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Found 3 hits Enz. Inhib. hit(s) with Target = 'Thyroid-stimulating hormone subunit beta (bTSH)' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thyroid-stimulating hormone subunit beta (bTSH)


(Bos taurus (Bovine))
BDBM60862
PNG
(BDBM189328 | US9174940, 32)
Show SMILES CC(=O)N1CCC(C)(C2C=C(NC(=O)OC3CCCC3)C=CC12)c1ccccc1
Show InChI InChI=1/C24H30N2O3/c1-17(27)26-15-14-24(2,18-8-4-3-5-9-18)21-16-19(12-13-22(21)26)25-23(28)29-20-10-6-7-11-20/h3-5,8-9,12-13,16,20-22H,6-7,10-11,14-15H2,1-2H3,(H,25,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 48n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone subunit beta (bTSH)


(Bos taurus (Bovine))
BDBM189329
PNG
((+)-(1-Acetyl-4-methyl-4-phenyl-1,2,3,4-tetrahydro...)
Show SMILES CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)OCc3ccc(F)c(Cl)c3)ccc12
Show InChI InChI=1/C26H24ClFN2O3/c1-17(31)30-13-12-26(2,19-6-4-3-5-7-19)21-15-20(9-11-24(21)30)29-25(32)33-16-18-8-10-23(28)22(27)14-18/h3-11,14-15H,12-13,16H2,1-2H3,(H,29,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 192n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair
Thyroid-stimulating hormone subunit beta (bTSH)


(Bos taurus (Bovine))
BDBM189327
PNG
(Hexanoic acid (Compound A) | US9174940, Compound A)
Show SMILES CC(=O)N1c2ccc(cc2C(C)(CC1(C)C)c1ccccc1)C(N)=O
Show InChI InChI=1/C21H24N2O2/c1-14(24)23-18-11-10-15(19(22)25)12-17(18)21(4,13-20(23,2)3)16-8-6-5-7-9-16/h5-12H,13H2,1-4H3,(H2,22,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 368n/an/an/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...


US Patent US9174940 (2015)

More data for this
Ligand-Target Pair