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Found 109 hits Enz. Inhib. hit(s) with Target = 'Tau protein kinase 1 (TPK1)' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155160
PNG
(US9006232, 1.106)
Show SMILES COc1cccc(c1)N1CCCC(C1)Oc1nc(cc(=O)n1C)-c1ccncn1
Show InChI InChI=1/C21H23N5O3/c1-25-20(27)12-19(18-8-9-22-14-23-18)24-21(25)29-17-7-4-10-26(13-17)15-5-3-6-16(11-15)28-2/h3,5-6,8-9,11-12,14,17H,4,7,10,13H2,1-2H3
PDB

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US Patent
n/an/a 1.5n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155169
PNG
(US9006232, 1.203)
Show SMILES CN1CCN(Cc2ccc(cc2)N2CCC(CC2)Oc2nc(cc(=O)n2C)-c2ccncn2)CC1
Show InChI InChI=1S/C26H33N7O2/c1-30-13-15-32(16-14-30)18-20-3-5-21(6-4-20)33-11-8-22(9-12-33)35-26-29-24(17-25(34)31(26)2)23-7-10-27-19-28-23/h3-7,10,17,19,22H,8-9,11-16,18H2,1-2H3
PDB

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n/an/a 6.40n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau Protein Kinase 1 (TPK1)


(Bos taurus (Bovine))
BDBM142855
PNG
(US8940738, 11)
Show SMILES Cc1nc(no1)-c1ccc(cc1)[C@H]1CN(CCO1)c1nc(-c2ccncn2)c(O)c(=O)n1C
Show InChI InChI=1/C22H21N7O4/c1-13-25-20(27-33-13)15-5-3-14(4-6-15)17-11-29(9-10-32-17)22-26-18(16-7-8-23-12-24-16)19(30)21(31)28(22)2/h3-8,12,17,30H,9-11H2,1-2H3/t17-/s2
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n/an/a 6.70n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...


US Patent US8940738 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155226
PNG
(US9006232, 1.903)
Show SMILES CN1CCN(Cc2ccc(cc2)[C@H]2CC[C@@H](CC2)Oc2nc(cc(=O)n2C)-c2ccncn2)CC1
Show InChI InChI=1/C27H34N6O2/c1-31-13-15-33(16-14-31)18-20-3-5-21(6-4-20)22-7-9-23(10-8-22)35-27-30-25(17-26(34)32(27)2)24-11-12-28-19-29-24/h3-6,11-12,17,19,22-23H,7-10,13-16,18H2,1-2H3/t22-,23-
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n/an/a 7.80n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155185
PNG
(US9006232, 1.219)
Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3Cc4ccccc4C3)cc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C29H30N6O2/c1-33-28(36)16-27(26-10-13-30-20-31-26)32-29(33)37-25-11-14-35(15-12-25)24-8-6-21(7-9-24)17-34-18-22-4-2-3-5-23(22)19-34/h2-10,13,16,20,25H,11-12,14-15,17-19H2,1H3
PDB

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n/an/a 8.40n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau Protein Kinase 1 (TPK1)


(Bos taurus (Bovine))
BDBM142848
PNG
(US8940738, 4)
Show SMILES Cc1nc(no1)-c1ccc(cc1)[C@H]1CN(CCO1)c1nc(cc(=O)n1C)-c1ncncc1F
Show InChI InChI=1/C22H20FN7O3/c1-13-26-21(28-33-13)15-5-3-14(4-6-15)18-11-30(7-8-32-18)22-27-17(9-19(31)29(22)2)20-16(23)10-24-12-25-20/h3-6,9-10,12,18H,7-8,11H2,1-2H3/t18-/s2
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n/an/a 8.40n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...


