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Compile Data Set for Download or QSAR

Found 77 hits Enz. Inhib. hit(s) with Target = 'Sucrase-isomaltase' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sucrase-isomaltase


(Homo sapiens)
BDBM50327504
PNG
(1,4-Dideoxy-1,4-[[2S,3S,4R,5S]-2,4,5,6-tetrahydrox...)
Show SMILES CO[C@H]([C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO)[C@H](O)[C@@H](O)CO
Show InChI InChI=1S/C12H25O8S/c1-20-12(11(19)6(15)2-13)8(17)5-21-4-7(16)10(18)9(21)3-14/h6-19H,2-5H2,1H3/q+1/t6-,7+,8+,9+,10-,11+,12+,21-/m0/s1
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7n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant C-terminal Sucrase-isomaltase by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50327504
PNG
(1,4-Dideoxy-1,4-[[2S,3S,4R,5S]-2,4,5,6-tetrahydrox...)
Show SMILES CO[C@H]([C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO)[C@H](O)[C@@H](O)CO
Show InChI InChI=1S/C12H25O8S/c1-20-12(11(19)6(15)2-13)8(17)5-21-4-7(16)10(18)9(21)3-14/h6-19H,2-5H2,1H3/q+1/t6-,7+,8+,9+,10-,11+,12+,21-/m0/s1
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35n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal Sucrase-isomaltase by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50327502
PNG
((1R,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)-1-((...)
Show SMILES OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H23O8S/c12-1-5(14)10(18)11(19)7(16)4-20-3-6(15)9(17)8(20)2-13/h5-19H,1-4H2/q+1/t5-,6+,7+,8+,9-,10+,11+,20-/m0/s1
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103n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant C-terminal Sucrase-isomaltase by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50327502
PNG
((1R,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)-1-((...)
Show SMILES OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H23O8S/c12-1-5(14)10(18)11(19)7(16)4-20-3-6(15)9(17)8(20)2-13/h5-19H,1-4H2/q+1/t5-,6+,7+,8+,9-,10+,11+,20-/m0/s1
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302n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal Sucrase-isomaltase by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024139
PNG
(1-Hydroxymethyl-5-phenethylamino-cyclohexane-1,2,3...)
Show SMILES OCC1(O)C[C@H](NCCc2ccccc2)C(O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C15H23NO5/c17-9-15(21)8-11(12(18)13(19)14(15)20)16-7-6-10-4-2-1-3-5-10/h1-5,11-14,16-21H,6-9H2/t11-,12?,13-,14-,15?/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024116
PNG
(1-Hydroxymethyl-5-(2-hydroxy-2-phenyl-ethylamino)-...)
Show SMILES OC[C@@]1(O)C[C@H](NC[C@@H](O)c2ccccc2)[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C15H23NO6/c17-8-15(22)6-10(12(19)13(20)14(15)21)16-7-11(18)9-4-2-1-3-5-9/h1-5,10-14,16-22H,6-8H2/t10-,11+,12-,13-,14+,15-/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024120
PNG
(1-Hydroxymethyl-5-[(thiophen-2-ylmethyl)-amino]-cy...)
Show SMILES OCC1(O)C[C@H](NCc2cccs2)C(O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C12H19NO5S/c14-6-12(18)4-8(9(15)10(16)11(12)17)13-5-7-2-1-3-19-7/h1-3,8-11,13-18H,4-6H2/t8-,9?,10-,11-,12?/m0/s1
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n/an/a 3.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50009001
PNG
(5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...)
Show SMILES Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1
Show InChI InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
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n/an/a 3.5n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human intestinal sucrase in human Caco2 cell membrane


