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Compile Data Set for Download or QSAR

Found 43 hits Enz. Inhib. hit(s) with Target = 'Subtilisin/kexin type 6' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399749
PNG
(CHEMBL2179430)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C39H77N17O8/c1-21(2)19-24(41)31(58)56-29(20-22(3)4)35(62)54-27(13-9-17-49-38(44)45)33(60)53-26(12-8-16-48-37(42)43)32(59)51-23(5)30(57)52-25(11-6-7-15-40)34(61)55-28(36(63)64)14-10-18-50-39(46)47/h21-29H,6-20,40-41H2,1-5H3,(H,51,59)(H,52,57)(H,53,60)(H,54,62)(H,55,61)(H,56,58)(H,63,64)(H4,42,43,48)(H4,44,45,49)(H4,46,47,50)/t23-,24-,25-,26-,27-,28-,29-/m0/s1
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0.340n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399753
PNG
(CHEMBL2179835)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C37H74N18O9/c1-20(40)28(57)50-22(10-3-5-15-38)29(58)51-24(12-7-17-47-35(41)42)30(59)52-25(13-8-18-48-36(43)44)32(61)55-27(21(2)56)33(62)53-23(11-4-6-16-39)31(60)54-26(34(63)64)14-9-19-49-37(45)46/h20-27,56H,3-19,38-40H2,1-2H3,(H,50,57)(H,51,58)(H,52,59)(H,53,62)(H,54,60)(H,55,61)(H,63,64)(H4,41,42,47)(H4,43,44,48)(H4,45,46,49)/t20-,21+,22-,23-,24-,25-,26-,27-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50303774
PNG
(CHEMBL566340 | phenylacetyl-Arg-Val-Arg-4-amidinob...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H50N12O4/c1-20(2)27(45-30(48)25(11-7-17-41-33(38)39)43-26(46)18-21-8-4-3-5-9-21)31(49)44-24(10-6-16-40-32(36)37)29(47)42-19-22-12-14-23(15-13-22)28(34)35/h3-5,8-9,12-15,20,24-25,27H,6-7,10-11,16-19H2,1-2H3,(H3,34,35)(H,42,47)(H,43,46)(H,44,49)(H,45,48)(H4,36,37,40)(H4,38,39,41)/t24-,25-,27-/m0/s1
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0.600n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PACE4 expressed in Drosophila schneider 2 cells by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399754
PNG
(CHEMBL2179836)
Show SMILES NCCCC[C@H](NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C37H69N15O13/c38-15-3-1-7-21(47-29(58)20(40)11-13-27(54)55)30(59)50-24(12-14-28(56)57)33(62)48-23(9-5-17-45-36(41)42)32(61)52-26(19-53)34(63)49-22(8-2-4-16-39)31(60)51-25(35(64)65)10-6-18-46-37(43)44/h20-26,53H,1-19,38-40H2,(H,47,58)(H,48,62)(H,49,63)(H,50,59)(H,51,60)(H,52,61)(H,54,55)(H,56,57)(H,64,65)(H4,41,42,45)(H4,43,44,46)/t20-,21-,22-,23-,24-,25-,26-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399752
PNG
(CHEMBL2179429)
Show SMILES CC(C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C39H78N16O9/c1-22(2)29(43)35(61)52-25(13-5-8-18-41)32(58)50-24(12-4-7-17-40)31(57)51-27(15-10-20-48-38(44)45)34(60)55-30(23(3)56)36(62)53-26(14-6-9-19-42)33(59)54-28(37(63)64)16-11-21-49-39(46)47/h22-30,56H,4-21,40-43H2,1-3H3,(H,50,58)(H,51,57)(H,52,61)(H,53,62)(H,54,59)(H,55,60)(H,63,64)(H4,44,45,48)(H4,46,47,49)/t23-,24+,25+,26+,27+,28+,29+,30+/m1/s1
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1.30n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399751
PNG
(CHEMBL2179431)
