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Found 325 hits Enz. Inhib. hit(s) with Target = 'Synaptic vesicular amine transporter' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50301022
PNG
((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Show SMILES COc1cc2[C@H]3C[C@@H](O)[C@H](CC(C)C)CN3CCc2cc1OCCCF
Show InChI InChI=1S/C21H32FNO3/c1-14(2)9-16-13-23-7-5-15-10-21(26-8-4-6-22)20(25-3)11-17(15)18(23)12-19(16)24/h10-11,14,16,18-19,24H,4-9,12-13H2,1-3H3/t16-,18-,19-/m1/s1
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0.100n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal homogenate after 60 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50301022
PNG
((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Show SMILES COc1cc2[C@H]3C[C@@H](O)[C@H](CC(C)C)CN3CCc2cc1OCCCF
Show InChI InChI=1S/C21H32FNO3/c1-14(2)9-16-13-23-7-5-15-10-21(26-8-4-6-22)20(25-3)11-17(15)18(23)12-19(16)24/h10-11,14,16,18-19,24H,4-9,12-13H2,1-3H3/t16-,18-,19-/m1/s1
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0.240n/an/an/an/an/an/an/an/a



Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL


Assay Description
Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50301022
PNG
((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Show SMILES COc1cc2[C@H]3C[C@@H](O)[C@H](CC(C)C)CN3CCc2cc1OCCCF
Show InChI InChI=1S/C21H32FNO3/c1-14(2)9-16-13-23-7-5-15-10-21(26-8-4-6-22)20(25-3)11-17(15)18(23)12-19(16)24/h10-11,14,16,18-19,24H,4-9,12-13H2,1-3H3/t16-,18-,19-/m1/s1
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0.360n/an/an/an/an/an/an/an/a



Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL


Assay Description
Displacement of [3H]-DTBZ from VMAT2 in rat striatal membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50301021
PNG
((+)-dihydrotetrabenzaine | CHEMBL576222)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)[C@H](O)C[C@@H]3c2cc1OC
Show InChI InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3/t14-,16-,17-/m1/s1
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1.03n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal homogenate after 60 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50301021
PNG
((+)-dihydrotetrabenzaine | CHEMBL576222)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)[C@H](O)C[C@@H]3c2cc1OC
Show InChI InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3/t14-,16-,17-/m1/s1
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2.45n/an/an/an/an/an/an/an/a



Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL


Assay Description
Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50048893
PNG
((2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-2-methyl-1,...)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)[C@](C)(O)C[C@@H]3c2cc1OC
Show InChI InChI=1S/C20H31NO3/c1-13(2)8-15-12-21-7-6-14-9-18(23-4)19(24-5)10-16(14)17(21)11-20(15,3)22/h9-10,13,15,17,22H,6-8,11-12H2,1-5H3/t15-,17-,20-/m1/s1
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2.60n/an/an/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Compound was tested in vitro for the inhibition of [3H]- Methoxytetrabenazine binding to rat brain vesicular monoamine transporter 2 (VMAT2)


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50301021
PNG
((+)-dihydrotetrabenzaine | CHEMBL576222)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)[C@H](O)C[C@@H]3c2cc1OC
Show InChI InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3/t14-,16-,17-/m1/s1
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3.75n/an/an/an/an/an/an/an/a



Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL


Assay Description
Displacement of [3H]-DTBZ from VMAT2 in rat striatal membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50301021
PNG
((+)-dihydrotetrabenzaine | CHEMBL576222)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)[C@H](O)C[C@@H]3c2cc1OC
Show InChI InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3/t14-,16-,17-/m1/s1
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3.96n/an/an/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50080818
PNG
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Show SMILES CN1[C@H](C[C@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1
Show InChI InChI=1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3/t19-,20+,21-/m0/s1
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4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition constant against [3H]-nicotine binding to vesicular monoamine transporter-2 of rat brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50048891
PNG
((3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-...)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)C(=O)C[C@@H]3c2cc1OC
Show InChI InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m1/s1
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4.47n/an/an/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50344439
PNG
(CHEMBL1780005 | rac-(2R)-9,10-dimethoxy-3-(2-methy...)
Show SMILES COc1cc2CCN3CC(CC(C)=C)[C@H](O)CC3c2cc1OC
Show InChI InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,14,16-17,21H,1,5-7,10-11H2,2-4H3/t14?,16?,17-/m1/s1
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5.98n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal homogenate after 60 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50301025
PNG
(CHEMBL569074 | N-(3-fluoropropyl)-3-isobutyl-9,10-...)
Show SMILES COc1cc2CCN3CC(CC(C)C)C(CC3c2cc1OC)NCCCF
Show InChI InChI=1S/C22H35FN2O2/c1-15(2)10-17-14-25-9-6-16-11-21(26-3)22(27-4)12-18(16)20(25)13-19(17)24-8-5-7-23/h11-12,15,17,19-20,24H,5-10,13-14H2,1-4H3
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7.01n/an/an/an/an/an/an/an/a



Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL


Assay Description
Displacement of [3H]-DTBZ from VMAT2 in rat striatal membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50017701
PNG
(3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...)
Show SMILES COc1cc2CCN3CC(CC(C)C)C(=O)CC3c2cc1OC
Show InChI InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3
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7.62n/an/an/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50048891
PNG
((3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-...)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)C(=O)C[C@@H]3c2cc1OC
Show InChI InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m1/s1
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8.10n/an/an/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Compound was tested in vitro for the inhibition of [3H]- Methoxytetrabenazine binding to rat brain vesicular monoamine transporter 2 (VMAT2)


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50301024
PNG
(CHEMBL571308 | N-(2-fluoroethyl)-3-isobutyl-9,10-d...)
Show SMILES COc1cc2CCN3CC(CC(C)C)C(CC3c2cc1OC)NCCF
Show InChI InChI=1S/C21H33FN2O2/c1-14(2)9-16-13-24-8-5-15-10-20(25-3)21(26-4)11-17(15)19(24)12-18(16)23-7-6-22/h10-11,14,16,18-19,23H,5-9,12-13H2,1-4H3
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8.63n/an/an/an/an/an/an/an/a



Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL


Assay Description
Displacement of [3H]-DTBZ from VMAT2 in rat striatal membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50301025
PNG
(CHEMBL569074 | N-(3-fluoropropyl)-3-isobutyl-9,10-...)
Show SMILES COc1cc2CCN3CC(CC(C)C)C(CC3c2cc1OC)NCCCF
Show InChI InChI=1S/C22H35FN2O2/c1-15(2)10-17-14-25-9-6-16-11-21(26-3)22(27-4)12-18(16)20(25)13-19(17)24-8-5-7-23/h11-12,15,17,19-20,24H,5-10,13-14H2,1-4H3
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8.68n/an/an/an/an/an/an/an/a



Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL


Assay Description
Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50301024
PNG
(CHEMBL571308 | N-(2-fluoroethyl)-3-isobutyl-9,10-d...)
Show SMILES COc1cc2CCN3CC(CC(C)C)C(CC3c2cc1OC)NCCF
Show InChI InChI=1S/C21H33FN2O2/c1-14(2)9-16-13-24-8-5-15-10-20(25-3)21(26-4)11-17(15)19(24)12-18(16)23-7-6-22/h10-11,14,16,18-19,23H,5-9,12-13H2,1-4H3
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9.21n/an/an/an/an/an/an/an/a



Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL


Assay Description
Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Rattus norvegicus (Rat))
BDBM50175681
PNG
(CHEMBL3809963)
Show SMILES Cl.COc1ccccc1CCC1CCN(CCc2ccccc2OC)CC1
Show InChI InChI=1S/C23H31NO2.ClH/c1-25-22-9-5-3-7-20(22)12-11-19-13-16-24(17-14-19)18-15-21-8-4-6-10-23(21)26-2;/h3-10,19H,11-18H2,1-2H3;1H
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9.30n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation counting


Bioorg Med Chem Lett 26: 2997-3000 (2016)

More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50300428
PNG
(CHEMBL574179 | cis-2,5-Di(2-benzyl)-pyrrolidine)
Show SMILES C([C@H]1CC[C@@H](Cc2ccccc2)N1)c1ccccc1
Show InChI InChI=1S/C18H21N/c1-3-7-15(8-4-1)13-17-11-12-18(19-17)14-16-9-5-2-6-10-16/h1-10,17-19H,11-14H2/t17-,18+
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9.30n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50048892
PNG
((2S,3R,11bR)-3-Isobutyl-9,10-dimethoxy-2-methyl-1,...)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)[C@@](C)(O)C[C@@H]3c2cc1OC
Show InChI InChI=1S/C20H31NO3/c1-13(2)8-15-12-21-7-6-14-9-18(23-4)19(24-5)10-16(14)17(21)11-20(15,3)22/h9-10,13,15,17,22H,6-8,11-12H2,1-5H3/t15-,17-,20+/m1/s1
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12n/an/an/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Compound was tested in vitro for the inhibition of [3H]- Methoxytetrabenazine binding to rat brain vesicular monoamine transporter 2 (VMAT2)


Citation and Details
More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Rattus norvegicus (Rat))
BDBM50175683
PNG
(CHEMBL3808467)
Show SMILES Cl.COc1cccc(CCN2CCC(CCc3ccccc3OC)CC2)c1
Show InChI InChI=1S/C23H31NO2.ClH/c1-25-22-8-5-6-20(18-22)14-17-24-15-12-19(13-16-24)10-11-21-7-3-4-9-23(21)26-2;/h3-9,18-19H,10-17H2,1-2H3;1H
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13n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation counting


Bioorg Med Chem Lett 26: 2997-3000 (2016)

More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50017701
PNG
(3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...)
Show SMILES COc1cc2CCN3CC(CC(C)C)C(=O)CC3c2cc1OC
Show InChI InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3
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13n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50017701
PNG
(3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...)
Show SMILES COc1cc2CCN3CC(CC(C)C)C(=O)CC3c2cc1OC
Show InChI InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3
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13n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]DTBZ from VMAT2 dihydrotetrabenazine binding site in rat brain synaptic vesicle by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Rattus norvegicus (Rat))
BDBM50175859
PNG
(CHEMBL3809825)
Show SMILES Cl.COc1ccccc1CCC1CCN(CCc2ccc(F)cc2)CC1
Show InChI InChI=1S/C22H28FNO.ClH/c1-25-22-5-3-2-4-20(22)9-6-19-13-16-24(17-14-19)15-12-18-7-10-21(23)11-8-18;/h2-5,7-8,10-11,19H,6,9,12-17H2,1H3;1H
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13n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation counting


Bioorg Med Chem Lett 26: 2997-3000 (2016)

More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50342820
PNG
((2S,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,1...)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)[C@@H](O)C[C@@H]3c2cc1OC
Show InChI InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3/t14-,16-,17+/m1/s1
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13.4n/an/an/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50300430
PNG
(CHEMBL583692 | cis-2,5-Di(3-phenylpropyl)-pyrrolid...)
Show SMILES C(C[C@H]1CC[C@@H](CCCc2ccccc2)N1)Cc1ccccc1
Show InChI InChI=1S/C22H29N/c1-3-9-19(10-4-1)13-7-15-21-17-18-22(23-21)16-8-14-20-11-5-2-6-12-20/h1-6,9-12,21-23H,7-8,13-18H2/t21-,22+
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14n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50300429
PNG
(1-Methyl-cis-2,5-di(2-benzyl)-pyrrolidine | CHEMBL...)
Show SMILES CN1[C@@H](Cc2ccccc2)CC[C@H]1Cc1ccccc1
Show InChI InChI=1S/C19H23N/c1-20-18(14-16-8-4-2-5-9-16)12-13-19(20)15-17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3/t18-,19+
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19n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Rattus norvegicus (Rat))
BDBM50175779
PNG
(CHEMBL3810014)
Show SMILES Cl.COc1ccccc1CCC1CCN(CCc2ccccc2Cl)CC1
Show InChI InChI=1S/C22H28ClNO.ClH/c1-25-22-9-5-3-7-20(22)11-10-18-12-15-24(16-13-18)17-14-19-6-2-4-8-21(19)23;/h2-9,18H,10-17H2,1H3;1H
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20n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation counting


Bioorg Med Chem Lett 26: 2997-3000 (2016)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Rattus norvegicus (Rat))
BDBM50175682
PNG
(CHEMBL3810004)
Show SMILES Cl.COc1ccccc1CCC1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C22H29NO.ClH/c1-24-22-10-6-5-9-21(22)12-11-20-14-17-23(18-15-20)16-13-19-7-3-2-4-8-19;/h2-10,20H,11-18H2,1H3;1H
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22n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation counting


Bioorg Med Chem Lett 26: 2997-3000 (2016)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Rattus norvegicus (Rat))
BDBM50175677
PNG
(CHEMBL3809594)
Show SMILES Cl.COc1cccc(CCN2CCC(CCc3ccccc3)CC2)c1
Show InChI InChI=1S/C22H29NO.ClH/c1-24-22-9-5-8-21(18-22)14-17-23-15-12-20(13-16-23)11-10-19-6-3-2-4-7-19;/h2-9,18,20H,10-17H2,1H3;1H
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22n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation counting


Bioorg Med Chem Lett 26: 2997-3000 (2016)

More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50344443
PNG
(CHEMBL1780009 | rac-(2R)-9-(3-fluoropropoxy)-10-me...)
Show SMILES COc1cc2C3C[C@@H](O)C(CN3CCc2cc1OCCCF)\C=C\C
Show InChI InChI=1S/C20H28FNO3/c1-3-5-15-13-22-8-6-14-10-20(25-9-4-7-21)19(24-2)11-16(14)17(22)12-18(15)23/h3,5,10-11,15,17-18,23H,4,6-9,12-13H2,1-2H3/b5-3+/t15?,17?,18-/m1/s1
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22.4n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Displacement of [18F](+)-FP-DTBZ from VMAT2 in rat striatal homogenate after 60 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50171953
PNG
((2R,6S)-2,6-Diphenethyl-piperidine | CHEMBL192329 ...)
Show SMILES C(Cc1ccccc1)[C@H]1CCC[C@@H](CCc2ccccc2)N1
Show InChI InChI=1S/C21H27N/c1-3-8-18(9-4-1)14-16-20-12-7-13-21(22-20)17-15-19-10-5-2-6-11-19/h1-6,8-11,20-22H,7,12-17H2/t20-,21+
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23n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50442287
PNG
(CHEMBL2442145)
Show SMILES COc1ccc(CC[C@H]2C[C@@H](CCc3ccc(OC)cc3)N2)cc1
Show InChI InChI=1S/C21H27NO2/c1-23-20-11-5-16(6-12-20)3-9-18-15-19(22-18)10-4-17-7-13-21(24-2)14-8-17/h5-8,11-14,18-19,22H,3-4,9-10,15H2,1-2H3/t18-,19+
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24n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of VMAT2-mediated [3H]-dopamine uptake in rat striata isolated synaptic vesicles by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50344440
PNG
(CHEMBL1780006 | rac-(2R)-3-(cyclobutylmethyl)-9,10...)
Show SMILES COc1cc2CCN3CC(CC4CCC4)[C@H](O)CC3c2cc1OC
Show InChI InChI=1S/C20H29NO3/c1-23-19-9-14-6-7-21-12-15(8-13-4-3-5-13)18(22)11-17(21)16(14)10-20(19)24-2/h9-10,13,15,17-18,22H,3-8,11-12H2,1-2H3/t15?,17?,18-/m1/s1
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26.9n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal homogenate after 60 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50192902
PNG
(2-ethyl-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-he...)
Show SMILES CCC1(O)CC2N(CCc3cc(OC)c(OC)cc23)CC1CC(C)C
Show InChI InChI=1S/C21H33NO3/c1-6-21(23)12-18-17-11-20(25-5)19(24-4)10-15(17)7-8-22(18)13-16(21)9-14(2)3/h10-11,14,16,18,23H,6-9,12-13H2,1-5H3
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28n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membrane


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50301024
PNG
(CHEMBL571308 | N-(2-fluoroethyl)-3-isobutyl-9,10-d...)
Show SMILES COc1cc2CCN3CC(CC(C)C)C(CC3c2cc1OC)NCCF
Show InChI InChI=1S/C21H33FN2O2/c1-14(2)9-16-13-24-8-5-15-10-20(25-3)21(26-4)11-17(15)19(24)12-18(16)23-7-6-22/h10-11,14,16,18-19,23H,5-9,12-13H2,1-4H3
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28n/an/an/an/an/an/an/an/a



Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL


Assay Description
Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50300432
PNG
(CHEMBL583383 | cis-2,5-Di-(2-phenethyl)-pyrrolidin...)
Show SMILES C(Cc1ccccc1)[C@H]1CC[C@@H](CCc2ccccc2)N1
Show InChI InChI=1S/C20H25N/c1-3-7-17(8-4-1)11-13-19-15-16-20(21-19)14-12-18-9-5-2-6-10-18/h1-10,19-21H,11-16H2/t19-,20+
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29n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50433783
PNG
(CHEMBL2381721)
Show SMILES COc1ccc(CC[C@H]2CCC[C@@H](CCc3ccc(OC)cc3)N2C[C@@H](O)CO)cc1
Show InChI InChI=1S/C26H37NO4/c1-30-25-14-8-20(9-15-25)6-12-22-4-3-5-23(27(22)18-24(29)19-28)13-7-21-10-16-26(31-2)17-11-21/h8-11,14-17,22-24,28-29H,3-7,12-13,18-19H2,1-2H3/t22-,23+,24-/m1/s1
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29n/an/an/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of VMAT2-mediated [3H]DA uptake in rat striatal synaptic vesicles by liquid scintillation spectroscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50433783
PNG
(CHEMBL2381721)
Show SMILES COc1ccc(CC[C@H]2CCC[C@@H](CCc3ccc(OC)cc3)N2C[C@@H](O)CO)cc1
Show InChI InChI=1S/C26H37NO4/c1-30-25-14-8-20(9-15-25)6-12-22-4-3-5-23(27(22)18-24(29)19-28)13-7-21-10-16-26(31-2)17-11-21/h8-11,14-17,22-24,28-29H,3-7,12-13,18-19H2,1-2H3/t22-,23+,24-/m1/s1
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29n/an/an/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of VMAT2 in rat striatal synaptic vesicle assessed as reduction of [3H]dopamine uptake after 8 mins by liquid scintillation spectrometric ...


Bioorg Med Chem Lett 26: 2422-7 (2016)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Rattus norvegicus (Rat))
BDBM50175675
PNG
(CHEMBL3808752)
Show SMILES Cl.COc1ccccc1CCN1CCC(CCc2ccccc2)CC1
Show InChI InChI=1S/C22H29NO.ClH/c1-24-22-10-6-5-9-21(22)15-18-23-16-13-20(14-17-23)12-11-19-7-3-2-4-8-19;/h2-10,20H,11-18H2,1H3;1H
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30n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation counting


Bioorg Med Chem Lett 26: 2997-3000 (2016)

More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50442289
PNG
(CHEMBL2442143)
Show SMILES C(Cc1ccc2OCOc2c1)[C@@H]1C[C@@H](CCc2ccc3OCOc3c2)N1
Show InChI InChI=1S/C21H23NO4/c1(14-3-7-18-20(9-14)25-12-23-18)5-16-11-17(22-16)6-2-15-4-8-19-21(10-15)26-13-24-19/h3-4,7-10,16-17,22H,1-2,5-6,11-13H2/t16-,17-/m1/s1
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31n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of VMAT2-mediated [3H]-dopamine uptake in rat striata isolated synaptic vesicles by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50157190
PNG
(CHEMBL3793321)
Show SMILES Cl.Oc1ccc(CC[C@H]2CCC[C@@H](CCc3ccc(O)cc3)N2)cc1
Show InChI InChI=1/C21H27NO2.ClH/c23-20-12-6-16(7-13-20)4-10-18-2-1-3-19(22-18)11-5-17-8-14-21(24)15-9-17;/h6-9,12-15,18-19,22-24H,1-5,10-11H2;1H/t18-,19+;
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31n/an/an/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of VMAT2 in rat striatal synaptic vesicle assessed as reduction of [3H]dopamine uptake after 8 mins by liquid scintillation spectrometric ...


Bioorg Med Chem Lett 26: 2422-7 (2016)

More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50157301
PNG
(CHEMBL3792786)
Show SMILES Cl.CN1[C@@H](CCc2ccc(O)cc2)CCC[C@H]1CCc1ccc(OCCF)cc1
Show InChI InChI=1/C24H32FNO2.ClH/c1-26-21(11-5-19-7-13-23(27)14-8-19)3-2-4-22(26)12-6-20-9-15-24(16-10-20)28-18-17-25;/h7-10,13-16,21-22,27H,2-6,11-12,17-18H2,1H3;1H/t21-,22+;/s2
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31n/an/an/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of VMAT2 in rat striatal synaptic vesicle assessed as reduction of [3H]dopamine uptake after 8 mins by liquid scintillation spectrometric ...


Bioorg Med Chem Lett 26: 2422-7 (2016)

More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50157199
PNG
(CHEMBL3793860)
Show SMILES Cl.Oc1ccc(CC[C@H]2CCC[C@@H](CCc3ccc(OCCF)cc3)N2)cc1
Show InChI InChI=1/C23H30FNO2.ClH/c24-16-17-27-23-14-8-19(9-15-23)5-11-21-3-1-2-20(25-21)10-4-18-6-12-22(26)13-7-18;/h6-9,12-15,20-21,25-26H,1-5,10-11,16-17H2;1H/t20-,21+;/s2
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32n/an/an/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of VMAT2 in rat striatal synaptic vesicle assessed as reduction of [3H]dopamine uptake after 8 mins by liquid scintillation spectrometric ...


Bioorg Med Chem Lett 26: 2422-7 (2016)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Rattus norvegicus (Rat))
BDBM50175680
PNG
(CHEMBL3809460)
Show SMILES Cl.Fc1ccc(CCN2CCC(CCc3ccccc3)CC2)cc1
Show InChI InChI=1S/C21H26FN.ClH/c22-21-10-8-19(9-11-21)12-15-23-16-13-20(14-17-23)7-6-18-4-2-1-3-5-18;/h1-5,8-11,20H,6-7,12-17H2;1H
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32n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation counting


Bioorg Med Chem Lett 26: 2997-3000 (2016)

More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50080827
PNG
((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...)
Show SMILES CN1[C@@H](CCc2ccccc2)CCC[C@H]1CCc1ccccc1
Show InChI InChI=1S/C22H29N/c1-23-21(17-15-19-9-4-2-5-10-19)13-8-14-22(23)18-16-20-11-6-3-7-12-20/h2-7,9-12,21-22H,8,13-18H2,1H3/t21-,22+
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33n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopy


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More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50048895
PNG
((2S,3R,11bR)-2,3-Diisobutyl-9,10-dimethoxy-1,3,4,6...)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)[C@](O)(CC(C)C)C[C@@H]3c2cc1OC
Show InChI InChI=1S/C23H37NO3/c1-15(2)9-18-14-24-8-7-17-10-21(26-5)22(27-6)11-19(17)20(24)13-23(18,25)12-16(3)4/h10-11,15-16,18,20,25H,7-9,12-14H2,1-6H3/t18-,20-,23+/m1/s1
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33n/an/an/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Compound was tested in vitro for the inhibition of [3H]- Methoxytetrabenazine binding to rat brain vesicular monoamine transporter 2 (VMAT2)


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More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50300436
PNG
((2S,5S)-di-(2-phenethyl)-pyrrolidine | CHEMBL57304...)
Show SMILES C(Cc1ccccc1)[C@H]1CC[C@H](CCc2ccccc2)N1
Show InChI InChI=1S/C20H25N/c1-3-7-17(8-4-1)11-13-19-15-16-20(21-19)14-12-18-9-5-2-6-10-18/h1-10,19-21H,11-16H2/t19-,20-/m0/s1
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35n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50157191
PNG
(CHEMBL3793365)
Show SMILES Cl.OC[C@H](O)CN1[C@@H](CCc2ccc(O)cc2)CCC[C@H]1CCc1ccc(O)cc1
Show InChI InChI=1/C24H33NO4.ClH/c26-17-24(29)16-25-20(10-4-18-6-12-22(27)13-7-18)2-1-3-21(25)11-5-19-8-14-23(28)15-9-19;/h6-9,12-15,20-21,24,26-29H,1-5,10-11,16-17H2;1H/t20-,21+,24-;/s2
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39n/an/an/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of VMAT2 in rat striatal synaptic vesicle assessed as reduction of [3H]dopamine uptake after 8 mins by liquid scintillation spectrometric ...


Bioorg Med Chem Lett 26: 2422-7 (2016)

More data for this
Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2)


(Rattus norvegicus (Rat))
BDBM50157214
PNG
(CHEMBL3793720)
Show SMILES Cl.FCCOc1ccc(CC[C@H]2CCC[C@@H](CCc3ccc(OCCF)cc3)N2)cc1
Show InChI InChI=1/C25H33F2NO2.ClH/c26-16-18-29-24-12-6-20(7-13-24)4-10-22-2-1-3-23(28-22)11-5-21-8-14-25(15-9-21)30-19-17-27;/h6-9,12-15,22-23,28H,1-5,10-11,16-19H2;1H/t22-,23+;
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40n/an/an/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of VMAT2 in rat striatal synaptic vesicle assessed as reduction of [3H]dopamine uptake after 8 mins by liquid scintillation spectrometric ...


Bioorg Med Chem Lett 26: 2422-7 (2016)

More data for this
Ligand-Target Pair
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