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Compile Data Set for Download or QSAR

Found 858 hits Enz. Inhib. hit(s) with Target = 'Telomerase reverse transcriptase' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50339190
PNG
(CHEMBL443683 | telomestatin)
Show SMILES Cc1oc2nc1c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1SCc(n1)c1[nH]c2c(C)o1
Show InChI InChI=1S/C26H14N8O7S/c1-9-17-24-30-14(6-39-24)21-28-12(4-37-21)19-27-11(3-35-19)20-29-13(5-36-20)22-31-15(7-38-22)26-32-16(8-42-26)23-33-18(10(2)40-23)25(34-17)41-9/h3-7,33H,8H2,1-2H3/b20-11+,21-14+,26-15+
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n/an/a 0.640n/an/an/an/an/an/a



Institut National de la Sant£ et de la Recherche M£dicale

Curated by ChEMBL


Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50339190
PNG
(CHEMBL443683 | telomestatin)
Show SMILES Cc1oc2nc1c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1SCc(n1)c1[nH]c2c(C)o1
Show InChI InChI=1S/C26H14N8O7S/c1-9-17-24-30-14(6-39-24)21-28-12(4-37-21)19-27-11(3-35-19)20-29-13(5-36-20)22-31-15(7-38-22)26-32-16(8-42-26)23-33-18(10(2)40-23)25(34-17)41-9/h3-7,33H,8H2,1-2H3/b20-11+,21-14+,26-15+
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n/an/a 0.700n/an/an/an/an/an/a



Institut National de la Sant£ et de la Recherche M£dicale

Curated by ChEMBL


Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50339190
PNG
(CHEMBL443683 | telomestatin)
Show SMILES Cc1oc2nc1c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1SCc(n1)c1[nH]c2c(C)o1
Show InChI InChI=1S/C26H14N8O7S/c1-9-17-24-30-14(6-39-24)21-28-12(4-37-21)19-27-11(3-35-19)20-29-13(5-36-20)22-31-15(7-38-22)26-32-16(8-42-26)23-33-18(10(2)40-23)25(34-17)41-9/h3-7,33H,8H2,1-2H3/b20-11+,21-14+,26-15+
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n/an/a 0.700n/an/an/an/an/an/a



Universita` degli Studi La Sapienza

Curated by ChEMBL


Assay Description
Inhibition of human Telomerase activity in cell free system by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50376748
PNG
(CHEMBL259739 | Phen-DC3)
Show SMILES C[n+]1cc(NC(=O)c2ccc3ccc4ccc(nc4c3n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12
Show InChI InChI=1S/C34H24N6O2/c1-39-19-25(17-23-7-3-5-9-29(23)39)35-33(41)27-15-13-21-11-12-22-14-16-28(38-32(22)31(21)37-27)34(42)36-26-18-24-8-4-6-10-30(24)40(2)20-26/h3-20H,1-2H3/p+2
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n/an/a 1.5n/an/an/an/an/an/a



Institut National de la Sant£ et de la Recherche M£dicale

Curated by ChEMBL


Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50376748
PNG
(CHEMBL259739 | Phen-DC3)
Show SMILES C[n+]1cc(NC(=O)c2ccc3ccc4ccc(nc4c3n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12
Show InChI InChI=1S/C34H24N6O2/c1-39-19-25(17-23-7-3-5-9-29(23)39)35-33(41)27-15-13-21-11-12-22-14-16-28(38-32(22)31(21)37-27)34(42)36-26-18-24-8-4-6-10-30(24)40(2)20-26/h3-20H,1-2H3/p+2
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n/an/a 2.20n/an/an/an/an/an/a



Institut National de la Sant£ et de la Recherche M£dicale

Curated by ChEMBL


Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50310892
PNG
(CHEMBL1078511 | N,N'-(9-(2-(1-methylpyrrolidin-2-y...)
Show SMILES CN1CCCC1CCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Show InChI InChI=1S/C34H47N7O2/c1-39-16-6-7-27(39)12-15-35-34-28-10-8-25(36-32(42)13-21-40-17-2-3-18-40)23-30(28)38-31-24-26(9-11-29(31)34)37-33(43)14-22-41-19-4-5-20-41/h8-11,23-24,27H,2-7,12-22H2,1H3,(H,35,38)(H,36,42)(H,37,43)
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n/an/a 18n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50310892
PNG
(CHEMBL1078511 | N,N'-(9-(2-(1-methylpyrrolidin-2-y...)
Show SMILES CN1CCCC1CCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Show InChI InChI=1S/C34H47N7O2/c1-39-16-6-7-27(39)12-15-35-34-28-10-8-25(36-32(42)13-21-40-17-2-3-18-40)23-30(28)38-31-24-26(9-11-29(31)34)37-33(43)14-22-41-19-4-5-20-41/h8-11,23-24,27H,2-7,12-22H2,1H3,(H,35,38)(H,36,42)(H,37,43)
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n/an/a 18n/an/an/an/an/an/a



Universit£ degli Studi"Magna Gr£cia"

Curated by ChEMBL


Assay Description
Inhibition of telomerase (unknown origin) by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134027
PNG
(CHEMBL140180 | N,N'-(9-(2-(dimethylamino)ethylamin...)
Show SMILES CN(C)CCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Show InChI InChI=1S/C31H43N7O2/c1-36(2)20-13-32-31-25-9-7-23(33-29(39)11-18-37-14-3-4-15-37)21-27(25)35-28-22-24(8-10-26(28)31)34-30(40)12-19-38-16-5-6-17-38/h7-10,21-22H,3-6,11-20H2,1-2H3,(H,32,35)(H,33,39)(H,34,40)
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n/an/a 18n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50321611
PNG
(7-((6-chloropyridin-3-yl)methoxy)-2-(4-((6-chlorop...)
Show SMILES Clc1ccc(COc2ccc(cc2)-c2cc(=O)c3ccc(OCc4ccc(Cl)nc4)cc3o2)cn1
Show InChI InChI=1S/C27H18Cl2N2O4/c28-26-9-1-17(13-30-26)15-33-20-5-3-19(4-6-20)24-12-23(32)22-8-7-21(11-25(22)35-24)34-16-18-2-10-27(29)31-14-18/h1-14H,15-16H2
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n/an/a 18n/an/an/an/an/an/a



Punjabi University

Curated by ChEMBL


Assay Description
Inhibition of telomerase activity (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134010
PNG
(CHEMBL139511 | N,N'-(9-(2-aminophenylamino)acridin...)
Show SMILES Nc1ccccc1Nc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Show InChI InChI=1S/C33H39N7O2/c34-27-7-1-2-8-28(27)38-33-25-11-9-23(35-31(41)13-19-39-15-3-4-16-39)21-29(25)37-30-22-24(10-12-26(30)33)36-32(42)14-20-40-17-5-6-18-40/h1-2,7-12,21-22H,3-6,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
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n/an/a 20n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50440391
PNG
(CHEMBL2425367)
Show SMILES CN(C)CCCNCc1ccc2nc3c(ccc4nc5ccc(CNCCCN(C)C)cc5cc34)cc2c1
Show InChI InChI=1S/C32H40N6/c1-37(2)15-5-13-33-21-23-8-11-30-26(17-23)19-25-9-12-31-28(32(25)36-30)20-27-18-24(7-10-29(27)35-31)22-34-14-6-16-38(3)4/h7-12,17-20,33-34H,5-6,13-16,21-22H2,1-4H3
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n/an/a 28n/an/an/an/an/an/a



Universit£ degli Studi"Magna Gr£cia"

Curated by ChEMBL


Assay Description
Inhibition of telomerase (unknown origin) by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50196500
PNG
(CHEMBL224754 | trimethyl(2-{6,8,17,19-tetraoxo-18-...)
Show SMILES C[N+](C)(C)CCn1c(=O)c2ccc3c4ccc5c6c(ccc(c7ccc(c2c37)c1=O)c46)c(=O)n(CC[N+](C)(C)C)c5=O
Show InChI InChI=1S/C34H34N4O4/c1-37(2,3)17-15-35-31(39)23-11-7-19-21-9-13-25-30-26(34(42)36(33(25)41)16-18-38(4,5)6)14-10-22(28(21)30)20-8-12-24(32(35)40)29(23)27(19)20/h7-14H,15-18H2,1-6H3/q+2
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n/an/a 30n/an/an/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Inhibition of telomerase in JR8 cell extract by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134022
PNG
(CHEMBL336444 | N,N'-(9-(4-acetylphenylamino)acridi...)
Show SMILES CC(=O)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C35H40N6O3/c1-24(42)25-6-8-26(9-7-25)38-35-29-12-10-27(36-33(43)14-20-40-16-2-3-17-40)22-31(29)39-32-23-28(11-13-30(32)35)37-34(44)15-21-41-18-4-5-19-41/h6-13,22-23H,2-5,14-21H2,1H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/a 40n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50376747
PNG
(CHEMBL409247)
Show SMILES C[n+]1cc(NC(=O)c2cccc(n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12
Show InChI InChI=1S/C27H21N5O2/c1-31-16-20(14-18-8-3-5-12-24(18)31)28-26(33)22-10-7-11-23(30-22)27(34)29-21-15-19-9-4-6-13-25(19)32(2)17-21/h3-17H,1-2H3/p+2
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n/an/a 45n/an/an/an/an/an/a



Institut National de la Sant£ et de la Recherche M£dicale

Curated by ChEMBL


Assay Description
Inhibition of human telomerase expressed in in HEK293T cells in presence of primer (T2AG3)4 by primer extension assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134030
PNG
(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/a 45n/an/an/an/an/an/a



Institut National de la Sant£ et de la Recherche M£dicale

Curated by ChEMBL


Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134032
PNG
(CHEMBL138811 | N,N'-(9-(cyclopropylamino)acridine-...)
Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(NC3CC3)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1
Show InChI InChI=1S/C30H38N6O2/c37-28(11-17-35-13-1-2-14-35)31-22-7-9-24-26(19-22)34-27-20-23(8-10-25(27)30(24)33-21-5-6-21)32-29(38)12-18-36-15-3-4-16-36/h7-10,19-21H,1-6,11-18H2,(H,31,37)(H,32,38)(H,33,34)
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n/an/a 50n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50058033
PNG
(CHEMBL3330787)
Show SMILES Cl.CNCCNc1c2C(=O)c3ccccc3C(=O)c2c(NCCNC(N)=N)c2sccc12
Show InChI InChI=1S/C22H24N6O2S.ClH/c1-25-7-8-26-17-14-6-11-31-21(14)18(27-9-10-28-22(23)24)16-15(17)19(29)12-4-2-3-5-13(12)20(16)30;/h2-6,11,25-27H,7-10H2,1H3,(H4,23,24,28);1H
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n/an/a 50n/an/an/an/an/an/a



Russian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human telomerase transfected in human HEK293T cells assessed as DNA extension using 5'-d(AATCCGTCGAGCAGAGTT)-3' substrate by Real-time ...


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134002
PNG
(CHEMBL141540 | N,N'-(9-(2-(piperidin-1-yl)ethylami...)
Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(NCCN3CCCCC3)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1
Show InChI InChI=1S/C34H47N7O2/c42-32(12-21-39-17-4-5-18-39)36-26-8-10-28-30(24-26)38-31-25-27(37-33(43)13-22-40-19-6-7-20-40)9-11-29(31)34(28)35-14-23-41-15-2-1-3-16-41/h8-11,24-25H,1-7,12-23H2,(H,35,38)(H,36,42)(H,37,43)
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n/an/a 50n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50376747
PNG
(CHEMBL409247)
Show SMILES C[n+]1cc(NC(=O)c2cccc(n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12
Show InChI InChI=1S/C27H21N5O2/c1-31-16-20(14-18-8-3-5-12-24(18)31)28-26(33)22-10-7-11-23(30-22)27(34)29-21-15-19-9-4-6-13-25(19)32(2)17-21/h3-17H,1-2H3/p+2
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n/an/a 52n/an/an/an/an/an/a



Institut National de la Sant£ et de la Recherche M£dicale

Curated by ChEMBL


Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50339190
PNG
(CHEMBL443683 | telomestatin)
Show SMILES Cc1oc2nc1c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1SCc(n1)c1[nH]c2c(C)o1
Show InChI InChI=1S/C26H14N8O7S/c1-9-17-24-30-14(6-39-24)21-28-12(4-37-21)19-27-11(3-35-19)20-29-13(5-36-20)22-31-15(7-38-22)26-32-16(8-42-26)23-33-18(10(2)40-23)25(34-17)41-9/h3-7,33H,8H2,1-2H3/b20-11+,21-14+,26-15+
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n/an/a 58n/an/an/an/an/an/a



Institut National de la Sant£ et de la Recherche M£dicale

Curated by ChEMBL


Assay Description
Inhibition of human telomerase expressed in in HEK293T cells in presence of primer (T2AG3)4 by primer extension assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134019
PNG
(CHEMBL336417 | N,N'-(9-(3-aminophenylamino)acridin...)
Show SMILES Nc1cccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)c1
Show InChI InChI=1S/C33H39N7O2/c34-23-6-5-7-24(20-23)37-33-27-10-8-25(35-31(41)12-18-39-14-1-2-15-39)21-29(27)38-30-22-26(9-11-28(30)33)36-32(42)13-19-40-16-3-4-17-40/h5-11,20-22H,1-4,12-19,34H2,(H,35,41)(H,36,42)(H,37,38)
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n/an/a 60n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134009
PNG
(CHEMBL335132 | N,N'-(9-(3-(dimethylamino)propylami...)
Show SMILES CN(C)CCCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Show InChI InChI=1S/C32H45N7O2/c1-37(2)15-7-14-33-32-26-10-8-24(34-30(40)12-20-38-16-3-4-17-38)22-28(26)36-29-23-25(9-11-27(29)32)35-31(41)13-21-39-18-5-6-19-39/h8-11,22-23H,3-7,12-21H2,1-2H3,(H,33,36)(H,34,40)(H,35,41)
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n/an/a 60n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50196492
PNG
(2,9-bis-[2-(2-hydroxy-ethylamino)-ethyl]-anthra[2,...)
Show SMILES OCCNCCn1c(=O)c2ccc3c4ccc5c6c(ccc(c7ccc(c2c37)c1=O)c46)c(=O)n(CCNCCO)c5=O
Show InChI InChI=1S/C32H28N4O6/c37-15-11-33-9-13-35-29(39)21-5-1-17-18-2-6-23-28-24(32(42)36(31(23)41)14-10-34-12-16-38)8-4-20(26(18)28)19-3-7-22(30(35)40)27(21)25(17)19/h1-8,33-34,37-38H,9-16H2
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n/an/a 60n/an/an/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Inhibition of telomerase in JR8 cell extract by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134018
PNG
(CHEMBL335819 | N,N'-(9-(4-aminophenylamino)acridin...)
Show SMILES Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C33H39N7O2/c34-23-5-7-24(8-6-23)37-33-27-11-9-25(35-31(41)13-19-39-15-1-2-16-39)21-29(27)38-30-22-26(10-12-28(30)33)36-32(42)14-20-40-17-3-4-18-40/h5-12,21-22H,1-4,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
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n/an/a 60n/an/an/an/an/an/a



Universit£ degli Studi"Magna Gr£cia"

Curated by ChEMBL


Assay Description
Inhibition of telomerase (unknown origin) by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50107609
PNG
(5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin | C...)
Show SMILES C[n+]1ccc(cc1)-c1c2ccc(n2)c(-c2cc[n+](C)cc2)c2ccc([nH]2)c(-c2cc[n+](C)cc2)c2ccc([nH]2)c(-c2cc[n+](C)cc2)c2ccc1n2
Show InChI InChI=1S/C44H37N8/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31/h5-28H,1-4H3,(H,45,46,47,48)/q+3/p+1/b41-33-,41-34-,42-35-,42-37-,43-36-,43-38-,44-39-,44-40-
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n/an/a 60n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by te...


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50376747
PNG
(CHEMBL409247)
Show SMILES C[n+]1cc(NC(=O)c2cccc(n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12
Show InChI InChI=1S/C27H21N5O2/c1-31-16-20(14-18-8-3-5-12-24(18)31)28-26(33)22-10-7-11-23(30-22)27(34)29-21-15-19-9-4-6-13-25(19)32(2)17-21/h3-17H,1-2H3/p+2
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n/an/a 63n/an/an/an/an/an/a



Institut National de la Sant£ et de la Recherche M£dicale

Curated by ChEMBL


Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50376748
PNG
(CHEMBL259739 | Phen-DC3)
Show SMILES C[n+]1cc(NC(=O)c2ccc3ccc4ccc(nc4c3n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12
Show InChI InChI=1S/C34H24N6O2/c1-39-19-25(17-23-7-3-5-9-29(23)39)35-33(41)27-15-13-21-11-12-22-14-16-28(38-32(22)31(21)37-27)34(42)36-26-18-24-8-4-6-10-30(24)40(2)20-26/h3-20H,1-2H3/p+2
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n/an/a 63n/an/an/an/an/an/a



Institut National de la Sant£ et de la Recherche M£dicale

Curated by ChEMBL


Assay Description
Inhibition of human telomerase expressed in in HEK293T cells in presence of primer (T2AG3)4 by primer extension assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134030
PNG
(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/a 65n/an/an/an/an/an/a



Institut National de la Sant£ et de la Recherche M£dicale

Curated by ChEMBL


Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134025
PNG
(CHEMBL343795 | N,N'-(9-(4-fluorophenylamino)acridi...)
Show SMILES Fc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C33H37FN6O2/c34-23-5-7-24(8-6-23)37-33-27-11-9-25(35-31(41)13-19-39-15-1-2-16-39)21-29(27)38-30-22-26(10-12-28(30)33)36-32(42)14-20-40-17-3-4-18-40/h5-12,21-22H,1-4,13-20H2,(H,35,41)(H,36,42)(H,37,38)
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n/an/a 70n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50058035
PNG
(CHEMBL3330789)
Show SMILES Cl.NCCCNc1c2C(=O)c3ccccc3C(=O)c2c(NCCNC(N)=N)c2ccsc12
Show InChI InChI=1S/C22H24N6O2S.ClH/c23-7-3-8-26-18-16-15(19(29)12-4-1-2-5-13(12)20(16)30)17(14-6-11-31-21(14)18)27-9-10-28-22(24)25;/h1-2,4-6,11,26-27H,3,7-10,23H2,(H4,24,25,28);1H
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n/an/a 70n/an/an/an/an/an/a



Russian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human telomerase transfected in human HEK293T cells assessed as DNA extension using 5'-d(AATCCGTCGAGCAGAGTT)-3' substrate by Real-time ...


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134018
PNG
(CHEMBL335819 | N,N'-(9-(4-aminophenylamino)acridin...)
Show SMILES Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C33H39N7O2/c34-23-5-7-24(8-6-23)37-33-27-11-9-25(35-31(41)13-19-39-15-1-2-16-39)21-29(27)38-30-22-26(10-12-28(30)33)36-32(42)14-20-40-17-3-4-18-40/h5-12,21-22H,1-4,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
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n/an/a 74n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50058037
PNG
(CHEMBL3330791)
Show SMILES Cl.NC(=N)NCCNc1c2C(=O)c3ccccc3C(=O)c2c(NCCNC(N)=N)c2sccc12
Show InChI InChI=1S/C22H24N8O2S.ClH/c23-21(24)29-8-6-27-16-13-5-10-33-20(13)17(28-7-9-30-22(25)26)15-14(16)18(31)11-3-1-2-4-12(11)19(15)32;/h1-5,10,27-28H,6-9H2,(H4,23,24,29)(H4,25,26,30);1H
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n/an/a 80n/an/an/an/an/an/a



Russian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human telomerase transfected in human HEK293T cells assessed as DNA extension using 5'-d(AATCCGTCGAGCAGAGTT)-3' substrate by Real-time ...


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50150618
PNG
(CHEMBL182871 | Hexanedioic acid {4-[3,6-bis-(3-pyr...)
Show SMILES CCN(CC)CCCCCCNC(=O)CCCCC(=O)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C49H69N9O4/c1-3-56(4-2)28-10-6-5-9-27-50-45(59)15-7-8-16-46(60)51-37-17-19-38(20-18-37)54-49-41-23-21-39(52-47(61)25-33-57-29-11-12-30-57)35-43(41)55-44-36-40(22-24-42(44)49)53-48(62)26-34-58-31-13-14-32-58/h17-24,35-36H,3-16,25-34H2,1-2H3,(H,50,59)(H,51,60)(H,52,61)(H,53,62)(H,54,55)
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n/an/a 80n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134023
PNG
(CHEMBL337762 | N,N'-(9-(4-aminophenylamino)acridin...)
Show SMILES Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3ccc(NC(=O)CCN4CCCC4)cc23)cc1
Show InChI InChI=1S/C33H39N7O2/c34-23-5-7-24(8-6-23)37-33-27-11-9-26(36-32(42)14-20-40-17-3-4-18-40)22-30(27)38-29-12-10-25(21-28(29)33)35-31(41)13-19-39-15-1-2-16-39/h5-12,21-22H,1-4,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
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n/an/a 80n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134008
PNG
(CHEMBL138187 | N,N'-(9-(3-(dimethylamino)propylami...)
Show SMILES CN(C)CCCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2ccc(NC(=O)CCN3CCCC3)cc12
Show InChI InChI=1S/C32H45N7O2/c1-37(2)15-7-14-33-32-26-10-8-25(35-31(41)13-21-39-18-5-6-19-39)23-29(26)36-28-11-9-24(22-27(28)32)34-30(40)12-20-38-16-3-4-17-38/h8-11,22-23H,3-7,12-21H2,1-2H3,(H,33,36)(H,34,40)(H,35,41)
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n/an/a 80n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134030
PNG
(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/a 90n/an/an/an/an/an/a



Universit£ de Reims-Champagne-Ardenne

Curated by ChEMBL


Assay Description
Inhibition of human telomerase in A549 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134000
PNG
(CHEMBL139287 | N,N'-(9-(cyclohexylamino)acridine-3...)
Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(NC3CCCCC3)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1
Show InChI InChI=1S/C33H44N6O2/c40-31(14-20-38-16-4-5-17-38)34-25-10-12-27-29(22-25)37-30-23-26(35-32(41)15-21-39-18-6-7-19-39)11-13-28(30)33(27)36-24-8-2-1-3-9-24/h10-13,22-24H,1-9,14-21H2,(H,34,40)(H,35,41)(H,36,37)
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n/an/a 90n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50126186
PNG
(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Show SMILES C\C(=C/C(=O)Nc1ccccc1C(O)=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+
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n/an/a 93n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of human telomerase isolated from human HeLa cells nuclear extracts expressed in insect cells assessed as [33P]dCMP incorporation after 30...


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50126186
PNG
(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Show SMILES C\C(=C/C(=O)Nc1ccccc1C(O)=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+
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n/an/a 93n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human HeLa cells after 2 hrs by [alpha-32P]dGTP incorporation assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50126186
PNG
(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Show SMILES C\C(=C/C(=O)Nc1ccccc1C(O)=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+
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n/an/a 93n/an/an/an/an/an/a



Anhui Medical University

Curated by ChEMBL


Assay Description
Inhibition of human telomerase


Eur J Med Chem 112: 231-51 (2016)

More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50150622
PNG
(CHEMBL184587 | Hexanedioic acid {4-[3,6-bis-(3-pyr...)
Show SMILES CCN(CC)CCNC(=O)CCCCC(=O)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C45H61N9O4/c1-3-52(4-2)30-23-46-41(55)11-5-6-12-42(56)47-33-13-15-34(16-14-33)50-45-37-19-17-35(48-43(57)21-28-53-24-7-8-25-53)31-39(37)51-40-32-36(18-20-38(40)45)49-44(58)22-29-54-26-9-10-27-54/h13-20,31-32H,3-12,21-30H2,1-2H3,(H,46,55)(H,47,56)(H,48,57)(H,49,58)(H,50,51)
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n/an/a 98n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134020
PNG
(CHEMBL141661 | N,N'-(9-(3-acetamidophenylamino)acr...)
Show SMILES CC(=O)Nc1cccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)c1
Show InChI InChI=1S/C35H41N7O3/c1-24(43)36-25-7-6-8-26(21-25)39-35-29-11-9-27(37-33(44)13-19-41-15-2-3-16-41)22-31(29)40-32-23-28(10-12-30(32)35)38-34(45)14-20-42-17-4-5-18-42/h6-12,21-23H,2-5,13-20H2,1H3,(H,36,43)(H,37,44)(H,38,45)(H,39,40)
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n/an/a 100n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50058034
PNG
(CHEMBL3330788)
Show SMILES Cl.NCCNc1c2C(=O)c3ccccc3C(=O)c2c(NCCNC(N)=N)c2ccsc12
Show InChI InChI=1S/C21H22N6O2S.ClH/c22-6-7-25-17-15-14(18(28)11-3-1-2-4-12(11)19(15)29)16(13-5-10-30-20(13)17)26-8-9-27-21(23)24;/h1-5,10,25-26H,6-9,22H2,(H4,23,24,27);1H
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n/an/a 100n/an/an/an/an/an/a



Russian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human telomerase transfected in human HEK293T cells assessed as DNA extension using 5'-d(AATCCGTCGAGCAGAGTT)-3' substrate by Real-time ...


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50440390
PNG
(ISOMETAMIDIUM)
Show SMILES CCn1c(-c2ccccc2)c2cc(NN=Nc3cccc(c3)C(N)=N)ccc2c2ccc(=[NH2+])cc12
Show InChI InChI=1S/C28H25N7/c1-2-35-26-16-20(29)11-13-24(26)23-14-12-22(17-25(23)27(35)18-7-4-3-5-8-18)33-34-32-21-10-6-9-19(15-21)28(30)31/h3-17,29H,2H2,1H3,(H3,30,31)(H,32,33)/p+1
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n/an/a 100n/an/an/an/an/an/a



Universit£ degli Studi"Magna Gr£cia"

Curated by ChEMBL


Assay Description
Inhibition of telomerase (unknown origin) by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134026
PNG
(CHEMBL138487 | N,N'-(9-(3-(dimethylamino)phenylami...)
Show SMILES CN(C)c1cccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)c1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-9-7-8-25(22-28)38-35-29-12-10-26(36-33(43)14-20-41-16-3-4-17-41)23-31(29)39-32-24-27(11-13-30(32)35)37-34(44)15-21-42-18-5-6-19-42/h7-13,22-24H,3-6,14-21H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/a 100n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134030
PNG
(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/a 100n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134021
PNG
(CHEMBL138761 | N,N'-(9-(3-(methylthio)phenylamino)...)
Show SMILES CSc1cccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)c1
Show InChI InChI=1S/C34H40N6O2S/c1-43-27-8-6-7-24(21-27)37-34-28-11-9-25(35-32(41)13-19-39-15-2-3-16-39)22-30(28)38-31-23-26(10-12-29(31)34)36-33(42)14-20-40-17-4-5-18-40/h6-12,21-23H,2-5,13-20H2,1H3,(H,35,41)(H,36,42)(H,37,38)
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n/an/a 100n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50440389
PNG
(CHEMBL1997011)
Show SMILES CCNCC(=O)Nc1ccc2C(=O)c3cc(NC(=O)CNCC)ccc3C(=O)c2c1
Show InChI InChI=1S/C22H24N4O4/c1-3-23-11-19(27)25-13-5-7-15-17(9-13)21(29)16-8-6-14(10-18(16)22(15)30)26-20(28)12-24-4-2/h5-10,23-24H,3-4,11-12H2,1-2H3,(H,25,27)(H,26,28)
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n/an/a 100n/an/an/an/an/an/a



Universit£ degli Studi"Magna Gr£cia"

Curated by ChEMBL


Assay Description
Inhibition of telomerase (unknown origin) by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50134011
PNG
(CHEMBL343609 | N,N'-(9-(2-aminophenylamino)acridin...)
Show SMILES Nc1ccccc1Nc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2ccc(NC(=O)CCN3CCCC3)cc12
Show InChI InChI=1S/C33H39N7O2/c34-27-7-1-2-8-29(27)38-33-25-11-9-24(36-32(42)14-20-40-17-5-6-18-40)22-30(25)37-28-12-10-23(21-26(28)33)35-31(41)13-19-39-15-3-4-16-39/h1-2,7-12,21-22H,3-6,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
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n/an/a 110n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens)
BDBM50079528
PNG
(CHEMBL3417316)
Show SMILES CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(=O)NCCO
Show InChI InChI=1/C31H43NO4/c1-19-20-7-8-23-29(4,21(20)17-22(34)25(19)35)12-14-31(6)24-18-28(3,26(36)32-15-16-33)10-9-27(24,2)11-13-30(23,31)5/h7-8,17,24,33,35H,9-16,18H2,1-6H3,(H,32,36)/t24-,27-,28-,29+,30-,31+/s2
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n/an/a 110n/an/an/an/an/an/a



Anhui Medical University

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA


Citation and Details
More data for this
Ligand-Target Pair
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