Show SMILES CC(C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C40H80N18O8/c1-22(2)29(43)35(63)55-24(12-5-7-17-41)31(59)53-26(14-9-19-50-38(44)45)32(60)54-27(15-10-20-51-39(46)47)34(62)58-30(23(3)4)36(64)56-25(13-6-8-18-42)33(61)57-28(37(65)66)16-11-21-52-40(48)49/h22-30H,5-21,41-43H2,1-4H3,(H,53,59)(H,54,60)(H,55,63)(H,56,64)(H,57,61)(H,58,62)(H,65,66)(H4,44,45,50)(H4,46,47,51)(H4,48,49,52)/t24-,25-,26-,27-,28-,29-,30-/m0/s1
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2n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50303775
PNG
((S)-2-acetamido-N-((S)-1-((S)-1-(4-carbamimidoylbe...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H46N12O4/c1-15(2)21(39-24(42)20(37-16(3)40)7-5-13-35-27(32)33)25(43)38-19(6-4-12-34-26(30)31)23(41)36-14-17-8-10-18(11-9-17)22(28)29/h8-11,15,19-21H,4-7,12-14H2,1-3H3,(H3,28,29)(H,36,41)(H,37,40)(H,38,43)(H,39,42)(H4,30,31,34)(H4,32,33,35)/t19-,20-,21-/m0/s1
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2.40n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PACE4 expressed in Drosophila schneider 2 cells by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50303776
PNG
(CHEMBL568525 | N-((6S,9S,12S)-1,17-diamino-6-(4-ca...)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C35H62N12O4/c1-4-5-6-7-8-9-10-15-28(48)45-27(14-12-21-43-35(40)41)32(50)47-29(23(2)3)33(51)46-26(13-11-20-42-34(38)39)31(49)44-22-24-16-18-25(19-17-24)30(36)37/h16-19,23,26-27,29H,4-15,20-22H2,1-3H3,(H3,36,37)(H,44,49)(H,45,48)(H,46,51)(H,47,50)(H4,38,39,42)(H4,40,41,43)/t26-,27-,29-/m0/s1
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3n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PACE4 expressed in Drosophila schneider 2 cells by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446944
PNG
(CHEMBL3115771)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C51H90N14O8/c1-28(2)23-38(59-33(11)66)46(69)62-40(25-30(5)6)48(71)64-41(26-31(7)8)49(72)63-39(24-29(3)4)47(70)60-37(16-14-22-57-51(55)56)45(68)65-42(32(9)10)50(73)61-36(15-12-13-21-52)44(67)58-27-34-17-19-35(20-18-34)43(53)54/h17-20,28-32,36-42H,12-16,21-27,52H2,1-11H3,(H3,53,54)(H,58,67)(H,59,66)(H,60,70)(H,61,73)(H,62,69)(H,63,72)(H,64,71)(H,65,68)(H4,55,56,57)/t36-,37-,38-,39-,40-,41-,42-/m0/s1
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3.10n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446945
PNG
(CHEMBL3115770)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC\C=C\CN=C(N)N
Show InChI InChI=1S/C48H91N15O8/c1-27(2)23-35(57-32(11)64)42(67)60-37(25-29(5)6)44(69)62-38(26-30(7)8)45(70)61-36(24-28(3)4)43(68)58-34(18-16-22-56-48(52)53)41(66)63-39(31(9)10)46(71)59-33(17-12-13-19-49)40(65)54-20-14-15-21-55-47(50)51/h14-15,27-31,33-39H,12-13,16-26,49H2,1-11H3,(H,54,65)(H,57,64)(H,58,68)(H,59,71)(H,60,67)(H,61,70)(H,62,69)(H,63,66)(H4,50,51,55)(H4,52,53,56)/b15-14+/t33-,34-,35-,36-,37-,38-,39-/m0/s1
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5.30n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399750
PNG
(CHEMBL2179428)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C41H82N20O8/c1-22(2)21-24(43)31(62)56-26(12-7-17-52-38(44)45)32(63)57-27(13-8-18-53-39(46)47)33(64)58-28(14-9-19-54-40(48)49)35(66)61-30(23(3)4)36(67)59-25(11-5-6-16-42)34(65)60-29(37(68)69)15-10-20-55-41(50)51/h22-30H,5-21,42-43H2,1-4H3,(H,56,62)(H,57,63)(H,58,64)(H,59,67)(H,60,65)(H,61,66)(H,68,69)(H4,44,45,52)(H4,46,47,53)(H4,48,49,54)(H4,50,51,55)/t24-,25-,26-,27-,28-,29-,30-/m0/s1