US Patent US8940738 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155158
PNG
(US9006232, 1.104)
Show SMILES Cn1c(OC2CCCN(C2)c2cccc(F)c2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1/C20H20FN5O2/c1-25-19(27)11-18(17-7-8-22-13-23-17)24-20(25)28-16-6-3-9-26(12-16)15-5-2-4-14(21)10-15/h2,4-5,7-8,10-11,13,16H,3,6,9,12H2,1H3
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n/an/a 8.90n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155191
PNG
(US9006232, 1.225)
Show SMILES Cn1c(OC2CCN(CC2)c2ccc3CNCc3c2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C22H24N6O2/c1-27-21(29)11-20(19-4-7-23-14-25-19)26-22(27)30-18-5-8-28(9-6-18)17-3-2-15-12-24-13-16(15)10-17/h2-4,7,10-11,14,18,24H,5-6,8-9,12-13H2,1H3
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n/an/a 9.40n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155155
PNG
(US9006232, 1.101)
Show SMILES Cn1c(OC2CCCN(C2)c2ccccc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1/C20H21N5O2/c1-24-19(26)12-18(17-9-10-21-14-22-17)23-20(24)27-16-8-5-11-25(13-16)15-6-3-2-4-7-15/h2-4,6-7,9-10,12,14,16H,5,8,11,13H2,1H3
PDB

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n/an/a 9.40n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM38219
PNG
(US9006232, 1.223)
Show SMILES Cn1c(OC2CCN(CC2)c2cccc(CN3CCCCC3)c2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C20H17F6N3OS/c1-18(6-7-31-17(27)29-18)13-8-14(20(24,25)26)10-15(9-13)28-16(30)11-2-4-12(5-3-11)19(21,22)23/h2-5,8-10H,6-7H2,1H3,(H2,27,29)(H,28,30)
PDB

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n/an/a 9.40n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau Protein Kinase 1 (TPK1)


(Bos taurus (Bovine))
BDBM142850
PNG
(US8940738, 6)
Show SMILES Cn1c(nc(cc1=O)-c1ncncc1F)N1CCNC(C1)c1ccc(cc1)[N+]#[C-]
Show InChI InChI=1/C20H18FN7O/c1-22-14-5-3-13(4-6-14)17-11-28(8-7-24-17)20-26-16(9-18(29)27(20)2)19-15(21)10-23-12-25-19/h3-6,9-10,12,17,24H,7-8,11H2,2H3
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n/an/a 10.1n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...


US Patent US8940738 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155174
PNG
(US9006232, 1.208)
Show SMILES Cn1c(OC2CCN(CC2)c2ccc(cc2)N2CCNCC2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C24H29N7O2/c1-29-23(32)16-22(21-6-9-26-17-27-21)28-24(29)33-20-7-12-30(13-8-20)18-2-4-19(5-3-18)31-14-10-25-11-15-31/h2-6,9,16-17,20,25H,7-8,10-15H2,1H3
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n/an/a 10.7n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155182
PNG
(US9006232, 1.216)
Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3CCCCC3)cc2)nc(cc1=O)-c1ccncc1F
Show InChI InChI=1S/C27H32FN5O2/c1-31-26(34)17-25(23-9-12-29-18-24(23)28)30-27(31)35-22-10-15-33(16-11-22)21-7-5-20(6-8-21)19-32-13-3-2-4-14-32/h5-9,12,17-18,22H,2-4,10-11,13-16,19H2,1H3
PDB

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n/an/a 10.9n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155162
PNG
(US9006232, 1.108)
Show SMILES Cn1c(OC2CCCN(C2)c2ccccn2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1/C19H20N6O2/c1-24-18(26)11-16(15-7-9-20-13-22-15)23-19(24)27-14-5-4-10-25(12-14)17-6-2-3-8-21-17/h2-3,6-9,11,13-14H,4-5,10,12H2,1H3
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n/an/a 11.7n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155183
PNG
(US9006232, 1.217)
Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3CCCC3)cc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C25H30N6O2/c1-29-24(32)16-23(22-8-11-26-18-27-22)28-25(29)33-21-9-14-31(15-10-21)20-6-4-19(5-7-20)17-30-12-2-3-13-30/h4-8,11,16,18,21H,2-3,9-10,12-15,17H2,1H3
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n/an/a 12n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155197
PNG
(US9006232, 1.231)
Show SMILES Cn1c(OC2CCN(C2)c2ccc(CN3CCCCC3)cc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1/C25H30N6O2/c1-29-24(32)15-23(22-9-11-26-18-27-22)28-25(29)33-21-10-14-31(17-21)20-7-5-19(6-8-20)16-30-12-3-2-4-13-30/h5-9,11,15,18,21H,2-4,10,12-14,16-17H2,1H3
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n/an/a 12.8n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155168
PNG
(US9006232, 1.202)
Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3CCNCC3)cc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C25H31N7O2/c1-30-24(33)16-23(22-6-9-27-18-28-22)29-25(30)34-21-7-12-32(13-8-21)20-4-2-19(3-5-20)17-31-14-10-26-11-15-31/h2-6,9,16,18,21,26H,7-8,10-15,17H2,1H3
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n/an/a 13n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155202
PNG
(US9006232, 1.302)
Show SMILES CN1CCN(Cc2ccccc2N2CCC(CC2)Oc2nc(cc(=O)n2C)-c2ccncn2)CC1
Show InChI InChI=1S/C26H33N7O2/c1-30-13-15-32(16-14-30)18-20-5-3-4-6-24(20)33-11-8-21(9-12-33)35-26-29-23(17-25(34)31(26)2)22-7-10-27-19-28-22/h3-7,10,17,19,21H,8-9,11-16,18H2,1-2H3
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n/an/a 14.9n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau Protein Kinase 1 (TPK1)


