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Found 11 hits Enz. Inhib. hit(s) with Target = 'Thymidine phosphorylase (TP)' AND taxid = 83334   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152488
PNG
(5(4'-Hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thi...)
Show SMILES Oc1ccc(cc1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C8H6N2O2S/c11-6-3-1-5(2-4-6)7-9-10-8(13)12-7/h1-4,11H,(H,10,13)
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n/an/a 3.82E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Bioorg Chem 60: 37-41 (2015)

More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM50134399
PNG
(1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 7...)
Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1
Show InChI InChI=1S/C6H5N3O2/c10-5-3-1-2-7-4(3)8-6(11)9-5/h1-2H,(H3,7,8,9,10,11)
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n/an/a 3.87E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Bioorg Chem 60: 37-41 (2015)

More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152484
PNG
(5-Phenyl-1,3,4-oxadiazole-2(3H)-thione (1))
Show SMILES S=c1[nH]nc(o1)-c1ccccc1
Show InChI InChI=1S/C8H6N2OS/c12-8-10-9-7(11-8)6-4-2-1-3-5-6/h1-5H,(H,10,12)
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n/an/a 5.00E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Bioorg Chem 60: 37-41 (2015)

More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152490
PNG
(5-(3',4',5'-Trimethoxyphenyl)-1,3,4-ox...)
Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C11H12N2O4S/c1-14-7-4-6(10-12-13-11(18)17-10)5-8(15-2)9(7)16-3/h4-5H,1-3H3,(H,13,18)
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n/an/a 6.34E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Bioorg Chem 60: 37-41 (2015)

More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152493
PNG
(5-(4'-Bromophenyl)-1,3,4-oxadiazole-2(3H)-thio...)
Show SMILES Brc1ccc(cc1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C8H5BrN2OS/c9-6-3-1-5(2-4-6)7-10-11-8(13)12-7/h1-4H,(H,11,13)
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n/an/a 6.40E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Bioorg Chem 60: 37-41 (2015)

More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152492
PNG
(5-(4'-Chlorophenyl)-1,3,4-oxadiazole-2(3H)-thi...)
Show SMILES Clc1ccc(cc1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C8H5ClN2OS/c9-6-3-1-5(2-4-6)7-10-11-8(13)12-7/h1-4H,(H,11,13)
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n/an/a 6.40E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Bioorg Chem 60: 37-41 (2015)

More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152485
PNG
(5-(2'-Hydroxyphenyl)-2,3-dihydro-1,3,4-oxadiaz...)
Show SMILES Oc1ccccc1-c1n[nH]c(=S)o1
Show InChI InChI=1S/C8H6N2O2S/c11-6-4-2-1-3-5(6)7-9-10-8(13)12-7/h1-4,11H,(H,10,13)
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n/an/a 6.84E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Bioorg Chem 60: 37-41 (2015)

More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152489
PNG
(5-(4'-Methoxyphenyl)-1,3,4-oxadiazole-2(3H)-th...)
Show SMILES COc1ccc(cc1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C9H8N2O2S/c1-12-7-4-2-6(3-5-7)8-10-11-9(14)13-8/h2-5H,1H3,(H,11,14)
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n/an/a 7.24E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Bioorg Chem 60: 37-41 (2015)

More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152486
PNG
(5-(2'-Aminophenyl)-1,3,4-oxadiazole-2(3H)-thio...)
Show SMILES Nc1ccccc1-c1n[nH]c(=S)o1
Show InChI InChI=1S/C8H7N3OS/c9-6-4-2-1-3-5(6)7-10-11-8(13)12-7/h1-4H,9H2,(H,11,13)
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n/an/a 7.43E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Bioorg Chem 60: 37-41 (2015)

More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152487
PNG
(5-(3'-Methylphenyl)-1,3,4-oxadiazole-2(3H)-thi...)
Show SMILES Cc1cccc(c1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C9H8N2OS/c1-6-3-2-4-7(5-6)8-10-11-9(13)12-8/h2-5H,1H3,(H,11,13)
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n/an/a 9.18E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Bioorg Chem 60: 37-41 (2015)

More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152491
PNG
(5-(3'-Chlorophenyl)-1,3,4-oxadiazole-2(3H)-thi...)
Show SMILES Clc1cccc(c1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C8H5ClN2OS/c9-6-3-1-2-5(4-6)7-10-11-8(13)12-7/h1-4H,(H,11,13)
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n/an/a 2.58E+5n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Bioorg Chem 60: 37-41 (2015)

More data for this
Ligand-Target Pair