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7n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446937
PNG
(CHEMBL3115764)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-10-12-18-33(58-31(9)66)41(68)63-38(27-29(5)6)46(73)64-37(26-28(3)4)45(72)61-34(19-13-11-2)43(70)60-36(22-17-25-57-49(54)55)44(71)65-39(30(7)8)47(74)62-35(20-14-15-23-50)42(69)59-32(40(51)67)21-16-24-56-48(52)53/h28-30,32-39H,10-27,50H2,1-9H3,(H2,51,67)(H,58,66)(H,59,69)(H,60,70)(H,61,72)(H,62,74)(H,63,68)(H,64,73)(H,65,71)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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14n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399748
PNG
(CHEMBL2179434)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C43H83N15O8/c1-23(2)20-31(52-27(9)59)38(63)56-33(22-25(5)6)40(65)57-32(21-24(3)4)39(64)54-30(16-13-19-51-43(48)49)37(62)58-34(26(7)8)41(66)55-29(14-10-11-17-44)36(61)53-28(35(45)60)15-12-18-50-42(46)47/h23-26,28-34H,10-22,44H2,1-9H3,(H2,45,60)(H,52,59)(H,53,61)(H,54,64)(H,55,66)(H,56,63)(H,57,65)(H,58,62)(H4,46,47,50)(H4,48,49,51)/t28-,29-,30-,31-,32-,33-,34-/m0/s1
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18n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399747
PNG
(CHEMBL2179832)
Show SMILES CC(C)C[C@H](NCCOCCOCCOCCOCCOCCOCCOCCOC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C65H126N16O17/c1-42(2)38-51(72-22-23-91-24-25-92-26-27-93-28-29-94-30-31-95-32-33-96-34-35-97-36-37-98-47(11)82)59(86)78-53(40-44(5)6)61(88)80-54(41-45(7)8)62(89)79-52(39-43(3)4)60(87)76-50(18-15-21-74-65(70)71)58(85)81-55(46(9)10)63(90)77-49(16-12-13-19-66)57(84)75-48(56(67)83)17-14-20-73-64(68)69/h42-46,48-55,72H,12-41,66H2,1-11H3,(H2,67,83)(H,75,84)(H,76,87)(H,77,90)(H,78,86)(H,79,89)(H,80,88)(H,81,85)(H4,68,69,73)(H4,70,71,74)/t48-,49-,50-,51-,52-,53-,54-,55-/m0/s1
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19n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399746
PNG
(CHEMBL2179435)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-26(2)22-35(58-31(11)66)43(70)62-37(24-28(5)6)45(72)64-38(25-29(7)8)46(73)63-36(23-27(3)4)44(71)60-34(18-15-21-57-49(54)55)42(69)65-39(30(9)10)47(74)61-33(16-12-13-19-50)41(68)59-32(40(51)67)17-14-20-56-48(52)53/h26-30,32-39H,12-25,50H2,1-11H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,71)(H,61,74)(H,62,70)(H,63,73)(H,64,72)(H,65,69)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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20n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446951
PNG
(CHEMBL3115587)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-11-12-17-33(58-31(10)66)41(68)62-37(25-28(4)5)45(72)64-38(26-29(6)7)46(73)63-36(24-27(2)3)44(71)60-35(20-16-23-57-49(54)55)43(70)65-39(30(8)9)47(74)61-34(18-13-14-21-50)42(69)59-32(40(51)67)19-15-22-56-48(52)53/h27-30,32-39H,11-26,50H2,1-10H3,(H2,51,67)(H,58,66)(H,59,69)(H,60,71)(H,61,74)(H,62,68)(H,63,73)(H,64,72)(H,65,70)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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21n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399746
PNG