(Bos taurus (Bovine))
BDBM142845
PNG
(US8940738, 1)
Show SMILES CN1C(=O)CC(N=C1N1CCO[C@H](C1)c1ccc(F)cc1)c1ncncc1F
Show InChI InChI=1/C19H19F2N5O2/c1-25-17(27)8-15(18-14(21)9-22-11-23-18)24-19(25)26-6-7-28-16(10-26)12-2-4-13(20)5-3-12/h2-5,9,11,15-16H,6-8,10H2,1H3/t15?,16-/s2
PDB

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n/an/a 15.5n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...


US Patent US8940738 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155200
PNG
(US9006232, 1.234)
Show SMILES Cn1c(OCC2CCN(CC2)c2ccc(CN3CCCCC3)cc2)nc(cc1=O)-c1ccncc1F
Show InChI InChI=1S/C28H34FN5O2/c1-32-27(35)17-26(24-9-12-30-18-25(24)29)31-28(32)36-20-22-10-15-34(16-11-22)23-7-5-21(6-8-23)19-33-13-3-2-4-14-33/h5-9,12,17-18,22H,2-4,10-11,13-16,19-20H2,1H3
PDB

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n/an/a 15.6n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155193
PNG
(US9006232, 1.227)
Show SMILES Cn1c(OC2CCN(CC2)c2ccc3CN(Cc4ccccc4)Cc3c2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C29H30N6O2/c1-33-28(36)16-27(26-9-12-30-20-31-26)32-29(33)37-25-10-13-35(14-11-25)24-8-7-22-18-34(19-23(22)15-24)17-21-5-3-2-4-6-21/h2-9,12,15-16,20,25H,10-11,13-14,17-19H2,1H3
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n/an/a 16n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155180
PNG
(US9006232, 1.214)
Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3CCCCC3)cc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C26H32N6O2/c1-30-25(33)17-24(23-9-12-27-19-28-23)29-26(30)34-22-10-15-32(16-11-22)21-7-5-20(6-8-21)18-31-13-3-2-4-14-31/h5-9,12,17,19,22H,2-4,10-11,13-16,18H2,1H3
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n/an/a 16.1n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155175
PNG
(US9006232, 1.209)
Show SMILES CN1CCN(CC1)c1ccc(cc1)N1CCC(CC1)Oc1nc(cc(=O)n1C)-c1ccncn1
Show InChI InChI=1S/C25H31N7O2/c1-29-13-15-32(16-14-29)20-5-3-19(4-6-20)31-11-8-21(9-12-31)34-25-28-23(17-24(33)30(25)2)22-7-10-26-18-27-22/h3-7,10,17-18,21H,8-9,11-16H2,1-2H3
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n/an/a 17.9n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155237
PNG
(US9006232, 2.205)
Show SMILES Cn1c(OC[C@@H]2CCCN2c2ccc(F)cc2)nc(cc1=O)-c1ccncc1F
Show InChI InChI=1/C21H20F2N4O2/c1-26-20(28)11-19(17-8-9-24-12-18(17)23)25-21(26)29-13-16-3-2-10-27(16)15-6-4-14(22)5-7-15/h4-9,11-12,16H,2-3,10,13H2,1H3/t16-/s2
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n/an/a 18.4n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155167
PNG
(US9006232, 1.201)
Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3CCN(CC3)C(=O)OC(C)(C)C)cc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C30H39N7O4/c1-30(2,3)41-29(39)37-17-15-35(16-18-37)20-22-5-7-23(8-6-22)36-13-10-24(11-14-36)40-28-33-26(19-27(38)34(28)4)25-9-12-31-21-32-25/h5-9,12,19,21,24H,10-11,13-18,20H2,1-4H3
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n/an/a 19.1n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155179
PNG
(US9006232, 1.213)
Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3CCOCC3)cc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C25H30N6O3/c1-29-24(32)16-23(22-6-9-26-18-27-22)28-25(29)34-21-7-10-31(11-8-21)20-4-2-19(3-5-20)17-30-12-14-33-15-13-30/h2-6,9,16,18,21H,7-8,10-15,17H2,1H3
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n/an/a 19.4n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau Protein Kinase 1 (TPK1)


(Bos taurus (Bovine))
BDBM142846
PNG
(US8940738, 2)
Show SMILES C[C@@H]1COCCN1c1nc(cc(=O)n1C)-c1ncncc1F
Show InChI InChI=1/C14H16FN5O2/c1-9-7-22-4-3-20(9)14-18-11(5-12(21)19(14)2)13-10(15)6-16-8-17-13/h5-6,8-9H,3-4,7H2,1-2H3/t9-/s2
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n/an/a 19.7n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...


US Patent US8940738 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155244
PNG
(US9006232, 2.301)
Show SMILES Cn1c(OCC(=O)c2ccccc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C17H14N4O3/c1-21-16(23)9-14(13-7-8-18-11-19-13)20-17(21)24-10-15(22)12-5-3-2-4-6-12/h2-9,11H,10H2,1H3
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n/an/a 20n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155186
PNG
(US9006232, 1.220)
Show SMILES CN(C)Cc1ccc(cc1)N1CCC(CC1)Oc1nc(cc(=O)n1C)-c1ccncn1
Show InChI InChI=1S/C23H28N6O2/c1-27(2)15-17-4-6-18(7-5-17)29-12-9-19(10-13-29)31-23-26-21(14-22(30)28(23)3)20-8-11-24-16-25-20/h4-8,11,14,16,19H,9-10,12-13,15H2,1-3H3
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n/an/a 21.2n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155188
PNG
(US9006232, 1.222)
Show SMILES CN1CCN(Cc2cccc(c2)N2CCC(CC2)Oc2nc(cc(=O)n2C)-c2ccncn2)CC1
Show InChI InChI=1S/C26H33N7O2/c1-30-12-14-32(15-13-30)18-20-4-3-5-21(16-20)33-10-7-22(8-11-33)35-26-29-24(17-25(34)31(26)2)23-6-9-27-19-28-23/h3-6,9,16-17,19,22H,7-8,10-15,18H2,1-2H3
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n/an/a 21.5n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155215
PNG
(US9006232, 1.802)
Show SMILES Cn1c(OC2CCCCC2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C15H18N4O2/c1-19-14(20)9-13(12-7-8-16-10-17-12)18-15(19)21-11-5-3-2-4-6-11/h7-11H,2-6H2,1H3
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n/an/a 22.6n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155192
PNG
(US9006232, 1.226)
Show SMILES CN1Cc2ccc(cc2C1)N1CCC(CC1)Oc1nc(cc(=O)n1C)-c1ccncn1
Show InChI InChI=1S/C23H26N6O2/c1-27-13-16-3-4-18(11-17(16)14-27)29-9-6-19(7-10-29)31-23-26-21(12-22(30)28(23)2)20-5-8-24-15-25-20/h3-5,8,11-12,15,19H,6-7,9-10,13-14H2,1-2H3
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n/an/a 23.7n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155204
PNG
(US9006232, 1.304)
Show SMILES Cn1c(OC2CCN(CC2)c2ccccc2CN2Cc3ccccc3C2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C29H30N6O2/c1-33-28(36)16-26(25-10-13-30-20-31-25)32-29(33)37-24-11-14-35(15-12-24)27-9-5-4-8-23(27)19-34-17-21-6-2-3-7-22(21)18-34/h2-10,13,16,20,24H,11-12,14-15,17-19H2,1H3
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n/an/a 25.2n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155246
PNG
(US9006232, 2.303)
Show SMILES Cn1c(OCC(=O)c2ccc(Br)cc2)nc(cc1=O)-c1ccncc1F
Show InChI InChI=1S/C18H13BrFN3O3/c1-23-17(25)8-15(13-6-7-21-9-14(13)20)22-18(23)26-10-16(24)11-2-4-12(19)5-3-11/h2-9H,10H2,1H3
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n/an/a 27n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155176
PNG
(US9006232, 1.210)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(cc1)N1CCC(CC1)Oc1nc(cc(=O)n1C)-c1ccncn1
