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Compile Data Set for Download or QSAR

Found 47 hits Enz. Inhib. hit(s) with Target = 'Succinate receptor 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Succinate receptor 1


(Homo sapiens)
BDBM50393129
PNG
(CHEMBL2153461)
Show SMILES C[C@H](NC(=O)Cc1ccc(cc1)-c1ccc2cccnc2n1)c1ccc(cc1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C31H23F4N3O/c1-19(21-8-10-22(11-9-21)25-12-14-27(32)26(18-25)31(33,34)35)37-29(39)17-20-4-6-23(7-5-20)28-15-13-24-3-2-16-36-30(24)38-28/h2-16,18-19H,17H2,1H3,(H,37,39)/t19-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393123
PNG
(CHEMBL2153446)
Show SMILES C[C@H](NC(=O)CCCc1ccc2cccnc2n1)c1ccc(cc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C26H24ClN3O/c1-18(19-10-12-20(13-11-19)22-5-2-7-23(27)17-22)29-25(31)9-3-8-24-15-14-21-6-4-16-28-26(21)30-24/h2,4-7,10-18H,3,8-9H2,1H3,(H,29,31)/t18-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393133
PNG
(CHEMBL2153465)
Show SMILES C[C@H](NC(=O)C(C)(C)c1ccc(cc1)-c1ccc2cccnc2n1)c1ccc(cc1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C33H27F4N3O/c1-20(21-6-8-22(9-7-21)25-12-16-28(34)27(19-25)33(35,36)37)39-31(41)32(2,3)26-14-10-23(11-15-26)29-17-13-24-5-4-18-38-30(24)40-29/h4-20H,1-3H3,(H,39,41)/t20-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393136
PNG
(CHEMBL2153468)
Show SMILES C[C@H](NC(=O)C(O)(c1ccc(cc1)-c1ccc2cccnc2n1)C(F)(F)F)c1ccc(cc1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C32H22F7N3O2/c1-18(19-4-6-20(7-5-19)23-10-14-26(33)25(17-23)31(34,35)36)41-29(43)30(44,32(37,38)39)24-12-8-21(9-13-24)27-15-11-22-3-2-16-40-28(22)42-27/h2-18,44H,1H3,(H,41,43)/t18-,30?/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393122
PNG
(CHEMBL2153445)
Show SMILES CC(NC(=O)CCCc1ccc2cccnc2n1)c1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H24F3N3O/c1-18(19-10-12-20(13-11-19)22-5-2-7-23(17-22)27(28,29)30)32-25(34)9-3-8-24-15-14-21-6-4-16-31-26(21)33-24/h2,4-7,10-18H,3,8-9H2,1H3,(H,32,34)
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n/an/a 16n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393130
PNG
(CHEMBL2153462)
Show SMILES CC(C)(C(=O)NCc1ccc(cc1)-c1ccc(F)c(c1)C(F)(F)F)c1ccc(cc1)-c1ccc2cccnc2n1
Show InChI InChI=1S/C32H25F4N3O/c1-31(2,25-13-9-22(10-14-25)28-16-12-23-4-3-17-37-29(23)39-28)30(40)38-19-20-5-7-21(8-6-20)24-11-15-27(33)26(18-24)32(34,35)36/h3-18H,19H2,1-2H3,(H,38,40)
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n/an/a 17n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393135
PNG
(CHEMBL2153467)
Show SMILES C[C@H](NC(=O)C(O)c1ccc(cc1)-c1ccc2cccnc2n1)c1ccc(cc1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C31H23F4N3O2/c1-18(19-4-6-20(7-5-19)24-12-14-26(32)25(17-24)31(33,34)35)37-30(40)28(39)22-10-8-21(9-11-22)27-15-13-23-3-2-16-36-29(23)38-27/h2-18,28,39H,1H3,(H,37,40)/t18-,28?/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393134
PNG
(CHEMBL2153466)
Show SMILES C[C@H](NC(=O)C(F)(F)c1ccc(cc1)-c1ccc2cccnc2n1)c1ccc(cc1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C31H21F6N3O/c1-18(19-4-6-20(7-5-19)23-10-14-26(32)25(17-23)31(35,36)37)39-29(41)30(33,34)24-12-8-21(9-13-24)27-15-11-22-3-2-16-38-28(22)40-27/h2-18H,1H3,(H,39,41)/t18-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393118
PNG
(CHEMBL2153441)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)cc1