(CHEMBL2179435)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-26(2)22-35(58-31(11)66)43(70)62-37(24-28(5)6)45(72)64-38(25-29(7)8)46(73)63-36(23-27(3)4)44(71)60-34(18-15-21-57-49(54)55)42(69)65-39(30(9)10)47(74)61-33(16-12-13-19-50)41(68)59-32(40(51)67)17-14-20-56-48(52)53/h26-30,32-39H,12-25,50H2,1-11H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,71)(H,61,74)(H,62,70)(H,63,73)(H,64,72)(H,65,69)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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22n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399761
PNG
(CHEMBL2179833)
Show SMILES CC(C)C[C@H](NCCCCCCCCC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C57H110N16O9/c1-34(2)30-43(64-27-19-15-13-12-14-16-22-39(11)74)51(78)70-45(32-36(5)6)53(80)72-46(33-37(7)8)54(81)71-44(31-35(3)4)52(79)68-42(25-21-29-66-57(62)63)50(77)73-47(38(9)10)55(82)69-41(23-17-18-26-58)49(76)67-40(48(59)75)24-20-28-65-56(60)61/h34-38,40-47,64H,12-33,58H2,1-11H3,(H2,59,75)(H,67,76)(H,68,79)(H,69,82)(H,70,78)(H,71,81)(H,72,80)(H,73,77)(H4,60,61,65)(H4,62,63,66)/t40-,41-,42-,43-,44-,45-,46-,47-/m0/s1
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23n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446936
PNG
(CHEMBL2179834)
Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-26(2)22-35(58-31(11)66)43(70)62-37(24-28(5)6)45(72)64-38(25-29(7)8)46(73)63-36(23-27(3)4)44(71)60-34(18-15-21-57-49(54)55)42(69)65-39(30(9)10)47(74)61-33(16-12-13-19-50)41(68)59-32(40(51)67)17-14-20-56-48(52)53/h26-30,32-39H,12-25,50H2,1-11H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,71)(H,61,74)(H,62,70)(H,63,73)(H,64,72)(H,65,69)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35+,36-,37-,38-,39-/m0/s1
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24n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446948
PNG
(CHEMBL3115769)
Show SMILES CCCC[C@@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-11-12-17-33(58-31(10)66)41(68)62-37(25-28(4)5)45(72)64-38(26-29(6)7)46(73)63-36(24-27(2)3)44(71)60-35(20-16-23-57-49(54)55)43(70)65-39(30(8)9)47(74)61-34(18-13-14-21-50)42(69)59-32(40(51)67)19-15-22-56-48(52)53/h27-30,32-39H,11-26,50H2,1-10H3,(H2,51,67)(H,58,66)(H,59,69)(H,60,71)(H,61,74)(H,62,68)(H,63,73)(H,64,72)(H,65,70)(H4,52,53,56)(H4,54,55,57)/t32-,33+,34-,35-,36-,37-,38-,39-/m0/s1
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25n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446943
PNG
(CHEMBL3115590)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-11-12-17-33(61-45(72)37(25-28(4)5)64-46(73)38(26-29(6)7)63-44(71)36(24-27(2)3)58-31(10)66)42(69)60-35(20-16-23-57-49(54)55)43(70)65-39(30(8)9)47(74)62-34(18-13-14-21-50)41(68)59-32(40(51)67)19-15-22-56-48(52)53/h27-30,32-39H,11-26,50H2,1-10H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,69)(H,61,72)(H,62,74)(H,63,71)(H,64,73)(H,65,70)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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27n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446950
PNG
