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Found 26 hits Enz. Inhib. hit(s) with Target = 'Tankyrase 2 PARP catalytic domain (TNKS2P)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM50439807
PNG
(CHEMBL2419718 | US9227982, 4)
Show SMILES Fc1ccccc1CCC(=O)N(Cc1cccs1)Cc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C22H22FN3O3S/c23-18-6-2-1-4-15(18)7-8-21(27)26(12-16-5-3-11-30-16)13-20-24-19-9-10-29-14-17(19)22(28)25-20/h1-6,11H,7-10,12-14H2,(H,24,25,28)
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n/an/a 64n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM50439805
PNG
(CHEMBL2419692 | US9227982, 2)
Show SMILES Fc1ccc(CCC(=O)N(Cc2cccs2)Cc2nc3CCOCc3c(=O)[nH]2)cc1
Show InChI InChI=1S/C22H22FN3O3S/c23-16-6-3-15(4-7-16)5-8-21(27)26(12-17-2-1-11-30-17)13-20-24-19-9-10-29-14-18(19)22(28)25-20/h1-4,6-7,11H,5,8-10,12-14H2,(H,24,25,28)
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n/an/a 78n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM199992
PNG
(US9227982, 9)
Show SMILES O=c1[nH]c(CN(Cc2cccs2)S(=O)(=O)Cc2ccccc2)nc2CCOCc12
Show InChI InChI=1S/C20H21N3O4S2/c24-20-17-13-27-9-8-18(17)21-19(22-20)12-23(11-16-7-4-10-28-16)29(25,26)14-15-5-2-1-3-6-15/h1-7,10H,8-9,11-14H2,(H,21,22,24)
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n/an/a 177n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM50439803
PNG
(CHEMBL2419694 | US9227982, 7)
Show SMILES Oc1cccc(CCC(=O)N(Cc2cccs2)Cc2nc3CCOCc3c(=O)[nH]2)c1
Show InChI InChI=1S/C22H23N3O4S/c26-16-4-1-3-15(11-16)6-7-21(27)25(12-17-5-2-10-30-17)13-20-23-19-8-9-29-14-18(19)22(28)24-20/h1-5,10-11,26H,6-9,12-14H2,(H,23,24,28)
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n/an/a 178n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM50439811
PNG
(CHEMBL2419712 | US9227982, 1)
Show SMILES O=C(CCc1ccccc1)N(Cc1cccs1)Cc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C22H23N3O3S/c26-21(9-8-16-5-2-1-3-6-16)25(13-17-7-4-12-29-17)14-20-23-19-10-11-28-15-18(19)22(27)24-20/h1-7,12H,8-11,13-15H2,(H,23,24,27)
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n/an/a 222n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM200009
PNG
(US9227982, 26)
Show SMILES Fc1ccccc1CCC(=O)N(Cc1ccc[nH]1)Cc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C22H23FN4O3/c23-18-6-2-1-4-15(18)7-8-21(28)27(12-16-5-3-10-24-16)13-20-25-19-9-11-30-14-17(19)22(29)26-20/h1-6,10,24H,7-9,11-14H2,(H,25,26,29)
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n/an/a 235n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM50439806
PNG
(CHEMBL2419691 | US9227982, 5)
Show SMILES Fc1cccc(CCC(=O)N(Cc2cccs2)Cc2nc3CCOCc3c(=O)[nH]2)c1
Show InChI InChI=1S/C22H22FN3O3S/c23-16-4-1-3-15(11-16)6-7-21(27)26(12-17-5-2-10-30-17)13-20-24-19-8-9-29-14-18(19)22(28)25-20/h1-5,10-11H,6-9,12-14H2,(H,24,25,28)
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n/an/a 284n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM200002
PNG
(US9227982, 21)
Show SMILES Clc1ccc(CN(Cc2nc3CCOCc3c(=O)[nH]2)C(=O)CCc2ccccc2)s1
Show InChI InChI=1S/C22H22ClN3O3S/c23-19-8-7-16(30-19)12-26(21(27)9-6-15-4-2-1-3-5-15)13-20-24-18-10-11-29-14-17(18)22(28)25-20/h1-5,7-8H,6,9-14H2,(H,24,25,28)
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n/an/a 318n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM50439802
PNG
(CHEMBL2419695 | US9227982, 8)
Show SMILES Oc1ccc(CCC(=O)N(Cc2cccs2)Cc2nc3CCOCc3c(=O)[nH]2)cc1
Show InChI InChI=1S/C22H23N3O4S/c26-16-6-3-15(4-7-16)5-8-21(27)25(12-17-2-1-11-30-17)13-20-23-19-9-10-29-14-18(19)22(28)24-20/h1-4,6-7,11,26H,5,8-10,12-14H2,(H,23,24,28)
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n/an/a 341n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM50439804
PNG
(CHEMBL2419693 | US9227982, 6)
Show SMILES Oc1ccccc1CCC(=O)N(Cc1cccs1)Cc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C22H23N3O4S/c26-19-6-2-1-4-15(19)7-8-21(27)25(12-16-5-3-11-30-16)13-20-23-18-9-10-29-14-17(18)22(28)24-20/h1-6,11,26H,7-10,12-14H2,(H,23,24,28)
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NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM199993
PNG
(US9227982, 10)
Show SMILES O=c1[nH]c(CN(Cc2cccs2)S(=O)(=O)CCc2ccccc2)nc2CCOCc12
Show InChI InChI=1S/C21H23N3O4S2/c25-21-18-15-28-10-8-19(18)22-20(23-21)14-24(13-17-7-4-11-29-17)30(26,27)12-9-16-5-2-1-3-6-16/h1-7,11H,8-10,12-15H2,(H,22,23,25)
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n/an/a 910n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM50439809
PNG
(CHEMBL2417574 | US9227982, 11)
Show SMILES O=C(CCc1ccncc1)N(Cc1cccs1)Cc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C21H22N4O3S/c26-20(4-3-15-5-8-22-9-6-15)25(12-16-2-1-11-29-16)13-19-23-18-7-10-28-14-17(18)21(27)24-19/h1-2,5-6,8-9,11H,3-4,7,10,12-14H2,(H,23,24,27)
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NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM199994
PNG
(US9227982, 13)
Show SMILES O=C(CCc1ccccc1)N(CC1CCCC1)Cc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C23H29N3O3/c27-22(11-10-17-6-2-1-3-7-17)26(14-18-8-4-5-9-18)15-21-24-20-12-13-29-16-19(20)23(28)25-21/h1-3,6-7,18H,4-5,8-16H2,(H,24,25,28)
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NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM50439810
PNG
(CHEMBL2419716 | US9227982, 18)
Show SMILES O=C(CCc1ccccc1)N(Cc1ccsc1)Cc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C22H23N3O3S/c26-21(7-6-16-4-2-1-3-5-16)25(12-17-9-11-29-15-17)13-20-23-19-8-10-28-14-18(19)22(27)24-20/h1-5,9,11,15H,6-8,10,12-14H2,(H,23,24,27)
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n/an/a 1.03E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM199997
PNG
(US9227982, 14)
Show SMILES Fc1ccccc1CN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C24H24FN3O3/c25-20-9-5-4-8-18(20)14-28(23(29)11-10-17-6-2-1-3-7-17)15-22-26-21-12-13-31-16-19(21)24(30)27-22/h1-9H,10-16H2,(H,26,27,30)
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NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM199991
PNG
(US9227982, 3)
Show SMILES O=C(CCc1c[nH]c2ccccc12)N(Cc1cccs1)Cc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C24H24N4O3S/c29-23(8-7-16-12-25-20-6-2-1-5-18(16)20)28(13-17-4-3-11-32-17)14-22-26-21-9-10-31-15-19(21)24(30)27-22/h1-6,11-12,25H,7-10,13-15H2,(H,26,27,30)
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n/an/a 1.58E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM200001
PNG
(US9227982, 20)
Show SMILES O=C(CCc1ccccc1)N(Cc1ncco1)Cc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C21H22N4O4/c26-20(7-6-15-4-2-1-3-5-15)25(13-19-22-9-11-29-19)12-18-23-17-8-10-28-14-16(17)21(27)24-18/h1-5,9,11H,6-8,10,12-14H2,(H,23,24,27)
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n/an/a 1.70E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM200007
PNG
(US9227982, 25)
Show SMILES C[C@@H](N(Cc1nc2CCOCc2c(=O)[nH]1)S(=O)(=O)Cc1ccccc1)c1ccccc1
Show InChI InChI=1/C23H25N3O4S/c1-17(19-10-6-3-7-11-19)26(31(28,29)16-18-8-4-2-5-9-18)14-22-24-21-12-13-30-15-20(21)23(27)25-22/h2-11,17H,12-16H2,1H3,(H,24,25,27)/t17-/s2
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NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM200000
PNG
(US9227982, 19)
Show SMILES O=C(CCc1ccccc1)N(Cc1nccs1)Cc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C21H22N4O3S/c26-20(7-6-15-4-2-1-3-5-15)25(13-19-22-9-11-29-19)12-18-23-17-8-10-28-14-16(17)21(27)24-18/h1-5,9,11H,6-8,10,12-14H2,(H,23,24,27)
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n/an/a 2.03E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM200005
PNG
(US9227982, 23)
Show SMILES OCCN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C19H23N3O4/c23-10-9-22(18(24)7-6-14-4-2-1-3-5-14)12-17-20-16-8-11-26-13-15(16)19(25)21-17/h1-5,23H,6-13H2,(H,20,21,25)
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n/an/a 2.68E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM199999
PNG
(US9227982, 17)
Show SMILES CC(C)(C)C(=O)CN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C23H29N3O4/c1-23(2,3)19(27)13-26(21(28)10-9-16-7-5-4-6-8-16)14-20-24-18-11-12-30-15-17(18)22(29)25-20/h4-8H,9-15H2,1-3H3,(H,24,25,29)
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NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM200006
PNG
(US9227982, 24)
Show SMILES C[C@H](N(Cc1nc2CCOCc2c(=O)[nH]1)S(=O)(=O)Cc1ccccc1)c1ccccc1
Show InChI InChI=1/C23H25N3O4S/c1-17(19-10-6-3-7-11-19)26(31(28,29)16-18-8-4-2-5-9-18)14-22-24-21-12-13-30-15-20(21)23(27)25-22/h2-11,17H,12-16H2,1H3,(H,24,25,27)/t17-/s2
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n/an/a 3.12E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM200003
PNG
(US9227982, 22)
Show SMILES O=C(CCc1ccccc1)N(Cc1cncs1)Cc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C21H22N4O3S/c26-20(7-6-15-4-2-1-3-5-15)25(11-16-10-22-14-29-16)12-19-23-18-8-9-28-13-17(18)21(27)24-19/h1-5,10,14H,6-9,11-13H2,(H,23,24,27)
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n/an/a 3.48E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM50439831
PNG
(CHEMBL2419713 | US9227982, 15)
Show SMILES CCN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C19H23N3O3/c1-2-22(18(23)9-8-14-6-4-3-5-7-14)12-17-20-16-10-11-25-13-15(16)19(24)21-17/h3-7H,2,8-13H2,1H3,(H,20,21,24)
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n/an/a 4.78E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM199998
PNG
(US9227982, 16)
Show SMILES CC(C)N(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C20H25N3O3/c1-14(2)23(19(24)9-8-15-6-4-3-5-7-15)12-18-21-17-10-11-26-13-16(17)20(25)22-18/h3-7,14H,8-13H2,1-2H3,(H,21,22,25)
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n/an/a 5.39E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair
Tankyrase 2 PARP catalytic domain (TNKS2P)


(Homo sapiens (human))
BDBM50439808
PNG
(CHEMBL2419717 | US9227982, 12)
Show SMILES O=C(CCc1cccnc1)N(Cc1cccs1)Cc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C21H22N4O3S/c26-20(6-5-15-3-1-8-22-11-15)25(12-16-4-2-10-29-16)13-19-23-18-7-9-28-14-17(18)21(27)24-19/h1-4,8,10-11H,5-7,9,12-14H2,(H,23,24,27)
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n/an/a 1.01E+4n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent US9227982 (2016)

More data for this
Ligand-Target Pair