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024140
PNG
(5-(2-Hydroxy-1-hydroxymethyl-ethylamino)-1-hydroxy...)
Show SMILES OCC(CO)N[C@H]1CC(O)(CO)[C@@H](O)[C@@H](O)C1O
Show InChI InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7?,8-,9-,10?/m0/s1
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n/an/a 4.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024119
PNG
(5-(2-Hydroxy-cyclohexylamino)-1-hydroxymethyl-cycl...)
Show SMILES OCC1(O)C[C@H](N[C@H]2CCCC[C@@H]2O)C(O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C13H25NO6/c15-6-13(20)5-8(10(17)11(18)12(13)19)14-7-3-1-2-4-9(7)16/h7-12,14-20H,1-6H2/t7-,8-,9-,10?,11-,12-,13?/m0/s1
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n/an/a 5.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024124
PNG
(1-Hydroxymethyl-5-(2-hydroxy-1-phenyl-ethylamino)-...)
Show SMILES OC[C@H](N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O)c1ccccc1
Show InChI InChI=1S/C15H23NO6/c17-7-11(9-4-2-1-3-5-9)16-10-6-15(22,8-18)14(21)13(20)12(10)19/h1-5,10-14,16-22H,6-8H2/t10-,11-,12-,13+,14-,15-/m0/s1
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n/an/a 6.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024136
PNG
(5-(3,5-Di-tert-butyl-4-hydroxy-benzylamino)-1-hydr...)
Show SMILES CC(C)(C)c1cc(CN[C@H]2CC(O)(CO)[C@@H](O)[C@@H](O)C2O)cc(c1O)C(C)(C)C
Show InChI InChI=1S/C22H37NO6/c1-20(2,3)13-7-12(8-14(16(13)25)21(4,5)6)10-23-15-9-22(29,11-24)19(28)18(27)17(15)26/h7-8,15,17-19,23-29H,9-11H2,1-6H3/t15-,17?,18-,19-,22?/m0/s1
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n/an/a 6.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50405395
PNG
(CHEMBL2051761)
Show SMILES C[C@H]1C[C@H](N)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C14H28N2O7/c1-5-2-6(15)9(18)11(20)8(5)16-7-3-14(23,4-17)13(22)12(21)10(7)19/h5-13,16-23H,2-4,15H2,1H3/t5-,6-,7-,8+,9-,10-,11-,12+,13-,14-/m0/s1
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n/an/a 7.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024114
PNG
(5-(Cyclohexylmethyl-amino)-1-hydroxymethyl-cyclohe...)
Show SMILES OCC1(O)C[C@H](NCC2CCCCC2)C(O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H27NO5/c16-8-14(20)6-10(11(17)12(18)13(14)19)15-7-9-4-2-1-3-5-9/h9-13,15-20H,1-8H2/t10-,11?,12-,13-,14?/m0/s1
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n/an/a 9.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50405397
PNG
(CHEMBL2051983)
Show SMILES CO[C@H]1O[C@H](C)[C@@H](N[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C14H27NO9/c1-5-7(9(18)11(20)13(23-2)24-5)15-6-3-14(22,4-16)12(21)10(19)8(6)17/h5-13,15-22H,3-4H2,1-2H3/t5-,6+,7-,8+,9+,10-,11-,12+,13+,14+/m1/s1
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024118
PNG
(5-(3,7-Dimethyl-octa-2,6-dienylamino)-1-hydroxymet...)
Show SMILES CC(C)=CCC\C(C)=C\CN[C@H]1CC(O)(CO)[C@@H](O)[C@@H](O)C1O
Show InChI InChI=1S/C17H31NO5/c1-11(2)5-4-6-12(3)7-8-18-13-9-17(23,10-19)16(22)15(21)14(13)20/h5,7,13-16,18-23H,4,6,8-10H2,1-3H3/b12-7+/t13-,14?,15-,16-,17?/m0/s1
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n/an/a 11n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024133
PNG
(1-Hydroxymethyl-5-(3-phenyl-allylamino)-cyclohexan...)
Show SMILES OCC1(O)C[C@H](NC\C=C\c2ccccc2)C(O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C16H23NO5/c18-10-16(22)9-12(13(19)14(20)15(16)21)17-8-4-7-11-5-2-1-3-6-11/h1-7,12-15,17-22H,8-10H2/b7-4+/t12-,13?,14-,15-,16?/m0/s1
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n/an/a 14n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024128
PNG
(5-(4-Bromo-benzylamino)-1-hydroxymethyl-cyclohexan...)
Show SMILES OCC1(O)C[C@H](NCc2ccc(Br)cc2)C(O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H20BrNO5/c15-9-3-1-8(2-4-9)6-16-10-5-14(21,7-17)13(20)12(19)11(10)18/h1-4,10-13,16-21H,5-7H2/t10-,11?,12-,13-,14?/m0/s1
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024126
PNG
(1-Hydroxymethyl-5-[(pyridin-3-ylmethyl)-amino]-cyc...)
Show SMILES OCC1(O)C[C@H](NCc2cccnc2)C(O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C13H20N2O5/c16-7-13(20)4-9(10(17)11(18)12(13)19)15-6-8-2-1-3-14-5-8/h1-3,5,9-12,15-20H,4,6-7H2/t9-,10?,11-,12-,13?/m0/s1
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024117
PNG
(5-Cyclohexylamino-1-hydroxymethyl-cyclohexane-1,2,...)
Show SMILES OCC1(O)C[C@H](NC2CCCCC2)C(O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C13H25NO5/c15-7-13(19)6-9(10(16)11(17)12(13)18)14-8-4-2-1-3-5-8/h8-12,14-19H,1-7H2/t9-,10?,11-,12-,13?/m0/s1
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50405389
PNG
(CHEMBL2051982)
Show SMILES C[C@H]1C[C@@H](O)[C@H](O)[C@@H](O)[C@H]1N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C14H27NO8/c1-5-2-7(17)10(19)11(20)8(5)15-6-3-14(23,4-16)13(22)12(21)9(6)18/h5-13,15-23H,2-4H2,1H3/t5-,6-,7+,8-,9-,10-,11-,12+,13-,14-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50405396
PNG
(CHEMBL2051762)
Show SMILES C[C@H]1C[C@H](O)[C@H](O)[C@@H](O)[C@H]1N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C14H27NO8/c1-5-2-7(17)10(19)11(20)8(5)15-6-3-14(23,4-16)13(22)12(21)9(6)18/h5-13,15-23H,2-4H2,1H3/t5-,6-,7-,8-,9-,10-,11-,12+,13-,14-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024129