(CHEMBL3115588)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-11-12-17-33(60-44(71)36(24-27(2)3)58-31(10)66)42(69)63-38(26-29(6)7)46(73)64-37(25-28(4)5)45(72)61-35(20-16-23-57-49(54)55)43(70)65-39(30(8)9)47(74)62-34(18-13-14-21-50)41(68)59-32(40(51)67)19-15-22-56-48(52)53/h27-30,32-39H,11-26,50H2,1-10H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,71)(H,61,72)(H,62,74)(H,63,69)(H,64,73)(H,65,70)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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39n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50303777
PNG
((S)-5-guanidino-N-((S)-1-((S)-5-guanidino-1-(3-gua...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCN=C(N)N
Show InChI InChI=1S/C30H53N13O4/c1-19(2)24(27(47)42-21(12-8-16-39-29(33)34)25(45)37-14-6-7-15-38-28(31)32)43-26(46)22(13-9-17-40-30(35)36)41-23(44)18-20-10-4-3-5-11-20/h3-5,10-11,19,21-22,24H,6-9,12-18H2,1-2H3,(H,37,45)(H,41,44)(H,42,47)(H,43,46)(H4,31,32,38)(H4,33,34,39)(H4,35,36,40)/t21-,22-,24-/m0/s1
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42n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PACE4 expressed in Drosophila schneider 2 cells by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446941
PNG
(CHEMBL3115760)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-10-12-18-33(58-31(9)66)41(68)60-34(19-13-11-2)43(70)63-38(27-29(5)6)46(73)64-37(26-28(3)4)45(72)61-36(22-17-25-57-49(54)55)44(71)65-39(30(7)8)47(74)62-35(20-14-15-23-50)42(69)59-32(40(51)67)21-16-24-56-48(52)53/h28-30,32-39H,10-27,50H2,1-9H3,(H2,51,67)(H,58,66)(H,59,69)(H,60,68)(H,61,72)(H,62,74)(H,63,70)(H,64,73)(H,65,71)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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57n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446940
PNG
(CHEMBL3115761)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-9-12-19-33(58-31(8)66)41(68)60-35(21-14-11-3)44(71)64-38(28-29(4)5)46(73)62-34(20-13-10-2)43(70)61-37(24-18-27-57-49(54)55)45(72)65-39(30(6)7)47(74)63-36(22-15-16-25-50)42(69)59-32(40(51)67)23-17-26-56-48(52)53/h29-30,32-39H,9-28,50H2,1-8H3,(H2,51,67)(H,58,66)(H,59,69)(H,60,68)(H,61,70)(H,62,73)(H,63,74)(H,64,71)(H,65,72)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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60n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50303778
PNG
((S)-N-((1-carbamimidoylpiperidin-4-yl)methyl)-5-gu...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC1CCN(CC1)C(N)=N
Show InChI InChI=1S/C32H55N13O4/c1-20(2)26(44-28(48)24(11-7-15-40-31(35)36)42-25(46)18-21-8-4-3-5-9-21)29(49)43-23(10-6-14-39-30(33)34)27(47)41-19-22-12-16-45(17-13-22)32(37)38/h3-5,8-9,20,22-24,26H,6-7,10-19H2,1-2H3,(H3,37,38)(H,41,47)(H,42,46)(H,43,49)(H,44,48)(H4,33,34,39)(H4,35,36,40)/t23-,24-,26-/m0/s1
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67n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PACE4 expressed in Drosophila schneider 2 cells by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399759
PNG
(CHEMBL2179436)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C55H105N17O10/c1-29(2)24-39(64-35(13)73)48(77)68-41(26-31(5)6)50(79)70-43(28-33(9)10)52(81)71-42(27-32(7)8)51(80)69-40(25-30(3)4)49(78)66-38(20-17-23-63-55(60)61)47(76)72-44(34(11)12)53(82)67-37(18-14-15-21-56)46(75)65-36(45(57)74)19-16-22-62-54(58)59/h29-34,36-44H,14-28,56H2,1-13H3,(H2,57,74)(H,64,73)(H,65,75)(H,66,78)(H,67,82)(H,68,77)(H,69,80)(H,70,79)(H,71,81)(H,72,76)(H4,58,59,62)(H4,60,61,63)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1