Show InChI InChI=1S/C26H31N7O3/c1-19(34)31-13-15-33(16-14-31)21-5-3-20(4-6-21)32-11-8-22(9-12-32)36-26-29-24(17-25(35)30(26)2)23-7-10-27-18-28-23/h3-7,10,17-18,22H,8-9,11-16H2,1-2H3
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n/an/a 27.4n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155156
PNG
(US9006232, 1.102)
Show SMILES COC(=O)N1CCCC(C1)Oc1nc(cc(=O)n1C)-c1ccncn1
Show InChI InChI=1/C16H19N5O4/c1-20-14(22)8-13(12-5-6-17-10-18-12)19-15(20)25-11-4-3-7-21(9-11)16(23)24-2/h5-6,8,10-11H,3-4,7,9H2,1-2H3
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n/an/a 28.2n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155190
PNG
(US9006232, 1.224)
Show SMILES Cn1c(OC2CCN(CC2)c2cccnc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C19H20N6O2/c1-24-18(26)11-17(16-4-8-21-13-22-16)23-19(24)27-15-5-9-25(10-6-15)14-3-2-7-20-12-14/h2-4,7-8,11-13,15H,5-6,9-10H2,1H3
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n/an/a 29.8n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155227
PNG
(US9006232, 1.904)
Show SMILES CN1CCN(Cc2ccc(cc2)[C@@H]2CC[C@@H](CC2)Oc2nc(cc(=O)n2C)-c2ccncn2)CC1
Show InChI InChI=1/C27H34N6O2/c1-31-13-15-33(16-14-31)18-20-3-5-21(6-4-20)22-7-9-23(10-8-22)35-27-30-25(17-26(34)32(27)2)24-11-12-28-19-29-24/h3-6,11-12,17,19,22-23H,7-10,13-16,18H2,1-2H3/t22-,23+
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n/an/a 30.3n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155213
PNG
(US9006232, 1.701)
Show SMILES Cn1c(OC2CCCN(CC2)c2ccc(cc2)C#N)nc(cc1=O)-c1ccncn1
Show InChI InChI=1/C22H22N6O2/c1-27-21(29)13-20(19-8-10-24-15-25-19)26-22(27)30-18-3-2-11-28(12-9-18)17-6-4-16(14-23)5-7-17/h4-8,10,13,15,18H,2-3,9,11-12H2,1H3
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n/an/a 30.3n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155187
PNG
(US9006232, 1.221)
Show SMILES Cn1c(OC2CCN(CC2)c2cccc(CN3CCOCC3)c2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C25H30N6O3/c1-29-24(32)16-23(22-5-8-26-18-27-22)28-25(29)34-21-6-9-31(10-7-21)20-4-2-3-19(15-20)17-30-11-13-33-14-12-30/h2-5,8,15-16,18,21H,6-7,9-14,17H2,1H3
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n/an/a 31.5n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155173
PNG
(US9006232, 1.207)
Show SMILES Cn1c(OC2CCN(CC2)c2ccc(cc2)-c2ccncc2)nc(cc1=O)-c1ccncc1F
Show InChI InChI=1S/C26H24FN5O2/c1-31-25(33)16-24(22-8-13-29-17-23(22)27)30-26(31)34-21-9-14-32(15-10-21)20-4-2-18(3-5-20)19-6-11-28-12-7-19/h2-8,11-13,16-17,21H,9-10,14-15H2,1H3
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n/an/a 32.6n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau Protein Kinase 1 (TPK1)


(Bos taurus (Bovine))
BDBM142849
PNG
(US8940738, 5)
Show SMILES Cn1c(nc(cc1=O)-c1ncncc1F)N1CCCC(C1)c1ccc(cc1)N1CCCC1
Show InChI InChI=1/C24H27FN6O/c1-29-22(32)13-21(23-20(25)14-26-16-27-23)28-24(29)31-12-4-5-18(15-31)17-6-8-19(9-7-17)30-10-2-3-11-30/h6-9,13-14,16,18H,2-5,10-12,15H2,1H3
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n/an/a 33.1n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...