PNG
(5-Amino-1-hydroxymethyl-cyclohexane-1,2,3,4-tetrao...)
Show SMILES NC1CC(O)(CO)C(O)C(O)C1O
Show InChI InChI=1S/C7H15NO5/c8-3-1-7(13,2-9)6(12)5(11)4(3)10/h3-6,9-13H,1-2,8H2
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n/an/a 49n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50405393
PNG
(CHEMBL2051981)
Show SMILES CO[C@H]1O[C@H](CO)[C@@H](N[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C14H27NO10/c1-24-13-11(21)9(19)7(6(3-16)25-13)15-5-2-14(23,4-17)12(22)10(20)8(5)18/h5-13,15-23H,2-4H2,1H3/t5-,6+,7+,8-,9-,10+,11+,12-,13-,14-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024127
PNG
(5-(2-Hydroxy-cyclohexylamino)-1-hydroxymethyl-cycl...)
Show SMILES OCC1(O)C[C@H](N[C@@H]2CCCCC2O)C(O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C13H25NO6/c15-6-13(20)5-8(10(17)11(18)12(13)19)14-7-3-1-2-4-9(7)16/h7-12,14-20H,1-6H2/t7-,8+,9?,10?,11+,12+,13?/m1/s1
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n/an/a 160n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024122
PNG
(6-(2-Hydroxy-1-hydroxymethyl-ethylamino)-4-hydroxy...)
Show SMILES OCC(CO)N[C@H]1C=C(CO)[C@@H](O)[C@@H](O)C1O
Show InChI InChI=1S/C10H19NO6/c12-2-5-1-7(11-6(3-13)4-14)9(16)10(17)8(5)15/h1,6-17H,2-4H2/t7-,8+,9?,10+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024130
PNG
(4-(2-Hydroxy-1-hydroxymethyl-ethylamino)-6-hydroxy...)
Show SMILES OCC(CO)N[C@H]1CC(CO)[C@@H](O)[C@@H](O)C1O
Show InChI InChI=1S/C10H21NO6/c12-2-5-1-7(11-6(3-13)4-14)9(16)10(17)8(5)15/h5-17H,1-4H2/t5?,7-,8+,9?,10+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024137
PNG
(1-Hydroxymethyl-5-(2-hydroxy-2-phenyl-ethylamino)-...)
Show SMILES OC[C@@]1(O)C[C@H](NC[C@H](O)c2ccccc2)[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C15H23NO6/c17-8-15(22)6-10(12(19)13(20)14(15)21)16-7-11(18)9-4-2-1-3-5-9/h1-5,10-14,16-22H,6-8H2/t10-,11-,12-,13-,14+,15-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50028173
PNG
(CHEMBL3354063)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1cccc(c1)-c1ccccc1
Show InChI InChI=1/C24H33NO5/c26-16-21-23(28)24(29)22(27)15-25(21)12-5-2-6-13-30-17-18-8-7-11-20(14-18)19-9-3-1-4-10-19/h1,3-4,7-11,14,21-24,26-29H,2,5-6,12-13,15-17H2/t21-,22+,23-,24-/s2
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n/an/a 200n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal sucrase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50028243
PNG
(CHEMBL3354062)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccccc1-c1ccccc1
Show InChI InChI=1/C24H33NO5/c26-16-21-23(28)24(29)22(27)15-25(21)13-7-2-8-14-30-17-19-11-5-6-12-20(19)18-9-3-1-4-10-18/h1,3-6,9-12,21-24,26-29H,2,7-8,13-17H2/t21-,22+,23-,24-/s2
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n/an/a 200n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal sucrase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50405387
PNG
(CHEMBL2051759)
Show SMILES CO[C@H]1O[C@H](CO)[C@H](N[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C14H27NO10/c1-24-13-11(21)9(19)7(6(3-16)25-13)15-5-2-14(23,4-17)12(22)10(20)8(5)18/h5-13,15-23H,2-4H2,1H3/t5-,6+,7-,8-,9-,10+,11+,12-,13-,14-/m0/s1
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n/an/a 230n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50028207
PNG
(CHEMBL3354025)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C24H33NO5/c26-16-21-23(28)24(29)22(27)15-25(21)13-5-2-6-14-30-17-18-9-11-20(12-10-18)19-7-3-1-4-8-19/h1,3-4,7-12,21-24,26-29H,2,5-6,13-17H2/t21-,22+,23-,24-/s2
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n/an/a 250n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal sucrase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50405388
PNG
(CHEMBL2051760)
Show SMILES CO[C@H]1O[C@H](C)[C@H](N[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C14H27NO9/c1-5-7(9(18)11(20)13(23-2)24-5)15-6-3-14(22,4-16)12(21)10(19)8(6)17/h5-13,15-22H,3-4H2,1-2H3/t5-,6+,7+,8+,9+,10-,11-,12+,13+,14+/m1/s1
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n/an/a 250n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50028179
PNG
(CHEMBL3354624)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1F)-c1ccccc1
Show InChI InChI=1/C24H32FNO5/c25-20-13-18(17-7-3-1-4-8-17)9-10-19(20)16-31-12-6-2-5-11-26-14-22(28)24(30)23(29)21(26)15-27/h1,3-4,7-10,13,21-24,27-30H,2,5-6,11-12,14-16H2/t21-,22+,23-,24-/s2
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n/an/a 250n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal sucrase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50028177
PNG
(CHEMBL3354622)
Show SMILES C[C@H](OCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C25H35NO5/c1-18(19-10-12-21(13-11-19)20-8-4-2-5-9-20)31-15-7-3-6-14-26-16-23(28)25(30)24(29)22(26)17-27/h2,4-5,8-13,18,22-25,27-30H,3,6-7,14-17H2,1H3/t18-,22+,23-,24+,25+/s2
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n/an/a 250n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal sucrase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50163440
PNG
((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6-/m1/s1
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n/an/a 260n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of sucrase by HPLC


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50024123
PNG
(1-Hydroxymethyl-5-(2-hydroxy-1-phenyl-ethylamino)-...)
Show SMILES OC[C@@H](N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O)c1ccccc1
Show InChI InChI=1S/C15H23NO6/c17-7-11(9-4-2-1-3-5-9)16-10-6-15(22,8-18)14(21)13(20)12(10)19/h1-5,10-14,16-22H,6-8H2/t10-,11+,12-,13+,14-,15-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50405391
PNG
(CHEMBL2051763)
Show SMILES CO[C@H]1O[C@H](CO)[C@@H](N[C@H]2C=C(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C14H25NO9/c1-23-14-13(22)11(20)8(7(4-17)24-14)15-6-2-5(3-16)9(18)12(21)10(6)19/h2,6-22H,3-4H2,1H3/t6-,7+,8+,9+,10-,11-,12-,13+,14-/m0/s1
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n/an/a 320n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50028180
PNG
(CHEMBL3354625)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(c(F)c1)-c1ccccc1
Show InChI InChI=1/C24H32FNO5/c25-20-13-17(9-10-19(20)18-7-3-1-4-8-18)16-31-12-6-2-5-11-26-14-22(28)24(30)23(29)21(26)15-27/h1,3-4,7-10,13,21-24,27-30H,2,5-6,11-12,14-16H2/t21-,22+,23-,24-/s2
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n/an/a 400n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal sucrase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50028176
PNG
(CHEMBL3354621)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCC(F)(F)COCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C24H31F2NO5/c25-24(26,11-4-12-27-13-21(29)23(31)22(30)20(27)14-28)16-32-15-17-7-9-19(10-8-17)18-5-2-1-3-6-18/h1-3,5-10,20-23,28-31H,4,11-16H2/t20-,21+,22-,23-/s2
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n/an/a 400n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal sucrase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50312528
PNG
(CHEMBL1086997 | N-Butyl-D-galacto-1-deoxynojirimyc...)
Show SMILES CCCCN1C[C@H](O)[C@@H](O)[C@@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9+,10-/m1/s1
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n/an/a 460n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of sucrase by HPLC