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70n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446939
PNG
(CHEMBL3115762)
Show SMILES CCCC[C@H](NC(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-10-12-18-33(61-45(72)37(26-28(3)4)58-31(9)66)42(69)60-34(19-13-11-2)43(70)64-38(27-29(5)6)46(73)62-36(22-17-25-57-49(54)55)44(71)65-39(30(7)8)47(74)63-35(20-14-15-23-50)41(68)59-32(40(51)67)21-16-24-56-48(52)53/h28-30,32-39H,10-27,50H2,1-9H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,69)(H,61,72)(H,62,73)(H,63,74)(H,64,70)(H,65,71)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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170n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50387003
PNG
(CHEMBL2049156)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C37H72N14O7/c1-20(2)18-27(46-23(7)52)33(56)50-28(19-21(3)4)34(57)48-26(14-11-17-45-37(42)43)32(55)51-29(22(5)6)35(58)49-25(12-8-9-15-38)31(54)47-24(30(39)53)13-10-16-44-36(40)41/h20-22,24-29H,8-19,38H2,1-7H3,(H2,39,53)(H,46,52)(H,47,54)(H,48,57)(H,49,58)(H,50,56)(H,51,55)(H4,40,41,44)(H4,42,43,45)/t24-,25-,26-,27-,28-,29-/m0/s1
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240n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399756
PNG
(CHEMBL2179437)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C61H116N18O11/c1-32(2)26-43(70-39(15)80)53(84)74-45(28-34(5)6)55(86)76-47(30-36(9)10)57(88)78-48(31-37(11)12)58(89)77-46(29-35(7)8)56(87)75-44(27-33(3)4)54(85)72-42(22-19-25-69-61(66)67)52(83)79-49(38(13)14)59(90)73-41(20-16-17-23-62)51(82)71-40(50(63)81)21-18-24-68-60(64)65/h32-38,40-49H,16-31,62H2,1-15H3,(H2,63,81)(H,70,80)(H,71,82)(H,72,85)(H,73,90)(H,74,84)(H,75,87)(H,76,86)(H,77,89)(H,78,88)(H,79,83)(H4,64,65,68)(H4,66,67,69)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
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300n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446938
PNG
(CHEMBL3115763)
Show SMILES CCCC[C@H](NC(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-10-12-18-33(60-43(70)34(19-13-11-2)62-46(73)38(27-29(5)6)64-45(72)37(26-28(3)4)58-31(9)66)42(69)61-36(22-17-25-57-49(54)55)44(71)65-39(30(7)8)47(74)63-35(20-14-15-23-50)41(68)59-32(40(51)67)21-16-24-56-48(52)53/h28-30,32-39H,10-27,50H2,1-9H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,70)(H,61,69)(H,62,73)(H,63,74)(H,64,72)(H,65,71)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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350n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446949
PNG
(CHEMBL3115589)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-11-12-17-33(60-46(73)38(26-29(6)7)64-44(71)36(24-27(2)3)58-31(10)66)42(69)63-37(25-28(4)5)45(72)61-35(20-16-23-57-49(54)55)43(70)65-39(30(8)9)47(74)62-34(18-13-14-21-50)41(68)59-32(40(51)67)19-15-22-56-48(52)53/h27-30,32-39H,11-26,50H2,1-10H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,73)(H,61,72)(H,62,74)(H,63,69)(H,64,71)(H,65,70)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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385n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446946