Show InChI InChI=1S/C26H21F4N3O/c27-23-13-11-20(15-22(23)26(28,29)30)18-8-6-17(7-9-18)16-32-24(34)5-1-4-21-12-10-19-3-2-14-31-25(19)33-21/h2-3,6-15H,1,4-5,16H2,(H,32,34)
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n/an/a 22n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393161
PNG
(CHEMBL2153439)
Show SMILES Cc1cccc(c1)-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)cc1
Show InChI InChI=1S/C26H25N3O/c1-19-5-2-6-23(17-19)21-12-10-20(11-13-21)18-28-25(30)9-3-8-24-15-14-22-7-4-16-27-26(22)29-24/h2,4-7,10-17H,3,8-9,18H2,1H3,(H,28,30)
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n/an/a 30n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393127
PNG
(CHEMBL2153459)
Show SMILES Fc1ccc(cc1Cl)-c1ccc(CNC(=O)Cc2ccc(cc2)-c2ccc3cccnc3n2)cc1
Show InChI InChI=1S/C29H21ClFN3O/c30-25-17-24(11-13-26(25)31)21-7-5-20(6-8-21)18-33-28(35)16-19-3-9-22(10-4-19)27-14-12-23-2-1-15-32-29(23)34-27/h1-15,17H,16,18H2,(H,33,35)
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n/an/a 31n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393131
PNG
(CHEMBL2153463)
Show SMILES OC(C(=O)NCc1ccc(cc1)-c1ccc(F)c(c1)C(F)(F)F)(c1ccc(cc1)-c1ccc2cccnc2n1)C(F)(F)F
Show InChI InChI=1S/C31H20F7N3O2/c32-25-13-9-22(16-24(25)30(33,34)35)19-5-3-18(4-6-19)17-40-28(42)29(43,31(36,37)38)23-11-7-20(8-12-23)26-14-10-21-2-1-15-39-27(21)41-26/h1-16,43H,17H2,(H,40,42)
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n/an/a 34n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393143
PNG
(CHEMBL2153581)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1cc(CNC(=O)CCCc2ccc3cccnc3n2)on1
Show InChI InChI=1S/C23H18F4N4O2/c24-19-9-7-15(11-18(19)23(25,26)27)20-12-17(33-31-20)13-29-21(32)5-1-4-16-8-6-14-3-2-10-28-22(14)30-16/h2-3,6-12H,1,4-5,13H2,(H,29,32)
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n/an/a 35n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393119
PNG
(CHEMBL2153442)
Show SMILES Fc1ccc(cc1Cl)-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)cc1
Show InChI InChI=1S/C25H21ClFN3O/c26-22-15-20(11-13-23(22)27)18-8-6-17(7-9-18)16-29-24(31)5-1-4-21-12-10-19-3-2-14-28-25(19)30-21/h2-3,6-15H,1,4-5,16H2,(H,29,31)
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n/an/a 38n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393148
PNG
(CHEMBL2153586)
Show SMILES Clc1cccc(c1)-c1ccc(cc1)-c1nnc(CCCc2ccc3cccnc3n2)o1
Show InChI InChI=1S/C25H19ClN4O/c26-21-6-1-4-20(16-21)17-9-11-19(12-10-17)25-30-29-23(31-25)8-2-7-22-14-13-18-5-3-15-27-24(18)28-22/h1,3-6,9-16H,2,7-8H2
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n/an/a 40n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393117
PNG
(CHEMBL2153440)
Show SMILES Clc1cccc(c1)-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)cc1
Show InChI InChI=1S/C25H22ClN3O/c26-22-6-1-4-21(16-22)19-11-9-18(10-12-19)17-28-24(30)8-2-7-23-14-13-20-5-3-15-27-25(20)29-23/h1,3-6,9-16H,2,7-8,17H2,(H,28,30)
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n/an/a 40n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393120
PNG
(CHEMBL2153443)
Show SMILES Fc1cc(ccc1CNC(=O)CCCc1ccc2cccnc2n1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H21F4N3O/c27-23-15-19(18-4-1-6-21(14-18)26(28,29)30)9-10-20(23)16-32-24(34)8-2-7-22-12-11-17-5-3-13-31-25(17)33-22/h1,3-6,9-15H,2,7-8,16H2,(H,32,34)