US Patent US8940738 (2015)

More data for this
Ligand-Target Pair
Tau Protein Kinase 1 (TPK1)


(Bos taurus (Bovine))
BDBM142847
PNG
(US8940738, 3)
Show SMILES Cn1c(nc(cc1=O)-c1ncncc1F)N1CCOC[C@H]1CF
Show InChI InChI=1/C14H15F2N5O2/c1-20-12(22)4-11(13-10(16)6-17-8-18-13)19-14(20)21-2-3-23-7-9(21)5-15/h4,6,8-9H,2-3,5,7H2,1H3/t9-/s2
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n/an/a 33.4n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...


US Patent US8940738 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155208
PNG
(US9006232, 1.502)
Show SMILES Cn1c(OC2CCN(CCC3CCN(Cc4ccccc4)CC3)CC2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C28H36N6O2/c1-32-27(35)19-26(25-7-13-29-21-30-25)31-28(32)36-24-11-17-33(18-12-24)14-8-22-9-15-34(16-10-22)20-23-5-3-2-4-6-23/h2-7,13,19,21-22,24H,8-12,14-18,20H2,1H3
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n/an/a 33.9n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155171
PNG
(US9006232, 1.205)
Show SMILES Cn1c(OC2CCN(CC2)c2ccccc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C20H21N5O2/c1-24-19(26)13-18(17-7-10-21-14-22-17)23-20(24)27-16-8-11-25(12-9-16)15-5-3-2-4-6-15/h2-7,10,13-14,16H,8-9,11-12H2,1H3
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n/an/a 37.6n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155236
PNG
(US9006232, 2.204)
Show SMILES Cn1c(OC[C@@H]2CCCN2c2ccc(F)cc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1/C20H20FN5O2/c1-25-19(27)11-18(17-8-9-22-13-23-17)24-20(25)28-12-16-3-2-10-26(16)15-6-4-14(21)5-7-15/h4-9,11,13,16H,2-3,10,12H2,1H3/t16-/s2
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n/an/a 37.6n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155212
PNG
(US9006232, 1.601)
Show SMILES CN(C)Cc1ccc(cc1)C(=O)N1CCC(CC1)Oc1nc(cc(=O)n1C)-c1ccncn1
Show InChI InChI=1S/C24H28N6O3/c1-28(2)15-17-4-6-18(7-5-17)23(32)30-12-9-19(10-13-30)33-24-27-21(14-22(31)29(24)3)20-8-11-25-16-26-20/h4-8,11,14,16,19H,9-10,12-13,15H2,1-3H3
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n/an/a 39.8n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155199
PNG
(US9006232, 1.233)
Show SMILES Cn1c(OCC2CCN(CC2)c2ccc(CN3CCCCC3)cc2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C27H34N6O2/c1-31-26(34)17-25(24-9-12-28-20-29-24)30-27(31)35-19-22-10-15-33(16-11-22)23-7-5-21(6-8-23)18-32-13-3-2-4-14-32/h5-9,12,17,20,22H,2-4,10-11,13-16,18-19H2,1H3
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n/an/a 41.6n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155235
PNG
(US9006232, 2.203)
Show SMILES Cn1c(OC[C@H]2CCCN2c2ccc(F)cc2)nc(cc1=O)-c1ccncc1F
Show InChI InChI=1/C21H20F2N4O2/c1-26-20(28)11-19(17-8-9-24-12-18(17)23)25-21(26)29-13-16-3-2-10-27(16)15-6-4-14(22)5-7-15/h4-9,11-12,16H,2-3,10,13H2,1H3/t16-/s2
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n/an/a 43.1n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
Tau protein kinase 1 (TPK1)


(Bos taurus (cattle))
BDBM155206
PNG
(US9006232, 1.401)
Show SMILES Cn1c(OC2CCN(CC2)c2ccc3NC(=O)OCc3c2)nc(cc1=O)-c1ccncn1
Show InChI InChI=1S/C22H22N6O4/c1-27-20(29)11-19(18-4-7-23-13-24-18)25-21(27)32-16-5-8-28(9-6-16)15-2-3-17-14(10-15)12-31-22(30)26-17/h2-4,7,10-11,13,16H,5-6,8-9,12H2,1H3,(H,26,30)
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n/an/a 43.7n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...


US Patent US9006232 (2015)

More data for this
Ligand-Target Pair
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