PNG
(CHEMBL3115586)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NN(CCCN=C(N)N)CC(N)=O
Show InChI InChI=1S/C49H95N17O9/c1-27(2)22-35(58-32(11)67)42(70)61-37(24-29(5)6)44(72)63-38(25-30(7)8)45(73)62-36(23-28(3)4)43(71)59-33(17-14-19-56-48(52)53)41(69)64-40(31(9)10)47(75)60-34(16-12-13-18-50)46(74)65-66(26-39(51)68)21-15-20-57-49(54)55/h27-31,33-38,40H,12-26,50H2,1-11H3,(H2,51,68)(H,58,67)(H,59,71)(H,60,75)(H,61,70)(H,62,73)(H,63,72)(H,64,69)(H,65,74)(H4,52,53,56)(H4,54,55,57)/t33-,34-,35-,36-,37-,38-,40-/m0/s1
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400n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446942
PNG
(CHEMBL3115591)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-8-12-20-33(58-31(7)66)41(68)60-34(21-13-9-2)43(70)61-35(22-14-10-3)44(71)62-36(23-15-11-4)45(72)63-38(26-19-29-57-49(54)55)46(73)65-39(30(5)6)47(74)64-37(24-16-17-27-50)42(69)59-32(40(51)67)25-18-28-56-48(52)53/h30,32-39H,8-29,50H2,1-7H3,(H2,51,67)(H,58,66)(H,59,69)(H,60,68)(H,61,70)(H,62,71)(H,63,72)(H,64,74)(H,65,73)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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500n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446935
PNG
(CHEMBL3115765)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-26(2)22-35(58-31(11)66)43(70)62-37(24-28(5)6)45(72)64-38(25-29(7)8)46(73)63-36(23-27(3)4)44(71)60-34(18-15-21-57-49(54)55)42(69)65-39(30(9)10)47(74)61-33(16-12-13-19-50)41(68)59-32(40(51)67)17-14-20-56-48(52)53/h26-30,32-39H,12-25,50H2,1-11H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,71)(H,61,74)(H,62,70)(H,63,73)(H,64,72)(H,65,69)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37+,38-,39-/m0/s1
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700n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446947
PNG
(CHEMBL3115772)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(cc1)N=C(N)N)C(N)=O
Show InChI InChI=1S/C53H94N16O9/c1-28(2)23-39(61-33(11)70)47(74)66-41(25-30(5)6)49(76)68-42(26-31(7)8)50(77)67-40(24-29(3)4)48(75)63-37(16-14-22-60-52(56)57)46(73)69-43(32(9)10)51(78)64-36(15-12-13-21-54)45(72)65-38(44(55)71)27-34-17-19-35(20-18-34)62-53(58)59/h17-20,28-32,36-43H,12-16,21-27,54H2,1-11H3,(H2,55,71)(H,61,70)(H,63,75)(H,64,78)(H,65,72)(H,66,74)(H,67,77)(H,68,76)(H,69,73)(H4,56,57,60)(H4,58,59,62)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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960n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399760
PNG
(CHEMBL2179427)
Show SMILES NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C39H67N15O10/c40-16-6-4-12-24(32(58)51-25(13-5-7-17-41)34(60)53-27(37(63)64)15-9-19-48-39(45)46)50-33(59)26(14-8-18-47-38(43)44)52-36(62)29(21-31(56)57)54-35(61)28(49-30(55)22-42)20-23-10-2-1-3-11-23/h1-3,10-11,24-29H,4-9,12-22,40-42H2,(H,49,55)(H,50,59)(H,51,58)(H,52,62)(H,53,60)(H,54,61)(H,56,57)(H,63,64)(H4,43,44,47)(H4,45,46,48)/t24-,25-,26-,27-,28-,29-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399755
PNG
