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Compile Data Set for Download or QSAR

Found 19 hits Enz. Inhib. hit(s) with Target = 'Syk protein' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Syk protein


(Mus musculus)
BDBM50360610
PNG
(CHEMBL1933552)
Show SMILES C[C@@H]1CCC(CN1)N1CC[C@@]2(C1)CN(C(=O)c1cc3ccc(F)cc3[nH]1)c1ccccc21
Show InChI InChI=1S/C26H29FN4O/c1-17-6-9-20(14-28-17)30-11-10-26(15-30)16-31(24-5-3-2-4-21(24)26)25(32)23-12-18-7-8-19(27)13-22(18)29-23/h2-5,7-8,12-13,17,20,28-29H,6,9-11,14-16H2,1H3/t17-,20?,26-/m1/s1
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n/an/a 189n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360609
PNG
(CHEMBL1933551)
Show SMILES C[C@@H]1CCC(CN1)N1CC[C@@]2(C1)CN(C(=O)c1cc3ccccc3[nH]1)c1ccccc21
Show InChI InChI=1S/C26H30N4O/c1-18-10-11-20(15-27-18)29-13-12-26(16-29)17-30(24-9-5-3-7-21(24)26)25(31)23-14-19-6-2-4-8-22(19)28-23/h2-9,14,18,20,27-28H,10-13,15-17H2,1H3/t18-,20?,26-/m1/s1
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n/an/a 246n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360605
PNG
(CHEMBL1933538)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)N1C[C@]2(CCN(C2)C2CCCNC2)c2ccccc12
Show InChI InChI=1S/C25H27FN4O/c26-18-7-8-21-17(12-18)13-22(28-21)24(31)30-16-25(20-5-1-2-6-23(20)30)9-11-29(15-25)19-4-3-10-27-14-19/h1-2,5-8,12-13,19,27-28H,3-4,9-11,14-16H2/t19?,25-/m1/s1
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n/an/a 476n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360603
PNG
(CHEMBL1933536)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)N1C[C@]2(CCN(C2)C2CCNC2)c2ccccc12
Show InChI InChI=1S/C24H25ClN4O/c25-17-5-6-20-16(11-17)12-21(27-20)23(30)29-15-24(19-3-1-2-4-22(19)29)8-10-28(14-24)18-7-9-26-13-18/h1-6,11-12,18,26-27H,7-10,13-15H2/t18?,24-/m1/s1
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n/an/a 495n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360616
PNG
(CHEMBL1933545)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)N1C[C@]2(CCN(C2)C2CCNC2)c2ccccc12
Show InChI InChI=1S/C25H28N4O2/c1-31-19-6-7-21-17(12-19)13-22(27-21)24(30)29-16-25(20-4-2-3-5-23(20)29)9-11-28(15-25)18-8-10-26-14-18/h2-7,12-13,18,26-27H,8-11,14-16H2,1H3/t18?,25-/m1/s1
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n/an/a 501n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360620
PNG
(CHEMBL1933549)
Show SMILES Clc1cccc2[nH]c(cc12)C(=O)N1C[C@]2(CCN(C2)C2CCNC2)c2ccccc12
Show InChI InChI=1S/C24H25ClN4O/c25-19-5-3-6-20-17(19)12-21(27-20)23(30)29-15-24(18-4-1-2-7-22(18)29)9-11-28(14-24)16-8-10-26-13-16/h1-7,12,16,26-27H,8-11,13-15H2/t16?,24-/m1/s1
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n/an/a 560n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360611
PNG
(CHEMBL1933550)
Show SMILES Fc1ccc2cc([nH]c2c1)C(=O)N1C[C@]2(CCN(C2)C2CCNC2)c2ccccc12
Show InChI InChI=1S/C24H25FN4O/c25-17-6-5-16-11-21(27-20(16)12-17)23(30)29-15-24(19-3-1-2-4-22(19)29)8-10-28(14-24)18-7-9-26-13-18/h1-6,11-12,18,26-27H,7-10,13-15H2/t18?,24-/m1/s1
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n/an/a 598n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360615
PNG
(CHEMBL1933544)
Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)N1C[C@]2(CCN(C2)C2CCNC2)c2ccccc12
Show InChI InChI=1S/C25H28N4O/c1-17-6-7-21-18(12-17)13-22(27-21)24(30)29-16-25(20-4-2-3-5-23(20)29)9-11-28(15-25)19-8-10-26-14-19/h2-7,12-13,19,26-27H,8-11,14-16H2,1H3/t19?,25-/m1/s1
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n/an/a 811n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360617
PNG
(CHEMBL1933546)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)N1C[C@]2(CCN(C2)C2CCNC2)c2ccccc12
Show InChI InChI=1S/C25H28N4O2/c1-31-19-7-6-17-12-22(27-21(17)13-19)24(30)29-16-25(20-4-2-3-5-23(20)29)9-11-28(15-25)18-8-10-26-14-18/h2-7,12-13,18,26-27H,8-11,14-16H2,1H3/t18?,25-/m1/s1
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n/an/a 843n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360602
PNG
(CHEMBL1933535)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)N1C[C@]2(CCN(C2)C2CCCNC2)c2ccccc12
Show InChI InChI=1S/C25H27ClN4O/c26-18-7-8-21-17(12-18)13-22(28-21)24(31)30-16-25(20-5-1-2-6-23(20)30)9-11-29(15-25)19-4-3-10-27-14-19/h1-2,5-8,12-13,19,27-28H,3-4,9-11,14-16H2/t19?,25-/m1/s1
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n/an/a 1.04E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360619
PNG
(CHEMBL1933548)
Show SMILES O=C(N1C[C@]2(CCN(C2)C2CCNC2)c2ccccc12)c1cc2ccc(cc2[nH]1)C#N
Show InChI InChI=1S/C25H25N5O/c26-13-17-5-6-18-12-22(28-21(18)11-17)24(31)30-16-25(20-3-1-2-4-23(20)30)8-10-29(15-25)19-7-9-27-14-19/h1-6,11-12,19,27-28H,7-10,14-16H2/t19?,25-/m1/s1
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n/an/a 1.13E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360606
PNG
(CHEMBL1933539)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)N1C[C@]2(CCN(C2)C2CNC2)c2ccccc12
Show InChI InChI=1S/C23H23FN4O/c24-16-5-6-19-15(9-16)10-20(26-19)22(29)28-14-23(18-3-1-2-4-21(18)28)7-8-27(13-23)17-11-25-12-17/h1-6,9-10,17,25-26H,7-8,11-14H2/t23-/m1/s1
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n/an/a 1.81E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360618
PNG
(CHEMBL1933547)
Show SMILES NC(=O)c1ccc2cc([nH]c2c1)C(=O)N1C[C@]2(CCN(C2)C2CCNC2)c2ccccc12
Show InChI InChI=1S/C25H27N5O2/c26-23(31)17-6-5-16-11-21(28-20(16)12-17)24(32)30-15-25(19-3-1-2-4-22(19)30)8-10-29(14-25)18-7-9-27-13-18/h1-6,11-12,18,27-28H,7-10,13-15H2,(H2,26,31)/t18?,25-/m1/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360607
PNG
(CHEMBL1933540)
Show SMILES CN1CCC(CC1)N1CC[C@@]2(C1)CN(C(=O)c1cc3cc(F)ccc3[nH]1)c1ccccc21
Show InChI InChI=1S/C26H29FN4O/c1-29-11-8-20(9-12-29)30-13-10-26(16-30)17-31(24-5-3-2-4-21(24)26)25(32)23-15-18-14-19(27)6-7-22(18)28-23/h2-7,14-15,20,28H,8-13,16-17H2,1H3/t26-/m1/s1
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n/an/a 2.88E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360608
PNG
(CHEMBL1933072)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)N1C[C@]2(CCN(CC3CCCNC3)C2)c2ccccc12
Show InChI InChI=1S/C26H29FN4O/c27-20-7-8-22-19(12-20)13-23(29-22)25(32)31-17-26(21-5-1-2-6-24(21)31)9-11-30(16-26)15-18-4-3-10-28-14-18/h1-2,5-8,12-13,18,28-29H,3-4,9-11,14-17H2/t18?,26-/m1/s1
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n/an/a 4.41E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360612
PNG
(CHEMBL1933541)
Show SMILES CCN1CCCC(C1)N1CC[C@@]2(C1)CN(C(=O)c1cc3cc(F)ccc3[nH]1)c1ccccc21
Show InChI InChI=1S/C27H31FN4O/c1-2-30-12-5-6-21(16-30)31-13-11-27(17-31)18-32(25-8-4-3-7-22(25)27)26(33)24-15-19-14-20(28)9-10-23(19)29-24/h3-4,7-10,14-15,21,29H,2,5-6,11-13,16-18H2,1H3/t21?,27-/m1/s1
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n/an/a 4.93E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360604
PNG
(CHEMBL1933537)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)N1C[C@]2(CCN(C2)C2CCNCC2)c2ccccc12
Show InChI InChI=1S/C25H27ClN4O/c26-18-5-6-21-17(13-18)14-22(28-21)24(31)30-16-25(20-3-1-2-4-23(20)30)9-12-29(15-25)19-7-10-27-11-8-19/h1-6,13-14,19,27-28H,7-12,15-16H2/t25-/m1/s1
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n/an/a 8.66E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360613
PNG
(CHEMBL1933542)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)N1C[C@]2(CCN(C2)C2CCCCC2)c2ccccc12
Show InChI InChI=1S/C26H28FN3O/c27-19-10-11-22-18(14-19)15-23(28-22)25(31)30-17-26(21-8-4-5-9-24(21)30)12-13-29(16-26)20-6-2-1-3-7-20/h4-5,8-11,14-15,20,28H,1-3,6-7,12-13,16-17H2/t26-/m1/s1
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n/an/a 2.79E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Syk protein


(Mus musculus)
BDBM50360614
PNG
(CHEMBL1933543)
Show SMILES Cc1ccc(cn1)N1CC[C@@]2(C1)CN(C(=O)c1cc3cc(F)ccc3[nH]1)c1ccccc21
Show InChI InChI=1S/C26H23FN4O/c1-17-6-8-20(14-28-17)30-11-10-26(15-30)16-31(24-5-3-2-4-21(24)26)25(32)23-13-18-12-19(27)7-9-22(18)29-23/h2-9,12-14,29H,10-11,15-16H2,1H3/t26-/m1/s1
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n/an/a 3.78E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA


Citation and Details
More data for this
Ligand-Target Pair