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n/an/a 41n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393137
PNG
(CHEMBL2153469)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1ncc(CNC(=O)CCCc2ccc3cccnc3n2)cn1
Show InChI InChI=1S/C24H19F4N5O/c25-20-9-7-17(11-19(20)24(26,27)28)22-31-13-15(14-32-22)12-30-21(34)5-1-4-18-8-6-16-3-2-10-29-23(16)33-18/h2-3,6-11,13-14H,1,4-5,12H2,(H,30,34)
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n/an/a 49n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393121
PNG
(CHEMBL2153444)
Show SMILES CCc1cccc(c1)-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)cc1
Show InChI InChI=1S/C27H27N3O/c1-2-20-6-3-7-24(18-20)22-13-11-21(12-14-22)19-29-26(31)10-4-9-25-16-15-23-8-5-17-28-27(23)30-25/h3,5-8,11-18H,2,4,9-10,19H2,1H3,(H,29,31)
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n/an/a 65n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393141
PNG
(CHEMBL2153579)
Show SMILES Clc1cccc(c1)-c1cc(CNC(=O)CCCc2ccc3cccnc3n2)on1
Show InChI InChI=1S/C22H19ClN4O2/c23-17-6-1-4-16(12-17)20-13-19(29-27-20)14-25-21(28)8-2-7-18-10-9-15-5-3-11-24-22(15)26-18/h1,3-6,9-13H,2,7-8,14H2,(H,25,28)
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n/an/a 65n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393128
PNG
(CHEMBL2153460)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1ccc(CNC(=O)Cc2ccc(cc2)-c2ccc3cccnc3n2)cc1
Show InChI InChI=1S/C30H21F4N3O/c31-26-13-11-24(17-25(26)30(32,33)34)21-7-5-20(6-8-21)18-36-28(38)16-19-3-9-22(10-4-19)27-14-12-23-2-1-15-35-29(23)37-27/h1-15,17H,16,18H2,(H,36,38)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393142
PNG
(CHEMBL2153580)
Show SMILES Fc1ccc(cc1Cl)-c1cc(CNC(=O)CCCc2ccc3cccnc3n2)on1
Show InChI InChI=1S/C22H18ClFN4O2/c23-18-11-15(7-9-19(18)24)20-12-17(30-28-20)13-26-21(29)5-1-4-16-8-6-14-3-2-10-25-22(14)27-16/h2-3,6-12H,1,4-5,13H2,(H,26,29)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393149
PNG
(CHEMBL2153587)
Show SMILES Fc1ccc(cc1Cl)-c1ccc(cc1)-c1nnc(CCCc2ccc3cccnc3n2)o1
Show InChI InChI=1S/C25H18ClFN4O/c26-21-15-19(11-13-22(21)27)16-6-8-18(9-7-16)25-31-30-23(32-25)5-1-4-20-12-10-17-3-2-14-28-24(17)29-20/h2-3,6-15H,1,4-5H2
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393158
PNG
(CHEMBL2153596)
Show SMILES FC(F)(F)c1cc(ccc1Cl)-c1nnc(CCCCc2ccc3cccnc3n2)o1
Show InChI InChI=1S/C21H16ClF3N4O/c22-17-10-8-14(12-16(17)21(23,24)25)20-29-28-18(30-20)6-2-1-5-15-9-7-13-4-3-11-26-19(13)27-15/h3-4,7-12H,1-2,5-6H2
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393156
PNG
(CHEMBL2153594)
Show SMILES FC(F)(F)c1ccc(cc1C(F)(F)F)-c1nnc(CCCCc2ccc3cccnc3n2)o1
Show InChI InChI=1S/C22H16F6N4O/c23-21(24,25)16-10-8-14(12-17(16)22(26,27)28)20-32-31-18(33-20)6-2-1-5-15-9-7-13-4-3-11-29-19(13)30-15/h3-4,7-12H,1-2,5-6H2
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393157
PNG
(CHEMBL2153595)
Show SMILES FC(F)(F)Oc1ccc(cc1Cl)-c1nnc(CCCCc2ccc3cccnc3n2)o1
Show InChI InChI=1S/C21H16ClF3N4O2/c22-16-12-14(8-10-17(16)31-21(23,24)25)20-29-28-18(30-20)6-2-1-5-15-9-7-13-4-3-11-26-19(13)27-15/h3-4,7-12H,1-2,5-6H2
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393138
PNG
(CHEMBL2153470)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1cnc(CNC(=O)CCCc2ccc3cccnc3n2)nc1
Show InChI InChI=1S/C24H19F4N5O/c25-20-9-7-16(11-19(20)24(26,27)28)17-12-30-21(31-13-17)14-32-22(34)5-1-4-18-8-6-15-3-2-10-29-23(15)33-18/h2-3,6-13H,1,4-5,14H2,(H,32,34)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393150
PNG
(CHEMBL2153588)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(cc1)-c1nnc(CCCc2ccc3cccnc3n2)o1
Show InChI InChI=1S/C26H19F3N4O/c27-26(28,29)21-6-1-4-20(16-21)17-9-11-19(12-10-17)25-33-32-23(34-25)8-2-7-22-14-13-18-5-3-15-30-24(18)31-22/h1,3-6,9-16H,2,7-8H2
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393140
PNG
(CHEMBL2153472)
Show SMILES Fc1ccc(cc1C(F)(F)F)-n1cc(CNC(=O)CCCc2ccc3cccnc3n2)cn1
Show InChI InChI=1S/C23H19F4N5O/c24-20-9-8-18(11-19(20)23(25,26)27)32-14-15(13-30-32)12-29-21(33)5-1-4-17-7-6-16-3-2-10-28-22(16)31-17/h2-3,6-11,13-14H,1,4-5,12H2,(H,29,33)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393147
PNG
(CHEMBL2153585)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1nnc(CNC(=O)CCCc2ccc3cccnc3n2)s1
Show InChI InChI=1S/C22H17F4N5OS/c23-17-9-7-14(11-16(17)22(24,25)26)21-31-30-19(33-21)12-28-18(32)5-1-4-15-8-6-13-3-2-10-27-20(13)29-15/h2-3,6-11H,1,4-5,12H2,(H,28,32)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393126
PNG
(CHEMBL2153457)
Show SMILES Cc1cc(ccc1Cl)-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)cc1
Show InChI InChI=1S/C26H24ClN3O/c1-18-16-22(12-14-24(18)27)20-9-7-19(8-10-20)17-29-25(31)6-2-5-23-13-11-21-4-3-15-28-26(21)30-23/h3-4,7-16H,2,5-6,17H2,1H3,(H,29,31)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393145
PNG
(CHEMBL2153583)
Show SMILES Clc1cccc(c1)-c1csc(CNC(=O)CCCc2ccc3cccnc3n2)n1
Show InChI InChI=1S/C22H19ClN4OS/c23-17-6-1-4-16(12-17)19-14-29-21(27-19)13-25-20(28)8-2-7-18-10-9-15-5-3-11-24-22(15)26-18/h1,3-6,9-12,14H,2,7-8,13H2,(H,25,28)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393132
PNG
(CHEMBL2153464)
Show SMILES NC(C(=O)NCc1ccc(cc1)-c1ccc(F)c(c1)C(F)(F)F)c1ccc(cc1)-c1ccc2cccnc2n1
Show InChI InChI=1S/C30H22F4N4O/c31-25-13-11-23(16-24(25)30(32,33)34)19-5-3-18(4-6-19)17-37-29(39)27(35)21-9-7-20(8-10-21)26-14-12-22-2-1-15-36-28(22)38-26/h1-16,27H,17,35H2,(H,37,39)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393125
PNG
(CHEMBL2153448)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)cc1
Show InChI InChI=1S/C26H22F3N3O2/c27-26(28,29)34-23-7-1-4-21(16-23)19-11-9-18(10-12-19)17-31-24(33)8-2-6-22-14-13-20-5-3-15-30-25(20)32-22/h1,3-5,7,9-16H,2,6,8,17H2,(H,31,33)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393144
PNG
(CHEMBL2153582)
Show SMILES Clc1cccc(c1)-c1nc(CNC(=O)CCCc2ccc3cccnc3n2)cs1
Show InChI InChI=1S/C22H19ClN4OS/c23-17-6-1-4-16(12-17)22-27-19(14-29-22)13-25-20(28)8-2-7-18-10-9-15-5-3-11-24-21(15)26-18/h1,3-6,9-12,14H,2,7-8,13H2,(H,25,28)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393139
PNG
(CHEMBL2153471)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)nn1
Show InChI InChI=1S/C24H19F4N5O/c25-20-10-7-16(13-19(20)24(26,27)28)21-11-9-18(32-33-21)14-30-22(34)5-1-4-17-8-6-15-3-2-12-29-23(15)31-17/h2-3,6-13H,1,4-5,14H2,(H,30,34)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393162
PNG
(CHEMBL2153436)
Show SMILES COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)c(F)c1
Show InChI InChI=1S/C27H23F2N3O3/c1-35-27(34)25-21(7-3-8-22(25)28)18-10-11-19(23(29)15-18)16-31-24(33)9-2-6-20-13-12-17-5-4-14-30-26(17)32-20/h3-5,7-8,10-15H,2,6,9,16H2,1H3,(H,31,33)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393152