(CHEMBL2179438)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-26(2)22-35(58-31(11)66)43(70)62-37(24-28(5)6)45(72)64-38(25-29(7)8)46(73)63-36(23-27(3)4)44(71)60-34(18-15-21-57-49(54)55)42(69)65-39(30(9)10)47(74)61-33(16-12-13-19-50)41(68)59-32(40(51)67)17-14-20-56-48(52)53/h26-30,32-39H,12-25,50H2,1-11H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,71)(H,61,74)(H,62,70)(H,63,73)(H,64,72)(H,65,69)(H4,52,53,56)(H4,54,55,57)/t32-,33+,34+,35+,36+,37+,38+,39+/m1/s1
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1.38E+3n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399757
PNG
(CHEMBL2179433)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C31H61N13O6/c1-17(2)16-23(40-19(5)45)28(49)42-22(12-9-15-39-31(36)37)27(48)44-24(18(3)4)29(50)43-21(10-6-7-13-32)26(47)41-20(25(33)46)11-8-14-38-30(34)35/h17-18,20-24H,6-16,32H2,1-5H3,(H2,33,46)(H,40,45)(H,41,47)(H,42,49)(H,43,50)(H,44,48)(H4,34,35,38)(H4,36,37,39)/t20-,21-,22-,23-,24-/m0/s1
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1.60E+3n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50399758
PNG
(CHEMBL2179432)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C25H50N12O5/c1-14(2)19(37-22(41)17(34-15(3)38)10-7-13-33-25(30)31)23(42)36-18(8-4-5-11-26)21(40)35-16(20(27)39)9-6-12-32-24(28)29/h14,16-19H,4-13,26H2,1-3H3,(H2,27,39)(H,34,38)(H,35,40)(H,36,42)(H,37,41)(H4,28,29,32)(H4,30,31,33)/t16-,17-,18-,19-/m0/s1
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1.60E+3n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446934
PNG
(CHEMBL3115766)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-26(2)22-35(58-31(11)66)43(70)62-37(24-28(5)6)45(72)64-38(25-29(7)8)46(73)63-36(23-27(3)4)44(71)60-34(18-15-21-57-49(54)55)42(69)65-39(30(9)10)47(74)61-33(16-12-13-19-50)41(68)59-32(40(51)67)17-14-20-56-48(52)53/h26-30,32-39H,12-25,50H2,1-11H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,71)(H,61,74)(H,62,70)(H,63,73)(H,64,72)(H,65,69)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38+,39-/m0/s1
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6.26E+3n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446933
PNG
(CHEMBL3115767)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-26(2)22-35(58-31(11)66)43(70)62-37(24-28(5)6)45(72)64-38(25-29(7)8)46(73)63-36(23-27(3)4)44(71)60-34(18-15-21-57-49(54)55)42(69)65-39(30(9)10)47(74)61-33(16-12-13-19-50)41(68)59-32(40(51)67)17-14-20-56-48(52)53/h26-30,32-39H,12-25,50H2,1-11H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,71)(H,61,74)(H,62,70)(H,63,73)(H,64,72)(H,65,69)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36+,37-,38-,39-/m0/s1
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1.40E+4n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens)
BDBM50446932
PNG
(CHEMBL3115768)
Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C49H94N16O9/c1-26(2)22-35(58-31(11)66)43(70)62-37(24-28(5)6)45(72)64-38(25-29(7)8)46(73)63-36(23-27(3)4)44(71)60-34(18-15-21-57-49(54)55)42(69)65-39(30(9)10)47(74)61-33(16-12-13-19-50)41(68)59-32(40(51)67)17-14-20-56-48(52)53/h26-30,32-39H,12-25,50H2,1-11H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,71)(H,61,74)(H,62,70)(H,63,73)(H,64,72)(H,65,69)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35+,36+,37+,38+,39-/m0/s1
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1.40E+4n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair