BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 27 hits Enz. Inhib. hit(s) with Target = 'Thyroid-stimulating hormone receptor (TSH)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60862
PNG
(BDBM189328 | US9174940, 32)
Show SMILES CC(=O)N1CCC(C)(C2C=C(NC(=O)OC3CCCC3)C=CC12)c1ccccc1
Show InChI InChI=1/C24H30N2O3/c1-17(27)26-15-14-24(2,18-8-4-3-5-9-18)21-16-19(12-13-22(21)26)25-23(28)29-20-10-6-7-11-20/h3-5,8-9,12-13,16,20-22H,6-7,10-11,14-15H2,1-2H3,(H,25,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 12n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM189329
PNG
((+)-(1-Acetyl-4-methyl-4-phenyl-1,2,3,4-tetrahydro...)
Show SMILES CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)OCc3ccc(F)c(Cl)c3)ccc12
Show InChI InChI=1/C26H24ClFN2O3/c1-17(31)30-13-12-26(2,19-6-4-3-5-7-19)21-15-20(9-11-24(21)30)29-25(32)33-16-18-8-10-23(28)22(27)14-18/h3-11,14-15H,12-13,16H2,1-2H3,(H,29,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 47n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM189327
PNG
(Hexanoic acid (Compound A) | US9174940, Compound A)
Show SMILES CC(=O)N1c2ccc(cc2C(C)(CC1(C)C)c1ccccc1)C(N)=O
Show InChI InChI=1/C21H24N2O2/c1-14(24)23-18-11-10-15(19(22)25)12-17(18)21(4,13-20(23,2)3)16-8-6-5-7-9-16/h5-12H,13H2,1-4H3,(H2,22,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 88n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60866
PNG
(US9174940, 36)
Show SMILES CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)NCc3cccc(Cl)c3)ccc12
Show InChI InChI=1/C26H26ClN3O2/c1-18(31)30-14-13-26(2,20-8-4-3-5-9-20)23-16-22(11-12-24(23)30)29-25(32)28-17-19-7-6-10-21(27)15-19/h3-12,15-16H,13-14,17H2,1-2H3,(H2,28,29,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60853
PNG
(US9174940, 27)
Show SMILES CC(C)CCOC(=O)Nc1ccc2N(CCC(C)(c3ccccc3)c2c1)C(C)=O
Show InChI InChI=1/C24H30N2O3/c1-17(2)12-15-29-23(28)25-20-10-11-22-21(16-20)24(4,13-14-26(22)18(3)27)19-8-6-5-7-9-19/h5-11,16-17H,12-15H2,1-4H3,(H,25,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60867
PNG
(US9174940, 37)
Show SMILES CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2[C@](C)(CC1(C)C)c1ccccc1
Show InChI InChI=1/C29H31ClN2O2/c1-20(33)32-26-15-14-24(31-27(34)16-13-21-9-8-12-23(30)17-21)18-25(26)29(4,19-28(32,2)3)22-10-6-5-7-11-22/h5-12,14-15,17-18H,13,16,19H2,1-4H3,(H,31,34)/t29-/s2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60849
PNG
(US9174940, 12)
Show SMILES CC(=O)N1c2ccc(NC(=O)CCc3cccs3)cc2C(C)(CC1(C)C)c1ccccc1
Show InChI InChI=1/C27H30N2O2S/c1-19(30)29-24-14-12-21(28-25(31)15-13-22-11-8-16-32-22)17-23(24)27(4,18-26(29,2)3)20-9-6-5-7-10-20/h5-12,14,16-17H,13,15,18H2,1-4H3,(H,28,31)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60855
PNG
(US9174940, 28)
Show SMILES CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)OCC3(C)CC3)ccc12
Show InChI InChI=1/C24H28N2O3/c1-17(27)26-14-13-24(3,18-7-5-4-6-8-18)20-15-19(9-10-21(20)26)25-22(28)29-16-23(2)11-12-23/h4-10,15H,11-14,16H2,1-3H3,(H,25,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60843
PNG
(US9174940, 1)
Show SMILES CCCCCC(=O)Nc1ccc2N(C(C)=O)C(C)(C)CC(C)(c3ccccc3)c2c1
Show InChI InChI=1/C26H34N2O2/c1-6-7-9-14-24(30)27-21-15-16-23-22(17-21)26(5,20-12-10-8-11-13-20)18-25(3,4)28(23)19(2)29/h8,10-13,15-17H,6-7,9,14,18H2,1-5H3,(H,27,30)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60844
PNG
(US9174940, 4)
Show SMILES CC(=O)N1c2ccc(NC(=O)c3ccccn3)cc2C(C)(CC1(C)C)c1ccccc1
Show InChI InChI=1/C26H27N3O2/c1-18(30)29-23-14-13-20(28-24(31)22-12-8-9-15-27-22)16-21(23)26(4,17-25(29,2)3)19-10-6-5-7-11-19/h5-16H,17H2,1-4H3,(H,28,31)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60845
PNG
(US9174940, 6)
Show SMILES CC(=O)N1c2ccc(NC(=O)OCCOc3ccccc3)cc2C(C)(CC1(C)C)c1ccccc1
Show InChI InChI=1/C29H32N2O4/c1-21(32)31-26-16-15-23(30-27(33)35-18-17-34-24-13-9-6-10-14-24)19-25(26)29(4,20-28(31,2)3)22-11-7-5-8-12-22/h5-16,19H,17-18,20H2,1-4H3,(H,30,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60847
PNG
(US9174940, 7)
Show SMILES CCCCOC(=O)Nc1ccc2N(C(C)=O)C(C)(C)CC(C)(c3ccccc3)c2c1
Show InChI InChI=1/C25H32N2O3/c1-6-7-15-30-23(29)26-20-13-14-22-21(16-20)25(5,19-11-9-8-10-12-19)17-24(3,4)27(22)18(2)28/h8-14,16H,6-7,15,17H2,1-5H3,(H,26,29)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60848
PNG
(US9174940, 11 | US9174940, 26)
Show SMILES CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2C(C)(CC1(C)C)c1ccccc1
Show InChI InChI=1/C29H31ClN2O2/c1-20(33)32-26-15-14-24(31-27(34)16-13-21-9-8-12-23(30)17-21)18-25(26)29(4,19-28(32,2)3)22-10-6-5-7-11-22/h5-12,14-15,17-18H,13,16,19H2,1-4H3,(H,31,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60872
PNG
(US9174940, 40)
Show SMILES CC(=O)N1CC[C@](C)(c2ccccc2)c2cc(NC(=O)Cc3ccc(F)c(Cl)c3)ccc12
Show InChI InChI=1/C26H24ClFN2O2/c1-17(31)30-13-12-26(2,19-6-4-3-5-7-19)21-16-20(9-11-24(21)30)29-25(32)15-18-8-10-23(28)22(27)14-18/h3-11,14,16H,12-13,15H2,1-2H3,(H,29,32)/t26-/s2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60850
PNG
(US9174940, 13)
Show SMILES CC(=O)N1c2ccc(NC(=O)NCc3ccc(Cl)cc3)cc2C(C)(CC1(C)C)c1ccccc1
Show InChI InChI=1/C28H30ClN3O2/c1-19(33)32-25-15-14-23(31-26(34)30-17-20-10-12-22(29)13-11-20)16-24(25)28(4,18-27(32,2)3)21-8-6-5-7-9-21/h5-16H,17-18H2,1-4H3,(H2,30,31,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60856
PNG
(US9174940, 29)
Show SMILES CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)OCC3CCC3)ccc12
Show InChI InChI=1/C24H28N2O3/c1-17(27)26-14-13-24(2,19-9-4-3-5-10-19)21-15-20(11-12-22(21)26)25-23(28)29-16-18-7-6-8-18/h3-5,9-12,15,18H,6-8,13-14,16H2,1-2H3,(H,25,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60851
PNG
(US9174940, 18)
Show SMILES CC(=O)N1c2ccc(NC(=O)CCc3ccc(Cl)cc3)cc2C(C)(CC1(C)C)c1ccccc1
Show InChI InChI=1/C29H31ClN2O2/c1-20(33)32-26-16-15-24(31-27(34)17-12-21-10-13-23(30)14-11-21)18-25(26)29(4,19-28(32,2)3)22-8-6-5-7-9-22/h5-11,13-16,18H,12,17,19H2,1-4H3,(H,31,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60848
PNG
(US9174940, 11 | US9174940, 26)
Show SMILES CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2C(C)(CC1(C)C)c1ccccc1
Show InChI InChI=1/C29H31ClN2O2/c1-20(33)32-26-15-14-24(31-27(34)16-13-21-9-8-12-23(30)17-21)18-25(26)29(4,19-28(32,2)3)22-10-6-5-7-11-22/h5-12,14-15,17-18H,13,16,19H2,1-4H3,(H,31,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60857
PNG
(US9174940, 30)
Show SMILES CC(C)[C@H](C)OC(=O)Nc1ccc2N(CCC(C)(c3ccccc3)c2c1)C(C)=O
Show InChI InChI=1/C24H30N2O3/c1-16(2)17(3)29-23(28)25-20-11-12-22-21(15-20)24(5,13-14-26(22)18(4)27)19-9-7-6-8-10-19/h6-12,15-17H,13-14H2,1-5H3,(H,25,28)/t17-,24?/s2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60860
PNG
(US9174940, 31)
Show SMILES CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)O[C@H]3CC4CC[C@H]3C4)ccc12
Show InChI InChI=1/C26H30N2O3/c1-17(29)28-13-12-26(2,20-6-4-3-5-7-20)22-16-21(10-11-23(22)28)27-25(30)31-24-15-18-8-9-19(24)14-18/h3-7,10-11,16,18-19,24H,8-9,12-15H2,1-2H3,(H,27,30)/t18?,19-,24-,26?/s2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60862
PNG
(BDBM189328 | US9174940, 32)
Show SMILES CC(=O)N1CCC(C)(C2C=C(NC(=O)OC3CCCC3)C=CC12)c1ccccc1
Show InChI InChI=1/C24H30N2O3/c1-17(27)26-15-14-24(2,18-8-4-3-5-9-18)21-16-19(12-13-22(21)26)25-23(28)29-20-10-6-7-11-20/h3-5,8-9,12-13,16,20-22H,6-7,10-11,14-15H2,1-2H3,(H,25,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60863
PNG
(US9174940, 33)
Show SMILES CC(=O)N1c2ccc(NC(=O)CCc3cccc(c3)C(F)(F)F)cc2C(C)(CC1(C)C)c1ccccc1
Show InChI InChI=1/C30H31F3N2O2/c1-20(36)35-26-15-14-24(34-27(37)16-13-21-9-8-12-23(17-21)30(31,32)33)18-25(26)29(4,19-28(35,2)3)22-10-6-5-7-11-22/h5-12,14-15,17-18H,13,16,19H2,1-4H3,(H,34,37)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60864
PNG
(US9174940, 34)
Show SMILES CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)Cc3ccc(F)c(Cl)c3)ccc12
Show InChI InChI=1/C26H24ClFN2O2/c1-17(31)30-13-12-26(2,19-6-4-3-5-7-19)21-16-20(9-11-24(21)30)29-25(32)15-18-8-10-23(28)22(27)14-18/h3-11,14,16H,12-13,15H2,1-2H3,(H,29,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60865
PNG
(US9174940, 35)
Show SMILES CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)c3ccc(Br)s3)ccc12
Show InChI InChI=1/C23H21BrN2O2S/c1-15(27)26-13-12-23(2,16-6-4-3-5-7-16)18-14-17(8-9-19(18)26)25-22(28)20-10-11-21(24)29-20/h3-11,14H,12-13H2,1-2H3,(H,25,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60869
PNG
(US9174940, 38)
Show SMILES CC(=O)N1c2ccc(NC(=O)CCc3cccc(c3)C(F)(F)F)cc2[C@](C)(CC1(C)C)c1ccccc1
Show InChI InChI=1/C30H31F3N2O2/c1-20(36)35-26-15-14-24(34-27(37)16-13-21-9-8-12-23(17-21)30(31,32)33)18-25(26)29(4,19-28(35,2)3)22-10-6-5-7-11-22/h5-12,14-15,17-18H,13,16,19H2,1-4H3,(H,34,37)/t29-/s2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM60870
PNG
(US9174940, 39)
Show SMILES CC(=O)N1CC[C@@](C)(C2C=C(NC(=O)OC3CCCC3)C=CC12)c1ccccc1
Show InChI InChI=1/C24H30N2O3/c1-17(27)26-15-14-24(2,18-8-4-3-5-9-18)21-16-19(12-13-22(21)26)25-23(28)29-20-10-6-7-11-20/h3-5,8-9,12-13,16,20-22H,6-7,10-11,14-15H2,1-2H3,(H,25,28)/t21?,22?,24-/s2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a<100n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM50189778
PNG
(CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...)
Show SMILES COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
Show InChI InChI=1S/C19H22N4O2S2/c1-19(2,3)23-16(24)15-13(20)12-14(10-7-6-8-11(9-10)25-4)21-18(26-5)22-17(12)27-15/h6-9H,20H2,1-5H3,(H,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 6.50E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at TSHR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)

More data for this
Ligand-Target Pair