PNG
(CHEMBL2153590)
Show SMILES Fc1ccc(cc1Cl)-c1ccc(cc1)-c1nnc(CCCc2ccc3cccnc3n2)[nH]1
Show InChI InChI=1S/C25H19ClFN5/c26-21-15-19(11-13-22(21)27)16-6-8-18(9-7-16)25-30-23(31-32-25)5-1-4-20-12-10-17-3-2-14-28-24(17)29-20/h2-3,6-15H,1,4-5H2,(H,30,31,32)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393146
PNG
(CHEMBL2153584)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1nnc(CNC(=O)CCCc2ccc3cccnc3n2)o1
Show InChI InChI=1S/C22H17F4N5O2/c23-17-9-7-14(11-16(17)22(24,25)26)21-31-30-19(33-21)12-28-18(32)5-1-4-15-8-6-13-3-2-10-27-20(13)29-15/h2-3,6-11H,1,4-5,12H2,(H,28,32)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393163
PNG
(CHEMBL2153438)
Show SMILES O=C(CCCc1ccc2cccnc2n1)NCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H23N3O/c29-24(10-4-9-23-16-15-22-8-5-17-26-25(22)28-23)27-18-19-11-13-21(14-12-19)20-6-2-1-3-7-20/h1-3,5-8,11-17H,4,9-10,18H2,(H,27,29)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393124
PNG
(CHEMBL2153447)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)cc1
Show InChI InChI=1S/C26H25N3O2/c1-31-24-8-2-5-22(17-24)20-12-10-19(11-13-20)18-28-25(30)9-3-7-23-15-14-21-6-4-16-27-26(21)29-23/h2,4-6,8,10-17H,3,7,9,18H2,1H3,(H,28,30)
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Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393159
PNG
(CHEMBL2153597)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1nnc(CCCCc2ccc3cccnc3n2)o1
Show InChI InChI=1S/C21H16F4N4O/c22-17-10-8-14(12-16(17)21(23,24)25)20-29-28-18(30-20)6-2-1-5-15-9-7-13-4-3-11-26-19(13)27-15/h3-4,7-12H,1-2,5-6H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393151
PNG
(CHEMBL2153589)
Show SMILES Clc1cccc(c1)-c1ccc(cc1)-c1nnc(CCCc2ccc3cccnc3n2)s1
Show InChI InChI=1S/C25H19ClN4S/c26-21-6-1-4-20(16-21)17-9-11-19(12-10-17)25-30-29-23(31-25)8-2-7-22-14-13-18-5-3-15-27-24(18)28-22/h1,3-6,9-16H,2,7-8H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393153
PNG
(CHEMBL2153591)
Show SMILES FC(F)(F)c1ccc(cc1)-c1nnc(CCCCc2ccc3cccnc3n2)o1
Show InChI InChI=1S/C21H17F3N4O/c22-21(23,24)16-10-7-15(8-11-16)20-28-27-18(29-20)6-2-1-5-17-12-9-14-4-3-13-25-19(14)26-17/h3-4,7-13H,1-2,5-6H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393154
PNG
(CHEMBL2153592)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1nnc(CCCCc2ccc3cccnc3n2)o1
Show InChI InChI=1S/C21H17F3N4O2/c22-21(23,24)30-17-11-8-15(9-12-17)20-28-27-18(29-20)6-2-1-5-16-10-7-14-4-3-13-25-19(14)26-16/h3-4,7-13H,1-2,5-6H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393155
PNG
(CHEMBL2153593)
Show SMILES Clc1ccc(cc1)-c1nnc(CCCCc2ccc3cccnc3n2)o1
Show InChI InChI=1S/C20H17ClN4O/c21-16-10-7-15(8-11-16)20-25-24-18(26-20)6-2-1-5-17-12-9-14-4-3-13-22-19(14)23-17/h3-4,7-13H,1-2,5-6H2
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n/an/a>3.00E+3n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair
Succinate receptor 1


(Homo sapiens)
BDBM50393160
PNG
(CHEMBL2153598)
Show SMILES Fc1ccc(cc1OC(F)(F)F)-c1nnc(CCCCc2ccc3cccnc3n2)o1
Show InChI InChI=1S/C21H16F4N4O2/c22-16-10-8-14(12-17(16)31-21(23,24)25)20-29-28-18(30-20)6-2-1-5-15-9-7-13-4-3-11-26-19(13)27-15/h3-4,7-12H,1-2,5-6H2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Advinus Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-ind...


Citation and Details
More data for this
Ligand-Target Pair