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50242271
PNG
((2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)...)
Show SMILES OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of sucrase by HPLC


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM18355
PNG
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Show SMILES CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of sucrase by HPLC


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50299749
PNG
((2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]...)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20-,21-,22?/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of sucrase by HPLC


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50028178
PNG
(CHEMBL3354623)
Show SMILES C[C@@H](OCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C25H35NO5/c1-18(19-10-12-21(13-11-19)20-8-4-2-5-9-20)31-15-7-3-6-14-26-16-23(28)25(30)24(29)22(26)17-27/h2,4-5,8-13,18,22-25,27-30H,3,6-7,14-17H2,1H3/t18-,22-,23+,24-,25-/s2
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n/an/a 500n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal sucrase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50299749
PNG
((2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]...)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20-,21-,22?/m1/s1
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n/an/a 600n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal sucrase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50028244
PNG
(CHEMBL3354627)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2ccccc2)c(c1)C(F)(F)F
Show InChI InChI=1/C25H32F3NO5/c26-25(27,28)20-13-17(9-10-19(20)18-7-3-1-4-8-18)16-34-12-6-2-5-11-29-14-22(31)24(33)23(32)21(29)15-30/h1,3-4,7-10,13,21-24,30-33H,2,5-6,11-12,14-16H2/t21-,22+,23-,24-/s2
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n/an/a 1.25E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal sucrase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50028181
PNG
(CHEMBL3354626)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1/C25H32F3NO5/c26-25(27,28)20-13-18(17-7-3-1-4-8-17)9-10-19(20)16-34-12-6-2-5-11-29-14-22(31)24(33)23(32)21(29)15-30/h1,3-4,7-10,13,21-24,30-33H,2,5-6,11-12,14-16H2/t21-,22+,23-,24-/s2
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n/an/a 1.50E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal sucrase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of sucrase by HPLC


Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50312529
PNG
(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20+,21-,22?/m1/s1
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n/an/a 3.50E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of sucrase by HPLC


Citation and Details
More data for this
Ligand-Target Pair
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