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Found 11 hits Enz. Inhib. hit(s) with Target = 'Thymidine phosphorylase (TP)' AND taxid = 83334   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152488
PNG
(5(4'-Hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thi...)
Show SMILES Oc1ccc(cc1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C8H6N2O2S/c11-6-3-1-5(2-4-6)7-9-10-8(13)12-7/h1-4,11H,(H,10,13)
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n/an/a 3.82E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Citation and Details
More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM50134399
PNG
(1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 7...)
Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1
Show InChI InChI=1S/C6H5N3O2/c10-5-3-1-2-7-4(3)8-6(11)9-5/h1-2H,(H3,7,8,9,10,11)
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n/an/a 3.87E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Citation and Details
More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152484
PNG
(5-Phenyl-1,3,4-oxadiazole-2(3H)-thione (1))
Show SMILES S=c1[nH]nc(o1)-c1ccccc1
Show InChI InChI=1S/C8H6N2OS/c12-8-10-9-7(11-8)6-4-2-1-3-5-6/h1-5H,(H,10,12)
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n/an/a 5.00E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Citation and Details
More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152490
PNG
(5-(3',4',5'-Trimethoxyphenyl)-1,3,4-ox...)
Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C11H12N2O4S/c1-14-7-4-6(10-12-13-11(18)17-10)5-8(15-2)9(7)16-3/h4-5H,1-3H3,(H,13,18)
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n/an/a 6.34E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Citation and Details
More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152493
PNG
(5-(4'-Bromophenyl)-1,3,4-oxadiazole-2(3H)-thio...)
Show SMILES Brc1ccc(cc1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C8H5BrN2OS/c9-6-3-1-5(2-4-6)7-10-11-8(13)12-7/h1-4H,(H,11,13)
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n/an/a 6.40E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Citation and Details
More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152492
PNG
(5-(4'-Chlorophenyl)-1,3,4-oxadiazole-2(3H)-thi...)
Show SMILES Clc1ccc(cc1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C8H5ClN2OS/c9-6-3-1-5(2-4-6)7-10-11-8(13)12-7/h1-4H,(H,11,13)
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n/an/a 6.40E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Citation and Details
More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152485
PNG
(5-(2'-Hydroxyphenyl)-2,3-dihydro-1,3,4-oxadiaz...)
Show SMILES Oc1ccccc1-c1n[nH]c(=S)o1
Show InChI InChI=1S/C8H6N2O2S/c11-6-4-2-1-3-5(6)7-9-10-8(13)12-7/h1-4,11H,(H,10,13)
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n/an/a 6.84E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Citation and Details
More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152489
PNG
(5-(4'-Methoxyphenyl)-1,3,4-oxadiazole-2(3H)-th...)
Show SMILES COc1ccc(cc1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C9H8N2O2S/c1-12-7-4-2-6(3-5-7)8-10-11-9(14)13-8/h2-5H,1H3,(H,11,14)
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n/an/a 7.24E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Citation and Details
More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152486
PNG
(5-(2'-Aminophenyl)-1,3,4-oxadiazole-2(3H)-thio...)
Show SMILES Nc1ccccc1-c1n[nH]c(=S)o1
Show InChI InChI=1S/C8H7N3OS/c9-6-4-2-1-3-5(6)7-10-11-8(13)12-7/h1-4H,9H2,(H,11,13)
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n/an/a 7.43E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Citation and Details
More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152487
PNG
(5-(3'-Methylphenyl)-1,3,4-oxadiazole-2(3H)-thi...)
Show SMILES Cc1cccc(c1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C9H8N2OS/c1-6-3-2-4-7(5-6)8-10-11-9(13)12-8/h2-5H,1H3,(H,11,13)
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n/an/a 9.18E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Citation and Details
More data for this
Ligand-Target Pair
Thymidine phosphorylase (TP)


(Escherichia coli (Enterobacteria))
BDBM152491
PNG
(5-(3'-Chlorophenyl)-1,3,4-oxadiazole-2(3H)-thi...)
Show SMILES Clc1cccc(c1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C8H5ClN2OS/c9-6-3-1-2-5(4-6)7-10-11-8(13)12-7/h1-4H,(H,11,13)
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n/an/a 2.58E+5n/an/an/an/an/an/a



COMSATS Institute of Information Technology



Assay Description
Briefly, a total reaction mixture of 200 Ál contained 145 Ál of potassium phosphate buffer (pH 7.4), 30 Ál of enzyme at concentration 0.05 and 0.002 ...


Citation and Details
More data for this
Ligand-Target Pair