1OC
Show InChI InChI=1S/C18H18N2OS/c1-3-6-14-11-13(9-10-19-14)18-20-16(12-22-18)15-7-4-5-8-17(15)21-2/h4-5,7-12H,3,6H2,1-2H3
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n/an/a 3.20E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351536
PNG
(CHEMBL1824671)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NCC2CC2)cc1
Show InChI InChI=1S/C21H23N3S/c1-2-3-19-12-17(10-11-22-19)21-24-20(14-25-21)16-6-8-18(9-7-16)23-13-15-4-5-15/h6-12,14-15,23H,2-5,13H2,1H3
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n/an/a 4.90E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM78179
PNG
(2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole;hydrobr...)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(C)cc1
Show InChI InChI=1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3
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n/an/a 5.60E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351521
PNG
(CHEMBL1824658)
Show SMILES CCc1cc(ccn1)-c1nc(cs1)-c1ccc(C)cc1
Show InChI InChI=1S/C17H16N2S/c1-3-15-10-14(8-9-18-15)17-19-16(11-20-17)13-6-4-12(2)5-7-13/h4-11H,3H2,1-2H3
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n/an/a 6.80E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351537
PNG
(CHEMBL1824672)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C19H19N3OS/c1-3-4-17-11-15(9-10-20-17)19-22-18(12-24-19)14-5-7-16(8-6-14)21-13(2)23/h5-12H,3-4H2,1-2H3,(H,21,23)
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n/an/a 7.10E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351542
PNG
(CHEMBL1824661)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(OC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C24H20N2O2S/c1-2-6-20-15-19(13-14-25-20)23-26-22(16-29-23)17-9-11-21(12-10-17)28-24(27)18-7-4-3-5-8-18/h3-5,7-16H,2,6H2,1H3
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n/an/a 7.70E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351533
PNG
(CHEMBL1824668)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(N)cc1
Show InChI InChI=1S/C17H17N3S/c1-2-3-15-10-13(8-9-19-15)17-20-16(11-21-17)12-4-6-14(18)7-5-12/h4-11H,2-3,18H2,1H3
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n/an/a 8.60E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351531
PNG
(CHEMBL1824666)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1cccc(O)c1
Show InChI InChI=1S/C17H16N2OS/c1-2-4-14-9-13(7-8-18-14)17-19-16(11-21-17)12-5-3-6-15(20)10-12/h3,5-11,20H,2,4H2,1H3
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n/an/a 9.50E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351530
PNG
(CHEMBL1824665)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(O)cc1
Show InChI InChI=1S/C17H16N2OS/c1-2-3-14-10-13(8-9-18-14)17-19-16(11-21-17)12-4-6-15(20)7-5-12/h4-11,20H,2-3H2,1H3
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n/an/a 9.60E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351526
PNG
(CHEMBL1616869)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(Br)cc1
Show InChI InChI=1S/C17H15BrN2S/c1-2-3-15-10-13(8-9-19-15)17-20-16(11-21-17)12-4-6-14(18)7-5-12/h4-11H,2-3H2,1H3
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n/an/a 9.80E+3n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM78179
PNG
(2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole;hydrobr...)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(C)cc1
Show InChI InChI=1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells by densitometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351528
PNG
(CHEMBL1824663)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1cccc(OC)c1
Show InChI InChI=1S/C18H18N2OS/c1-3-5-15-10-14(8-9-19-15)18-20-17(12-22-18)13-6-4-7-16(11-13)21-2/h4,6-12H,3,5H2,1-2H3
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n/an/a 1.02E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM93773
PNG
(4-(4-chlorophenyl)-2-(2-propyl-4-pyridinyl)thiazol...)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15ClN2S/c1-2-3-15-10-13(8-9-19-15)17-20-16(11-21-17)12-4-6-14(18)7-5-12/h4-11H,2-3H2,1H3
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n/an/a 1.07E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351524
PNG
(CHEMBL1824660)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2S/c1-2-3-15-10-13(8-9-19-15)17-20-16(11-21-17)12-4-6-14(18)7-5-12/h4-11H,2-3H2,1H3
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n/an/a 1.24E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351527
PNG
(CHEMBL1824662)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H18N2OS/c1-3-4-15-11-14(9-10-19-15)18-20-17(12-22-18)13-5-7-16(21-2)8-6-13/h5-12H,3-4H2,1-2H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351532
PNG
(CHEMBL1824667)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccccc1O
Show InChI InChI=1S/C17H16N2OS/c1-2-5-13-10-12(8-9-18-13)17-19-15(11-21-17)14-6-3-4-7-16(14)20/h3-4,6-11,20H,2,5H2,1H3
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n/an/a 1.44E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351518
PNG
(CHEMBL1824655)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1cccs1
Show InChI InChI=1S/C15H14N2S2/c1-2-4-12-9-11(6-7-16-12)15-17-13(10-19-15)14-5-3-8-18-14/h3,5-10H,2,4H2,1H3
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n/an/a 1.47E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351519
PNG
(CHEMBL1824656)
Show SMILES Cc1ccc(cc1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C16H13NS/c1-12-7-9-13(10-8-12)15-11-18-16(17-15)14-5-3-2-4-6-14/h2-11H,1H3
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n/an/a 1.86E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351523
PNG
(CHEMBL1824659)
Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C17H16N2S/c1-2-6-15-11-14(9-10-18-15)17-19-16(12-20-17)13-7-4-3-5-8-13/h3-5,7-12H,2,6H2,1H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351522
PNG
(CHEMBL1300882 | cid_715106)
Show SMILES Cc1ccc(cc1)-c1csc(n1)-c1ccncc1
Show InChI InChI=1S/C15H12N2S/c1-11-2-4-12(5-3-11)14-10-18-15(17-14)13-6-8-16-9-7-13/h2-10H,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50351520
PNG
(CHEMBL1824657)
Show SMILES CCCc1cc(ccn1)-c1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1S/C21H21N/c1-3-4-21-15-20(13-14-22-21)19-11-9-18(10-12-19)17-7-5-16(2)6-8-17/h5-15H,3-4H2,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2...


Citation and Details
More data for this
Ligand-Target Pair